CA2543338A1 - Nouvelles utilisations medicales de composes a activite antagoniste de cb1 et traitement combine impliquant ces composes - Google Patents

Nouvelles utilisations medicales de composes a activite antagoniste de cb1 et traitement combine impliquant ces composes Download PDF

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Publication number
CA2543338A1
CA2543338A1 CA002543338A CA2543338A CA2543338A1 CA 2543338 A1 CA2543338 A1 CA 2543338A1 CA 002543338 A CA002543338 A CA 002543338A CA 2543338 A CA2543338 A CA 2543338A CA 2543338 A1 CA2543338 A1 CA 2543338A1
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Prior art keywords
group
alkyl
substituted
compound
treatment
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CA002543338A
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Inventor
Jochen Antel
Peter-Colin Gregory
Harald Waldeck
Guenter Krause
Josephus Hubertus Maria Lange
Chris Kruse
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Abbott Products GmbH
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Individual
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

La présente invention concerne une nouvelle utilisation médicale de composés présentant une activité de récepteur de CB¿1?, choisis dans le groupe des dérivés 4,5-dihydro-1H-pyrazole, des dérivés 1H-lmidazole, des dérivés thiazole, et/ou des dérivés 1H-1,2,4-triazole-3-carboxamide, tels que définis dans les spécifications, ou de certains de leurs promédicaments, tautomères ou sels. Les utilisations considérées concerne la fabrication de médicaments destinés au traitement et/ou à la prophylaxie d'affections en relation avec le récepteur du CB¿1? chez l'enfant, et/ou pour le traitement et/ou la prophylaxie de l'obésité médicamenteuse chez l'enfant ou l'adolescent. En outre, l'invention concerne l'utilisation de tels composés à activité de récepteur du CB¿1? en association avec des inhibiteurs des lipases. Ces composés conviennent particulièrement, en association avec des inhibiteurs des lipases, à la fabrication de médicaments destinés au traitement et/ou à la prophylaxie de l'obésité de l'adolescent ou de l'enfant, et/ou au traitement et/ou à la prophylaxie de l'obésité médicamenteuse de l'enfant et de l'adolescent. Les inhibiteurs de lipases préférés sont l'orlistat, les panclicines, l'ATL-962 et/ou la lipstatine.
CA002543338A 2003-10-24 2004-10-22 Nouvelles utilisations medicales de composes a activite antagoniste de cb1 et traitement combine impliquant ces composes Abandoned CA2543338A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP03103961 2003-10-24
EP03103961.3 2003-10-24
EP03103967.0 2003-10-27
EP03103967 2003-10-27
PCT/EP2004/052639 WO2005039550A2 (fr) 2003-10-24 2004-10-22 Nouvelles utilisations medicales de composes a activite antagoniste de cb1 et traitement combine impliquant ces composes

Publications (1)

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CA2543338A1 true CA2543338A1 (fr) 2005-05-06

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CA002543338A Abandoned CA2543338A1 (fr) 2003-10-24 2004-10-22 Nouvelles utilisations medicales de composes a activite antagoniste de cb1 et traitement combine impliquant ces composes

Country Status (8)

Country Link
EP (1) EP1753413A2 (fr)
JP (1) JP2007513872A (fr)
AU (1) AU2004283056A1 (fr)
BR (1) BRPI0415851A (fr)
CA (1) CA2543338A1 (fr)
MX (1) MXPA06004434A (fr)
RU (1) RU2006117627A (fr)
WO (1) WO2005039550A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004058145A2 (fr) 2002-12-19 2004-07-15 Merck & Co., Inc. Amides substitues
AR046132A1 (es) * 2003-10-24 2005-11-23 Solvay Pharm Gmbh Composicin farmaceutica que contiene al menos un compuesto con actividad de receptor de cb1, o un profarmaco , tautomero o sal del mismo, como componente activo adecuado para el tratamiento y/o profilaxis de enfermedades relacionadas con el receptor cb1 en pacientes juveniles y/o para el tratamiento
MX2007003327A (es) 2004-09-20 2007-06-05 Xenon Pharmaceuticals Inc Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa.
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AU2004283056A1 (en) 2005-05-06
EP1753413A2 (fr) 2007-02-21
JP2007513872A (ja) 2007-05-31
WO2005039550A2 (fr) 2005-05-06
RU2006117627A (ru) 2007-12-10
WO2005039550A3 (fr) 2007-03-22

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