CA2601702A1 - 2, 4, 5-substituted piperidines as renin inhibitors - Google Patents

2, 4, 5-substituted piperidines as renin inhibitors Download PDF

Info

Publication number
CA2601702A1
CA2601702A1 CA002601702A CA2601702A CA2601702A1 CA 2601702 A1 CA2601702 A1 CA 2601702A1 CA 002601702 A CA002601702 A CA 002601702A CA 2601702 A CA2601702 A CA 2601702A CA 2601702 A1 CA2601702 A1 CA 2601702A1
Authority
CA
Canada
Prior art keywords
methoxy
alkyl
alkoxy
propyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002601702A
Other languages
English (en)
French (fr)
Inventor
Peter Herold
Robert Mah
Vincenzo Tschinke
Christiane Marti
Stefan Stutz
Stjepan Jelakovic
Frank Hollinger
Zenon D. Konteatis
Jennifer L. Ludington
Michael Quirmbach
Aleksandar Stojanovic
Dirk Behnke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Speedel Experimenta AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2601702A1 publication Critical patent/CA2601702A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
CA002601702A 2005-03-31 2006-03-30 2, 4, 5-substituted piperidines as renin inhibitors Abandoned CA2601702A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US66655605P 2005-03-31 2005-03-31
US60/666,556 2005-03-31
US75085305P 2005-12-16 2005-12-16
US60/750,853 2005-12-16
PCT/EP2006/061197 WO2006103277A2 (en) 2005-03-31 2006-03-30 2 , 4 , 5-substituted piperidines as renin inhibitors

Publications (1)

Publication Number Publication Date
CA2601702A1 true CA2601702A1 (en) 2006-10-05

Family

ID=36586065

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002601702A Abandoned CA2601702A1 (en) 2005-03-31 2006-03-30 2, 4, 5-substituted piperidines as renin inhibitors

Country Status (13)

Country Link
US (2) US20100029628A1 (cg-RX-API-DMAC7.html)
EP (1) EP1863803B1 (cg-RX-API-DMAC7.html)
JP (2) JP2008534558A (cg-RX-API-DMAC7.html)
AR (2) AR055756A1 (cg-RX-API-DMAC7.html)
AT (1) ATE479681T1 (cg-RX-API-DMAC7.html)
BR (2) BRPI0608758A2 (cg-RX-API-DMAC7.html)
CA (1) CA2601702A1 (cg-RX-API-DMAC7.html)
DE (1) DE602006016573D1 (cg-RX-API-DMAC7.html)
IL (2) IL186130A0 (cg-RX-API-DMAC7.html)
PL (1) PL1863803T3 (cg-RX-API-DMAC7.html)
PT (1) PT1863803E (cg-RX-API-DMAC7.html)
TW (2) TW200716622A (cg-RX-API-DMAC7.html)
WO (1) WO2006103277A2 (cg-RX-API-DMAC7.html)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE462703T1 (de) 2004-08-25 2010-04-15 Actelion Pharmaceuticals Ltd Bicyclononen-derivate als renin-inhibitoren
TW200716622A (en) * 2005-03-31 2007-05-01 Speedel Experimenta Ag Substituted piperidines
JP4297972B2 (ja) 2005-05-27 2009-07-15 アクテリオン ファーマシューティカルズ リミテッド 新規なピペリジンカルボン酸アミド誘導体
GB0514203D0 (en) 2005-07-11 2005-08-17 Novartis Ag Organic compounds
ES2373792T3 (es) 2006-05-19 2012-02-08 Abbott Laboratories Derivados de alcanos azabicíclicos sustituidos con bicicloheterociclo condensado activos en el snc.
JP2009539806A (ja) * 2006-06-08 2009-11-19 シュペーデル・エクスペリメンタ・アーゲー ２，５−二置換ピペリジン
TW200821303A (en) * 2006-08-08 2008-05-16 Speedel Experimenta Ag Organic compounds
EP1958634A3 (en) * 2007-02-14 2008-09-24 Speedel Experimenta AG Substituted piperidines as inhibitors of beta-secretase, cathepsin D, plasmepsin II and/or HIV protease
AR069005A1 (es) * 2007-10-25 2009-12-23 Speedel Experimenta Ag Piperidinas 4,4-disustituidas
EA201000720A1 (ru) * 2007-11-02 2010-10-29 Новартис Аг 4,4-дизамещённые пиперидины как ингибиторы ренина
AU2008339351B2 (en) 2007-12-19 2013-02-28 Sumitomo Dainippon Pharma Co., Ltd. Bicyclic heterocyclic derivative
WO2009098275A1 (en) * 2008-02-08 2009-08-13 Novartis Ag Substituted piperidines as renin inhibitors
BRPI0907933A2 (pt) 2008-02-08 2015-07-28 Novartis Ag Pepiridinas substituídas como inibidoras da renina
PL2274295T3 (pl) 2008-05-05 2016-01-29 Idorsia Pharmaceuticals Ltd 3,4–podstawione pochodne piperydyny jako inhibitory reniny
EP2163245A1 (en) 2008-09-10 2010-03-17 Novartis Ag Renin inhibitors for the treatment of psoriasis
WO2010132873A2 (en) 2009-05-15 2010-11-18 Northwestern University Chiral pyrrolidine core compounds en route to inhibitors of nitric oxide synthase
US8658639B2 (en) 2009-06-24 2014-02-25 Dainippon Sumitomo Pharma Co., Ltd N-substituted-cyclic amino derivative
AU2016205036B2 (en) * 2015-01-09 2019-12-19 J.W. Speaker Corporation Tracking and lighting systems and methods for a vehicle
DE102015013191A1 (de) * 2015-10-10 2017-04-13 Daimler Ag Verfahren zum Betrieb einer Leuchteinheit und Leuchteinheit

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2167865C2 (ru) * 1995-09-07 2001-05-27 Ф. Хоффманн-Ля Рош Аг Производные пиперидина, способ их получения, фармацевтическая композиция на их основе и промежуточные вещества
US6197959B1 (en) * 1999-04-27 2001-03-06 Hoffmann-La Roche Inc. Piperidine derivatives
US6376672B1 (en) * 1999-04-27 2002-04-23 Hoffmann-La Roche Inc. Naphthalenylmethoxypiperidines as renin inhibitors
US20040204455A1 (en) * 2003-04-10 2004-10-14 Cody Wayne Livingston Piperidine derivative rennin inhibitors
TW200716622A (en) * 2005-03-31 2007-05-01 Speedel Experimenta Ag Substituted piperidines

Also Published As

Publication number Publication date
EP1863803A2 (en) 2007-12-12
US20100029628A1 (en) 2010-02-04
IL189429A0 (en) 2008-06-05
BRPI0621969A2 (pt) 2011-07-19
PL1863803T3 (pl) 2011-02-28
BRPI0608758A2 (pt) 2009-07-07
IL186130A0 (en) 2008-01-20
AR055756A1 (es) 2007-09-05
TW200833687A (en) 2008-08-16
WO2006103277A3 (en) 2006-12-28
JP2008201787A (ja) 2008-09-04
AR065188A2 (es) 2009-05-20
JP2008534558A (ja) 2008-08-28
US7687495B2 (en) 2010-03-30
DE602006016573D1 (de) 2010-10-14
WO2006103277A2 (en) 2006-10-05
EP1863803B1 (en) 2010-09-01
PT1863803E (pt) 2010-11-18
ATE479681T1 (de) 2010-09-15
TW200716622A (en) 2007-05-01
US20080171748A1 (en) 2008-07-17

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20130402