CA2571449C - Compositions comprising strontium and vitamin d and uses thereof - Google Patents
Compositions comprising strontium and vitamin d and uses thereof Download PDFInfo
- Publication number
- CA2571449C CA2571449C CA2571449A CA2571449A CA2571449C CA 2571449 C CA2571449 C CA 2571449C CA 2571449 A CA2571449 A CA 2571449A CA 2571449 A CA2571449 A CA 2571449A CA 2571449 C CA2571449 C CA 2571449C
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- CA
- Canada
- Prior art keywords
- strontium
- medicament
- calcium
- vitamin
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims abstract description 87
- 229940046008 vitamin d Drugs 0.000 title claims abstract description 44
- 229910052712 strontium Inorganic materials 0.000 title claims description 123
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 title claims description 115
- 239000003814 drug Substances 0.000 claims abstract description 189
- 159000000008 strontium salts Chemical class 0.000 claims abstract description 69
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims abstract description 60
- AHBGXTDRMVNFER-UHFFFAOYSA-L strontium dichloride Chemical class [Cl-].[Cl-].[Sr+2] AHBGXTDRMVNFER-UHFFFAOYSA-L 0.000 claims abstract description 54
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 49
- 238000011282 treatment Methods 0.000 claims abstract description 48
- 229910000018 strontium carbonate Inorganic materials 0.000 claims abstract description 47
- 229930003316 Vitamin D Natural products 0.000 claims abstract description 43
- 235000019166 vitamin D Nutrition 0.000 claims abstract description 43
- 239000011710 vitamin D Substances 0.000 claims abstract description 43
- BDAGIHXWWSANSR-NJFSPNSNSA-N hydroxyformaldehyde Chemical compound O[14CH]=O BDAGIHXWWSANSR-NJFSPNSNSA-N 0.000 claims abstract description 42
- -1 vitamin D compound Chemical class 0.000 claims abstract description 30
- 208000020084 Bone disease Diseases 0.000 claims abstract description 29
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims abstract description 25
- 208000001132 Osteoporosis Diseases 0.000 claims abstract description 19
- 235000005282 vitamin D3 Nutrition 0.000 claims abstract description 17
- 239000011647 vitamin D3 Substances 0.000 claims abstract description 17
- 229940021056 vitamin d3 Drugs 0.000 claims abstract description 17
- 230000002265 prevention Effects 0.000 claims abstract description 14
- 229910001631 strontium chloride Inorganic materials 0.000 claims description 51
- 229940013553 strontium chloride Drugs 0.000 claims description 42
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 18
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- 159000000007 calcium salts Chemical class 0.000 claims description 8
- 229940047908 strontium chloride hexahydrate Drugs 0.000 claims description 8
- AMGRXJSJSONEEG-UHFFFAOYSA-L strontium dichloride hexahydrate Chemical compound O.O.O.O.O.O.Cl[Sr]Cl AMGRXJSJSONEEG-UHFFFAOYSA-L 0.000 claims description 8
- 239000002775 capsule Substances 0.000 claims description 7
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 64
- 229960005069 calcium Drugs 0.000 description 64
- 235000001465 calcium Nutrition 0.000 description 64
- 239000011575 calcium Substances 0.000 description 64
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- 238000000034 method Methods 0.000 description 44
- 150000001875 compounds Chemical class 0.000 description 35
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- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 16
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- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 10
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- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 9
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- 239000012530 fluid Substances 0.000 description 9
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- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 8
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- 229940001593 sodium carbonate Drugs 0.000 description 7
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 7
- 208000029725 Metabolic bone disease Diseases 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 description 6
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- 210000000936 intestine Anatomy 0.000 description 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
- 239000011159 matrix material Substances 0.000 description 6
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- 235000001892 vitamin D2 Nutrition 0.000 description 6
- 239000011653 vitamin D2 Substances 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 239000001354 calcium citrate Substances 0.000 description 5
- 229960004256 calcium citrate Drugs 0.000 description 5
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- LEDMRZGFZIAGGB-UHFFFAOYSA-L strontium carbonate Chemical compound [Sr+2].[O-]C([O-])=O LEDMRZGFZIAGGB-UHFFFAOYSA-L 0.000 description 5
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- 235000019640 taste Nutrition 0.000 description 5
- 235000013337 tricalcium citrate Nutrition 0.000 description 5
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 4
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- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 description 4
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- DHEQXMRUPNDRPG-UHFFFAOYSA-N strontium nitrate Chemical compound [Sr+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O DHEQXMRUPNDRPG-UHFFFAOYSA-N 0.000 description 4
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- 201000008482 osteoarthritis Diseases 0.000 description 1
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- 208000005368 osteomalacia Diseases 0.000 description 1
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- 229920001277 pectin Polymers 0.000 description 1
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- 230000002572 peristaltic effect Effects 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- PDTFCHSETJBPTR-UHFFFAOYSA-N phenylmercuric nitrate Chemical compound [O-][N+](=O)O[Hg]C1=CC=CC=C1 PDTFCHSETJBPTR-UHFFFAOYSA-N 0.000 description 1
- DLNKOYKMWOXYQA-APPZFPTMSA-N phenylpropanolamine Chemical compound C[C@@H](N)[C@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-APPZFPTMSA-N 0.000 description 1
- 229960000395 phenylpropanolamine Drugs 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 230000037081 physical activity Effects 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
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- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
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- 230000008092 positive effect Effects 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 201000009395 primary hyperaldosteronism Diseases 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- MCSINKKTEDDPNK-UHFFFAOYSA-N propyl propionate Chemical compound CCCOC(=O)CC MCSINKKTEDDPNK-UHFFFAOYSA-N 0.000 description 1
- 239000011251 protective drug Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 229940070376 protein Drugs 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 208000007442 rickets Diseases 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 210000005077 saccule Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000009645 skeletal growth Effects 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 229940018038 sodium carbonate decahydrate Drugs 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000006104 solid solution Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000003270 steroid hormone Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- PWYYWQHXAPXYMF-UHFFFAOYSA-N strontium(2+) Chemical compound [Sr+2] PWYYWQHXAPXYMF-UHFFFAOYSA-N 0.000 description 1
- VUWAXXIHYHUOJV-TYYBGVCCSA-L strontium;(e)-but-2-enedioate Chemical compound [Sr+2].[O-]C(=O)\C=C\C([O-])=O VUWAXXIHYHUOJV-TYYBGVCCSA-L 0.000 description 1
- CPKHHOBKIQHTLE-UHFFFAOYSA-L strontium;1,2,2-trimethylcyclopentane-1,3-dicarboxylate Chemical compound [Sr+2].CC1(C)C(C([O-])=O)CCC1(C)C([O-])=O CPKHHOBKIQHTLE-UHFFFAOYSA-L 0.000 description 1
- USBIHMTWQAZQAG-UHFFFAOYSA-L strontium;ethanesulfonate Chemical compound [Sr+2].CCS([O-])(=O)=O.CCS([O-])(=O)=O USBIHMTWQAZQAG-UHFFFAOYSA-L 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 238000009492 tablet coating Methods 0.000 description 1
- 239000002700 tablet coating Substances 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 238000009475 tablet pressing Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000005979 thermal decomposition reaction Methods 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
- 230000001562 ulcerogenic effect Effects 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
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- 239000011345 viscous material Substances 0.000 description 1
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- 239000000080 wetting agent Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Inorganic Chemistry (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200400991 | 2004-06-25 | ||
| DKPA200400991 | 2004-06-25 | ||
| DKPA200401733 | 2004-11-10 | ||
| DKPA200401733 | 2004-11-10 | ||
| PCT/DK2005/000425 WO2006000224A2 (en) | 2004-06-25 | 2005-06-24 | Compositions comprising strontium and vitamin d and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2571449A1 CA2571449A1 (en) | 2006-01-05 |
| CA2571449C true CA2571449C (en) | 2015-12-08 |
Family
ID=34972075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2571449A Expired - Fee Related CA2571449C (en) | 2004-06-25 | 2005-06-24 | Compositions comprising strontium and vitamin d and uses thereof |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8658206B2 (enExample) |
| EP (1) | EP1768748B2 (enExample) |
| JP (2) | JP5070046B2 (enExample) |
| KR (1) | KR20070034075A (enExample) |
| AT (1) | ATE443541T1 (enExample) |
| AU (1) | AU2005256317B2 (enExample) |
| BR (1) | BRPI0512357A (enExample) |
| CA (1) | CA2571449C (enExample) |
| DE (1) | DE602005016803D1 (enExample) |
| DK (1) | DK1768748T4 (enExample) |
| EA (1) | EA011814B1 (enExample) |
| IL (1) | IL180144A0 (enExample) |
| MX (1) | MXPA06015187A (enExample) |
| NO (1) | NO20070206L (enExample) |
| WO (1) | WO2006000224A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2097137T3 (pl) * | 2006-11-21 | 2013-02-28 | Mokwalo Spf S A | Kompozycje zawierające stront i ich zastosowanie w leczeniu lub zapobieganiu zapaleniu dziąseł, zapaleniu przyzębia, zapaleniu przyzębia będącemu manifestacją chorób układowych i martwiczym chorobom przyzębia |
| US20080118603A1 (en) * | 2006-11-21 | 2008-05-22 | Lada Mark W | Nutritional beverage for optimal bone health |
| EP2142224B1 (en) * | 2007-04-23 | 2016-03-23 | Baxter International Inc. | Fibrin compositions containing strontium compounds |
| EP2173321B1 (en) * | 2007-07-19 | 2024-12-18 | DSM IP Assets B.V. | Tablettable formulations of lipophilic health ingredients |
| CA2695504C (en) * | 2007-08-03 | 2017-05-30 | Nucitec S.A. De C.V. | Compositions and methods for treatment and prevention of osteoarthritis |
| WO2010117346A2 (en) * | 2009-04-10 | 2010-10-14 | Mahmut Bilgic | Stable pharmaceutical compositions with high bioavailibility |
| FR2945748A1 (fr) * | 2009-05-20 | 2010-11-26 | Debregeas Et Associes Pharma | Medicament a base de calcium et de vitamine d. |
| FR2953139B1 (fr) * | 2009-11-27 | 2012-04-13 | Servier Lab | Composition pharmaceutique comprenant un sel de strontium, de la vitamine d et une cyclodextrine |
| WO2012006477A1 (en) | 2010-07-07 | 2012-01-12 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| EP2590965B1 (en) | 2010-07-07 | 2016-04-20 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| WO2012006475A1 (en) * | 2010-07-07 | 2012-01-12 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| EP2590655B1 (en) | 2010-07-07 | 2015-06-24 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| EP2590656B1 (en) | 2010-07-07 | 2017-11-15 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| WO2012103575A1 (en) * | 2011-02-02 | 2012-08-09 | Ent Technologies Pty Ltd | Compositions and methods for the treatment of nasal passages |
| EP2530068A1 (en) | 2011-05-31 | 2012-12-05 | Lacer, S.A. | New strontium salts, synthesis and use thereof in the treatment of osteoporosis |
| WO2014044756A1 (en) * | 2012-09-20 | 2014-03-27 | Mokwalo SA | Strontium as anti microbial compound |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3345265A (en) * | 1963-10-09 | 1967-10-03 | Kendall & Co | Multiple layer tablet with calcium salt central core separated from soluble fluoride outer coating |
| US3699221A (en) * | 1965-02-23 | 1972-10-17 | Murray L Schole | Dental preparations |
| US3988434A (en) | 1972-08-07 | 1976-10-26 | Schole Murray L | Dental preparation |
| FR2633619B1 (fr) | 1988-06-29 | 1991-02-08 | Adir | Nouveau sel de strontium, son procede de preparation et les compositions pharmaceutiques le renfermant |
| FR2651497B1 (fr) | 1989-09-01 | 1991-10-25 | Adir | Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
| FR2658816A1 (fr) * | 1990-02-27 | 1991-08-30 | Adir | Nouveaux sels de metaux alcalinoterreux d'oxa-polyacides leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US5380530A (en) | 1992-12-29 | 1995-01-10 | Whitehill Oral Technologies | Oral care composition coated gum |
| US5624906A (en) * | 1994-12-08 | 1997-04-29 | Lever Brothers Company, Division Of Conopco, Inc. | Oral hygiene compositions comprising heteroatom containing alkyl aldonamide compounds |
| FR2749759B1 (fr) * | 1996-06-17 | 1999-11-26 | Adir | Utilisation de sels de strontium pour l'obtention de compositions pharmaceutiques destinees au traitement de l'arthrose |
| CN1164603C (zh) | 2001-09-29 | 2004-09-01 | 南京化工大学 | 1，6－二磷酸果糖锶盐系列化合物及其制备方法和在医药中的应用 |
| FR2844797B1 (fr) | 2002-09-24 | 2004-10-22 | Servier Lab | Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis (carboxymethyl)]-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
| FR2844795B1 (fr) | 2002-09-24 | 2004-10-22 | Servier Lab | Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates |
| FR2844796A1 (fr) | 2002-09-24 | 2004-03-26 | Servier Lab | Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
| EP1534305B9 (en) | 2003-05-07 | 2007-03-07 | Osteologix A/S | Treating cartilage / bone conditions with water-soluble strontium salts |
| PT2266585E (pt) * | 2003-05-07 | 2013-07-09 | Osteologix As | Sais de estrôncio hidrossolúveis para uso no tratamento de afeções cartilagíneas e/ou ósseas |
| JP5049589B2 (ja) * | 2003-05-07 | 2012-10-17 | オステオロジックス エイ／エス | ストロンチウム塩含有の放出制御組成物 |
-
2005
- 2005-06-24 AU AU2005256317A patent/AU2005256317B2/en not_active Ceased
- 2005-06-24 KR KR1020077001916A patent/KR20070034075A/ko not_active Withdrawn
- 2005-06-24 EP EP05750580.2A patent/EP1768748B2/en not_active Expired - Lifetime
- 2005-06-24 US US11/570,767 patent/US8658206B2/en not_active Expired - Fee Related
- 2005-06-24 DE DE602005016803T patent/DE602005016803D1/de not_active Expired - Lifetime
- 2005-06-24 DK DK05750580.2T patent/DK1768748T4/da active
- 2005-06-24 BR BRPI0512357-7A patent/BRPI0512357A/pt not_active IP Right Cessation
- 2005-06-24 WO PCT/DK2005/000425 patent/WO2006000224A2/en not_active Ceased
- 2005-06-24 EA EA200700130A patent/EA011814B1/ru active IP Right Revival
- 2005-06-24 AT AT05750580T patent/ATE443541T1/de not_active IP Right Cessation
- 2005-06-24 CA CA2571449A patent/CA2571449C/en not_active Expired - Fee Related
- 2005-06-24 JP JP2007516973A patent/JP5070046B2/ja not_active Expired - Fee Related
- 2005-06-24 MX MXPA06015187A patent/MXPA06015187A/es not_active Application Discontinuation
-
2006
- 2006-12-18 IL IL180144A patent/IL180144A0/en unknown
-
2007
- 2007-01-11 NO NO20070206A patent/NO20070206L/no not_active Application Discontinuation
-
2012
- 2012-07-13 JP JP2012157477A patent/JP2012193208A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU2005256317B2 (en) | 2011-09-15 |
| EP1768748A2 (en) | 2007-04-04 |
| EP1768748B1 (en) | 2009-09-23 |
| IL180144A0 (en) | 2007-06-03 |
| AU2005256317A1 (en) | 2006-01-05 |
| EP1768748B2 (en) | 2019-03-13 |
| US8658206B2 (en) | 2014-02-25 |
| MXPA06015187A (es) | 2007-09-27 |
| DK1768748T3 (da) | 2010-02-01 |
| NO20070206L (no) | 2007-03-22 |
| WO2006000224A2 (en) | 2006-01-05 |
| KR20070034075A (ko) | 2007-03-27 |
| DK1768748T4 (da) | 2019-06-11 |
| DE602005016803D1 (de) | 2009-11-05 |
| US20080026037A1 (en) | 2008-01-31 |
| EA011814B1 (ru) | 2009-06-30 |
| JP2012193208A (ja) | 2012-10-11 |
| BRPI0512357A (pt) | 2008-03-04 |
| HK1102427A1 (en) | 2007-11-23 |
| WO2006000224A3 (en) | 2006-05-18 |
| JP2008503504A (ja) | 2008-02-07 |
| ATE443541T1 (de) | 2009-10-15 |
| EA200700130A1 (ru) | 2007-06-29 |
| JP5070046B2 (ja) | 2012-11-07 |
| CA2571449A1 (en) | 2006-01-05 |
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Effective date: 20210625 |