CA2519022A1 - 2-(butyl-1-sulfonylamino)-n-[1(r)-(6-methoxy-pyridin-3-yl)-propyl]-benzamid, the use thereof in the form of drug an pharmaceutical preparations containing said compound - Google Patents
2-(butyl-1-sulfonylamino)-n-[1(r)-(6-methoxy-pyridin-3-yl)-propyl]-benzamid, the use thereof in the form of drug an pharmaceutical preparations containing said compound Download PDFInfo
- Publication number
- CA2519022A1 CA2519022A1 CA002519022A CA2519022A CA2519022A1 CA 2519022 A1 CA2519022 A1 CA 2519022A1 CA 002519022 A CA002519022 A CA 002519022A CA 2519022 A CA2519022 A CA 2519022A CA 2519022 A1 CA2519022 A1 CA 2519022A1
- Authority
- CA
- Canada
- Prior art keywords
- sulfonylamino
- butyl
- methoxypyridin
- propyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000002571 phosphodiesterase inhibitor Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 230000009090 positive inotropic effect Effects 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 229960003401 ramipril Drugs 0.000 description 1
- HDACQVRGBOVJII-JBDAPHQKSA-N ramipril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 HDACQVRGBOVJII-JBDAPHQKSA-N 0.000 description 1
- 230000002336 repolarization Effects 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- RSIJVJUOQBWMIM-UHFFFAOYSA-L sodium sulfate decahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].[O-]S([O-])(=O)=O RSIJVJUOQBWMIM-UHFFFAOYSA-L 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229960002370 sotalol Drugs 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000012916 structural analysis Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 125000000565 sulfonamide group Chemical group 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 239000002511 suppository base Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000001975 sympathomimetic effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000006794 tachycardia Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10312073A DE10312073A1 (de) | 2003-03-18 | 2003-03-18 | 2-(Butyl-1-sulfonylamino)-N-[1(R)-(6-methoxy-pyridin-3yl)-propyl]-benzamid, dessen Verwendung als Medikament sowie dieses enthaltende pharmazeutische Zubereitungen |
| DE10312073.4 | 2003-03-18 | ||
| PCT/EP2004/002247 WO2004083157A1 (de) | 2003-03-18 | 2004-03-05 | 2-(butyl-1-sulfonylamino)-n-[1(r)-(6-methoxy-pyridin-3-yl)-propyl]-benzamid, dessen verwendung als medikament sowie dieses enthaltende pharmazeutische zubereitungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2519022A1 true CA2519022A1 (en) | 2004-09-30 |
Family
ID=32920928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002519022A Abandoned CA2519022A1 (en) | 2003-03-18 | 2004-03-05 | 2-(butyl-1-sulfonylamino)-n-[1(r)-(6-methoxy-pyridin-3-yl)-propyl]-benzamid, the use thereof in the form of drug an pharmaceutical preparations containing said compound |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP1606237A1 (https=) |
| JP (1) | JP2006520343A (https=) |
| KR (1) | KR20050110681A (https=) |
| CN (1) | CN100361943C (https=) |
| AR (1) | AR043622A1 (https=) |
| AU (1) | AU2004222137A1 (https=) |
| BR (1) | BRPI0408441A (https=) |
| CA (1) | CA2519022A1 (https=) |
| DE (1) | DE10312073A1 (https=) |
| HR (1) | HRP20050815A2 (https=) |
| MA (1) | MA27749A1 (https=) |
| MX (1) | MXPA05009763A (https=) |
| MY (1) | MY176510A (https=) |
| NO (1) | NO20054472L (https=) |
| NZ (1) | NZ542476A (https=) |
| PE (1) | PE20050307A1 (https=) |
| RS (1) | RS20050690A (https=) |
| RU (1) | RU2333202C2 (https=) |
| TW (1) | TW200500342A (https=) |
| WO (1) | WO2004083157A1 (https=) |
| ZA (1) | ZA200506328B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004009931A1 (de) * | 2004-02-26 | 2005-09-15 | Aventis Pharma Deutschland Gmbh | Kv1.5-Blocker zur selektiven Steigerung der Vorhofkontraktilität und Behandlung der Herzinsuffizienz |
| US7569589B2 (en) | 2004-07-29 | 2009-08-04 | Merck & Co., Inc. | Potassium channel inhibitors |
| DE102005028845A1 (de) * | 2005-06-22 | 2006-12-28 | Sanofi-Aventis Deutschland Gmbh | Substituierte Heterocyclen, ihre Verwendung als Medikament sowie enthaltende pharmazeutische Zubereitungen |
| WO2007015775A2 (en) * | 2005-07-22 | 2007-02-08 | Merck & Co., Inc. | Potassium channel inhibitors |
| EP2435407B1 (en) * | 2009-05-29 | 2019-12-25 | RaQualia Pharma Inc. | Aryl substituted carboxamide derivatives as calcium or sodium channel blockers |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0472053B1 (en) * | 1990-08-20 | 1998-06-17 | Eisai Co., Ltd. | Sulfonamide derivatives |
| DE10121003A1 (de) * | 2001-04-28 | 2002-12-19 | Aventis Pharma Gmbh | Anthranilsäureamide, Verfahren zur Herstellung, ihrer Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
-
2003
- 2003-03-18 DE DE10312073A patent/DE10312073A1/de not_active Withdrawn
-
2004
- 2004-03-05 NZ NZ542476A patent/NZ542476A/en unknown
- 2004-03-05 BR BRPI0408441-1A patent/BRPI0408441A/pt not_active IP Right Cessation
- 2004-03-05 AU AU2004222137A patent/AU2004222137A1/en not_active Abandoned
- 2004-03-05 MX MXPA05009763A patent/MXPA05009763A/es active IP Right Grant
- 2004-03-05 RU RU2005132163/04A patent/RU2333202C2/ru not_active IP Right Cessation
- 2004-03-05 HR HR20050815A patent/HRP20050815A2/xx not_active Application Discontinuation
- 2004-03-05 PE PE2004000245A patent/PE20050307A1/es not_active Application Discontinuation
- 2004-03-05 CA CA002519022A patent/CA2519022A1/en not_active Abandoned
- 2004-03-05 KR KR1020057017498A patent/KR20050110681A/ko not_active Ceased
- 2004-03-05 JP JP2006504553A patent/JP2006520343A/ja not_active Abandoned
- 2004-03-05 RS YUP-2005/0690A patent/RS20050690A/sr unknown
- 2004-03-05 WO PCT/EP2004/002247 patent/WO2004083157A1/de not_active Ceased
- 2004-03-05 CN CNB2004800060168A patent/CN100361943C/zh not_active Expired - Fee Related
- 2004-03-05 EP EP04717628A patent/EP1606237A1/de not_active Withdrawn
- 2004-03-16 AR ARP040100866A patent/AR043622A1/es unknown
- 2004-03-16 TW TW093106899A patent/TW200500342A/zh unknown
- 2004-03-17 MY MYPI20040938A patent/MY176510A/en unknown
-
2005
- 2005-08-08 ZA ZA200506328A patent/ZA200506328B/en unknown
- 2005-09-19 MA MA28502A patent/MA27749A1/fr unknown
- 2005-09-27 NO NO20054472A patent/NO20054472L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PE20050307A1 (es) | 2005-06-08 |
| DE10312073A1 (de) | 2004-09-30 |
| TW200500342A (en) | 2005-01-01 |
| HK1086819A1 (en) | 2006-09-29 |
| RU2005132163A (ru) | 2006-04-10 |
| RS20050690A (sr) | 2008-04-04 |
| MY176510A (en) | 2020-08-12 |
| WO2004083157A1 (de) | 2004-09-30 |
| RU2333202C2 (ru) | 2008-09-10 |
| ZA200506328B (en) | 2006-04-26 |
| MA27749A1 (fr) | 2006-02-01 |
| MXPA05009763A (es) | 2006-01-27 |
| CN100361943C (zh) | 2008-01-16 |
| BRPI0408441A (pt) | 2006-04-04 |
| JP2006520343A (ja) | 2006-09-07 |
| NZ542476A (en) | 2008-05-30 |
| CN1756728A (zh) | 2006-04-05 |
| AU2004222137A1 (en) | 2004-09-30 |
| KR20050110681A (ko) | 2005-11-23 |
| AR043622A1 (es) | 2005-08-03 |
| NO20054472L (no) | 2005-09-27 |
| HRP20050815A2 (en) | 2006-09-30 |
| EP1606237A1 (de) | 2005-12-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |