CA2550187C - Non-nucleoside reverse transcriptase inhibitors - Google Patents
Non-nucleoside reverse transcriptase inhibitors Download PDFInfo
- Publication number
- CA2550187C CA2550187C CA2550187A CA2550187A CA2550187C CA 2550187 C CA2550187 C CA 2550187C CA 2550187 A CA2550187 A CA 2550187A CA 2550187 A CA2550187 A CA 2550187A CA 2550187 C CA2550187 C CA 2550187C
- Authority
- CA
- Canada
- Prior art keywords
- mmol
- cis
- alkyl
- cyclopropa
- tetrahydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0400021A SE0400021D0 (sv) | 2004-01-08 | 2004-01-08 | Non-nucleoside reverse transcriptase inhibitors |
| SE0400021-2 | 2004-01-08 | ||
| SE0400585-6 | 2004-03-09 | ||
| SE0400585A SE0400585D0 (sv) | 2004-03-09 | 2004-03-09 | NNRTI Antivirals |
| PCT/SE2004/002034 WO2005066131A1 (en) | 2004-01-08 | 2004-12-30 | Non-nucleotide reverse transcriptase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2550187A1 CA2550187A1 (en) | 2005-07-21 |
| CA2550187C true CA2550187C (en) | 2012-08-07 |
Family
ID=34752289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2550187A Expired - Fee Related CA2550187C (en) | 2004-01-08 | 2004-12-30 | Non-nucleoside reverse transcriptase inhibitors |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7915295B2 (OSRAM) |
| EP (1) | EP1701942B1 (OSRAM) |
| JP (1) | JP4762917B2 (OSRAM) |
| AT (1) | ATE451357T1 (OSRAM) |
| AU (1) | AU2004312284B2 (OSRAM) |
| BR (1) | BRPI0418306B8 (OSRAM) |
| CA (1) | CA2550187C (OSRAM) |
| DE (1) | DE602004024584D1 (OSRAM) |
| DK (1) | DK1701942T3 (OSRAM) |
| EA (1) | EA009700B1 (OSRAM) |
| ES (1) | ES2337794T3 (OSRAM) |
| IL (1) | IL176740A (OSRAM) |
| NZ (1) | NZ548367A (OSRAM) |
| SG (1) | SG149070A1 (OSRAM) |
| WO (1) | WO2005066131A1 (OSRAM) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05002545A (es) * | 2002-09-05 | 2005-09-30 | Medivir Ab | Inhibidores de transcriptasa inversa sin nucleosidos. |
| US7388008B2 (en) | 2004-08-02 | 2008-06-17 | Ambrilia Biopharma Inc. | Lysine based compounds |
| ES2539527T3 (es) * | 2005-04-27 | 2015-07-01 | Taimed Biologics, Inc. | Método para mejorar la farmacocinética de los inhibidores de las proteasas y de los precursores de los inhibidores de las proteasas |
| JP2009517412A (ja) | 2005-11-30 | 2009-04-30 | アンブリリア バイオファーマ インコーポレイテッド | アスパルチルプロテアーゼ阻害物質のリジンベースのプロドラッグ及びその調製方法 |
| GB0608876D0 (en) * | 2006-05-05 | 2006-06-14 | Medivir Ab | Combination therapy |
| WO2007136572A2 (en) * | 2006-05-15 | 2007-11-29 | Merck & Co., Inc. | Antidiabetic bicyclic compounds |
| US8410300B2 (en) | 2006-09-21 | 2013-04-02 | Taimed Biologics, Inc. | Protease inhibitors |
| JP6636031B2 (ja) * | 2015-01-30 | 2020-01-29 | ジェネンテック， インコーポレイテッド | 治療用化合物およびその使用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA003327B1 (ru) * | 1998-01-16 | 2003-04-24 | Медивир Аб | Антивирусные соединения |
| WO1999051613A1 (en) * | 1998-04-03 | 1999-10-14 | Medivir Ab | Prodrugs of phosphorous-containing pharmaceuticals |
| SE0100733D0 (sv) * | 2001-03-05 | 2001-03-05 | Medivir Ab | Non-nucleoside reverse transcriptase inhibitors |
| SE0102867D0 (sv) * | 2001-08-28 | 2001-08-28 | Medivir Ab | Non-nucleoside reverse transcriptase inhibitors |
| MXPA05002545A (es) * | 2002-09-05 | 2005-09-30 | Medivir Ab | Inhibidores de transcriptasa inversa sin nucleosidos. |
-
2004
- 2004-12-30 AT AT04809207T patent/ATE451357T1/de not_active IP Right Cessation
- 2004-12-30 EA EA200601289A patent/EA009700B1/ru not_active IP Right Cessation
- 2004-12-30 WO PCT/SE2004/002034 patent/WO2005066131A1/en not_active Ceased
- 2004-12-30 DE DE602004024584T patent/DE602004024584D1/de not_active Expired - Lifetime
- 2004-12-30 ES ES04809207T patent/ES2337794T3/es not_active Expired - Lifetime
- 2004-12-30 CA CA2550187A patent/CA2550187C/en not_active Expired - Fee Related
- 2004-12-30 SG SG200809639-8A patent/SG149070A1/en unknown
- 2004-12-30 AU AU2004312284A patent/AU2004312284B2/en not_active Ceased
- 2004-12-30 EP EP04809207A patent/EP1701942B1/en not_active Expired - Lifetime
- 2004-12-30 DK DK04809207.6T patent/DK1701942T3/da active
- 2004-12-30 US US10/584,933 patent/US7915295B2/en not_active Expired - Fee Related
- 2004-12-30 JP JP2006549182A patent/JP4762917B2/ja not_active Expired - Fee Related
- 2004-12-30 BR BRPI0418306A patent/BRPI0418306B8/pt not_active IP Right Cessation
- 2004-12-30 NZ NZ548367A patent/NZ548367A/en not_active IP Right Cessation
-
2006
- 2006-07-06 IL IL176740A patent/IL176740A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ548367A (en) | 2010-06-25 |
| JP4762917B2 (ja) | 2011-08-31 |
| US20080070951A1 (en) | 2008-03-20 |
| CA2550187A1 (en) | 2005-07-21 |
| ES2337794T3 (es) | 2010-04-29 |
| HK1101400A1 (en) | 2007-10-18 |
| IL176740A (en) | 2011-09-27 |
| BRPI0418306B1 (pt) | 2018-09-18 |
| DK1701942T3 (da) | 2010-04-06 |
| ATE451357T1 (de) | 2009-12-15 |
| IL176740A0 (en) | 2006-10-31 |
| EA200601289A1 (ru) | 2006-12-29 |
| EP1701942A1 (en) | 2006-09-20 |
| DE602004024584D1 (de) | 2010-01-21 |
| EP1701942B1 (en) | 2009-12-09 |
| AU2004312284A2 (en) | 2005-07-21 |
| EA009700B1 (ru) | 2008-02-28 |
| BRPI0418306B8 (pt) | 2021-05-25 |
| BRPI0418306A (pt) | 2007-05-02 |
| WO2005066131A1 (en) | 2005-07-21 |
| SG149070A1 (en) | 2009-01-29 |
| US7915295B2 (en) | 2011-03-29 |
| JP2007519640A (ja) | 2007-07-19 |
| AU2004312284A1 (en) | 2005-07-21 |
| AU2004312284B2 (en) | 2010-08-05 |
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| Publication | Publication Date | Title |
|---|---|---|
| JP2009102436A (ja) | 非ヌクレオシド逆転写酵素インヒビターとしてのシクロプロパヘテロ環 | |
| CA2550187C (en) | Non-nucleoside reverse transcriptase inhibitors | |
| AU2003260492B2 (en) | Non-nucleoside reverse transcriptase inhibitors | |
| AU2002308231A1 (en) | Cyclopropaheterocycles as non-nucleoside reverse transcriptase inhibitors | |
| CN1926108B (zh) | 非核苷酸逆转录酶抑制剂 | |
| US6610714B2 (en) | Non-nucleoside reverse transcriptase inhibitors | |
| MXPA06007726A (en) | Non-nucleotide reverse transcriptase inhibitors | |
| HK1101400B (en) | Non-nucleotide reverse transcriptase inhibitors | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20201230 |