CA2528010C - 3-oxa-8-azaprostaglandin analogs as agents for lowering intraocular pressure - Google Patents
3-oxa-8-azaprostaglandin analogs as agents for lowering intraocular pressure Download PDFInfo
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- CA2528010C CA2528010C CA2528010A CA2528010A CA2528010C CA 2528010 C CA2528010 C CA 2528010C CA 2528010 A CA2528010 A CA 2528010A CA 2528010 A CA2528010 A CA 2528010A CA 2528010 C CA2528010 C CA 2528010C
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- chlorophenyl
- oxo
- covalent bond
- butoxy
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
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|---|---|---|---|
| US10/453,207 US6734206B1 (en) | 2003-06-02 | 2003-06-02 | 3-oxa-8-azaprostaglandin analogs as agents for lowering intraocular pressure |
| US10/453,207 | 2003-06-02 | ||
| PCT/US2004/016516 WO2004108670A1 (en) | 2003-06-02 | 2004-05-25 | 3-oxa-8-azaprostaglandin analogs as agents for lowering intraocular pressure |
Publications (2)
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| CA2528010A1 CA2528010A1 (en) | 2004-12-16 |
| CA2528010C true CA2528010C (en) | 2012-01-24 |
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| EP (1) | EP1638936B1 (enExample) |
| JP (1) | JP2006526638A (enExample) |
| AT (1) | ATE496886T1 (enExample) |
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| BR (1) | BRPI0410926A (enExample) |
| CA (1) | CA2528010C (enExample) |
| DE (1) | DE602004031225D1 (enExample) |
| ES (1) | ES2358513T3 (enExample) |
| WO (1) | WO2004108670A1 (enExample) |
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| US6734201B1 (en) * | 2003-06-02 | 2004-05-11 | Allergan, Inc. | 8-Azaprostaglandin carbonate and thiocarbonate analogs as therapeutic agents |
| DK1960353T3 (da) * | 2005-11-03 | 2014-05-26 | Allergan Inc | Prostaglandiner og analoger som midler til sænkning af intraokulært tryk |
| US20110293549A1 (en) | 2009-02-03 | 2011-12-01 | Athena Cosmetics, Inc. | Composition, method and kit for enhancing hair |
| US8783923B2 (en) * | 2010-03-18 | 2014-07-22 | Chung Yuan Christian University | Auto lamp structure |
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| US5034413A (en) | 1989-07-27 | 1991-07-23 | Allergan, Inc. | Intraocular pressure reducing 9,11-diacyl prostaglandins |
| US5028624A (en) | 1989-07-27 | 1991-07-02 | Allergan, Inc. | Intraocular pressure reducing 9,15-diacyl prostaglandins |
| US4994274A (en) | 1989-07-27 | 1991-02-19 | Allergan, Inc. | Intraocular pressure reducing 11,15-diacyl prostaglandins and method of using |
| CA2021316C (en) | 1989-07-27 | 2000-10-24 | Ming Fai Chan | Intraocular pressure reducing 11-acyl prostaglandins |
| WO2000038667A2 (en) * | 1998-12-24 | 2000-07-06 | Alcon Laboratories, Inc. | Prostaglandin e agonists for treatment of glaucoma |
| AP2002002555A0 (en) | 1999-12-22 | 2002-06-30 | Pfizer Prod Inc | EP4 Receptor selective agonists in the treatment of osteoporosis. |
| DE60120007T2 (de) | 2000-01-31 | 2006-11-16 | Pfizer Products Inc., Groton | Verwendung von Aktivatoren des Prostaglandinrezeptores 4 zur Behandlung von akuter oder chronischer Niereninsuffizienz |
| US20010056060A1 (en) | 2000-02-07 | 2001-12-27 | Cameron Kimberly O. | Treatment of osteoporsis with EP2/EP4 receptor selective agonists |
| JP4063468B2 (ja) | 2000-02-22 | 2008-03-19 | 株式会社カネボウ化粧品 | 寒天被覆処理顔料およびメイクアップ化粧料 |
| AU2001290250A1 (en) | 2000-09-21 | 2002-04-02 | Ono Pharmaceutical Co. Ltd. | Ep4 receptor agonists containing 8-azaprostaglandin derivatives as the active ingredient |
| IL155368A0 (en) * | 2000-11-27 | 2003-11-23 | Pfizer Prod Inc | Ep4 receptor selective agonists in the treatment of osteoporosis |
| AU2002259210B2 (en) * | 2001-06-14 | 2007-11-08 | Allergan, Inc. | 3, 7 or 3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure |
| AU2002328855B2 (en) * | 2001-07-16 | 2005-11-24 | F. Hoffmann-La Roche Ag | Prostaglandin Analogues As EP4 Receptor Agonists |
| JP4211605B2 (ja) | 2001-07-16 | 2009-01-21 | 小野薬品工業株式会社 | プロスタノイドアゴニストとしての２ピロリドン誘導体 |
| US7608637B2 (en) | 2001-07-23 | 2009-10-27 | Ono Pharmaceutical Co., Ltd. | Pharmaceutical composition for treatment of diseases associated with decrease in bone mass comprising EP4 agonist as the active ingredient |
| DE60307607T2 (de) * | 2002-03-18 | 2007-08-09 | Pfizer Products Inc., Groton | Verwendung von selektiven ep4 rezeptor agonisten zur behandlung von krankheiten |
| BR0308493A (pt) * | 2002-03-18 | 2005-01-11 | Pfizer Prod Inc | Uso de agonistas de receptor seletivo de ep4 para o tratamento da insuficiência hepática, perda de permeabilidade do canal arterial, glaucoma ou hipertensão ocular |
-
2003
- 2003-06-02 US US10/453,207 patent/US6734206B1/en not_active Expired - Fee Related
-
2004
- 2004-05-25 BR BRPI0410926-0A patent/BRPI0410926A/pt not_active IP Right Cessation
- 2004-05-25 AU AU2004245492A patent/AU2004245492B2/en not_active Ceased
- 2004-05-25 WO PCT/US2004/016516 patent/WO2004108670A1/en not_active Ceased
- 2004-05-25 AT AT04753359T patent/ATE496886T1/de not_active IP Right Cessation
- 2004-05-25 ES ES04753359T patent/ES2358513T3/es not_active Expired - Lifetime
- 2004-05-25 EP EP04753359A patent/EP1638936B1/en not_active Expired - Lifetime
- 2004-05-25 CA CA2528010A patent/CA2528010C/en not_active Expired - Fee Related
- 2004-05-25 DE DE602004031225T patent/DE602004031225D1/de not_active Expired - Lifetime
- 2004-05-25 JP JP2006514964A patent/JP2006526638A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1638936B1 (en) | 2011-01-26 |
| AU2004245492A1 (en) | 2004-12-16 |
| US6734206B1 (en) | 2004-05-11 |
| ES2358513T3 (es) | 2011-05-11 |
| AU2004245492B2 (en) | 2010-08-19 |
| CA2528010A1 (en) | 2004-12-16 |
| DE602004031225D1 (de) | 2011-03-10 |
| WO2004108670A1 (en) | 2004-12-16 |
| EP1638936A1 (en) | 2006-03-29 |
| BRPI0410926A (pt) | 2006-06-27 |
| JP2006526638A (ja) | 2006-11-24 |
| ATE496886T1 (de) | 2011-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20160525 |