CA2567686A1 - Use of vegf inhibitors for the treatment of human cancer - Google Patents
Use of vegf inhibitors for the treatment of human cancer Download PDFInfo
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- CA2567686A1 CA2567686A1 CA002567686A CA2567686A CA2567686A1 CA 2567686 A1 CA2567686 A1 CA 2567686A1 CA 002567686 A CA002567686 A CA 002567686A CA 2567686 A CA2567686 A CA 2567686A CA 2567686 A1 CA2567686 A1 CA 2567686A1
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- cancer
- vegf
- subsequent doses
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- CILBMBUYJCWATM-PYGJLNRPSA-N vinorelbine ditartrate Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC CILBMBUYJCWATM-PYGJLNRPSA-N 0.000 description 1
- 201000005102 vulva cancer Diseases 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229940053867 xeloda Drugs 0.000 description 1
- 229950009268 zinostatin Drugs 0.000 description 1
- 229960000641 zorubicin Drugs 0.000 description 1
- FBTUMDXHSRTGRV-ALTNURHMSA-N zorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(\C)=N\NC(=O)C=1C=CC=CC=1)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 FBTUMDXHSRTGRV-ALTNURHMSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57849904P | 2004-06-10 | 2004-06-10 | |
| US60/578,499 | 2004-06-10 | ||
| PCT/US2005/020762 WO2005123104A2 (en) | 2004-06-10 | 2005-06-10 | Use of vegf inhibitors for the treatment of human cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2567686A1 true CA2567686A1 (en) | 2005-12-29 |
Family
ID=35510259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002567686A Abandoned CA2567686A1 (en) | 2004-06-10 | 2005-06-10 | Use of vegf inhibitors for the treatment of human cancer |
Country Status (9)
| Country | Link |
|---|---|
| US (7) | US7354580B2 (enExample) |
| EP (2) | EP2583685A1 (enExample) |
| JP (2) | JP2008502738A (enExample) |
| CN (1) | CN101102786A (enExample) |
| AU (1) | AU2005254058A1 (enExample) |
| CA (1) | CA2567686A1 (enExample) |
| IL (1) | IL179515A0 (enExample) |
| MX (1) | MXPA06014421A (enExample) |
| WO (1) | WO2005123104A2 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1968709A (zh) * | 2004-06-18 | 2007-05-23 | 瑞泽恩制药公司 | 用于治疗恶性胸腔积液的vegf抑制剂 |
| US20060217311A1 (en) * | 2005-03-25 | 2006-09-28 | Daniel Dix | VEGF antagonist formulations |
| AU2006279658A1 (en) | 2005-08-12 | 2007-02-22 | Regeneron Pharmaceuticals, Inc. | Treatment of diseases by subcutaneous administration of a VEGF antagonist |
| US8093259B2 (en) * | 2006-05-25 | 2012-01-10 | Novartis Ag | 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-N-[5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl]-benzamide for treatment of melanoma |
| LT2944306T (lt) | 2006-06-16 | 2021-02-25 | Regeneron Pharmaceuticals, Inc. | Vfgf antagonisto kompozicijos, tinkamos įvedimui intravitrealiniu būdu |
| GB0612721D0 (en) * | 2006-06-27 | 2006-08-09 | Novartis Ag | Organic compounds |
| ME02371B (me) | 2006-09-29 | 2016-06-20 | Oncomed Pharm Inc | Sastojci i postupci za dijagnstikovanje i tretman raka |
| AU2007333735A1 (en) * | 2006-12-19 | 2008-06-26 | Genentech, Inc. | VEGF-specific antagonists for adjuvant and neoadjuvant therapy and the treatment of early stage tumors |
| AU2014201795B2 (en) * | 2006-12-19 | 2016-05-19 | Genentech, Inc. | VEGF-specific antagonists for adjuvant and neoadjuvant therapy and the treatment of early stage tumors |
| TWI580694B (zh) | 2007-11-30 | 2017-05-01 | 建南德克公司 | 抗-ｖｅｇｆ抗體 |
| CA2746120A1 (en) * | 2008-12-23 | 2010-07-01 | Genentech, Inc. | Methods and compositions for diagnostic use in cancer patients |
| EP2434891B9 (en) | 2009-05-27 | 2021-05-05 | PTC Therapeutics, Inc. | Methods for treating cancer and non-neoplastic conditions |
| EP3485908B1 (en) | 2009-10-16 | 2021-08-18 | Mereo BioPharma 5, Inc. | Therapeutic combination and use of dll4 antagonist antibodies and anti-hypertensive agents |
| CN103140761B (zh) * | 2010-07-19 | 2015-11-25 | 霍夫曼-拉罗奇有限公司 | 贝伐单抗组合疗法用于治疗胰腺癌的血浆生物标志物 |
| US8551479B2 (en) | 2010-09-10 | 2013-10-08 | Oncomed Pharmaceuticals, Inc. | Methods for treating melanoma |
| SG10202111177VA (en) | 2011-01-13 | 2021-11-29 | Regeneron Pharma | Use of a vegf antagonist to treat angiogenic eye disorders |
| JO3283B1 (ar) | 2011-04-26 | 2018-09-16 | Sanofi Sa | تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI) |
| EP2546268A1 (en) | 2011-07-13 | 2013-01-16 | F-Star Biotechnologische Forschungs - und Entwicklungsges. M.B.H. | Internalising immunoglobulin |
| JP6170496B2 (ja) | 2011-09-23 | 2017-07-26 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Ｖｅｇｆ／ｄｌｌ４結合剤およびその使用 |
| WO2014071018A1 (en) | 2012-10-31 | 2014-05-08 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a dll4 antagonist |
| EP2956476B1 (en) | 2013-02-18 | 2019-12-25 | Vegenics Pty Limited | Ligand binding molecules and uses thereof |
| KR101789501B1 (ko) | 2014-01-25 | 2017-10-26 | 쳉두 캉홍 바이오테크놀로지스 코. 리미티드 | 혈관의 신생 또는 성장을 억제하는 융합 단백질 및 그 용도 |
| CN104004058B (zh) * | 2014-06-23 | 2016-06-08 | 栾晓鹏 | 有关白介素-33抑制剂多肽及其应用 |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| HRP20191145T1 (hr) | 2014-07-18 | 2019-10-04 | Sanofi | Postupak predviđanja ishoda liječenja s afliberceptom kod pacijenta za kojeg se sumnja da ima rak |
| AU2015338974B2 (en) | 2014-10-31 | 2021-08-26 | Oncomed Pharmaceuticals, Inc. | Combination therapy for treatment of disease |
| CA2966216A1 (en) * | 2014-11-14 | 2016-05-19 | Genentech, Inc. | Predicting response to a vegf antagonist |
| US11339213B2 (en) | 2015-09-23 | 2022-05-24 | Mereo Biopharma 5, Inc. | Methods and compositions for treatment of cancer |
| KR20250057128A (ko) | 2015-12-30 | 2025-04-28 | 코디악 사이언시스 인코포레이티드 | 항체 및 이의 접합체 |
| TWI746505B (zh) * | 2016-01-25 | 2021-11-21 | 法商賽諾菲公司 | 通過測量血漿生物標記的水平預測疑似患有癌症的患者使用阿柏西普的治療的結果的方法 |
| US10947537B2 (en) | 2016-02-18 | 2021-03-16 | University Of Massachusetts | Method of treating VEGF/VEGFR resistant prostate cancer by combining the therapy with RAC1 inhibitors |
| KR101685532B1 (ko) * | 2016-04-26 | 2016-12-13 | 한국프라임제약주식회사 | 혈관내피성장인자 수용체 융합단백질 |
| EP3601343B1 (en) * | 2017-03-30 | 2022-05-04 | ECS-Progastrin SA | Compositions and methods for detecting and treating prostate cancer using progastrin binding molecule |
| US11458126B2 (en) | 2017-08-01 | 2022-10-04 | Ptc Therapeutics, Inc. | DHODH inhibitor for use in treating hematologic cancers |
| KR102147721B1 (ko) * | 2017-10-24 | 2020-08-25 | (주)엠디바이오랩 | 스트렙토니그린 및 라파마이신을 유효성분으로 포함하는, 암 예방 또는 치료용 약학적 조성물 |
| WO2019108770A1 (en) | 2017-11-30 | 2019-06-06 | Regeneron Pharmaceuticals, Inc. | Use of a vegf antagonist to treat angiogenic eye disorders |
| IL276158B2 (en) | 2018-01-26 | 2024-07-01 | Univ California | Methods and preparations for the treatment of angiogenic disorders using anti-VEGF factors |
| JP2021514656A (ja) | 2018-03-02 | 2021-06-17 | コディアック サイエンシーズ インコーポレイテッドＫｏｄｉａｋ Ｓｃｉｅｎｃｅｓ Ｉｎｃ． | Ｉｌ−６抗体ならびにその融合構築物およびコンジュゲート |
| WO2020106049A1 (ko) * | 2018-11-20 | 2020-05-28 | (주)엠디바이오랩 | 스트렙토니그린 및 항암제를 모두 포함하는 암 예방 또는 치료에 사용하기 위한 약학적 조성 |
| WO2020159203A1 (ko) * | 2019-01-29 | 2020-08-06 | (주)엠디바이오랩 | 스트렙토니그린 및 항암제를 포함하는 뇌종양 예방 또는 치료용 조성물 |
| KR102358632B1 (ko) * | 2019-02-01 | 2022-02-04 | (주)엠디바이오랩 | 스트렙토니그린 및 항암제를 포함하는 대장암 예방 또는 치료용 약학적 조성물 |
| US11912784B2 (en) | 2019-10-10 | 2024-02-27 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| BR112022010113A2 (pt) | 2019-11-25 | 2022-09-06 | Univ California | Inibidores de vegf de longa ação para neovascularização intraocular |
| KR20230008830A (ko) | 2020-05-08 | 2023-01-16 | 리제너론 파마슈티칼스 인코포레이티드 | Vegf 트랩 및 미니-트랩 및 안구 장애 및 암의 치료 방법 |
| US20220196166A1 (en) * | 2020-12-18 | 2022-06-23 | Nibco Inc. | L-ball union drain valve |
| US11898643B1 (en) | 2022-12-28 | 2024-02-13 | Nibco Inc. | Dual union ball drain valve with T-flow adjustability |
| US12140236B2 (en) | 2023-02-08 | 2024-11-12 | Nibco Inc. | Dual union drain valve with reversible check inserts |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6100071A (en) * | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
| US7264801B2 (en) * | 1998-08-11 | 2007-09-04 | Genentech, Inc. | EG-VEGF nucleic acids and polypeptides and method of use |
| US7087411B2 (en) * | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
| US6833349B2 (en) | 1999-06-08 | 2004-12-21 | Regeneron Pharmaceuticals, Inc. | Methods of treating inflammatory skin diseases |
| CN103349781B (zh) * | 1999-06-08 | 2015-04-01 | 里珍纳龙药品有限公司 | 具有改善的药物动力学特性的修饰嵌合多肽 |
| EP1626989A2 (en) * | 2003-05-28 | 2006-02-22 | Regeneron Pharmaceuticals, Inc. | Method of treating corneal transplant rejection by using vegf antagonists |
| US7186699B2 (en) * | 2003-06-03 | 2007-03-06 | Cell Genesys, Inc. | Method for treating cancer by vector-mediated delivery of one or more anti-angiogenic or pro-apoptotic genes |
| US7354578B2 (en) | 2003-06-06 | 2008-04-08 | Regeneron Pharmaceuticals, Inc. | Method of tumor regression with VEGF inhibitors |
-
2005
- 2005-06-10 JP JP2007527795A patent/JP2008502738A/ja not_active Withdrawn
- 2005-06-10 AU AU2005254058A patent/AU2005254058A1/en not_active Abandoned
- 2005-06-10 WO PCT/US2005/020762 patent/WO2005123104A2/en not_active Ceased
- 2005-06-10 MX MXPA06014421A patent/MXPA06014421A/es not_active Application Discontinuation
- 2005-06-10 EP EP12176929.3A patent/EP2583685A1/en not_active Withdrawn
- 2005-06-10 US US11/149,738 patent/US7354580B2/en active Active
- 2005-06-10 EP EP05750079A patent/EP1753442A2/en not_active Ceased
- 2005-06-10 CA CA002567686A patent/CA2567686A1/en not_active Abandoned
- 2005-06-10 CN CNA2005800189582A patent/CN101102786A/zh active Pending
-
2006
- 2006-11-23 IL IL179515A patent/IL179515A0/en unknown
-
2008
- 2008-02-29 US US12/072,967 patent/US7479272B2/en not_active Expired - Lifetime
- 2008-02-29 US US12/074,104 patent/US7479274B2/en not_active Expired - Lifetime
- 2008-02-29 US US12/072,965 patent/US7482001B2/en not_active Expired - Lifetime
- 2008-02-29 US US12/074,096 patent/US7479273B2/en not_active Expired - Lifetime
- 2008-02-29 US US12/072,966 patent/US7482002B2/en not_active Expired - Lifetime
- 2008-02-29 US US12/074,140 patent/US7479275B2/en not_active Expired - Lifetime
-
2011
- 2011-11-10 JP JP2011246211A patent/JP2012067116A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US20080171703A1 (en) | 2008-07-17 |
| US20080214465A1 (en) | 2008-09-04 |
| US7479273B2 (en) | 2009-01-20 |
| AU2005254058A1 (en) | 2005-12-29 |
| EP1753442A2 (en) | 2007-02-21 |
| IL179515A0 (en) | 2007-05-15 |
| US7482001B2 (en) | 2009-01-27 |
| MXPA06014421A (es) | 2007-05-04 |
| US7479272B2 (en) | 2009-01-20 |
| WO2005123104A3 (en) | 2006-04-27 |
| US7479274B2 (en) | 2009-01-20 |
| US7482002B2 (en) | 2009-01-27 |
| US20080214466A1 (en) | 2008-09-04 |
| US20080188420A1 (en) | 2008-08-07 |
| WO2005123104A2 (en) | 2005-12-29 |
| JP2008502738A (ja) | 2008-01-31 |
| US20080188418A1 (en) | 2008-08-07 |
| JP2012067116A (ja) | 2012-04-05 |
| US7479275B2 (en) | 2009-01-20 |
| US20080188419A1 (en) | 2008-08-07 |
| EP2583685A1 (en) | 2013-04-24 |
| CN101102786A (zh) | 2008-01-09 |
| US20050276808A1 (en) | 2005-12-15 |
| US7354580B2 (en) | 2008-04-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20161114 |