CA2588994A1 - Methods and compositions for the treatment of pulmonary hypertension of the newborn - Google Patents
Methods and compositions for the treatment of pulmonary hypertension of the newborn Download PDFInfo
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- CA2588994A1 CA2588994A1 CA002588994A CA2588994A CA2588994A1 CA 2588994 A1 CA2588994 A1 CA 2588994A1 CA 002588994 A CA002588994 A CA 002588994A CA 2588994 A CA2588994 A CA 2588994A CA 2588994 A1 CA2588994 A1 CA 2588994A1
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- AWDRATDZQPNJFN-VAYUFCLWSA-N taurodeoxycholic acid Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS(O)(=O)=O)C)[C@@]2(C)[C@@H](O)C1 AWDRATDZQPNJFN-VAYUFCLWSA-N 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| US60/634,147 | 2004-12-08 | ||
| PCT/US2005/044587 WO2006063215A2 (en) | 2004-12-08 | 2005-12-08 | Methods and compositions for the treatment of pulmonary hypertension of the newborn |
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| CA2588994A1 true CA2588994A1 (en) | 2006-06-15 |
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| CA (1) | CA2588994A1 (enExample) |
| WO (1) | WO2006063215A2 (enExample) |
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| CN101132776A (zh) | 2004-11-17 | 2008-02-27 | 生物马林药物股份有限公司 | 稳定的四氢生物喋呤片剂制剂 |
| JP4864400B2 (ja) * | 2005-09-22 | 2012-02-01 | トヨタホーム株式会社 | ラック |
| CA2631740A1 (en) * | 2005-12-05 | 2007-06-14 | Biomarin Pharmaceutical Inc. | Methods and compositions for the treatment of disease |
| SI2076501T1 (sl) * | 2006-09-25 | 2016-05-31 | Ptc Therapeutics, Inc. | Kristalinične oblike 3-(5-(2-florofenil)-1,2,4) oksadiazol-3-il)-benzojske kisline |
| ES2524026T3 (es) | 2008-01-03 | 2014-12-03 | Biomarin Pharmaceutical Inc. | Análogo de pterina para tratar una afección que responde a BH4 |
| JP2011010865A (ja) | 2009-06-30 | 2011-01-20 | Ikaria Holdings Inc | 肺高血圧の臨床的または超音波心臓検査上の証拠を伴う低酸素性呼吸器不全に罹った満期産およびほぼ満期産の新生児を治療する方法 |
| US8641613B2 (en) | 2011-03-10 | 2014-02-04 | Medicalcue, Inc. | Umbilical probe system |
| US8727980B2 (en) | 2011-03-10 | 2014-05-20 | Medicalcue, Inc. | Umbilical probe system |
| US8641614B2 (en) * | 2011-03-10 | 2014-02-04 | Medicalcue, Inc. | Umbilical probe measurement systems |
| EP2713723B1 (en) * | 2011-05-27 | 2018-09-12 | Geno LLC | Method of determining vasoreactivity using inhaled nitric oxide |
| US9216178B2 (en) | 2011-11-02 | 2015-12-22 | Biomarin Pharmaceutical Inc. | Dry blend formulation of tetrahydrobiopterin |
| AU2014203438B2 (en) | 2013-06-25 | 2019-06-20 | Mallinckrodt Hospital Products IP Limited | Methods of reducing the risk of mortality associated with a medical treatment |
| MA46972A (fr) | 2016-11-29 | 2019-10-09 | Censa Pharmaceuticals Inc | Forme polymorphe de sépiaptérine |
| NZ753504A (en) | 2016-11-29 | 2025-10-31 | Ptc Therapeutics Mp Inc | Polymorphs of sepiapterin and salts thereof |
| CN111491635A (zh) | 2017-09-01 | 2020-08-04 | 显莎制药公司 | 包含墨蝶呤的药物组合物及其用途 |
| JP7547215B2 (ja) | 2018-05-30 | 2024-09-09 | ピーティーシー セラピューティクス エムピー,インコーポレイテッド | テトラヒドロビオプテリン血漿曝露を増加させるための組成物及び方法 |
| US11617752B2 (en) | 2018-05-30 | 2023-04-04 | Ptc Therapeutics Mp, Inc. | Methods for increasing sepiapterin plasma exposure |
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| US2601215A (en) * | 1948-03-17 | 1952-06-17 | American Cyanamid Co | Process of preparing dihydropterins |
| US3505329A (en) * | 1968-02-06 | 1970-04-07 | Smithkline Corp | Process for the synthesis of biopterin |
| JPS5883691A (ja) * | 1981-11-13 | 1983-05-19 | Kanegafuchi Chem Ind Co Ltd | 1′,2′−ジアシル−(6r,s)−5,6,7,8−テトラヒドロ−l−ビオプテリンおよびその製法 |
| JPS5925323A (ja) * | 1982-03-03 | 1984-02-09 | 鐘淵化学工業株式会社 | プテリン誘導体からなる脳内神経伝達物質の関わる疾病の治療剤 |
| GB8318833D0 (en) * | 1983-07-12 | 1983-08-10 | Wellcome Found | Chemical compounds |
| ZA836957B (en) * | 1982-09-20 | 1985-04-24 | Wellcome Found | Neurologically active chemical compounds |
| US5196533A (en) * | 1983-04-11 | 1993-03-23 | South Alabama Medical Science Foundation, Usa | Cyclization of 5 amino-pyrimidines to quinoid 6,6 disubstituted dihydropteridines |
| US4587340A (en) * | 1983-09-19 | 1986-05-06 | Burroughs Wellcome Co. | Biopterin analogs |
| JPS60178887A (ja) * | 1984-02-23 | 1985-09-12 | Kanegafuchi Chem Ind Co Ltd | 5,6,7,8−テトラヒドロ−l−ビオプテリンの製造法 |
| JPS60199889A (ja) * | 1984-03-24 | 1985-10-09 | Kanegafuchi Chem Ind Co Ltd | 5,6,7,8−テトラヒドロ−l−エリスロ−ビオプテリンの硫酸塩およびその製法 |
| US4550109A (en) * | 1984-05-31 | 1985-10-29 | The Board Of Regents, The University Of Texas System | Lipoidal biopterin compounds |
| DE3437944A1 (de) * | 1984-10-17 | 1986-07-31 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Verwendung von pterinen zur steigerung der aktivitaet von lymphokinen und anderen blutfaktoren, sowie ein diagnostisches oder therapeutisches praeparat, das pterine in kombination mit lymphokinen enthaelt |
| CA1262347A (en) * | 1985-01-28 | 1989-10-17 | Suntory Limited | Preparation process of (6r)-tetrahydro-l-biopterin |
| JPS61277618A (ja) * | 1985-06-04 | 1986-12-08 | Suntory Ltd | 自閉症治療剤 |
| DE3853711T2 (de) * | 1987-11-30 | 1996-01-11 | Vitamin Kenkyusho Kk | Zwischenverbindungen für die Synthese von 5,6,7,8-Tetrahydro-L-erythro-biopterin und seiner Derivate. |
| JP2534423B2 (ja) * | 1991-12-26 | 1996-09-18 | コーネル・リサーチ・ファンデーション・インコーポレイテッド | 酸化窒素の過剰生産から生じる血管失調を阻止する阻害剤 |
| US5198547A (en) * | 1992-03-16 | 1993-03-30 | South Alabama Medical Science Foundation, Usa | Process for N5-formylating tetrahydropteridines |
| DE4308739C1 (de) * | 1993-03-19 | 1994-06-23 | Henning Berlin Gmbh | Pterinderivate, ihre Herstellung und ihre Verwendung |
| CH686369A5 (de) * | 1994-05-09 | 1996-03-15 | Eprova Ag | Stabile kristalline (6S)- und (6R)-Tetrahydrofolseure. |
| US5945452A (en) * | 1993-06-11 | 1999-08-31 | The Board Of Trustees Of The Leland Stanford Junior University | Treatment of vascular degenerative diseases by modulation of endogenous nitric oxide production or activity |
| US5502050A (en) * | 1993-11-29 | 1996-03-26 | Cornell Research Foundation, Inc. | Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis |
| ES2177654T3 (es) * | 1994-08-05 | 2002-12-16 | Suntory Ltd | Remedio contra la degeneracion espinocerebelosa. |
| US20020076782A1 (en) * | 1996-07-05 | 2002-06-20 | John P.N. Rosazza | Purified nitric oxide synthase |
| US6720309B1 (en) * | 1996-07-17 | 2004-04-13 | Leuven Research And Development, V.Z.W. | Method of inducing vasodilation and treating pulmonary hypertension using adenoviral-mediated transfer of the nitric oxide synthase gene |
| GB9617990D0 (en) * | 1996-08-29 | 1996-10-09 | Scotia Holdings Plc | Treatment of pain |
| DE69725721T3 (de) * | 1996-08-30 | 2007-10-31 | Daiichi Asubio Pharma Co., Ltd. | Vorbeugende oder heilende mittel für krankheiten, die durch mangel an stickoxid-synthase (nos) ausgelöst sind |
| CH693255A5 (de) * | 1997-06-13 | 2003-05-15 | Eprova Ag | Verwendung von Tetrahydrofolaten in der natürlichenstereoisomeren Form zur Herstellung einer pharmazeutischenZubereitung geeignet zur Beeinflussung des Homocystein-Spiegels. |
| US5922713A (en) * | 1997-06-26 | 1999-07-13 | Werner; Ernst | Inhibition of nitric oxide synthase |
| JP4306825B2 (ja) * | 1998-02-27 | 2009-08-05 | アスビオファーマ株式会社 | インスリン抵抗性が関与する血管機能異常を伴う疾患の予防または治療剤 |
| US6200758B1 (en) * | 1999-02-19 | 2001-03-13 | New York State Office Of Mental Health | Phenylalanine hydroxylase gene variants, and amino acid and pterin homeostasis, in the definition, detection, treatment and prevention of psychotic, mood and personality disorders |
| US6521212B1 (en) * | 1999-03-18 | 2003-02-18 | United Therapeutics Corporation | Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation |
| WO2000056328A1 (en) * | 1999-03-19 | 2000-09-28 | Enos Pharmaceuticals, Inc. | Increasing cerebral bioavailability of drugs |
| CH693905A5 (de) * | 1999-04-15 | 2004-04-15 | Eprova Ag | Stabile kristalline Salze von 5-Methyltetrahydrofolsäure. |
| GB2355191A (en) * | 1999-10-12 | 2001-04-18 | Laxdale Ltd | Combination formulations for fatigue, head injury and strokes |
| US6544994B2 (en) * | 2000-06-07 | 2003-04-08 | Eprov Ag | Pharmaceutical preparation for treating or preventing cardiovascular or neurological disorders by modulating of the activity of nitric oxide synthase |
-
2005
- 2005-12-08 JP JP2007545655A patent/JP2008523090A/ja not_active Withdrawn
- 2005-12-08 EP EP05853492A patent/EP1819340A2/en not_active Withdrawn
- 2005-12-08 US US11/720,815 patent/US20100130500A1/en not_active Abandoned
- 2005-12-08 WO PCT/US2005/044587 patent/WO2006063215A2/en not_active Ceased
- 2005-12-08 AU AU2005313940A patent/AU2005313940A1/en not_active Abandoned
- 2005-12-08 CA CA002588994A patent/CA2588994A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006063215A3 (en) | 2006-12-07 |
| US20100130500A1 (en) | 2010-05-27 |
| JP2008523090A (ja) | 2008-07-03 |
| EP1819340A2 (en) | 2007-08-22 |
| WO2006063215A2 (en) | 2006-06-15 |
| AU2005313940A1 (en) | 2006-06-15 |
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| FZDE | Discontinued |