CA2586177A1 - Polymorphic forms of 6-[2-(methylcarbamoyl)phenylsulfanyl]-3-e-[2-(pyridin-2-yl)ethenyl]indazole - Google Patents
Polymorphic forms of 6-[2-(methylcarbamoyl)phenylsulfanyl]-3-e-[2-(pyridin-2-yl)ethenyl]indazole Download PDFInfo
- Publication number
- CA2586177A1 CA2586177A1 CA002586177A CA2586177A CA2586177A1 CA 2586177 A1 CA2586177 A1 CA 2586177A1 CA 002586177 A CA002586177 A CA 002586177A CA 2586177 A CA2586177 A CA 2586177A CA 2586177 A1 CA2586177 A1 CA 2586177A1
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- Canada
- Prior art keywords
- compound
- crystalline form
- pharmaceutically acceptable
- acceptable salt
- peaks
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 title claims abstract description 16
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62466504P | 2004-11-02 | 2004-11-02 | |
| US60/624,665 | 2004-11-02 | ||
| PCT/IB2005/003312 WO2006048751A1 (en) | 2004-11-02 | 2005-10-21 | Polymorphic forms of 6-[2-(methylcarbamoyl)phenylsulfanyl]-3-e-[2-(pyridin-2-yl)ethenyl]indazole |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2586177A1 true CA2586177A1 (en) | 2006-05-11 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002586177A Abandoned CA2586177A1 (en) | 2004-11-02 | 2005-10-21 | Polymorphic forms of 6-[2-(methylcarbamoyl)phenylsulfanyl]-3-e-[2-(pyridin-2-yl)ethenyl]indazole |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20060094763A1 (OSRAM) |
| EP (1) | EP1819696A1 (OSRAM) |
| JP (1) | JP2008518904A (OSRAM) |
| KR (1) | KR20070060145A (OSRAM) |
| AR (1) | AR051945A1 (OSRAM) |
| AU (1) | AU2005300317A1 (OSRAM) |
| BR (1) | BRPI0517924A (OSRAM) |
| CA (1) | CA2586177A1 (OSRAM) |
| IL (1) | IL182580A0 (OSRAM) |
| MX (1) | MX2007005273A (OSRAM) |
| RU (1) | RU2007116150A (OSRAM) |
| TW (1) | TW200630356A (OSRAM) |
| WO (1) | WO2006048751A1 (OSRAM) |
| ZA (1) | ZA200702976B (OSRAM) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080274192A1 (en) * | 2005-05-19 | 2008-11-06 | Pfizer Inc. | Pharmaceutical Compositions Comprising an Amorphous Form of a Vegf-R-Inhibitor |
| PT2134702T (pt) * | 2007-04-05 | 2017-07-31 | Pfizer Prod Inc | Formas cristalinas de 6-[2-(metilcarbamoil)fenilsulfanil]-3-e-[2-(piridin-2-il)etenil]indazol adequadas para o tratamento de crescimento celular anormal em mamíferos |
| AU2012313885A1 (en) | 2011-09-30 | 2014-03-13 | Pfizer Inc. | Pharmaceutical compositions of N-methyl-2-[3-((E)-2-pyridin-2-yl-vinyl)-1H-indazol-6-ylsulfanyl]-benzamide |
| BR112014011453A2 (pt) | 2011-11-11 | 2017-05-02 | Pfizer | n-metil-2-[3-((e)-2-piridin-2-il-vinil)-1h-indazol-6-ilsulfanil]-benzamida para o tratamento de leucemia mielógena crônica |
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| US20220370606A1 (en) | 2018-12-21 | 2022-11-24 | Pfizer Inc. | Combination Treatments Of Cancer Comprising A TLR Agonist |
| EA202192731A1 (ru) | 2019-04-18 | 2022-02-04 | Синтон Б.В. | СПОСОБ ПОЛУЧЕНИЯ АКСИТИНИБА, СПОСОБ ОЧИСТКИ ПРОМЕЖУТОЧНОГО СОЕДИНЕНИЯ 2-((3-ЙОД-1H-ИНДАЗОЛ-6-ИЛ)ТИО)-N-МЕТИЛБЕНЗАМИДА, СПОСОБ ОЧИСТКИ АКСИТИНИБА ЧЕРЕЗ HCl СОЛЬ АКСИТИНИБА, ТВЕРДАЯ ФОРМА HCl СОЛИ АКСИТИНИБА |
| US12290601B2 (en) | 2019-05-09 | 2025-05-06 | Synthon B.V. | Pharmaceutical composition comprising axitinib |
| CA3171563A1 (en) | 2020-03-25 | 2021-09-30 | Charles D. Blizzard | Ocular implant containing a tyrosine kinase inhibitor |
| CN113943271B (zh) * | 2020-07-15 | 2023-11-14 | 鲁南制药集团股份有限公司 | 一种阿昔替尼晶型及其制备方法 |
| CN112174933A (zh) * | 2020-08-07 | 2021-01-05 | 天津理工大学 | 一种阿西替尼富马酸盐的新晶型及其制备方法 |
| CN114685437B (zh) * | 2020-12-25 | 2022-12-09 | 鲁南制药集团股份有限公司 | 阿昔替尼与糖精共晶 |
| CN114685436B (zh) * | 2020-12-25 | 2022-12-02 | 鲁南制药集团股份有限公司 | 阿昔替尼糖精共晶水合物 |
| CN114685431B (zh) * | 2020-12-26 | 2022-11-29 | 鲁南制药集团股份有限公司 | 一种阿昔替尼柠檬酸盐晶型 |
| CN114685432B (zh) * | 2020-12-28 | 2022-11-25 | 鲁南制药集团股份有限公司 | 阿昔替尼盐晶型及其制备方法 |
| CN114685435B (zh) * | 2020-12-28 | 2023-01-31 | 鲁南制药集团股份有限公司 | 阿昔替尼马来酸盐晶型及其制备 |
| CN114685438B (zh) * | 2020-12-28 | 2023-06-13 | 鲁南制药集团股份有限公司 | 一种阿昔替尼苹果酸新盐 |
| CN114685433B (zh) * | 2020-12-28 | 2022-11-25 | 鲁南制药集团股份有限公司 | 一种阿昔替尼香草酸共晶盐及其制备 |
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| TW202448436A (zh) * | 2023-04-11 | 2024-12-16 | 美商視爾普斯眼科公司 | 含有酪胺酸激酶抑制劑之眼部植入物 |
| KR20250108329A (ko) | 2024-01-08 | 2025-07-15 | (주)유케이케미팜 | 엑시티닙의 제조방법 |
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| TWI262914B (en) * | 1999-07-02 | 2006-10-01 | Agouron Pharma | Compounds and pharmaceutical compositions for inhibiting protein kinases |
| PE20010306A1 (es) * | 1999-07-02 | 2001-03-29 | Agouron Pharma | Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa |
| US6627646B2 (en) * | 2001-07-17 | 2003-09-30 | Sepracor Inc. | Norastemizole polymorphs |
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2005
- 2005-10-21 KR KR1020077010040A patent/KR20070060145A/ko not_active Ceased
- 2005-10-21 RU RU2007116150/04A patent/RU2007116150A/ru not_active Application Discontinuation
- 2005-10-21 AU AU2005300317A patent/AU2005300317A1/en not_active Abandoned
- 2005-10-21 BR BRPI0517924-6A patent/BRPI0517924A/pt not_active IP Right Cessation
- 2005-10-21 CA CA002586177A patent/CA2586177A1/en not_active Abandoned
- 2005-10-21 JP JP2007538541A patent/JP2008518904A/ja active Pending
- 2005-10-21 MX MX2007005273A patent/MX2007005273A/es not_active Application Discontinuation
- 2005-10-21 EP EP05796896A patent/EP1819696A1/en not_active Withdrawn
- 2005-10-21 WO PCT/IB2005/003312 patent/WO2006048751A1/en not_active Ceased
- 2005-10-31 US US11/264,493 patent/US20060094763A1/en not_active Abandoned
- 2005-11-01 AR ARP050104569A patent/AR051945A1/es unknown
- 2005-11-01 TW TW094138274A patent/TW200630356A/zh unknown
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2007
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- 2007-04-16 IL IL182580A patent/IL182580A0/en unknown
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| IL182580A0 (en) | 2007-07-24 |
| ZA200702976B (en) | 2008-08-27 |
| TW200630356A (en) | 2006-09-01 |
| WO2006048751A1 (en) | 2006-05-11 |
| AR051945A1 (es) | 2007-02-21 |
| US20060094763A1 (en) | 2006-05-04 |
| BRPI0517924A (pt) | 2008-10-21 |
| JP2008518904A (ja) | 2008-06-05 |
| EP1819696A1 (en) | 2007-08-22 |
| MX2007005273A (es) | 2007-07-19 |
| RU2007116150A (ru) | 2008-11-10 |
| KR20070060145A (ko) | 2007-06-12 |
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