CA2583353A1 - Thienopyridinone compounds and methods of treatment - Google Patents

Info

Publication number

CA2583353A1

CA2583353A1 CA002583353A CA2583353A CA2583353A1 CA 2583353 A1 CA2583353 A1 CA 2583353A1 CA 002583353 A CA002583353 A CA 002583353A CA 2583353 A CA2583353 A CA 2583353A CA 2583353 A1 CA2583353 A1 CA 2583353A1

Authority

CA

Canada

Prior art keywords

compound

disorders

disease

substituted

pharmaceutically acceptable

Prior art date

2004-10-07

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

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• 239000000018 receptor agonist Substances 0.000 claims abstract description 8
• 125000000217 alkyl group Chemical group 0.000 claims description 43
• 125000003342 alkenyl group Chemical group 0.000 claims description 31
• 125000000304 alkynyl group Chemical group 0.000 claims description 29
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• 125000003118 aryl group Chemical group 0.000 claims description 27
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• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 3
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• HMNQLBCOMSQPPW-UHFFFAOYSA-N 4-hydroxy-6-oxo-n-(1-pentylpiperidin-4-yl)-7-propan-2-ylthieno[2,3-b]pyridine-5-carboxamide Chemical compound C1CN(CCCCC)CCC1NC(=O)C(C(N1C(C)C)=O)=C(O)C2=C1SC=C2 HMNQLBCOMSQPPW-UHFFFAOYSA-N 0.000 claims 1
• WMQSLPSOCLFDNW-UHFFFAOYSA-N 4-hydroxy-n-[1-(2-methylpropyl)piperidin-4-yl]-6-oxo-7-propan-2-ylthieno[2,3-b]pyridine-5-carboxamide Chemical compound C1CN(CC(C)C)CCC1NC(=O)C(C(N1C(C)C)=O)=C(O)C2=C1SC=C2 WMQSLPSOCLFDNW-UHFFFAOYSA-N 0.000 claims 1
• HFPUPAKVVYAMOB-UHFFFAOYSA-N 4-hydroxy-n-[1-(3-hydroxypropyl)piperidin-4-yl]-6-oxo-7-propan-2-ylthieno[2,3-b]pyridine-5-carboxamide Chemical compound O=C1N(C(C)C)C=2SC=CC=2C(O)=C1C(=O)NC1CCN(CCCO)CC1 HFPUPAKVVYAMOB-UHFFFAOYSA-N 0.000 claims 1
• WMUMXZLPXACSEQ-UHFFFAOYSA-N 7-ethyl-4-hydroxy-6-oxo-n-(1-propylpiperidin-4-yl)thieno[2,3-b]pyridine-5-carboxamide Chemical compound C1CN(CCC)CCC1NC(=O)C(C(N1CC)=O)=C(O)C2=C1SC=C2 WMUMXZLPXACSEQ-UHFFFAOYSA-N 0.000 claims 1
• BOWNZMVJDFFHNF-UHFFFAOYSA-N 7-ethyl-4-hydroxy-n-[1-(3-hydroxypropyl)piperidin-4-yl]-6-oxothieno[2,3-b]pyridine-5-carboxamide Chemical compound O=C1N(CC)C=2SC=CC=2C(O)=C1C(=O)NC1CCN(CCCO)CC1 BOWNZMVJDFFHNF-UHFFFAOYSA-N 0.000 claims 1
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