CA2538284C - Modulateurs du ligand 1 de la glycoproteine p-selectine - Google Patents

Modulateurs du ligand 1 de la glycoproteine p-selectine Download PDF

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Publication number
CA2538284C
CA2538284C CA2538284A CA2538284A CA2538284C CA 2538284 C CA2538284 C CA 2538284C CA 2538284 A CA2538284 A CA 2538284A CA 2538284 A CA2538284 A CA 2538284A CA 2538284 C CA2538284 C CA 2538284C
Authority
CA
Canada
Prior art keywords
psgl
cell
multimeric compound
binding
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2538284A
Other languages
English (en)
Other versions
CA2538284A1 (fr
Inventor
Rong-Hwa Lin
Chung Nan Chang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abgenomics Cooperatief UA
Original Assignee
Abgenomics Cooperatief UA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/662,906 external-priority patent/US20040116333A1/en
Application filed by Abgenomics Cooperatief UA filed Critical Abgenomics Cooperatief UA
Publication of CA2538284A1 publication Critical patent/CA2538284A1/fr
Application granted granted Critical
Publication of CA2538284C publication Critical patent/CA2538284C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056—Lectin superfamily, e.g. CD23, CD72
    • C07K14/70564—Selectins, e.g. CD62
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Les composés multimères qui se lient à la glycoprotéine 1 p-sélectine (PSGL-1) sur la surface de lymphocytes T ou des cellules NK peuvent s'utiliser pour induire la déplétion et/ou l'apoptose desdites cellules. On peut utiliser ces composés multimères et les méthodes de l'invention pour réduire une réponse immunitaire indésirable induite par des lymphocytes T ou des cellules NK dans le cas notamment de maladies inflammatoires, de maladies auto-immunes, de rejets de transplantations ou d'affections allergiques.
CA2538284A 2003-09-15 2004-09-09 Modulateurs du ligand 1 de la glycoproteine p-selectine Expired - Fee Related CA2538284C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/662,906 2003-09-15
US10/662,906 US20040116333A1 (en) 2001-08-03 2003-09-15 Modulators of P-selectin glycoprotein ligand 1
PCT/US2004/029520 WO2005027831A2 (fr) 2001-08-03 2004-09-09 Modulateurs du ligand 1 de la glycoproteine p-selectine

Publications (2)

Publication Number Publication Date
CA2538284A1 CA2538284A1 (fr) 2005-03-31
CA2538284C true CA2538284C (fr) 2015-10-20

Family

ID=36242362

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2538284A Expired - Fee Related CA2538284C (fr) 2003-09-15 2004-09-09 Modulateurs du ligand 1 de la glycoproteine p-selectine

Country Status (16)

Country Link
EP (1) EP1663290A4 (fr)
JP (1) JP5808879B2 (fr)
KR (1) KR101159140B1 (fr)
CN (1) CN1852730B (fr)
AU (1) AU2004273807B2 (fr)
BR (1) BRPI0414402A (fr)
CA (1) CA2538284C (fr)
EC (1) ECSP066507A (fr)
IL (1) IL174172A (fr)
NO (1) NO20061306L (fr)
NZ (1) NZ546203A (fr)
RU (1) RU2407539C2 (fr)
SG (1) SG146670A1 (fr)
TW (2) TWI359024B (fr)
UA (1) UA91004C2 (fr)
ZA (1) ZA200602151B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1751300B1 (fr) * 2004-05-11 2017-11-08 AbGenomics Coöperatief U.A. Epitopes induisant la mort des lymphocytes t
JP5493234B2 (ja) * 2008-05-15 2014-05-14 国立大学法人 岡山大学 Ｐｓｇｌ−１阻害によるメタボリックシンドロームの予防及び治療法
CN108713026B (zh) * 2016-01-08 2023-01-06 美国全心医药生技股份有限公司 四价抗psgl-1抗体及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843707A (en) * 1992-10-23 1998-12-01 Genetics Institute, Inc. Nucleic acid encoding a novel P-selectin ligand protein
US6117977A (en) * 1996-04-24 2000-09-12 Genentech, Inc. Type C lectins
ZA973051B (en) * 1996-04-24 1998-10-12 Genentech Inc Type c lectins
US7744888B2 (en) * 2001-08-03 2010-06-29 Abgenomics Cooperatief U.A. Methods of modulating T cell or natural killer cell activity with anti-P-selectin glycoprotein ligand 1 antibodies

Also Published As

Publication number Publication date
JP2007533618A (ja) 2007-11-22
CA2538284A1 (fr) 2005-03-31
TW201012472A (en) 2010-04-01
RU2006112399A (ru) 2006-08-10
AU2004273807A1 (en) 2005-03-31
CN1852730A (zh) 2006-10-25
RU2407539C2 (ru) 2010-12-27
ZA200602151B (en) 2013-08-28
TW200513262A (en) 2005-04-16
EP1663290A2 (fr) 2006-06-07
IL174172A (en) 2011-12-29
JP5808879B2 (ja) 2015-11-10
BRPI0414402A (pt) 2006-11-14
IL174172A0 (en) 2006-08-01
CN1852730B (zh) 2012-05-30
UA91004C2 (uk) 2010-06-25
NZ546203A (en) 2009-05-31
KR101159140B1 (ko) 2012-06-22
TWI359024B (en) 2012-03-01
AU2004273807B2 (en) 2011-06-09
KR20060088104A (ko) 2006-08-03
SG146670A1 (en) 2008-10-30
NO20061306L (no) 2006-06-14
EP1663290A4 (fr) 2009-07-01
ECSP066507A (es) 2006-10-10

Similar Documents

Publication Publication Date Title
US8628775B2 (en) Methods of reducing T cell-mediated immune responses with multimeric P-selectin and/or E-selectin compounds
US8557579B2 (en) Screening for modulators of PSGL-1 with respect to T cell or NK cell death
AU2002305041A1 (en) Modulators of P-selectin glycoprotein ligand 1
IL174172A (en) Multimeric compound that binds psgl-1 proteins, uses thereof and kits comprising the same
MXPA06002968A (en) Modulators of p-selectin glycoprotein ligand 1

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20220309

MKLA Lapsed

Effective date: 20200909