CA2559360A1 - Methode de production d'acides gras polyinsatures c18, c20 et c22 dans les plantes transgeniques - Google Patents

Methode de production d'acides gras polyinsatures c18, c20 et c22 dans les plantes transgeniques Download PDF

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Publication number
CA2559360A1
CA2559360A1 CA002559360A CA2559360A CA2559360A1 CA 2559360 A1 CA2559360 A1 CA 2559360A1 CA 002559360 A CA002559360 A CA 002559360A CA 2559360 A CA2559360 A CA 2559360A CA 2559360 A1 CA2559360 A1 CA 2559360A1
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seq
nucleic acid
desaturase
acid molecule
sequence shown
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CA002559360A
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Petra Cirpus
Jorg Bauer
Xiao Qiu
Guohai Wu
Nagamani Datla
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BASF Plant Science GmbH
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Individual
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Priority claimed from DE102004017518A external-priority patent/DE102004017518A1/de
Priority claimed from PCT/EP2004/007957 external-priority patent/WO2005012316A2/fr
Priority claimed from DE200410062543 external-priority patent/DE102004062543A1/de
Application filed by Individual filed Critical Individual
Priority to CA3045858A priority Critical patent/CA3045858C/fr
Publication of CA2559360A1 publication Critical patent/CA2559360A1/fr
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    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23D—EDIBLE OILS OR FATS, e.g. MARGARINES, SHORTENINGS, COOKING OILS
    • A23D9/00—Other edible oils or fats, e.g. shortenings, cooking oils
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
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    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083—Miscellaneous (1.14.99)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/86—Products or compounds obtained by genetic engineering
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    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/19—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (1.14.19)

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Abstract

La présente invention concerne un procédé pour la production d'acides gras polyinsaturés cis-, C20- et C22- dans la graine d'une plante transgénique. Le procédé comprend l'ajout d'une molécule d'acide nucléique codant une A6-désaturase, A8-désaturase ou une A6-élongase, A5-désaturase, A5-élongase, A4-désaturase, la molécule d'acide nucléique codant la A6-désaturase, une molécule d'acide nucléique codant pour une séquence d'acides aminés comprenant une séquence possédant un rapport de 60 % d'identité avec la séquence d'acides aminés dans SEQ ID NO: 90. L'invention concerne également des molécules d'acide nucléique recombinant comprenant les séquences d'acides nucléiques et des plantes transgéniques qui comprennent lesdites molécules d'acide nucléique recombinant. Une autre partie de l'invention concerne des huiles, des lipides et/ou des acides gras produits par le procédé selon l'invention et concerne leur utilisation.
CA002559360A 2004-02-27 2005-02-23 Methode de production d'acides gras polyinsatures c18, c20 et c22 dans les plantes transgeniques Pending CA2559360A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3045858A CA3045858C (fr) 2004-02-27 2005-02-23 Procede de production d'acides gras polyinsatures dans les plants transgeniques

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
DE102004009457.8 2004-02-27
DE102004009457 2004-02-27
DE102004012370.5 2004-03-13
DE102004012370 2004-03-13
DE102004017518A DE102004017518A1 (de) 2004-04-08 2004-04-08 Verfahren zur Herstellung von mehrfach ungesättigten Fettsäuren
DE102004017518.7 2004-04-08
DE102004024014.0 2004-05-14
DE102004024014 2004-05-14
EPPCT/EP/04/07957 2004-07-16
PCT/EP2004/007957 WO2005012316A2 (fr) 2003-08-01 2004-07-16 Procede de production d'acides gras polyinsatures dans des organismes transgeniques
DE200410062543 DE102004062543A1 (de) 2004-12-24 2004-12-24 Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in transgenen Pflanzen
DE102004062543.3 2004-12-24
PCT/EP2005/001863 WO2005083093A2 (fr) 2004-02-27 2005-02-23 Procede de production d'acides gras polyinsatures chez des plantes transgeniques

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3045858A Division CA3045858C (fr) 2004-02-27 2005-02-23 Procede de production d'acides gras polyinsatures dans les plants transgeniques

Publications (1)

Publication Number Publication Date
CA2559360A1 true CA2559360A1 (fr) 2005-09-09

Family

ID=34916613

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002559360A Pending CA2559360A1 (fr) 2004-02-27 2005-02-23 Methode de production d'acides gras polyinsatures c18, c20 et c22 dans les plantes transgeniques
CA3045858A Active CA3045858C (fr) 2004-02-27 2005-02-23 Procede de production d'acides gras polyinsatures dans les plants transgeniques

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3045858A Active CA3045858C (fr) 2004-02-27 2005-02-23 Procede de production d'acides gras polyinsatures dans les plants transgeniques

Country Status (6)

Country Link
EP (2) EP4219670A3 (fr)
AU (1) AU2005217079C1 (fr)
CA (2) CA2559360A1 (fr)
PL (1) PL1723220T3 (fr)
RU (1) RU2449007C2 (fr)
WO (1) WO2005083093A2 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110039010A1 (en) * 2008-04-25 2011-02-17 Basf Plant Science Gmbh Plant Seed Oil
US8134046B2 (en) 2005-08-09 2012-03-13 Basf Plant Science Gmbh Method for producing arachidonic acid and/or eicosapentaenoic acid in useful transgenic plants
RU2469092C2 (ru) * 2006-05-17 2012-12-10 Е.И.Дюпон Де Немур Энд Компани Дельта-5-десатураза и ее применение для получения полиненасыщенных жирных кислот
US8901374B2 (en) 2008-06-03 2014-12-02 Basf Plant Science Gmbh Fatty acid dehydratases and uses thereof
US9458477B2 (en) 2010-10-21 2016-10-04 Basf Plant Science Company Gmbh Fatty acid desaturases, elongases, elongation components and uses thereof
US10035989B2 (en) 2004-02-27 2018-07-31 Basf Plant Science Gmbh Method for producing polyunsaturated fatty acids in transgenic plants
US10190131B2 (en) 2006-02-21 2019-01-29 Basf Plant Science Gmbh Method for producing polyunsaturated fatty acids
US10731169B2 (en) 2013-07-05 2020-08-04 Basf Plant Science Company Gmbh Gene expression or activity enhancing elements
US11180769B2 (en) 2003-08-01 2021-11-23 Basf Plant Science Gmbh Method for the production of multiple-unsaturated fatty acids in transgenic organisms
US11952581B2 (en) 2003-08-01 2024-04-09 Basf Plant Science Gmbh Process for the production of polyunsaturated fatty acids in transgenic organisms

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1720988B1 (fr) 2004-02-27 2011-10-12 BASF Plant Science GmbH PROCEDE POUR PRODUIRE DES ACIDES GRAS omega-3 INSATURES DANS DES ORGANISMES TRANSGENIQUES
PL1756280T3 (pl) 2004-04-22 2015-04-30 Commw Scient Ind Res Org Synteza długołańcuchowych wielonienasyconych kwasów tłuszczowych w komórkach rekombinowanych
AU2011232757B2 (en) * 2004-04-22 2013-10-03 Commonwealth Scientific And Industrial Research Organisation Synthesis of long-chain polyunsaturated fatty acids by recombinant cells
ES2529572T3 (es) 2004-04-22 2015-02-23 Commonwealth Scientific And Industrial Research Organisation Síntesis de ácidos grasos poliinsaturados de cadena larga por células recombinantes
AU2005235627B2 (en) * 2004-04-22 2011-07-07 Commonwealth Scientific And Industrial Research Organisation Synthesis of long-chain polyunsaturated fatty acids by recombinant cells
US7256033B2 (en) 2004-06-25 2007-08-14 E. I. Du Pont De Nemours And Company Delta-8 desaturase and its use in making polyunsaturated fatty acids
DE102004063326A1 (de) * 2004-12-23 2006-07-06 Basf Plant Science Gmbh Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in transgenen Organismen
KR20080071190A (ko) 2005-11-23 2008-08-01 이 아이 듀폰 디 네모아 앤드 캄파니 델타-９ 일롱가제, 및 다중불포화 지방산 생성에 있어서의이들의 용도
GB0603160D0 (en) * 2006-02-16 2006-03-29 Rothamsted Res Ltd Nucleic acid
CN100410376C (zh) * 2006-03-06 2008-08-13 中国科学院遗传与发育生物学研究所 与油脂代谢调控相关的转录因子GmDofC及其编码基因与应用
US7465793B2 (en) 2006-04-20 2008-12-16 E.I. Du Pont De Nemours And Company Synthetic Δ17 desaturase derived from Phytophthora ramourum and its use in making polyunsaturated fatty acids
US20070254299A1 (en) 2006-05-01 2007-11-01 Yadav Narendra S Fungal delta 12 desaturase and delta 15 desaturase motifs
DE102006034313A1 (de) * 2006-07-21 2008-01-24 Basf Plant Science Gmbh Verfahren zur Herstellung von Arachidonsäure und/oder Eicosapentaensäure
AU2013202498B2 (en) * 2006-08-24 2015-04-30 Basf Plant Science Gmbh Isolation and characterization of a novel Pythium omega 3 desaturase with specificity to all omega 6 fatty acids longer than 18 carbon chains
RU2009111266A (ru) 2006-08-29 2010-10-10 Коммонвелт Сайентифик энд Индастриал Рисерч Организейшн (AU) Синтез жирных кислот
AU2013273704C1 (en) * 2006-10-06 2023-03-16 Basf Plant Science Gmbh Process for the production of polyunsaturated fatty acids in transgenic organisms
DK2087105T3 (da) 2006-10-30 2015-05-26 Du Pont Delta 17-desaturase og anvendelse heraf ved fremstilling af flerumættede fedtsyrer
US8916361B2 (en) 2006-11-17 2014-12-23 Abbott Laboratories Elongase gene and uses thereof
US7709239B2 (en) 2006-12-07 2010-05-04 E.I. Du Pont De Nemours And Company Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids
WO2008073275A2 (fr) 2006-12-07 2008-06-19 E. I. Du Pont De Nemours And Company Gènes mutants de la désaturase delta 8 modifiés par mutagenèse ciblée et utilisation de ceux-ci dans la fabrication d'acides gras polyinsaturés
AU2008203869B2 (en) 2007-01-03 2013-07-11 Monsanto Technology, Llc Food compositions incorporating additional long chain fatty acids
AU2008216707B2 (en) * 2007-02-12 2014-06-19 E. I. Du Pont De Nemours And Company Production of arachidonic acid in oilseed plants
WO2008104559A1 (fr) * 2007-02-27 2008-09-04 Norddeutsche Pflanzenzucht Procédé de production d'acides gras polyinsaturés dans des organismes transgéniques
US7794701B2 (en) 2007-04-16 2010-09-14 E.I. Du Pont De Nemours And Company Δ-9 elongases and their use in making polyunsaturated fatty acids
EP2171049A4 (fr) 2007-07-13 2010-12-29 Ocean Nutrition Canada Ltd D4 désaturases et d5 élongases
JP5757870B2 (ja) * 2008-08-26 2015-08-05 ビーエーエスエフ プラント サイエンス ゲーエムベーハー デサチュラーゼをコードする核酸および改変植物油
CN102317459A (zh) 2008-11-18 2012-01-11 联邦科学技术研究组织 产生ω-3脂肪酸的酶和方法
JP2012529277A (ja) 2009-06-08 2012-11-22 ロザムステッド リサーチ リミテッド 新規の脂肪酸伸長成分およびその使用
WO2011006948A1 (fr) 2009-07-17 2011-01-20 Basf Plant Science Company Gmbh Nouvelles désaturases et élongases d'acide gras et leurs utilisations
KR20170116226A (ko) * 2009-09-24 2017-10-18 고쿠리쓰다이가쿠호진 규슈다이가쿠 스트라메노파일의 형질전환 방법
US20130101723A1 (en) 2009-11-03 2013-04-25 Daniel Verkoeijen Vegetable oil comprising a polyunsaturated fatty acid having at least 20 carbon atoms
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AU2005217079A1 (en) 2005-09-09
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AU2005217079B2 (en) 2012-02-02
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