CA2598889A1 - Compositions and methods for classifying biological samples - Google Patents
Compositions and methods for classifying biological samples Download PDFInfo
- Publication number
- CA2598889A1 CA2598889A1 CA002598889A CA2598889A CA2598889A1 CA 2598889 A1 CA2598889 A1 CA 2598889A1 CA 002598889 A CA002598889 A CA 002598889A CA 2598889 A CA2598889 A CA 2598889A CA 2598889 A1 CA2598889 A1 CA 2598889A1
- Authority
- CA
- Canada
- Prior art keywords
- epitopes
- class
- sample
- samples
- nsclc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 title claims description 87
- 239000012472 biological sample Substances 0.000 title claims description 13
- 239000000203 mixture Substances 0.000 title description 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 94
- 230000027455 binding Effects 0.000 claims description 249
- 239000000523 sample Substances 0.000 claims description 186
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 54
- 238000002493 microarray Methods 0.000 claims description 51
- 238000001514 detection method Methods 0.000 abstract description 15
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 165
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 164
- 206010028980 Neoplasm Diseases 0.000 description 121
- 206010041067 Small cell lung cancer Diseases 0.000 description 115
- 208000000587 small cell lung carcinoma Diseases 0.000 description 115
- 238000003359 percent control normalization Methods 0.000 description 99
- 201000011510 cancer Diseases 0.000 description 97
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 52
- 108090000623 proteins and genes Proteins 0.000 description 52
- 201000010099 disease Diseases 0.000 description 50
- 102000004169 proteins and genes Human genes 0.000 description 46
- 235000018102 proteins Nutrition 0.000 description 44
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 39
- 201000005202 lung cancer Diseases 0.000 description 39
- 208000020816 lung neoplasm Diseases 0.000 description 39
- 208000026310 Breast neoplasm Diseases 0.000 description 38
- 206010006187 Breast cancer Diseases 0.000 description 37
- 230000000875 corresponding effect Effects 0.000 description 33
- 239000013598 vector Substances 0.000 description 27
- 238000009739 binding Methods 0.000 description 25
- 238000004458 analytical method Methods 0.000 description 22
- 238000004422 calculation algorithm Methods 0.000 description 22
- 210000002966 serum Anatomy 0.000 description 18
- 108091007433 antigens Proteins 0.000 description 16
- 102000036639 antigens Human genes 0.000 description 16
- 238000003909 pattern recognition Methods 0.000 description 16
- 239000000427 antigen Substances 0.000 description 15
- 238000003745 diagnosis Methods 0.000 description 14
- 238000012549 training Methods 0.000 description 14
- 238000011282 treatment Methods 0.000 description 13
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 238000002790 cross-validation Methods 0.000 description 12
- 229940079593 drug Drugs 0.000 description 12
- 239000003814 drug Substances 0.000 description 12
- 238000012706 support-vector machine Methods 0.000 description 11
- 210000002381 plasma Anatomy 0.000 description 10
- 230000004083 survival effect Effects 0.000 description 10
- 241000282414 Homo sapiens Species 0.000 description 9
- 238000012360 testing method Methods 0.000 description 9
- 102000040945 Transcription factor Human genes 0.000 description 8
- 108091023040 Transcription factor Proteins 0.000 description 8
- 230000006870 function Effects 0.000 description 8
- 230000004044 response Effects 0.000 description 8
- 238000000692 Student's t-test Methods 0.000 description 7
- 230000003247 decreasing effect Effects 0.000 description 7
- 230000014509 gene expression Effects 0.000 description 7
- 238000010606 normalization Methods 0.000 description 7
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 229920001213 Polysorbate 20 Polymers 0.000 description 6
- 238000003491 array Methods 0.000 description 6
- 230000002860 competitive effect Effects 0.000 description 6
- 108020004999 messenger RNA Proteins 0.000 description 6
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 6
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 6
- 102100028796 Chromosome transmission fidelity protein 18 homolog Human genes 0.000 description 5
- 102100024827 Dynamin-1-like protein Human genes 0.000 description 5
- 101000721661 Homo sapiens Cellular tumor antigen p53 Proteins 0.000 description 5
- 101000916387 Homo sapiens Chromosome transmission fidelity protein 18 homolog Proteins 0.000 description 5
- 101000973629 Homo sapiens Ribosome quality control complex subunit NEMF Proteins 0.000 description 5
- 102100022213 Ribosome quality control complex subunit NEMF Human genes 0.000 description 5
- 238000013528 artificial neural network Methods 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 210000000481 breast Anatomy 0.000 description 5
- 230000002596 correlated effect Effects 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 238000001914 filtration Methods 0.000 description 5
- 102100030840 AT-rich interactive domain-containing protein 4B Human genes 0.000 description 4
- 102100026337 BAI1-associated protein 3 Human genes 0.000 description 4
- 101710049498 BAIAP3 Proteins 0.000 description 4
- 102100033641 Bromodomain-containing protein 2 Human genes 0.000 description 4
- 102100021999 Cytosolic Fe-S cluster assembly factor NUBP2 Human genes 0.000 description 4
- 101000792935 Homo sapiens AT-rich interactive domain-containing protein 4B Proteins 0.000 description 4
- 101000909218 Homo sapiens Dynamin-1-like protein Proteins 0.000 description 4
- 102100040544 Hydroxyacylglutathione hydrolase, mitochondrial Human genes 0.000 description 4
- 206010020772 Hypertension Diseases 0.000 description 4
- 102100026758 Serine/threonine-protein kinase 16 Human genes 0.000 description 4
- 210000003719 b-lymphocyte Anatomy 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 230000002163 immunogen Effects 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 3
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 3
- 208000023275 Autoimmune disease Diseases 0.000 description 3
- 102100038415 ELKS/Rab6-interacting/CAST family member 1 Human genes 0.000 description 3
- 102100025654 Endosome-associated-trafficking regulator 1 Human genes 0.000 description 3
- 102000000805 Galectin 4 Human genes 0.000 description 3
- 108010001515 Galectin 4 Proteins 0.000 description 3
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 description 3
- 101000871850 Homo sapiens Bromodomain-containing protein 2 Proteins 0.000 description 3
- 101001056455 Homo sapiens Endosome-associated-trafficking regulator 1 Proteins 0.000 description 3
- 101000961707 Homo sapiens Enoyl-[acyl-carrier-protein] reductase, mitochondrial Proteins 0.000 description 3
- 101000628578 Homo sapiens Serine/threonine-protein kinase 16 Proteins 0.000 description 3
- 101000889087 Homo sapiens Spliceosome-associated protein CWC27 homolog Proteins 0.000 description 3
- 101000671653 Homo sapiens U3 small nucleolar RNA-associated protein 14 homolog A Proteins 0.000 description 3
- 108700018351 Major Histocompatibility Complex Proteins 0.000 description 3
- 102100038995 Nischarin Human genes 0.000 description 3
- 206010060862 Prostate cancer Diseases 0.000 description 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 3
- 102100030000 Recombining binding protein suppressor of hairless Human genes 0.000 description 3
- 102100037221 Serologically defined colon cancer antigen 8 Human genes 0.000 description 3
- 102100039667 Solute carrier family 2, facilitated glucose transporter member 11 Human genes 0.000 description 3
- 102100039430 Spliceosome-associated protein CWC27 homolog Human genes 0.000 description 3
- 102100040099 U3 small nucleolar RNA-associated protein 14 homolog A Human genes 0.000 description 3
- 102100028431 Zinc finger protein 292 Human genes 0.000 description 3
- 230000000259 anti-tumor effect Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000002512 chemotherapy Methods 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 239000002131 composite material Substances 0.000 description 3
- 238000005094 computer simulation Methods 0.000 description 3
- 238000007405 data analysis Methods 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 208000019622 heart disease Diseases 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 3
- 230000008105 immune reaction Effects 0.000 description 3
- 230000028993 immune response Effects 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 239000003550 marker Substances 0.000 description 3
- 208000037819 metastatic cancer Diseases 0.000 description 3
- 208000011575 metastatic malignant neoplasm Diseases 0.000 description 3
- 230000001537 neural effect Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000011002 quantification Methods 0.000 description 3
- 230000035939 shock Effects 0.000 description 3
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 3
- 238000012353 t test Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 102100040084 A-kinase anchor protein 9 Human genes 0.000 description 2
- 102100034527 AP-1 complex subunit gamma-like 2 Human genes 0.000 description 2
- 102100028704 Acetyl-CoA acetyltransferase, cytosolic Human genes 0.000 description 2
- 102100029589 Acylpyruvase FAHD1, mitochondrial Human genes 0.000 description 2
- 102100020775 Adenylosuccinate lyase Human genes 0.000 description 2
- 102100040359 Angiomotin-like protein 2 Human genes 0.000 description 2
- 102100036822 Ankyrin repeat and KH domain-containing protein 1 Human genes 0.000 description 2
- 102100034614 Ankyrin repeat domain-containing protein 11 Human genes 0.000 description 2
- 102100034609 Ankyrin repeat domain-containing protein 17 Human genes 0.000 description 2
- 102100037211 Aryl hydrocarbon receptor nuclear translocator-like protein 1 Human genes 0.000 description 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 2
- 102000007371 Ataxin-3 Human genes 0.000 description 2
- 108010032947 Ataxin-3 Proteins 0.000 description 2
- 102100026008 Breakpoint cluster region protein Human genes 0.000 description 2
- 102100037397 Casein kinase I isoform gamma-1 Human genes 0.000 description 2
- 102100035673 Centrosomal protein of 290 kDa Human genes 0.000 description 2
- 102100023506 Chloride intracellular channel protein 6 Human genes 0.000 description 2
- 102100031725 Cortactin-binding protein 2 Human genes 0.000 description 2
- 101710139686 Cytosolic Fe-S cluster assembly factor NUBP2 Proteins 0.000 description 2
- 102100029587 DDB1- and CUL4-associated factor 6 Human genes 0.000 description 2
- 102100024441 Dihydropyrimidinase-related protein 5 Human genes 0.000 description 2
- 102100035966 DnaJ homolog subfamily A member 2 Human genes 0.000 description 2
- 102100040856 Dual specificity protein kinase CLK3 Human genes 0.000 description 2
- 102100037334 E3 ubiquitin-protein ligase CHIP Human genes 0.000 description 2
- 102100031418 EF-hand domain-containing protein D2 Human genes 0.000 description 2
- 102100034235 ELAV-like protein 1 Human genes 0.000 description 2
- 102100021664 ELAV-like protein 3 Human genes 0.000 description 2
- 102100021665 ELAV-like protein 4 Human genes 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- 102100039327 Enoyl-[acyl-carrier-protein] reductase, mitochondrial Human genes 0.000 description 2
- 102100026063 Exosome complex component MTR3 Human genes 0.000 description 2
- 102100026059 Exosome complex component RRP45 Human genes 0.000 description 2
- 102100026060 Exosome component 10 Human genes 0.000 description 2
- 102100021066 Fibroblast growth factor receptor substrate 2 Human genes 0.000 description 2
- 102100029115 Fumarylacetoacetase Human genes 0.000 description 2
- 102100039632 Glioma pathogenesis-related protein 1 Human genes 0.000 description 2
- 102100035857 Glutamate decarboxylase 2 Human genes 0.000 description 2
- 102100032564 Golgin subfamily A member 2 Human genes 0.000 description 2
- 102100032560 Golgin subfamily A member 4 Human genes 0.000 description 2
- 102100028976 HLA class I histocompatibility antigen, B alpha chain Human genes 0.000 description 2
- 102100028971 HLA class I histocompatibility antigen, C alpha chain Human genes 0.000 description 2
- 102100028765 Heat shock 70 kDa protein 4 Human genes 0.000 description 2
- 102100034051 Heat shock protein HSP 90-alpha Human genes 0.000 description 2
- 102100035617 Heterogeneous nuclear ribonucleoprotein A/B Human genes 0.000 description 2
- 102100021453 Histone deacetylase 5 Human genes 0.000 description 2
- 101000833679 Homo sapiens A-kinase anchor protein 13 Proteins 0.000 description 2
- 101000890598 Homo sapiens A-kinase anchor protein 9 Proteins 0.000 description 2
- 101000924648 Homo sapiens AP-1 complex subunit gamma-like 2 Proteins 0.000 description 2
- 101000837584 Homo sapiens Acetyl-CoA acetyltransferase, cytosolic Proteins 0.000 description 2
- 101000917337 Homo sapiens Acylpyruvase FAHD1, mitochondrial Proteins 0.000 description 2
- 101000891151 Homo sapiens Angiomotin-like protein 2 Proteins 0.000 description 2
- 101000928335 Homo sapiens Ankyrin repeat and KH domain-containing protein 1 Proteins 0.000 description 2
- 101000924481 Homo sapiens Ankyrin repeat domain-containing protein 17 Proteins 0.000 description 2
- 101000740484 Homo sapiens Aryl hydrocarbon receptor nuclear translocator-like protein 1 Proteins 0.000 description 2
- 101001026384 Homo sapiens Casein kinase I isoform gamma-1 Proteins 0.000 description 2
- 101000906631 Homo sapiens Chloride intracellular channel protein 6 Proteins 0.000 description 2
- 101001107795 Homo sapiens Cytosolic Fe-S cluster assembly factor NUBP2 Proteins 0.000 description 2
- 101000917420 Homo sapiens DDB1- and CUL4-associated factor 6 Proteins 0.000 description 2
- 101001053479 Homo sapiens Dihydropyrimidinase-related protein 5 Proteins 0.000 description 2
- 101000931210 Homo sapiens DnaJ homolog subfamily A member 2 Proteins 0.000 description 2
- 101000879619 Homo sapiens E3 ubiquitin-protein ligase CHIP Proteins 0.000 description 2
- 101000866913 Homo sapiens EF-hand domain-containing protein D2 Proteins 0.000 description 2
- 101000888759 Homo sapiens Glioma pathogenesis-related protein 1 Proteins 0.000 description 2
- 101001014629 Homo sapiens Golgin subfamily A member 2 Proteins 0.000 description 2
- 101001014636 Homo sapiens Golgin subfamily A member 4 Proteins 0.000 description 2
- 101001078692 Homo sapiens Heat shock 70 kDa protein 4 Proteins 0.000 description 2
- 101001016865 Homo sapiens Heat shock protein HSP 90-alpha Proteins 0.000 description 2
- 101001040270 Homo sapiens Hydroxyacylglutathione hydrolase, mitochondrial Proteins 0.000 description 2
- 101001068011 Homo sapiens Hydroxyacylglutathione hydrolase-like protein Proteins 0.000 description 2
- 101000990976 Homo sapiens Mitochondrial Rho GTPase 2 Proteins 0.000 description 2
- 101001072477 Homo sapiens N-acetylglucosamine-1-phosphotransferase subunit gamma Proteins 0.000 description 2
- 101000637249 Homo sapiens Nexilin Proteins 0.000 description 2
- 101000603223 Homo sapiens Nischarin Proteins 0.000 description 2
- 101001107586 Homo sapiens Nuclear pore complex protein Nup107 Proteins 0.000 description 2
- 101001003584 Homo sapiens Prelamin-A/C Proteins 0.000 description 2
- 101001099586 Homo sapiens Pyridoxal kinase Proteins 0.000 description 2
- 101001076715 Homo sapiens RNA-binding protein 39 Proteins 0.000 description 2
- 101000584743 Homo sapiens Recombining binding protein suppressor of hairless Proteins 0.000 description 2
- 101001092206 Homo sapiens Replication protein A 32 kDa subunit Proteins 0.000 description 2
- 101000740529 Homo sapiens Serologically defined colon cancer antigen 8 Proteins 0.000 description 2
- 101000739205 Homo sapiens Small G protein signaling modulator 3 Proteins 0.000 description 2
- 101000653533 Homo sapiens Telomerase Cajal body protein 1 Proteins 0.000 description 2
- 101000687911 Homo sapiens Transcription factor SOX-3 Proteins 0.000 description 2
- 101000642528 Homo sapiens Transcription factor SOX-8 Proteins 0.000 description 2
- 101000795074 Homo sapiens Tryptase alpha/beta-1 Proteins 0.000 description 2
- 101000796737 Homo sapiens Tryptase delta Proteins 0.000 description 2
- 101000823782 Homo sapiens Y-box-binding protein 3 Proteins 0.000 description 2
- 101000723761 Homo sapiens Zinc finger protein 28 Proteins 0.000 description 2
- 101000723902 Homo sapiens Zinc finger protein 292 Proteins 0.000 description 2
- 101000744322 Homo sapiens eIF5-mimic protein 1 Proteins 0.000 description 2
- 102100034468 Hydroxyacylglutathione hydrolase-like protein Human genes 0.000 description 2
- 102100033421 Keratin, type I cytoskeletal 18 Human genes 0.000 description 2
- 102100024299 Maternal embryonic leucine zipper kinase Human genes 0.000 description 2
- 101710154611 Maternal embryonic leucine zipper kinase Proteins 0.000 description 2
- 102100028389 Melanoma antigen recognized by T-cells 1 Human genes 0.000 description 2
- 102100030325 Mitochondrial Rho GTPase 2 Human genes 0.000 description 2
- 102100036713 N-acetylglucosamine-1-phosphotransferase subunit gamma Human genes 0.000 description 2
- 102100031801 Nexilin Human genes 0.000 description 2
- 102000007999 Nuclear Proteins Human genes 0.000 description 2
- 108010089610 Nuclear Proteins Proteins 0.000 description 2
- 102100035397 Nuclear factor related to kappa-B-binding protein Human genes 0.000 description 2
- 102100021976 Nuclear pore complex protein Nup107 Human genes 0.000 description 2
- 101150042165 Ogfr gene Proteins 0.000 description 2
- 102100026949 Opioid growth factor receptor Human genes 0.000 description 2
- 108010067902 Peptide Library Proteins 0.000 description 2
- 102100026531 Prelamin-A/C Human genes 0.000 description 2
- 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 description 2
- 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 description 2
- 102100038517 Pyridoxal kinase Human genes 0.000 description 2
- 102100039692 RNA-binding motif, single-stranded-interacting protein 1 Human genes 0.000 description 2
- 102100027478 RNA-binding protein 25 Human genes 0.000 description 2
- 102100025858 RNA-binding protein 39 Human genes 0.000 description 2
- 102100035525 Replication protein A 32 kDa subunit Human genes 0.000 description 2
- 102100039314 Rho-associated protein kinase 2 Human genes 0.000 description 2
- 108091006306 SLC2A11 Proteins 0.000 description 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 2
- 102100037275 Small G protein signaling modulator 3 Human genes 0.000 description 2
- 102100021588 Sterol carrier protein 2 Human genes 0.000 description 2
- 102100030629 Telomerase Cajal body protein 1 Human genes 0.000 description 2
- 102100024276 Transcription factor SOX-3 Human genes 0.000 description 2
- 102100036731 Transcription factor SOX-8 Human genes 0.000 description 2
- 102100026002 Transcription factor TFIIIB component B'' homolog Human genes 0.000 description 2
- 102100029639 Tryptase alpha/beta-1 Human genes 0.000 description 2
- 102100032760 Tryptase delta Human genes 0.000 description 2
- 102100022221 Y-box-binding protein 3 Human genes 0.000 description 2
- 102100028399 Zinc finger protein 28 Human genes 0.000 description 2
- 229960001138 acetylsalicylic acid Drugs 0.000 description 2
- 239000012190 activator Substances 0.000 description 2
- 230000004075 alteration Effects 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 210000003793 centrosome Anatomy 0.000 description 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 2
- 210000000038 chest Anatomy 0.000 description 2
- 238000004737 colorimetric analysis Methods 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 230000004069 differentiation Effects 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 102100039119 eIF5-mimic protein 1 Human genes 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 108010022687 fumarylacetoacetase Proteins 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000028996 humoral immune response Effects 0.000 description 2
- 108010025042 hydroxyacylglutathione hydrolase Proteins 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 210000001161 mammalian embryo Anatomy 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 108091005601 modified peptides Proteins 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 210000000653 nervous system Anatomy 0.000 description 2
- 230000000683 nonmetastatic effect Effects 0.000 description 2
- 238000001558 permutation test Methods 0.000 description 2
- 229920000136 polysorbate Polymers 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- 238000004393 prognosis Methods 0.000 description 2
- 108700042226 ras Genes Proteins 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000013207 serial dilution Methods 0.000 description 2
- 230000000391 smoking effect Effects 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 210000001179 synovial fluid Anatomy 0.000 description 2
- 210000001550 testis Anatomy 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- UJCHIZDEQZMODR-BYPYZUCNSA-N (2r)-2-acetamido-3-sulfanylpropanamide Chemical compound CC(=O)N[C@@H](CS)C(N)=O UJCHIZDEQZMODR-BYPYZUCNSA-N 0.000 description 1
- AHOKKYCUWBLDST-QYULHYBRSA-N (2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[2-[[(2s)-2-[[(2s,3s)-2-[[(2s)-2,6-diaminohexanoyl]amino]-3-methylpentanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)[C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=CC=C1 AHOKKYCUWBLDST-QYULHYBRSA-N 0.000 description 1
- AGGRGODMKWLSDE-UHFFFAOYSA-N 1-[2,4,6-tri(propan-2-yl)phenyl]sulfonylimidazole Chemical compound CC(C)C1=CC(C(C)C)=CC(C(C)C)=C1S(=O)(=O)N1C=NC=C1 AGGRGODMKWLSDE-UHFFFAOYSA-N 0.000 description 1
- IDLAOWFFKWRNHB-UHFFFAOYSA-N 4,5,6,7-tetrachloroindene-1,3-dione Chemical compound ClC1=C(Cl)C(Cl)=C2C(=O)CC(=O)C2=C1Cl IDLAOWFFKWRNHB-UHFFFAOYSA-N 0.000 description 1
- 102100030310 5,6-dihydroxyindole-2-carboxylic acid oxidase Human genes 0.000 description 1
- 101710163881 5,6-dihydroxyindole-2-carboxylic acid oxidase Proteins 0.000 description 1
- QRXMUCSWCMTJGU-UHFFFAOYSA-N 5-bromo-4-chloro-3-indolyl phosphate Chemical compound C1=C(Br)C(Cl)=C2C(OP(O)(=O)O)=CNC2=C1 QRXMUCSWCMTJGU-UHFFFAOYSA-N 0.000 description 1
- 102100024049 A-kinase anchor protein 13 Human genes 0.000 description 1
- 101150012579 ADSL gene Proteins 0.000 description 1
- 108091006112 ATPases Proteins 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 108010085371 Activating Transcription Factor 3 Proteins 0.000 description 1
- 101710105037 Activating signal cointegrator 1 complex subunit 3-like Proteins 0.000 description 1
- 102000057290 Adenosine Triphosphatases Human genes 0.000 description 1
- 108700040193 Adenylosuccinate lyases Proteins 0.000 description 1
- 102100037399 Alanine-tRNA ligase, cytoplasmic Human genes 0.000 description 1
- 102100032959 Alpha-actinin-4 Human genes 0.000 description 1
- 101710115256 Alpha-actinin-4 Proteins 0.000 description 1
- 208000037540 Alveolar soft tissue sarcoma Diseases 0.000 description 1
- 102100037242 Amiloride-sensitive sodium channel subunit alpha Human genes 0.000 description 1
- 101710188804 Ankyrin repeat domain-containing protein 11 Proteins 0.000 description 1
- 102100034270 Ankyrin repeat domain-containing protein 13A Human genes 0.000 description 1
- 102100023003 Ankyrin repeat domain-containing protein 30A Human genes 0.000 description 1
- 108010049777 Ankyrins Proteins 0.000 description 1
- 102000008102 Ankyrins Human genes 0.000 description 1
- 102100034613 Annexin A2 Human genes 0.000 description 1
- 108090000668 Annexin A2 Proteins 0.000 description 1
- 102100037435 Antiviral innate immune response receptor RIG-I Human genes 0.000 description 1
- 101100465060 Arabidopsis thaliana PRK4 gene Proteins 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 102100022045 BTB/POZ domain-containing protein 10 Human genes 0.000 description 1
- 102100021663 Baculoviral IAP repeat-containing protein 5 Human genes 0.000 description 1
- 102100032441 Beta-1,3-galactosyltransferase 4 Human genes 0.000 description 1
- 102000015735 Beta-catenin Human genes 0.000 description 1
- 108060000903 Beta-catenin Proteins 0.000 description 1
- 101150108242 CDC27 gene Proteins 0.000 description 1
- 102000000905 Cadherin Human genes 0.000 description 1
- 108050007957 Cadherin Proteins 0.000 description 1
- 101100257359 Caenorhabditis elegans sox-2 gene Proteins 0.000 description 1
- 101710167800 Capsid assembly scaffolding protein Proteins 0.000 description 1
- 101710134389 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 Proteins 0.000 description 1
- 208000005623 Carcinogenesis Diseases 0.000 description 1
- 102100028003 Catenin alpha-1 Human genes 0.000 description 1
- 108010067316 Catenins Proteins 0.000 description 1
- 102000016362 Catenins Human genes 0.000 description 1
- 101710198317 Centrosomal protein of 290 kDa Proteins 0.000 description 1
- 108091006146 Channels Proteins 0.000 description 1
- 102000011591 Cleavage And Polyadenylation Specificity Factor Human genes 0.000 description 1
- 108010076130 Cleavage And Polyadenylation Specificity Factor Proteins 0.000 description 1
- 108010067499 Clk dual-specificity kinases Proteins 0.000 description 1
- 102100031552 Coactosin-like protein Human genes 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 108010037663 Cortactin Proteins 0.000 description 1
- 102000010958 Cortactin Human genes 0.000 description 1
- 101710113312 Cortactin-binding protein 2 Proteins 0.000 description 1
- 241000557626 Corvus corax Species 0.000 description 1
- 102100023032 Cyclic AMP-dependent transcription factor ATF-3 Human genes 0.000 description 1
- 108010072210 Cyclophilin C Proteins 0.000 description 1
- 102100037373 DNA-(apurinic or apyrimidinic site) endonuclease Human genes 0.000 description 1
- 101710109420 DNA-(apurinic or apyrimidinic site) endonuclease Proteins 0.000 description 1
- 102100020977 DnaJ homolog subfamily A member 1 Human genes 0.000 description 1
- 102100029721 DnaJ homolog subfamily B member 1 Human genes 0.000 description 1
- 102100039104 Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit DAD1 Human genes 0.000 description 1
- 241001669680 Dormitator maculatus Species 0.000 description 1
- 102100037573 Dual specificity protein phosphatase 12 Human genes 0.000 description 1
- 102000002266 Dual-Specificity Phosphatases Human genes 0.000 description 1
- 108010000518 Dual-Specificity Phosphatases Proteins 0.000 description 1
- 101710109538 Dynamin-1-like protein Proteins 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 108010053101 ELAV Proteins Proteins 0.000 description 1
- 102000016662 ELAV Proteins Human genes 0.000 description 1
- 102100034234 ELAV-like protein 2 Human genes 0.000 description 1
- 101710180090 ELKS/Rab6-interacting/CAST family member 1 Proteins 0.000 description 1
- 102100030808 Elongation factor 1-delta Human genes 0.000 description 1
- 102100031334 Elongation factor 2 Human genes 0.000 description 1
- 102100039246 Elongator complex protein 1 Human genes 0.000 description 1
- 102100021579 Enhancer of filamentation 1 Human genes 0.000 description 1
- 108010055191 EphA3 Receptor Proteins 0.000 description 1
- 102100030324 Ephrin type-A receptor 3 Human genes 0.000 description 1
- 102100036816 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A Human genes 0.000 description 1
- 101710141178 Exosome complex component MTR3 Proteins 0.000 description 1
- 101710120484 Exosome complex component RRP45 Proteins 0.000 description 1
- 102100038975 Exosome complex component RRP46 Human genes 0.000 description 1
- 101710092832 Exosome component 10 Proteins 0.000 description 1
- 102100028166 FACT complex subunit SSRP1 Human genes 0.000 description 1
- 101710126950 Fibroblast growth factor receptor substrate 2 Proteins 0.000 description 1
- 102100036552 GATOR complex protein WDR24 Human genes 0.000 description 1
- 102000013446 GTP Phosphohydrolases Human genes 0.000 description 1
- 101710113436 GTPase KRas Proteins 0.000 description 1
- 102100039788 GTPase NRas Human genes 0.000 description 1
- 108091006109 GTPases Proteins 0.000 description 1
- 108010012015 GVYDGREHTV Proteins 0.000 description 1
- 102100032864 General transcription factor IIH subunit 2 Human genes 0.000 description 1
- 102000018899 Glutamate Receptors Human genes 0.000 description 1
- 108010027915 Glutamate Receptors Proteins 0.000 description 1
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 description 1
- 108010052778 Golgi Matrix Proteins Proteins 0.000 description 1
- 102000018884 Golgi Matrix Proteins Human genes 0.000 description 1
- 102100032563 Golgin subfamily A member 1 Human genes 0.000 description 1
- 102100041033 Golgin subfamily B member 1 Human genes 0.000 description 1
- 102000009465 Growth Factor Receptors Human genes 0.000 description 1
- 108010009202 Growth Factor Receptors Proteins 0.000 description 1
- 102100021185 Guanine nucleotide-binding protein-like 3 Human genes 0.000 description 1
- 101710147092 Guanine nucleotide-binding protein-like 3 Proteins 0.000 description 1
- 101710142296 HLA class I histocompatibility antigen, B alpha chain Proteins 0.000 description 1
- 108010058607 HLA-B Antigens Proteins 0.000 description 1
- 108010052199 HLA-C Antigens Proteins 0.000 description 1
- 101710156363 Heterogeneous nuclear ribonucleoprotein A/B Proteins 0.000 description 1
- 108050004676 Histone deacetylase 5 Proteins 0.000 description 1
- 101000879354 Homo sapiens Alanine-tRNA ligase, cytoplasmic Proteins 0.000 description 1
- 101000740448 Homo sapiens Amiloride-sensitive sodium channel subunit alpha Proteins 0.000 description 1
- 101000924476 Homo sapiens Ankyrin repeat domain-containing protein 11 Proteins 0.000 description 1
- 101000780149 Homo sapiens Ankyrin repeat domain-containing protein 13A Proteins 0.000 description 1
- 101000757191 Homo sapiens Ankyrin repeat domain-containing protein 30A Proteins 0.000 description 1
- 101000952099 Homo sapiens Antiviral innate immune response receptor RIG-I Proteins 0.000 description 1
- 101000896834 Homo sapiens BTB/POZ domain-containing protein 10 Proteins 0.000 description 1
- 101000798401 Homo sapiens Beta-1,3-galactosyltransferase 4 Proteins 0.000 description 1
- 101000859063 Homo sapiens Catenin alpha-1 Proteins 0.000 description 1
- 101000715664 Homo sapiens Centrosomal protein of 290 kDa Proteins 0.000 description 1
- 101000940352 Homo sapiens Coactosin-like protein Proteins 0.000 description 1
- 101000941045 Homo sapiens Cortactin-binding protein 2 Proteins 0.000 description 1
- 101000650600 Homo sapiens DNA-directed RNA polymerase I subunit RPA2 Proteins 0.000 description 1
- 101001044612 Homo sapiens Density-regulated protein Proteins 0.000 description 1
- 101000931227 Homo sapiens DnaJ homolog subfamily A member 1 Proteins 0.000 description 1
- 101000866018 Homo sapiens DnaJ homolog subfamily B member 1 Proteins 0.000 description 1
- 101000884921 Homo sapiens Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit DAD1 Proteins 0.000 description 1
- 101000749304 Homo sapiens Dual specificity protein kinase CLK3 Proteins 0.000 description 1
- 101000881110 Homo sapiens Dual specificity protein phosphatase 12 Proteins 0.000 description 1
- 101000840931 Homo sapiens EF-hand domain-containing family member C2 Proteins 0.000 description 1
- 101000925870 Homo sapiens ELAV-like protein 1 Proteins 0.000 description 1
- 101000925866 Homo sapiens ELAV-like protein 2 Proteins 0.000 description 1
- 101000896237 Homo sapiens ELAV-like protein 3 Proteins 0.000 description 1
- 101000896244 Homo sapiens ELAV-like protein 4 Proteins 0.000 description 1
- 101000920062 Homo sapiens Elongation factor 1-delta Proteins 0.000 description 1
- 101000813117 Homo sapiens Elongator complex protein 1 Proteins 0.000 description 1
- 101000898310 Homo sapiens Enhancer of filamentation 1 Proteins 0.000 description 1
- 101000851788 Homo sapiens Eukaryotic peptide chain release factor GTP-binding subunit ERF3A Proteins 0.000 description 1
- 101001055984 Homo sapiens Exosome complex component MTR3 Proteins 0.000 description 1
- 101001055965 Homo sapiens Exosome complex component RRP45 Proteins 0.000 description 1
- 101000882125 Homo sapiens Exosome complex component RRP46 Proteins 0.000 description 1
- 101001055976 Homo sapiens Exosome component 10 Proteins 0.000 description 1
- 101000697353 Homo sapiens FACT complex subunit SSRP1 Proteins 0.000 description 1
- 101000818410 Homo sapiens Fibroblast growth factor receptor substrate 2 Proteins 0.000 description 1
- 101000782155 Homo sapiens GATOR complex protein WDR24 Proteins 0.000 description 1
- 101000744505 Homo sapiens GTPase NRas Proteins 0.000 description 1
- 101000655398 Homo sapiens General transcription factor IIH subunit 2 Proteins 0.000 description 1
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 description 1
- 101000873786 Homo sapiens Glutamate decarboxylase 2 Proteins 0.000 description 1
- 101001014628 Homo sapiens Golgin subfamily A member 1 Proteins 0.000 description 1
- 101001039321 Homo sapiens Golgin subfamily B member 1 Proteins 0.000 description 1
- 101000986084 Homo sapiens HLA class I histocompatibility antigen, C alpha chain Proteins 0.000 description 1
- 101001078626 Homo sapiens Heat shock protein HSP 90-alpha A2 Proteins 0.000 description 1
- 101000854036 Homo sapiens Heterogeneous nuclear ribonucleoprotein A/B Proteins 0.000 description 1
- 101000899255 Homo sapiens Histone deacetylase 5 Proteins 0.000 description 1
- 101001045123 Homo sapiens Hyccin Proteins 0.000 description 1
- 101001033293 Homo sapiens Interleukin enhancer-binding factor 3 Proteins 0.000 description 1
- 101000614616 Homo sapiens Junctophilin-4 Proteins 0.000 description 1
- 101001045822 Homo sapiens Kelch-like protein 2 Proteins 0.000 description 1
- 101000998020 Homo sapiens Keratin, type I cytoskeletal 18 Proteins 0.000 description 1
- 101001051207 Homo sapiens L-lactate dehydrogenase B chain Proteins 0.000 description 1
- 101001042351 Homo sapiens LIM and senescent cell antigen-like-containing domain protein 1 Proteins 0.000 description 1
- 101001055354 Homo sapiens Mediator of RNA polymerase II transcription subunit 6 Proteins 0.000 description 1
- 101000578784 Homo sapiens Melanoma antigen recognized by T-cells 1 Proteins 0.000 description 1
- 101001005720 Homo sapiens Melanoma-associated antigen 4 Proteins 0.000 description 1
- 101000576802 Homo sapiens Mesothelin Proteins 0.000 description 1
- 101000636665 Homo sapiens NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 Proteins 0.000 description 1
- 101001023768 Homo sapiens Nuclear factor related to kappa-B-binding protein Proteins 0.000 description 1
- 101000995979 Homo sapiens Nucleolar GTP-binding protein 2 Proteins 0.000 description 1
- 101000620711 Homo sapiens Peptidyl-prolyl cis-trans isomerase-like 4 Proteins 0.000 description 1
- 101000610208 Homo sapiens Poly(A) polymerase gamma Proteins 0.000 description 1
- 101000952113 Homo sapiens Probable ATP-dependent RNA helicase DDX5 Proteins 0.000 description 1
- 101000705766 Homo sapiens Proteasome activator complex subunit 3 Proteins 0.000 description 1
- 101000716750 Homo sapiens Protein SCAF11 Proteins 0.000 description 1
- 101000981742 Homo sapiens Protein lifeguard 1 Proteins 0.000 description 1
- 101000797990 Homo sapiens Putative activator of 90 kDa heat shock protein ATPase homolog 2 Proteins 0.000 description 1
- 101000668165 Homo sapiens RNA-binding motif, single-stranded-interacting protein 1 Proteins 0.000 description 1
- 101000580720 Homo sapiens RNA-binding protein 25 Proteins 0.000 description 1
- 101001130290 Homo sapiens Rab GTPase-binding effector protein 1 Proteins 0.000 description 1
- 101001061942 Homo sapiens Ras-related protein Rab-40C Proteins 0.000 description 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 1
- 101000591201 Homo sapiens Receptor-type tyrosine-protein phosphatase kappa Proteins 0.000 description 1
- 101000669921 Homo sapiens Rho-associated protein kinase 2 Proteins 0.000 description 1
- 101000708979 Homo sapiens Rhomboid-related protein 1 Proteins 0.000 description 1
- 101000631899 Homo sapiens Ribosome maturation protein SBDS Proteins 0.000 description 1
- 101001093937 Homo sapiens SEC14-like protein 1 Proteins 0.000 description 1
- 101000939246 Homo sapiens SUMO-conjugating enzyme UBC9 Proteins 0.000 description 1
- 101000829153 Homo sapiens Somatostatin receptor type 5 Proteins 0.000 description 1
- 101000829367 Homo sapiens Src substrate cortactin Proteins 0.000 description 1
- 101000642613 Homo sapiens Sterol O-acyltransferase 2 Proteins 0.000 description 1
- 101000687905 Homo sapiens Transcription factor SOX-2 Proteins 0.000 description 1
- 101000933296 Homo sapiens Transcription factor TFIIIB component B'' homolog Proteins 0.000 description 1
- 101001131930 Homo sapiens Transcriptional activator protein Pur-beta Proteins 0.000 description 1
- 101000823316 Homo sapiens Tyrosine-protein kinase ABL1 Proteins 0.000 description 1
- 101001087412 Homo sapiens Tyrosine-protein phosphatase non-receptor type 18 Proteins 0.000 description 1
- 101000659545 Homo sapiens U5 small nuclear ribonucleoprotein 200 kDa helicase Proteins 0.000 description 1
- 101001017896 Homo sapiens U6 snRNA-associated Sm-like protein LSm1 Proteins 0.000 description 1
- 101000748161 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 34 Proteins 0.000 description 1
- 101000841301 Homo sapiens Utrophin Proteins 0.000 description 1
- 101000855019 Homo sapiens WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 Proteins 0.000 description 1
- 101000797207 Homo sapiens tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 Proteins 0.000 description 1
- 241000701806 Human papillomavirus Species 0.000 description 1
- 102100022652 Hyccin Human genes 0.000 description 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 102100039062 Interleukin enhancer-binding factor 3 Human genes 0.000 description 1
- 108090001007 Interleukin-8 Proteins 0.000 description 1
- 102100040490 Junctophilin-4 Human genes 0.000 description 1
- 102100034872 Kallikrein-4 Human genes 0.000 description 1
- 102100022120 Kelch-like protein 2 Human genes 0.000 description 1
- 108010066327 Keratin-18 Proteins 0.000 description 1
- 102100024580 L-lactate dehydrogenase B chain Human genes 0.000 description 1
- 102100021754 LIM and senescent cell antigen-like-containing domain protein 1 Human genes 0.000 description 1
- 108010059255 MAGE-A10 antigen Proteins 0.000 description 1
- 108010010995 MART-1 Antigen Proteins 0.000 description 1
- 102000034655 MIF Human genes 0.000 description 1
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
- 108010048043 Macrophage Migration-Inhibitory Factors Proteins 0.000 description 1
- 102100028123 Macrophage colony-stimulating factor 1 Human genes 0.000 description 1
- 102100037791 Macrophage migration inhibitory factor Human genes 0.000 description 1
- 102000005727 Mammaglobin A Human genes 0.000 description 1
- 108010031030 Mammaglobin A Proteins 0.000 description 1
- 102100026174 Mediator of RNA polymerase II transcription subunit 6 Human genes 0.000 description 1
- 102000000440 Melanoma-associated antigen Human genes 0.000 description 1
- 108050008953 Melanoma-associated antigen Proteins 0.000 description 1
- 102100025077 Melanoma-associated antigen 4 Human genes 0.000 description 1
- 201000009906 Meningitis Diseases 0.000 description 1
- 102000003735 Mesothelin Human genes 0.000 description 1
- 108090000015 Mesothelin Proteins 0.000 description 1
- 102100025096 Mesothelin Human genes 0.000 description 1
- 101100310657 Mus musculus Sox1 gene Proteins 0.000 description 1
- 101100257363 Mus musculus Sox2 gene Proteins 0.000 description 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 1
- 102100031924 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 Human genes 0.000 description 1
- 108010071382 NF-E2-Related Factor 2 Proteins 0.000 description 1
- 102000000001 Netrin domains Human genes 0.000 description 1
- 108050008395 Netrin domains Proteins 0.000 description 1
- 101710085246 Nischarin Proteins 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- 102000015863 Nuclear Factor 90 Proteins Human genes 0.000 description 1
- 108010010424 Nuclear Factor 90 Proteins Proteins 0.000 description 1
- 102100031701 Nuclear factor erythroid 2-related factor 2 Human genes 0.000 description 1
- 101710189362 Nuclear factor related to kappa-B-binding protein Proteins 0.000 description 1
- 102100034507 Nucleolar GTP-binding protein 2 Human genes 0.000 description 1
- 102100022389 Nucleosome assembly protein 1-like 1 Human genes 0.000 description 1
- 101710192960 Nucleosome assembly protein 1-like 3 Proteins 0.000 description 1
- 102100022398 Nucleosome assembly protein 1-like 3 Human genes 0.000 description 1
- 101710147980 Nucleosome assembly protein 1;3 Proteins 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 102000036673 PRAME Human genes 0.000 description 1
- 108060006580 PRAME Proteins 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 108010077519 Peptide Elongation Factor 2 Proteins 0.000 description 1
- 102100024968 Peptidyl-prolyl cis-trans isomerase C Human genes 0.000 description 1
- 102100022943 Peptidyl-prolyl cis-trans isomerase-like 4 Human genes 0.000 description 1
- 108010001441 Phosphopeptides Proteins 0.000 description 1
- 108091000080 Phosphotransferase Proteins 0.000 description 1
- 102100040153 Poly(A) polymerase gamma Human genes 0.000 description 1
- 208000032236 Predisposition to disease Diseases 0.000 description 1
- 102100037434 Probable ATP-dependent RNA helicase DDX5 Human genes 0.000 description 1
- 101710130420 Probable capsid assembly scaffolding protein Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102100031298 Proteasome activator complex subunit 3 Human genes 0.000 description 1
- 108010029485 Protein Isoforms Proteins 0.000 description 1
- 102000001708 Protein Isoforms Human genes 0.000 description 1
- 102100020876 Protein SCAF11 Human genes 0.000 description 1
- 102100024139 Protein lifeguard 1 Human genes 0.000 description 1
- 108010024221 Proto-Oncogene Proteins c-bcr Proteins 0.000 description 1
- 102100032319 Putative activator of 90 kDa heat shock protein ATPase homolog 2 Human genes 0.000 description 1
- 108010009460 RNA Polymerase II Proteins 0.000 description 1
- 102000009572 RNA Polymerase II Human genes 0.000 description 1
- 102000015097 RNA Splicing Factors Human genes 0.000 description 1
- 108010039259 RNA Splicing Factors Proteins 0.000 description 1
- 101710089258 RNA-binding motif protein 25 Proteins 0.000 description 1
- 101710181777 RNA-binding motif, single-stranded-interacting protein 1 Proteins 0.000 description 1
- 101710205948 RNA-binding protein 25 Proteins 0.000 description 1
- 102100031523 Rab GTPase-binding effector protein 1 Human genes 0.000 description 1
- 102000002024 Rabaptin Human genes 0.000 description 1
- 108050009305 Rabaptin Proteins 0.000 description 1
- 102100029539 Ras-related protein Rab-40C Human genes 0.000 description 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 1
- 102100034089 Receptor-type tyrosine-protein phosphatase kappa Human genes 0.000 description 1
- 101710099920 Recombining binding protein suppressor of hairless Proteins 0.000 description 1
- 101710088493 Rho-associated protein kinase 2 Proteins 0.000 description 1
- 102100032681 Rhomboid-related protein 1 Human genes 0.000 description 1
- 102100028750 Ribosome maturation protein SBDS Human genes 0.000 description 1
- 208000032826 Ring chromosome 3 syndrome Diseases 0.000 description 1
- 102100035214 SEC14-like protein 1 Human genes 0.000 description 1
- 102000037054 SLC-Transporter Human genes 0.000 description 1
- 108091006207 SLC-Transporter Proteins 0.000 description 1
- 108091006307 SLC2A10 Proteins 0.000 description 1
- 102100029807 SUMO-conjugating enzyme UBC9 Human genes 0.000 description 1
- 101710204410 Scaffold protein Proteins 0.000 description 1
- 206010039710 Scleroderma Diseases 0.000 description 1
- 101710184778 Serine/threonine-protein kinase 16 Proteins 0.000 description 1
- 101710111739 Serologically defined colon cancer antigen 8 Proteins 0.000 description 1
- 101710173693 Short transient receptor potential channel 1 Proteins 0.000 description 1
- 201000004283 Shwachman-Diamond syndrome Diseases 0.000 description 1
- 208000021386 Sjogren Syndrome Diseases 0.000 description 1
- 102000039471 Small Nuclear RNA Human genes 0.000 description 1
- 108010052164 Sodium Channels Proteins 0.000 description 1
- 102000018674 Sodium Channels Human genes 0.000 description 1
- 102100023806 Somatostatin receptor type 5 Human genes 0.000 description 1
- 102100023719 Src substrate cortactin Human genes 0.000 description 1
- 108010002687 Survivin Proteins 0.000 description 1
- 230000005867 T cell response Effects 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 102000006288 Transcription Factor TFIIH Human genes 0.000 description 1
- 108010083256 Transcription Factor TFIIH Proteins 0.000 description 1
- 102100036535 Transcription factor IIIB 90 kDa subunit Human genes 0.000 description 1
- 101710101768 Transcription factor IIIB 90 kDa subunit Proteins 0.000 description 1
- 102100024270 Transcription factor SOX-2 Human genes 0.000 description 1
- 101710085854 Transcription factor TFIIIB component B'' homolog Proteins 0.000 description 1
- LVTKHGUGBGNBPL-UHFFFAOYSA-N Trp-P-1 Chemical compound N1C2=CC=CC=C2C2=C1C(C)=C(N)N=C2C LVTKHGUGBGNBPL-UHFFFAOYSA-N 0.000 description 1
- 102000001400 Tryptase Human genes 0.000 description 1
- 108060005989 Tryptase Proteins 0.000 description 1
- 108010078814 Tumor Suppressor Protein p53 Proteins 0.000 description 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
- 102100039094 Tyrosinase Human genes 0.000 description 1
- 108060008724 Tyrosinase Proteins 0.000 description 1
- 102100022596 Tyrosine-protein kinase ABL1 Human genes 0.000 description 1
- 102100036230 U5 small nuclear ribonucleoprotein 200 kDa helicase Human genes 0.000 description 1
- 102100033314 U6 snRNA-associated Sm-like protein LSm1 Human genes 0.000 description 1
- 102100040096 Ubiquitin carboxyl-terminal hydrolase 34 Human genes 0.000 description 1
- 102100025038 Ubiquitin carboxyl-terminal hydrolase isozyme L1 Human genes 0.000 description 1
- 101710186825 Ubiquitin carboxyl-terminal hydrolase isozyme L1 Proteins 0.000 description 1
- 102100025040 Ubiquitin carboxyl-terminal hydrolase isozyme L3 Human genes 0.000 description 1
- 101710186831 Ubiquitin carboxyl-terminal hydrolase isozyme L3 Proteins 0.000 description 1
- 102000003431 Ubiquitin-Conjugating Enzyme Human genes 0.000 description 1
- 108060008747 Ubiquitin-Conjugating Enzyme Proteins 0.000 description 1
- HSCJRCZFDFQWRP-UHFFFAOYSA-N Uridindiphosphoglukose Natural products OC1C(O)C(O)C(CO)OC1OP(O)(=O)OP(O)(=O)OCC1C(O)C(O)C(N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-UHFFFAOYSA-N 0.000 description 1
- 102100020722 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1 Human genes 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 101710147076 Zinc finger protein 292 Proteins 0.000 description 1
- 102100021124 Zinc finger protein 616 Human genes 0.000 description 1
- 101710144075 Zinc finger protein 616 Proteins 0.000 description 1
- 230000001594 aberrant effect Effects 0.000 description 1
- 208000008524 alveolar soft part sarcoma Diseases 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000030741 antigen processing and presentation Effects 0.000 description 1
- 210000000612 antigen-presenting cell Anatomy 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000005784 autoimmunity Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 108010056708 bcr-abl Fusion Proteins Proteins 0.000 description 1
- 102000004441 bcr-abl Fusion Proteins Human genes 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000000090 biomarker Substances 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000036952 cancer formation Effects 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 238000013145 classification model Methods 0.000 description 1
- 239000005516 coenzyme A Substances 0.000 description 1
- 229940093530 coenzyme a Drugs 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 239000003283 colorimetric indicator Substances 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 230000001010 compromised effect Effects 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 201000001981 dermatomyositis Diseases 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- KAKKHKRHCKCAGH-UHFFFAOYSA-L disodium;(4-nitrophenyl) phosphate;hexahydrate Chemical compound O.O.O.O.O.O.[Na+].[Na+].[O-][N+](=O)C1=CC=C(OP([O-])([O-])=O)C=C1 KAKKHKRHCKCAGH-UHFFFAOYSA-L 0.000 description 1
- 239000003596 drug target Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 230000013020 embryo development Effects 0.000 description 1
- 208000030172 endocrine system disease Diseases 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 230000000925 erythroid effect Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 238000005562 fading Methods 0.000 description 1
- -1 family A Proteins 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 238000005558 fluorometry Methods 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 238000003500 gene array Methods 0.000 description 1
- 238000011223 gene expression profiling Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 108010024780 glutamate decarboxylase 2 Proteins 0.000 description 1
- 108010002182 glycyl-phenylalanyl-lysyl-glutaminyl-seryl-seryl-lysyl-alanyl-leucine Proteins 0.000 description 1
- 108010014242 gp100(17-25) peptide Proteins 0.000 description 1
- 108010072094 gp100(280-288) melanoma antigen peptide Proteins 0.000 description 1
- 238000003875 gradient-accelerated spectroscopy Methods 0.000 description 1
- 230000008076 immune mechanism Effects 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 238000003064 k means clustering Methods 0.000 description 1
- 108010024383 kallikrein 4 Proteins 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 206010025135 lupus erythematosus Diseases 0.000 description 1
- 102000033952 mRNA binding proteins Human genes 0.000 description 1
- 108091000373 mRNA binding proteins Proteins 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 238000012775 microarray technology Methods 0.000 description 1
- 238000012737 microarray-based gene expression Methods 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 238000012243 multiplex automated genomic engineering Methods 0.000 description 1
- 108010037351 nascent-polypeptide-associated complex Proteins 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 230000004770 neurodegeneration Effects 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 102000039479 opioid growth factor receptor family Human genes 0.000 description 1
- 108091056482 opioid growth factor receptor family Proteins 0.000 description 1
- 229960005489 paracetamol Drugs 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000003950 pathogenic mechanism Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000013610 patient sample Substances 0.000 description 1
- 238000010647 peptide synthesis reaction Methods 0.000 description 1
- 238000002823 phage display Methods 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 102000028499 poly(A) binding Human genes 0.000 description 1
- 108091023021 poly(A) binding Proteins 0.000 description 1
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 description 1
- 208000005987 polymyositis Diseases 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 208000023958 prostate neoplasm Diseases 0.000 description 1
- 238000003498 protein array Methods 0.000 description 1
- 229940121649 protein inhibitor Drugs 0.000 description 1
- 239000012268 protein inhibitor Substances 0.000 description 1
- 230000006920 protein precipitation Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000000405 serological effect Effects 0.000 description 1
- 208000000649 small cell carcinoma Diseases 0.000 description 1
- 108091029842 small nuclear ribonucleic acid Proteins 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 102000004115 somatostatin receptor 5 Human genes 0.000 description 1
- 108090000680 somatostatin receptor 5 Proteins 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 108010058363 sterol carrier proteins Proteins 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 description 1
- 108010044720 telomerase reverse transcriptase (540-548) Proteins 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/14—Peptides being immobilised on, or in, an inorganic carrier
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Inorganic Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65685905P | 2005-02-24 | 2005-02-24 | |
| US60/656,859 | 2005-02-24 | ||
| PCT/US2006/006431 WO2006091734A2 (en) | 2005-02-24 | 2006-02-24 | Compositions and methods for classifying biological samples |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2598889A1 true CA2598889A1 (en) | 2006-08-31 |
Family
ID=36928007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002598889A Abandoned CA2598889A1 (en) | 2005-02-24 | 2006-02-24 | Compositions and methods for classifying biological samples |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20090075832A1 (enExample) |
| EP (1) | EP1859266A4 (enExample) |
| JP (1) | JP2008532014A (enExample) |
| KR (1) | KR20080003321A (enExample) |
| CN (1) | CN101160524A (enExample) |
| AU (1) | AU2006216683A1 (enExample) |
| CA (1) | CA2598889A1 (enExample) |
| IL (1) | IL185458A0 (enExample) |
| MX (1) | MX2007010349A (enExample) |
| RU (1) | RU2007135030A (enExample) |
| WO (1) | WO2006091734A2 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7842480B2 (en) | 2001-05-18 | 2010-11-30 | Mayo Foundation For Medical Education And Research | Chimeric antigen-specific t cell-activating polypeptides |
| US20060222656A1 (en) | 2005-04-01 | 2006-10-05 | University Of Maryland, Baltimore | MAGE-A3/HPV 16 peptide vaccines for head and neck cancer |
| JP5564249B2 (ja) * | 2006-06-23 | 2014-07-30 | アレシア・バイオセラピューティクス・インコーポレーテッド | 癌に関与するポリヌクレオチド配列およびポリペプチド配列 |
| WO2008053573A1 (fr) | 2006-10-30 | 2008-05-08 | National University Corporation Hokkaido University | Remède pour néoplasme malin |
| TWI615403B (zh) * | 2007-02-21 | 2018-02-21 | 腫瘤療法 科學股份有限公司 | 表現腫瘤相關抗原之癌症的胜肽疫苗 |
| EP2201024A1 (en) | 2007-08-28 | 2010-06-30 | Ramot At Tel Aviv University | Peptides inducing a cd4i conformation in hiv gp120 while retaining vacant cd4 binding site |
| TWI466680B (zh) * | 2008-08-01 | 2015-01-01 | Oncotherapy Science Inc | Ｍｅｌｋ抗原決定位胜肽及含此胜肽的疫苗 |
| TW201008574A (en) | 2008-08-19 | 2010-03-01 | Oncotherapy Science Inc | INHBB epitope peptides and vaccines containing the same |
| WO2010060186A1 (en) | 2008-11-03 | 2010-06-03 | Alethia Biotherapeutics Inc. | Antibodies that specifically block the biological activity of a tumor antigen |
| GB0823366D0 (en) * | 2008-12-22 | 2009-01-28 | Uni I Oslo | Synthesis |
| KR101067815B1 (ko) * | 2009-02-05 | 2011-09-27 | 서울대학교산학협력단 | 제1형 당뇨병의 신규한 진단 마커 |
| EP3444613B1 (en) | 2009-08-14 | 2021-05-19 | The Regents of The University of California | Methods of diagnosing and treating autism |
| US8075895B2 (en) * | 2009-09-22 | 2011-12-13 | Janssen Pharmaceutica N.V. | Identification of antigenic peptides from multiple myeloma cells |
| TWI485245B (zh) * | 2010-01-25 | 2015-05-21 | Oncotherapy Science Inc | 經修飾之ｍｅｌｋ胜肽及含此胜肽之疫苗 |
| JP6294221B2 (ja) | 2011-03-31 | 2018-03-14 | アー・デー・ツェー・セラピューティクス・エス・アー | 腎臓関連抗原１に対する抗体およびその抗原結合性フラグメント |
| EP2745115B1 (de) * | 2011-08-19 | 2016-05-18 | Protagen AG | Neues verfahren zur diagnostik von hochaffinen bindern und markersequenzen |
| WO2013031757A1 (ja) * | 2011-08-29 | 2013-03-07 | 東レ株式会社 | 膵癌、乳癌、肺癌又は前立腺癌の検出用マーカー及び検査方法 |
| TR201908872T4 (tr) | 2012-01-09 | 2019-07-22 | Adc Therapeutics Sa | Üçlü negatif meme kanserini tedavi etmek için ajanlar. |
| US20130183242A1 (en) * | 2012-01-18 | 2013-07-18 | University Of Connecticut | Methods for identifying tumor-specific polypeptides |
| GB201319446D0 (en) | 2013-11-04 | 2013-12-18 | Immatics Biotechnologies Gmbh | Personalized immunotherapy against several neuronal and brain tumors |
| WO2015172843A1 (en) * | 2014-05-16 | 2015-11-19 | Biontech Diagnostics Gmbh | Methods and kits for the diagnosis of cancer |
| EP3145516A4 (en) * | 2014-05-20 | 2018-06-13 | Kiromic, LLC | Methods and compositions for treating malignancies with dendritic cells |
| AU2016209247B2 (en) | 2015-01-21 | 2021-02-25 | Inhibrx Biosciences, Inc. | Non-immunogenic single domain antibodies |
| GB201505305D0 (en) * | 2015-03-27 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel Peptides and combination of peptides for use in immunotherapy against various tumors |
| EP4300101A3 (en) | 2015-06-26 | 2024-03-20 | The Regents Of The University Of California | Antigenic peptides and uses thereof for diagnosing and treating autism |
| EP3322734B1 (en) | 2015-07-16 | 2020-09-09 | Inhibrx, Inc. | Multivalent and multispecific dr5-binding fusion proteins |
| HK1258386A1 (zh) | 2015-10-05 | 2019-11-08 | Immatics Biotechnologies Gmbh | 用於小细胞肺癌和其他癌症免疫治疗的肽和肽组合物 |
| EP3193173A1 (en) * | 2016-01-14 | 2017-07-19 | Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts | Serological autoantibodies as biomarker for colorectal cancer |
| GB201604458D0 (en) * | 2016-03-16 | 2016-04-27 | Immatics Biotechnologies Gmbh | Peptides and combination of peptides for use in immunotherapy against cancers |
| DE102016123893A1 (de) | 2016-12-08 | 2018-06-14 | Immatics Biotechnologies Gmbh | T-Zellrezeptoren mit verbesserter Bindung |
| ES2946584T3 (es) * | 2017-01-27 | 2023-07-21 | Immatics Biotechnologies Gmbh | Nuevos péptidos y nuevas combinaciones de péptidos para el uso en la inmunoterapia contra el cáncer de ovario y otros tipos de cáncer |
| CN108948184B (zh) * | 2017-05-22 | 2021-04-23 | 香雪生命科学技术（广东）有限公司 | 一种识别衍生自prame抗原短肽的t细胞受体 |
| CN109400697B (zh) * | 2017-08-17 | 2021-04-23 | 香雪生命科学技术（广东）有限公司 | 一种识别prame抗原短肽的tcr及其相关组合物 |
| EP3756680A1 (en) * | 2019-06-26 | 2020-12-30 | Universitat de Lleida | Intermediate filament-derived peptides and their uses |
| EP3999525A4 (en) * | 2019-07-15 | 2023-08-09 | Geisinger Health System | COMPOSITIONS AND METHODS FOR THE TREATMENT OF BREAST CANCER WITH A NOVEL CAPER ALPHA MLL1 COMPLEX |
| CN110922492B (zh) * | 2019-12-18 | 2022-02-15 | 重庆医科大学 | 融合肽、ctp介导的诱导cml细胞免疫应答的dc疫苗及其制备方法 |
| CN111337678B (zh) * | 2020-02-21 | 2023-06-06 | 杭州凯保罗生物科技有限公司 | 与肿瘤免疫治疗效果相关的生物标志物及其应用 |
| CN116773798A (zh) * | 2023-06-16 | 2023-09-19 | 北京三品医疗科技有限公司 | 多肽的应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7625697B2 (en) * | 1994-06-17 | 2009-12-01 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for constructing subarrays and subarrays made thereby |
| CA2432639A1 (en) * | 2000-11-16 | 2002-05-23 | Cemines, Llc | Profiling tumor specific markers for the diagnosis and treatment of neoplastic disease |
| AU2002302410A1 (en) * | 2001-03-10 | 2002-09-24 | Affina Immuntechnik Gmbh | Method for identifying immune reactive epitopes on proteins |
| JP4594588B2 (ja) * | 2001-04-10 | 2010-12-08 | ザ ボード オブ トラスティーズ オブ ザ リランド スタンフォード ジュニア ユニヴァーシティ | 抗体特異的プロファイルの治療的および診断的使用方法 |
| AU2002347778A1 (en) * | 2001-09-28 | 2003-05-26 | Incyte Genomics, Inc. | Enzymes |
| WO2004058972A1 (de) * | 2002-12-23 | 2004-07-15 | Thiesen Hans-Juergen | Human-autoantigene und deren verwendung |
| JP2006524035A (ja) * | 2002-12-26 | 2006-10-26 | シーマインズ リミテッド ライアビリティ カンパニー | 癌の診断、予後診断および治療のための方法および組成物 |
-
2006
- 2006-02-24 JP JP2007557159A patent/JP2008532014A/ja not_active Withdrawn
- 2006-02-24 WO PCT/US2006/006431 patent/WO2006091734A2/en not_active Ceased
- 2006-02-24 US US11/817,010 patent/US20090075832A1/en not_active Abandoned
- 2006-02-24 CN CNA2006800126573A patent/CN101160524A/zh active Pending
- 2006-02-24 RU RU2007135030/15A patent/RU2007135030A/ru not_active Application Discontinuation
- 2006-02-24 KR KR1020077021910A patent/KR20080003321A/ko not_active Withdrawn
- 2006-02-24 MX MX2007010349A patent/MX2007010349A/es not_active Application Discontinuation
- 2006-02-24 CA CA002598889A patent/CA2598889A1/en not_active Abandoned
- 2006-02-24 AU AU2006216683A patent/AU2006216683A1/en not_active Abandoned
- 2006-02-24 EP EP06735911A patent/EP1859266A4/en not_active Withdrawn
-
2007
- 2007-08-22 IL IL185458A patent/IL185458A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20090075832A1 (en) | 2009-03-19 |
| KR20080003321A (ko) | 2008-01-07 |
| EP1859266A2 (en) | 2007-11-28 |
| WO2006091734A2 (en) | 2006-08-31 |
| WO2006091734A3 (en) | 2007-02-08 |
| JP2008532014A (ja) | 2008-08-14 |
| CN101160524A (zh) | 2008-04-09 |
| AU2006216683A1 (en) | 2006-08-31 |
| IL185458A0 (en) | 2008-01-06 |
| EP1859266A4 (en) | 2010-07-28 |
| RU2007135030A (ru) | 2009-03-27 |
| MX2007010349A (es) | 2008-04-09 |
| WO2006091734A9 (en) | 2006-10-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20090075832A1 (en) | Compositions and Methods for Classifying Biological Samples | |
| Vlahou et al. | A novel approach toward development of a rapid blood test for breast cancer | |
| M’Koma et al. | Detection of pre-neoplastic and neoplastic prostate disease by MADI profiling of urine | |
| US20080081339A1 (en) | Tumor associated markers in the diagnosis of prostate cancer | |
| Lacombe et al. | Use of autoantibodies to detect the onset of breast cancer | |
| US20060088894A1 (en) | Prostate cancer biomarkers | |
| EP2951592A1 (en) | Autoantibody signature for the early detection of ovarian cancer | |
| US20080026410A1 (en) | Biomarkers for Bladder Cancer | |
| AU2010264067A2 (en) | A method and system for the detection of cancer | |
| WO2010115077A2 (en) | Biomarker panels for barrett's esophagus and esophageal adenocarcinoma | |
| AU2005287074A1 (en) | Biomarkers for breast cancer | |
| Caiazzo Jr et al. | Protein microarrays as an application for disease biomarkers | |
| CN113702636B (zh) | 血浆自身抗体标志物在乳腺癌早期诊断及其分子亚型表征中的应用 | |
| Abols et al. | Survey of autoantibody responses against tumor-associated antigens in thyroid cancer | |
| US20180106810A1 (en) | Detectors of serum biomarkers for predicting ovarian cancer recurrence | |
| KR102131860B1 (ko) | 아르기닌이 메틸화된 ggt1에 특이적으로 결합하는 대장암 진단용 바이오마커 조성물 | |
| HK1120108A (en) | Compositions and methods for classifying biological samples | |
| WO2010063761A1 (en) | An in-vitro method or assay for detecting a tumor or a cancerous disease by screening for antibodies | |
| US20210080465A1 (en) | SH2 domain-based prognostic biomarker for chronic lymphocytic leukemia | |
| JP7575375B2 (ja) | 関節リウマチ自己抗体レパートリーのプロファイリング及びそのためのペプチド分類子 | |
| AU2005274726A1 (en) | Biomarkers for bladder cancer | |
| WO2006071843A2 (en) | Biomarkers for breast cancer | |
| CN121410263A (zh) | 胆道癌免疫治疗相关的尿液蛋白标志物及其应用 | |
| Sreekumar et al. | 16 Humoral Response Profiling Using Protein Microarrays |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |