CA2586122A1 - Metabolites of certain [1,4]diazepino[6,7,1-ij]quinoline derivatives and methods of preparation and use thereof - Google Patents
Metabolites of certain [1,4]diazepino[6,7,1-ij]quinoline derivatives and methods of preparation and use thereof Download PDFInfo
- Publication number
- CA2586122A1 CA2586122A1 CA002586122A CA2586122A CA2586122A1 CA 2586122 A1 CA2586122 A1 CA 2586122A1 CA 002586122 A CA002586122 A CA 002586122A CA 2586122 A CA2586122 A CA 2586122A CA 2586122 A1 CA2586122 A1 CA 2586122A1
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- Prior art keywords
- compound
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- salt
- metabolites
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 25
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/22—Pteridine radicals
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- Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Pharmacology & Pharmacy (AREA)
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- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62533504P | 2004-11-05 | 2004-11-05 | |
| US60/625,335 | 2004-11-05 | ||
| PCT/US2005/040289 WO2006052886A1 (en) | 2004-11-05 | 2005-11-04 | Metabolites of certain [1,4]diazepino[6,7,1-ij]quinoline derivatives and methods of preparation and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2586122A1 true CA2586122A1 (en) | 2006-05-18 |
Family
ID=36002462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002586122A Abandoned CA2586122A1 (en) | 2004-11-05 | 2005-11-04 | Metabolites of certain [1,4]diazepino[6,7,1-ij]quinoline derivatives and methods of preparation and use thereof |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20060111305A1 (enExample) |
| EP (1) | EP1812436A1 (enExample) |
| JP (1) | JP2008519056A (enExample) |
| KR (1) | KR20070084009A (enExample) |
| CN (1) | CN101124225A (enExample) |
| AR (1) | AR052227A1 (enExample) |
| AU (1) | AU2005304757A1 (enExample) |
| BR (1) | BRPI0517100A (enExample) |
| CA (1) | CA2586122A1 (enExample) |
| CR (1) | CR9092A (enExample) |
| GT (1) | GT200500319A (enExample) |
| IL (1) | IL182755A0 (enExample) |
| MX (1) | MX2007005475A (enExample) |
| NO (1) | NO20072165L (enExample) |
| PE (1) | PE20060939A1 (enExample) |
| RU (1) | RU2007116264A (enExample) |
| TW (1) | TW200635926A (enExample) |
| WO (1) | WO2006052886A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GT200500317A (es) * | 2004-11-05 | 2006-10-27 | Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos | |
| AR054849A1 (es) * | 2005-07-26 | 2007-07-18 | Wyeth Corp | Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas |
| TW200734334A (en) * | 2006-01-13 | 2007-09-16 | Wyeth Corp | Treatment of substance abuse |
| PE20081192A1 (es) * | 2006-03-24 | 2008-10-07 | Wyeth Corp | Tratamiento del dolor |
| EP2015749A2 (en) * | 2006-03-24 | 2009-01-21 | Wyeth | Methods for treating cognitive and other disorders |
| US20070225279A1 (en) * | 2006-03-24 | 2007-09-27 | Wyeth | Therapeutic combinations for the treatment of depression |
| CL2008002777A1 (es) * | 2007-09-21 | 2010-01-22 | Wyeth Corp | Metodo de preparacion de compuestos diazepinoquinolinicos quirales por recristalizacion en un sistema de solvente ternario. |
| WO2015066344A1 (en) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
| CN111303218B (zh) * | 2020-03-17 | 2021-03-30 | 连江仁泽生物科技有限公司 | 一种马鞭草苷的合成方法及应用 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3158619A (en) * | 1962-06-14 | 1964-11-24 | Searle & Co | Certain sulfur-containing ortho-fused polycyclic pyrazole derivatives |
| US3235564A (en) * | 1964-03-27 | 1966-02-15 | Searle & Co | Intermediates to certain sulfur-containing ortho-fused polycyclic pyrazole derivatives |
| US3335134A (en) * | 1964-04-02 | 1967-08-08 | Sandoz Ag | Certain 3, 4-dihydrofluoreno[1, 9a, 9-e, f]1, 4-diazepin-3(2h)-ones |
| US3296252A (en) * | 1964-04-02 | 1967-01-03 | Sandoz Ag | Tetracyclic diazepinone compounds |
| GB1120463A (en) * | 1964-07-06 | 1968-07-17 | Manuf Prod Pharma | Derivatives of 1,3-diazafluoranthene-1-oxide |
| US3329676A (en) * | 1964-11-09 | 1967-07-04 | American Home Prod | Fused 1, 4-diazepine ring systems |
| US3417101A (en) * | 1964-11-09 | 1968-12-17 | American Home Prod | Fused ring compounds |
| US3714149A (en) * | 1969-11-03 | 1973-01-30 | Upjohn Co | Pyridobenzodiazepinones |
| US3914250A (en) * | 1974-08-01 | 1975-10-21 | American Home Prod | 1,4-Diazepino{8 6,5,4-jk{9 carbazoles |
| US4880814A (en) * | 1987-11-13 | 1989-11-14 | Abbott Laboratories | 7-cycloalkyl naphthyridines |
| GB8812636D0 (en) * | 1988-05-27 | 1988-06-29 | Glaxo Group Ltd | Chemical compounds |
| US4997831A (en) * | 1988-09-01 | 1991-03-05 | Glaxo Group Limited | Lactam derivatives |
| KR0167346B1 (ko) * | 1989-06-09 | 1999-01-15 | 로버트 에이. 아미테이지 | 중추신경계 활성을 갖는 헤테로사이클릭 아민 |
| CA2195697A1 (en) * | 1996-02-02 | 1997-08-03 | Masahumi Kitano | Novel substituted guanidine derivatives, process for production thereof, and pharmaceutical uses thereof |
| US6380166B1 (en) * | 1999-09-13 | 2002-04-30 | American Home Products Corporation | Glucopyranosides conjugates of 2-(4-hydroxy-phenyl)-3-methyl-1-[4-(2-amin-1-yl-ethoxy)-benzyl]-1H-indol-5-ols |
| US6761904B2 (en) * | 2000-03-31 | 2004-07-13 | Nycomed Austria Gmbh | Pharmaceutical kit comprising midodrine as active drug substance |
| US6503900B2 (en) * | 2000-11-03 | 2003-01-07 | Wyeth | [1,4]diazepino [6,7,1-jk ]carbazoles and derivatives |
| US6414144B1 (en) * | 2000-11-03 | 2002-07-02 | Wyeth | Process for preparation of cyclopenta[b][1,4]diazepino[6,7,1-hi] indole derivatives |
| US6916922B2 (en) * | 2000-11-03 | 2005-07-12 | Wyeth | Process for the preparation of 1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta [B] [1,4] diazepino- [6,7,1-hi] indole derivatives |
| AR031199A1 (es) * | 2000-11-03 | 2003-09-10 | Wyeth Corp | Ciclohepta/b//1,4/diacepino/6,7,1-hi/indoles y derivados |
| AR031200A1 (es) * | 2000-11-03 | 2003-09-10 | Wyeth Corp | Cicloocta [b] [1,4] diazepino [6,7,1-hi] indoles y derivados |
| AR031196A1 (es) * | 2000-11-03 | 2003-09-10 | Wyeth Corp | Procedimiento para la preparacion de ciclopenta (b) (1,4)-diazepino (6,7,1-hi) indoles y derivados |
| AR031202A1 (es) * | 2000-11-03 | 2003-09-10 | Wyeth Corp | Ciclopenta(b) (1,4)diazepino(6,7,1-hi) indoles y derivados |
| US7141563B2 (en) * | 2000-11-03 | 2006-11-28 | Wyeth | Process for the preparation of 1, 2, 3, 4, 8, 9, 10, 10a-octahydro-7bH-cyclopenta[b] [1, 4]diazepino[6, 7, 1-hi] indole derivatives |
| HUP0303432A3 (en) * | 2000-12-20 | 2012-09-28 | Bristol Myers Squibb Co | Substituted pyridoindoles as serotonin agonists and antagonists and pharmaceutical compositions containing the compounds and their use |
| BR0211559A (pt) * | 2001-08-06 | 2004-07-13 | Upjohn Co | Compostos, composições de ligantes tetracìclicos terapeuticamente úteis e seus usos |
| TW200307540A (en) * | 2002-04-25 | 2003-12-16 | Wyeth Corp | [1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents |
| TWI312781B (en) * | 2002-04-25 | 2009-08-01 | [1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents | |
| TW200307682A (en) * | 2002-04-25 | 2003-12-16 | Wyeth Corp | 1,2,3,4,7,8-Hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents |
| ES2364046T3 (es) * | 2002-12-19 | 2011-08-23 | Bristol-Myers Squibb Company | Gamma-carbolinas tricíclicas sustituidas utilizadas como agonistas y antagonistas de los receptores de la serotonina. |
| TW200734334A (en) * | 2006-01-13 | 2007-09-16 | Wyeth Corp | Treatment of substance abuse |
| EP2015749A2 (en) * | 2006-03-24 | 2009-01-21 | Wyeth | Methods for treating cognitive and other disorders |
-
2005
- 2005-11-03 TW TW094138587A patent/TW200635926A/zh unknown
- 2005-11-03 AR ARP050104611A patent/AR052227A1/es unknown
- 2005-11-03 PE PE2005001292A patent/PE20060939A1/es not_active Application Discontinuation
- 2005-11-04 GT GT200500319A patent/GT200500319A/es unknown
- 2005-11-04 WO PCT/US2005/040289 patent/WO2006052886A1/en not_active Ceased
- 2005-11-04 CN CNA2005800449537A patent/CN101124225A/zh active Pending
- 2005-11-04 RU RU2007116264/04A patent/RU2007116264A/ru not_active Application Discontinuation
- 2005-11-04 AU AU2005304757A patent/AU2005304757A1/en not_active Abandoned
- 2005-11-04 BR BRPI0517100-8A patent/BRPI0517100A/pt not_active IP Right Cessation
- 2005-11-04 MX MX2007005475A patent/MX2007005475A/es unknown
- 2005-11-04 KR KR1020077010287A patent/KR20070084009A/ko not_active Withdrawn
- 2005-11-04 US US11/267,765 patent/US20060111305A1/en not_active Abandoned
- 2005-11-04 JP JP2007540134A patent/JP2008519056A/ja active Pending
- 2005-11-04 EP EP05824172A patent/EP1812436A1/en not_active Withdrawn
- 2005-11-04 CA CA002586122A patent/CA2586122A1/en not_active Abandoned
-
2007
- 2007-04-23 IL IL182755A patent/IL182755A0/en unknown
- 2007-04-26 NO NO20072165A patent/NO20072165L/no not_active Application Discontinuation
- 2007-05-02 CR CR9092A patent/CR9092A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TW200635926A (en) | 2006-10-16 |
| NO20072165L (no) | 2007-07-25 |
| MX2007005475A (es) | 2007-05-24 |
| US20060111305A1 (en) | 2006-05-25 |
| WO2006052886A1 (en) | 2006-05-18 |
| IL182755A0 (en) | 2007-07-24 |
| AR052227A1 (es) | 2007-03-07 |
| CN101124225A (zh) | 2008-02-13 |
| BRPI0517100A (pt) | 2008-09-30 |
| JP2008519056A (ja) | 2008-06-05 |
| AU2005304757A1 (en) | 2006-05-18 |
| CR9092A (es) | 2007-10-23 |
| WO2006052886A8 (en) | 2007-06-14 |
| GT200500319A (es) | 2006-06-02 |
| RU2007116264A (ru) | 2008-12-10 |
| KR20070084009A (ko) | 2007-08-24 |
| PE20060939A1 (es) | 2006-11-10 |
| EP1812436A1 (en) | 2007-08-01 |
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