CA2575912C - Procede de preparation d'acide indoline-2-carboxylique optiquement pur - Google Patents

Procede de preparation d'acide indoline-2-carboxylique optiquement pur Download PDF

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Publication number
CA2575912C
CA2575912C CA2575912A CA2575912A CA2575912C CA 2575912 C CA2575912 C CA 2575912C CA 2575912 A CA2575912 A CA 2575912A CA 2575912 A CA2575912 A CA 2575912A CA 2575912 C CA2575912 C CA 2575912C
Authority
CA
Canada
Prior art keywords
indoline
carboxylic acid
acid
enantiomer
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2575912A
Other languages
English (en)
Other versions
CA2575912A1 (fr
Inventor
Zhi-Xian Wang
Mohammed Abdul Raheem
Gamini Weeratunga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Apotex Pharmachem Inc
Original Assignee
Apotex Pharmachem Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apotex Pharmachem Inc filed Critical Apotex Pharmachem Inc
Priority to CA2575912A priority Critical patent/CA2575912C/fr
Publication of CA2575912A1 publication Critical patent/CA2575912A1/fr
Application granted granted Critical
Publication of CA2575912C publication Critical patent/CA2575912C/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Indole Compounds (AREA)
CA2575912A 2004-11-22 2004-11-22 Procede de preparation d'acide indoline-2-carboxylique optiquement pur Expired - Fee Related CA2575912C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2575912A CA2575912C (fr) 2004-11-22 2004-11-22 Procede de preparation d'acide indoline-2-carboxylique optiquement pur

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA 2488324 CA2488324A1 (fr) 2004-11-22 2004-11-22 Nouvelle methode de preparation d'isomeres optiques purs de l'acide indoline-2-carboxylique et de l'acide n-acetyl-indoline-2-carboxylique
CA2575912A CA2575912C (fr) 2004-11-22 2004-11-22 Procede de preparation d'acide indoline-2-carboxylique optiquement pur

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA 2488324 Division CA2488324A1 (fr) 2004-11-22 2004-11-22 Nouvelle methode de preparation d'isomeres optiques purs de l'acide indoline-2-carboxylique et de l'acide n-acetyl-indoline-2-carboxylique

Publications (2)

Publication Number Publication Date
CA2575912A1 CA2575912A1 (fr) 2006-05-22
CA2575912C true CA2575912C (fr) 2011-10-11

Family

ID=36406806

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2575912A Expired - Fee Related CA2575912C (fr) 2004-11-22 2004-11-22 Procede de preparation d'acide indoline-2-carboxylique optiquement pur
CA 2488324 Abandoned CA2488324A1 (fr) 2004-11-22 2004-11-22 Nouvelle methode de preparation d'isomeres optiques purs de l'acide indoline-2-carboxylique et de l'acide n-acetyl-indoline-2-carboxylique

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA 2488324 Abandoned CA2488324A1 (fr) 2004-11-22 2004-11-22 Nouvelle methode de preparation d'isomeres optiques purs de l'acide indoline-2-carboxylique et de l'acide n-acetyl-indoline-2-carboxylique

Country Status (2)

Country Link
CA (2) CA2575912C (fr)
WO (1) WO2006053440A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101774960B (zh) * 2009-12-31 2011-08-03 安徽美诺华药物化学有限公司 一种(2s)-二氢吲哚-2-甲酸的制备方法
CN109251163B (zh) * 2017-07-14 2022-12-27 江苏永达药业有限公司 一种吲哚啉-2-甲酸类化合物的拆分方法和其中间体
CN112375028A (zh) * 2020-12-14 2021-02-19 安徽美诺华药物化学有限公司 合成（2s）-二氢吲哚-甲酸的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE319668T1 (de) * 2003-04-09 2006-03-15 Servier Lab Verfahren zur synthese von (2s)-indolin-2- carbonsäure, und verwendung in der synthese von perindopril

Also Published As

Publication number Publication date
CA2488324A1 (fr) 2006-05-22
CA2575912A1 (fr) 2006-05-22
WO2006053440A1 (fr) 2006-05-26

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EEER Examination request
MKLA Lapsed

Effective date: 20161122