CA2534405A1 - Halogenated quinazolinyl nitrofurans as antibacterial agents - Google Patents
Halogenated quinazolinyl nitrofurans as antibacterial agents Download PDFInfo
- Publication number
- CA2534405A1 CA2534405A1 CA002534405A CA2534405A CA2534405A1 CA 2534405 A1 CA2534405 A1 CA 2534405A1 CA 002534405 A CA002534405 A CA 002534405A CA 2534405 A CA2534405 A CA 2534405A CA 2534405 A1 CA2534405 A1 CA 2534405A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- formula
- compound according
- substituted
- nitro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Communicable Diseases (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49333603P | 2003-08-08 | 2003-08-08 | |
US60/493,336 | 2003-08-08 | ||
PCT/CA2004/001466 WO2005014585A1 (en) | 2003-08-08 | 2004-08-06 | Halogenated quinazolinyl nitrofurans as antibacterial agents |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2534405A1 true CA2534405A1 (en) | 2005-02-17 |
Family
ID=34135234
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002534405A Abandoned CA2534405A1 (en) | 2003-08-08 | 2004-08-06 | Halogenated quinazolinyl nitrofurans as antibacterial agents |
Country Status (9)
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20010016646A1 (en) * | 1998-03-20 | 2001-08-23 | David C. Rueger | Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects |
CA2534405A1 (en) | 2003-08-08 | 2005-02-17 | Ulysses Pharmaceutical Products Inc. | Halogenated quinazolinyl nitrofurans as antibacterial agents |
US20080146562A1 (en) * | 2003-08-08 | 2008-06-19 | Ulysses Pharmaceutical Products Inc., | Halogenated quinazolinyl nitrofurans as antibacterial agents |
AU2005287825A1 (en) * | 2004-09-23 | 2006-03-30 | Ulysses Pharmaceutical Products Inc. | Carbo- and hetero-cyclic antibiotics and use thereof |
WO2007101274A2 (en) * | 2006-03-02 | 2007-09-07 | The Uab Research Foundation | Mycobacterial disease detection, treatment, and drug discovery |
CA2661223A1 (en) * | 2006-08-22 | 2008-02-28 | Concert Pharmaceuticals Inc. | 4-aminoquinazoline derivatives and methods of use thereof |
US20110053964A1 (en) * | 2006-08-22 | 2011-03-03 | Roger Tung | 4-aminoquinazoline derivatives and methods of use thereof |
WO2008113161A1 (en) * | 2007-03-19 | 2008-09-25 | Ulysses Pharmaceutical Products Inc. | Phosphate prodrugs of quinazolinyl nitrofurans, methods of obtaining, and use of same |
PT2552440T (pt) | 2010-03-30 | 2019-01-10 | Helperby Therapeutics Ltd | Nova combinação e uso |
GB201013207D0 (en) | 2010-08-05 | 2010-09-22 | Helperby Therapeutics Ltd | Novel combination |
PL2600869T3 (pl) | 2010-08-05 | 2021-04-06 | Helperby Therapeutics Limited | Kombinacja związku pirolochinolinowego i beta-laktamowego środka przeciwdrobnoustrojowego, mupirocyny lub chlorheksydyny |
GB201015079D0 (en) | 2010-09-10 | 2010-10-27 | Helperby Therapeutics Ltd | Novel use |
GB201305277D0 (en) | 2013-03-22 | 2013-05-01 | Helperby Therapeutics Ltd | Novel combination and use |
GB201307989D0 (en) | 2013-05-02 | 2013-06-12 | Helperby Therapeutics Ltd | Novel combinations and use |
GB201401617D0 (en) | 2014-01-30 | 2014-03-19 | Helperby Therapeutics Ltd | Novel combination and use |
HUE052575T2 (hu) | 2014-12-18 | 2021-05-28 | Helperby Therapeutics Ltd | Új kombináció és alkalmazás |
WO2016166515A1 (en) | 2015-04-11 | 2016-10-20 | Helperby Therapeutics Limited | Oral composition |
GB201518969D0 (en) | 2015-10-27 | 2015-12-09 | Helperby Therapeutics Ltd | Triple combination |
CN106924261A (zh) * | 2016-04-12 | 2017-07-07 | 郑海英 | 一种防治牙体牙髓感染的药物组合物 |
GB201610869D0 (en) | 2016-06-22 | 2016-08-03 | Helperby Therapeutics Ltd | Combination |
GB201612093D0 (en) | 2016-07-12 | 2016-08-24 | Helperby Therapeutics Ltd | Combination |
GB201616014D0 (en) | 2016-09-20 | 2016-11-02 | Helperby Therapeutics Ltd | Combination |
GB201616909D0 (en) | 2016-10-05 | 2016-11-16 | Helperby Therapeutics Ltd | Combination |
GB201703898D0 (en) | 2017-03-10 | 2017-04-26 | Helperby Therapeautics Ltd | Method |
GB201704620D0 (en) | 2017-03-23 | 2017-05-10 | Helperby Therapeautics Ltd | Combinations |
GB201709193D0 (en) | 2017-06-09 | 2017-07-26 | Helperby Therapeutics Ltd | Combination |
CN108690012A (zh) * | 2017-06-10 | 2018-10-23 | 曹艳 | 一种治疗革兰氏阳性菌引起的感染的药物及其合成方法 |
CN107021960B (zh) * | 2017-06-10 | 2018-07-31 | 上海普康药业有限公司 | 一种治疗恶性肿瘤的药物 |
GB201807046D0 (en) | 2018-04-30 | 2018-06-13 | Helperby Therapeutics Ltd | Combination |
GB201913068D0 (en) | 2019-09-10 | 2019-10-23 | Helperby Therapeutics Ltd | Combination |
GB201914847D0 (en) | 2019-10-14 | 2019-11-27 | Helperby Therapeutics Ltd | Combination |
GB202213753D0 (en) | 2022-09-20 | 2022-11-02 | Helperby Therapeutics Ltd | Antimicrobial combinations |
GB202213750D0 (en) | 2022-09-20 | 2022-11-02 | Helperby Therapeutics Ltd | Antimicrobial |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3324122A (en) * | 1964-12-14 | 1967-06-06 | Norwich Pharma Co | Series of 4-substituted-2-(5-nitro-2-furyl) quinazolines |
US3542784A (en) * | 1968-04-05 | 1970-11-24 | Norwich Pharma Co | 4-(hydroxyanilino)-2-(5-nitro-2-furyl)quinazolines |
DE2140280A1 (de) | 1970-08-12 | 1972-02-17 | Chemische Fabrik von Heyden GmbH, 8000 München | 4 Amino 2 eckige Klammer auf 2 (5 Nitro 2 furyl)vinyl eckige Klammer zu chinazolinderivate, Herstellungsver fahren dafür und Arzneimittel daraus |
US3970648A (en) * | 1974-09-06 | 1976-07-20 | Diamond Shamrock Corporation | 2-[2-(5-Nitro-2-furyl)vinyl]-4-(anilino)quinazolines |
US3974277A (en) * | 1974-09-06 | 1976-08-10 | Diamond Shamrock Corporation | 2-[2-(5-Nitro-2-furyl)vinyl]-4-(anilino)quinazolines as growth promotants and feed efficiency enhancing agents |
US3973021A (en) * | 1974-09-06 | 1976-08-03 | Diamond Shamrock Corporation | 2-[2-(5-Nitro-2-furyl)vinyl]-4-(phydroxyanilino)quinazoline as a bactericide |
JP2657760B2 (ja) * | 1992-07-15 | 1997-09-24 | 小野薬品工業株式会社 | 4−アミノキナゾリン誘導体およびそれを含有する医薬品 |
US6148377A (en) * | 1996-11-22 | 2000-11-14 | Mangosoft Corporation | Shared memory computer networks |
CA2279977A1 (en) | 1997-02-04 | 1998-08-06 | John S. Kiely | 4-substituted-quinoline derivatives and 4-substituted-quinoline combinatorial libraries |
US5925527A (en) | 1997-02-04 | 1999-07-20 | Trega Biosciences, Inc. | Tricyclic Tetrahydroquinoline derivatives and tricyclic tetrahydroquinoline combinatorial libraries |
US6380204B1 (en) * | 1997-02-28 | 2002-04-30 | Pfizer Inc | Atropisomers of 3-heteroaryl-4(3H)-quinazolinones for the treatment of neurodegenerative and CNS-trauma related conditions |
CA2282277C (en) * | 1997-02-28 | 2005-10-11 | Pfizer Products Inc. | Atropisomers of 3-aryl-4(3h)-quinazolinones and their use as ampa-receptor antagonists |
US6184377B1 (en) * | 1997-12-15 | 2001-02-06 | Sepracor Inc. | Compositions containing N-amino- and N-hydroxy-quinazolinones and methods for preparing libraries thereof |
US6943159B1 (en) * | 1998-02-18 | 2005-09-13 | Neurosearch A/S | Compounds and their use as positive AMPA receptor modulators |
US20020025968A1 (en) * | 1998-04-15 | 2002-02-28 | Rifat Pamukcu | Method for inhibiting neoplastic cells and related conditions by exposure to 4-aminoquinazoline derivatives |
US20040131628A1 (en) * | 2000-03-08 | 2004-07-08 | Bratzler Robert L. | Nucleic acids for the treatment of disorders associated with microorganisms |
PT1939203E (pt) | 2000-04-25 | 2015-02-04 | Icos Corp | Inibidores da isoforma delta da fosfatidil-inositol 3-quinase humana |
US6667300B2 (en) * | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
US6479499B1 (en) * | 2000-06-28 | 2002-11-12 | National Science Council | 2-phenyl-4-quinazolinone compounds, 2-phenyl-4-alkoxy-quinazoline compounds and their pharmaceutical compositions |
PE20021011A1 (es) * | 2001-03-23 | 2003-02-01 | Bayer Corp | Derivados quinazolinicos como inhibidores de la rho-quinasa |
US7645878B2 (en) * | 2002-03-22 | 2010-01-12 | Bayer Healthcare Llc | Process for preparing quinazoline Rho-kinase inhibitors and intermediates thereof |
MXPA04010539A (es) | 2002-04-26 | 2005-01-25 | Nippon Shinyaku Co Ltd | Derivados de quinazolina y medicamentos que los contienen. |
AU2003265264A1 (en) | 2002-07-09 | 2004-01-23 | Point Therapeutics, Inc. | Methods and compositions relating to isoleucine boroproline compounds |
CA2534405A1 (en) | 2003-08-08 | 2005-02-17 | Ulysses Pharmaceutical Products Inc. | Halogenated quinazolinyl nitrofurans as antibacterial agents |
-
2004
- 2004-08-06 CA CA002534405A patent/CA2534405A1/en not_active Abandoned
- 2004-08-06 JP JP2006522859A patent/JP2007501809A/ja not_active Withdrawn
- 2004-08-06 US US10/567,660 patent/US7410974B2/en not_active Expired - Fee Related
- 2004-08-06 AU AU2004262533A patent/AU2004262533A1/en not_active Abandoned
- 2004-08-06 EP EP04761630A patent/EP1660486A4/en not_active Withdrawn
- 2004-08-06 MX MXPA06001552A patent/MXPA06001552A/es not_active Application Discontinuation
- 2004-08-06 CN CNA2004800228169A patent/CN1832941A/zh active Pending
- 2004-08-06 WO PCT/CA2004/001466 patent/WO2005014585A1/en active Application Filing
- 2004-08-06 BR BRPI0413372-2A patent/BRPI0413372A/pt not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP1660486A1 (en) | 2006-05-31 |
US20060258693A1 (en) | 2006-11-16 |
WO2005014585A1 (en) | 2005-02-17 |
US7410974B2 (en) | 2008-08-12 |
EP1660486A4 (en) | 2006-12-13 |
AU2004262533A1 (en) | 2005-02-17 |
JP2007501809A (ja) | 2007-02-01 |
BRPI0413372A (pt) | 2006-10-17 |
WO2005014585A8 (en) | 2005-09-09 |
MXPA06001552A (es) | 2006-09-04 |
CN1832941A (zh) | 2006-09-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |