CA2571034A1 - New chiral columns with broad chiral selectivity - Google Patents
New chiral columns with broad chiral selectivity Download PDFInfo
- Publication number
- CA2571034A1 CA2571034A1 CA002571034A CA2571034A CA2571034A1 CA 2571034 A1 CA2571034 A1 CA 2571034A1 CA 002571034 A CA002571034 A CA 002571034A CA 2571034 A CA2571034 A CA 2571034A CA 2571034 A1 CA2571034 A1 CA 2571034A1
- Authority
- CA
- Canada
- Prior art keywords
- ipa
- pro
- chiral
- stationary phase
- fmoc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- YMWUJEATGCHHMB-DICFDUPASA-N dichloromethane-d2 Chemical compound [2H]C([2H])(Cl)Cl YMWUJEATGCHHMB-DICFDUPASA-N 0.000 description 1
- MQYQOVYIJOLTNX-UHFFFAOYSA-N dichloromethane;n,n-dimethylformamide Chemical compound ClCCl.CN(C)C=O MQYQOVYIJOLTNX-UHFFFAOYSA-N 0.000 description 1
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
- 238000002330 electrospray ionisation mass spectrometry Methods 0.000 description 1
- PYFMAAFCQDFHJX-UHFFFAOYSA-N ethyl pyrimidine-2-carboxylate Chemical compound CCOC(=O)C1=NC=CC=N1 PYFMAAFCQDFHJX-UHFFFAOYSA-N 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 238000003818 flash chromatography Methods 0.000 description 1
- 238000001640 fractional crystallisation Methods 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 229960001031 glucose Drugs 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- POPJHVWAPAEEHL-UHFFFAOYSA-N hexane Chemical compound CCCCCC.CCCCCC.CCCCCC POPJHVWAPAEEHL-UHFFFAOYSA-N 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229960002591 hydroxyproline Drugs 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- HXEACLLIILLPRG-RXMQYKEDSA-N l-pipecolic acid Natural products OC(=O)[C@H]1CCCCN1 HXEACLLIILLPRG-RXMQYKEDSA-N 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- IWYDHOAUDWTVEP-UHFFFAOYSA-M mandelate Chemical compound [O-]C(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-M 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- HXEACLLIILLPRG-UHFFFAOYSA-N pipecolic acid Chemical compound OC(=O)C1CCCCN1 HXEACLLIILLPRG-UHFFFAOYSA-N 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- 238000000825 ultraviolet detection Methods 0.000 description 1
- 238000002211 ultraviolet spectrum Methods 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/14—Peptides being immobilised on, or in, an inorganic carrier
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Pyrrole Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2004/018762 WO2006001798A1 (en) | 2004-06-15 | 2004-06-15 | New chiral columns with broad chiral selectivity |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2571034A1 true CA2571034A1 (en) | 2006-01-05 |
Family
ID=35782097
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002571034A Abandoned CA2571034A1 (en) | 2004-06-15 | 2004-06-15 | New chiral columns with broad chiral selectivity |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1781706A4 (pt) |
JP (1) | JP2008509883A (pt) |
CN (1) | CN101052656A (pt) |
AU (1) | AU2004321084A1 (pt) |
BR (1) | BRPI0418906A (pt) |
CA (1) | CA2571034A1 (pt) |
MX (1) | MXPA06014765A (pt) |
NO (1) | NO20070240L (pt) |
RU (1) | RU2007101314A (pt) |
WO (1) | WO2006001798A1 (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104645668B (zh) * | 2015-02-02 | 2016-05-25 | 云南师范大学 | 一种用于光学异构体拆分的手性多孔有机笼石英毛细管柱 |
US10766924B2 (en) | 2015-07-28 | 2020-09-08 | Jsr Corporation | Affinity support and method for isolating immunoglobulin |
CN109239252B (zh) * | 2018-09-10 | 2020-07-03 | 吉尔生化(上海)有限公司 | 一种针对连续多个脯氨酸多肽的检测方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0773227A1 (en) * | 1991-09-18 | 1997-05-14 | Affymax Technologies N.V. | Diverse collections of oligomers in use to prepare drugs, diagnostic reagents, pesticides or herbicides |
CA2755452C (en) * | 1998-02-02 | 2013-09-10 | Trustees Of Tufts College | Method of regulating glucose metabolism, and reagents related thereto |
-
2004
- 2004-06-15 MX MXPA06014765A patent/MXPA06014765A/es unknown
- 2004-06-15 CA CA002571034A patent/CA2571034A1/en not_active Abandoned
- 2004-06-15 BR BRPI0418906-0A patent/BRPI0418906A/pt not_active IP Right Cessation
- 2004-06-15 RU RU2007101314/04A patent/RU2007101314A/ru not_active Application Discontinuation
- 2004-06-15 AU AU2004321084A patent/AU2004321084A1/en not_active Abandoned
- 2004-06-15 JP JP2007516447A patent/JP2008509883A/ja not_active Ceased
- 2004-06-15 WO PCT/US2004/018762 patent/WO2006001798A1/en active Application Filing
- 2004-06-15 EP EP04809441A patent/EP1781706A4/en not_active Withdrawn
- 2004-06-15 CN CNA200480043803XA patent/CN101052656A/zh active Pending
-
2007
- 2007-01-15 NO NO20070240A patent/NO20070240L/no unknown
Also Published As
Publication number | Publication date |
---|---|
JP2008509883A (ja) | 2008-04-03 |
CN101052656A (zh) | 2007-10-10 |
BRPI0418906A (pt) | 2007-11-27 |
RU2007101314A (ru) | 2008-07-20 |
NO20070240L (no) | 2007-03-15 |
MXPA06014765A (es) | 2007-03-26 |
EP1781706A1 (en) | 2007-05-09 |
EP1781706A4 (en) | 2007-07-11 |
AU2004321084A1 (en) | 2006-01-05 |
WO2006001798A1 (en) | 2006-01-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |