CA2518509C - Immunoneutral silk-fiber-based medical devices - Google Patents
Immunoneutral silk-fiber-based medical devices Download PDFInfo
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- CA2518509C CA2518509C CA2518509A CA2518509A CA2518509C CA 2518509 C CA2518509 C CA 2518509C CA 2518509 A CA2518509 A CA 2518509A CA 2518509 A CA2518509 A CA 2518509A CA 2518509 C CA2518509 C CA 2518509C
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Classifications
-
- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04B—KNITTING
- D04B21/00—Warp knitting processes for the production of fabrics or articles not dependent on the use of particular machines; Fabrics or articles defined by such processes
- D04B21/14—Fabrics characterised by the incorporation by knitting, in one or more thread, fleece, or fabric layers, of reinforcing, binding, or decorative threads; Fabrics incorporating small auxiliary elements, e.g. for decorative purposes
- D04B21/16—Fabrics characterised by the incorporation by knitting, in one or more thread, fleece, or fabric layers, of reinforcing, binding, or decorative threads; Fabrics incorporating small auxiliary elements, e.g. for decorative purposes incorporating synthetic threads
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F4/00—Monocomponent artificial filaments or the like of proteins; Manufacture thereof
- D01F4/02—Monocomponent artificial filaments or the like of proteins; Manufacture thereof from fibroin
-
- D—TEXTILES; PAPER
- D02—YARNS; MECHANICAL FINISHING OF YARNS OR ROPES; WARPING OR BEAMING
- D02G—CRIMPING OR CURLING FIBRES, FILAMENTS, THREADS, OR YARNS; YARNS OR THREADS
- D02G3/00—Yarns or threads, e.g. fancy yarns; Processes or apparatus for the production thereof, not otherwise provided for
- D02G3/44—Yarns or threads characterised by the purpose for which they are designed
- D02G3/448—Yarns or threads for use in medical applications
-
- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04H—MAKING TEXTILE FABRICS, e.g. FROM FIBRES OR FILAMENTARY MATERIAL; FABRICS MADE BY SUCH PROCESSES OR APPARATUS, e.g. FELTS, NON-WOVEN FABRICS; COTTON-WOOL; WADDING ; NON-WOVEN FABRICS FROM STAPLE FIBRES, FILAMENTS OR YARNS, BONDED WITH AT LEAST ONE WEB-LIKE MATERIAL DURING THEIR CONSOLIDATION
- D04H1/00—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres
- D04H1/40—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties
- D04H1/42—Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres from fleeces or layers composed of fibres without existing or potential cohesive properties characterised by the use of certain kinds of fibres insofar as this use has no preponderant influence on the consolidation of the fleece
- D04H1/4266—Natural fibres not provided for in group D04H1/425
-
- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2211/00—Protein-based fibres, e.g. animal fibres
- D10B2211/01—Natural animal fibres, e.g. keratin fibres
- D10B2211/04—Silk
-
- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2509/00—Medical; Hygiene
- D10B2509/08—Hernia repair mesh
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Textile Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Transplantation (AREA)
- Mechanical Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Materials For Medical Uses (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Prostheses (AREA)
- Surgical Instruments (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45358403P | 2003-03-11 | 2003-03-11 | |
| US60/453,584 | 2003-03-11 | ||
| PCT/US2004/007647 WO2004080346A2 (en) | 2003-03-11 | 2004-03-11 | Immunoneutral silk-fiber-based medical devices |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2518509A1 CA2518509A1 (en) | 2004-09-23 |
| CA2518509C true CA2518509C (en) | 2014-04-29 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2518509A Expired - Fee Related CA2518509C (en) | 2003-03-11 | 2004-03-11 | Immunoneutral silk-fiber-based medical devices |
Country Status (9)
| Country | Link |
|---|---|
| EP (3) | EP1601826B1 (enExample) |
| JP (2) | JP4815554B2 (enExample) |
| AT (1) | ATE514805T1 (enExample) |
| CA (1) | CA2518509C (enExample) |
| DK (2) | DK1601826T3 (enExample) |
| ES (3) | ES2424313T3 (enExample) |
| PL (2) | PL2426241T3 (enExample) |
| PT (3) | PT2426241E (enExample) |
| WO (1) | WO2004080346A2 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110009960A1 (en) * | 2001-11-16 | 2011-01-13 | Allergan, Inc. | Prosthetic fabric structure |
| US6902932B2 (en) | 2001-11-16 | 2005-06-07 | Tissue Regeneration, Inc. | Helically organized silk fibroin fiber bundles for matrices in tissue engineering |
| WO2006113642A1 (en) * | 2005-04-18 | 2006-10-26 | Duke University | Three-dimensional fiber scaffolds for tissue engineering |
| CN100382772C (zh) * | 2005-09-28 | 2008-04-23 | 南通大学 | 含蚕丝丝素的医用神经移植物的制备方法 |
| JP4541336B2 (ja) * | 2006-09-25 | 2010-09-08 | 独立行政法人科学技術振興機構 | フィブロイン糸を使用した小動脈用人工血管 |
| US9808557B2 (en) | 2007-08-10 | 2017-11-07 | Trustees Of Tufts College | Tubular silk compositions and methods of use thereof |
| EP2291143B1 (en) | 2008-05-16 | 2020-07-08 | Mimedx, Inc. | Medical constructs of twisted lengths of collagen fibers and methods of making same |
| JP5392744B2 (ja) * | 2008-05-23 | 2014-01-22 | 国立大学法人東京農工大学 | 人工血管及びその製造方法 |
| KR100937736B1 (ko) * | 2008-09-23 | 2010-01-21 | 동국대학교 산학협력단 | 유도 조직 재생을 위한 다공성 지지체 및 그의 제조방법 |
| US9308070B2 (en) | 2008-12-15 | 2016-04-12 | Allergan, Inc. | Pliable silk medical device |
| US9326840B2 (en) | 2008-12-15 | 2016-05-03 | Allergan, Inc. | Prosthetic device and method of manufacturing the same |
| US9757132B2 (en) | 2010-03-24 | 2017-09-12 | Biorez, Inc. | Mechanically competent scaffold for rotator cuff and tendon augmentation |
| CA2832795C (en) | 2010-04-12 | 2018-01-09 | Tufts University | Silk electronic components and the method for fabricating the same |
| AP2013006698A0 (en) * | 2010-07-05 | 2013-01-31 | Achira Labs Pvt Ltd | Methods of making a diagnostic device by interweaving hydrophobic and hydrophilic fibers, and diagnostic device therefrom |
| CN102091349B (zh) * | 2011-01-27 | 2013-06-19 | 苏州大学 | 一种高强度生物支架材料及其制备方法 |
| JP5062867B2 (ja) * | 2011-02-18 | 2012-10-31 | 福井経編興業株式会社 | 人工血管用ダブルラッシェル編地管とその製造方法 |
| JP5783794B2 (ja) * | 2011-05-19 | 2015-09-24 | カジナイロン株式会社 | 人工血管や人工臓器等の医療用基材の絹糸の製造方法 |
| US9925301B2 (en) | 2012-04-06 | 2018-03-27 | Trustees Of Tufts College | Methods of producing and using silk microfibers |
| US20150164117A1 (en) * | 2012-07-13 | 2015-06-18 | Tufts University | Encapsulation of fragrance and/or flavors in silk fibroin biomaterials |
| US10035920B2 (en) | 2012-11-27 | 2018-07-31 | Tufts University | Biopolymer-based inks and use thereof |
| AU2013358983A1 (en) * | 2012-12-14 | 2015-07-02 | Allergan, Inc. | Silk medical device |
| US9433489B2 (en) | 2013-03-12 | 2016-09-06 | Soft Tissue Regeneration, Inc. | Absorbable synthetic braided matrix for breast reconstruction and hernia repair |
| US20150056261A1 (en) * | 2013-08-22 | 2015-02-26 | Allergan, Inc. | Silk medical devices |
| WO2015048527A1 (en) | 2013-09-27 | 2015-04-02 | Tufts University | Optically transparent silk hydrogels |
| US10925999B2 (en) | 2013-10-08 | 2021-02-23 | Trustees Of Tufts College | Tunable covalently crosslinked hydrogels and methods of making the same |
| WO2015070108A1 (en) | 2013-11-08 | 2015-05-14 | Tufts University | Peptide-based nanofibrillar materials |
| KR101582202B1 (ko) * | 2014-11-05 | 2016-01-05 | 대한민국 | 누에고치를 이용한 혈관용 패치 및 이의 제조방법 |
| ES2915384T3 (es) | 2015-03-12 | 2022-06-22 | Univ Tufts | Materiales de seda con memoria de forma |
| CN107407018B (zh) * | 2015-03-20 | 2018-10-19 | 拉尔赛菲股份公司 | 用于制造基于丝绸的织物的方法及该织物的用途 |
| US10314696B2 (en) | 2015-04-09 | 2019-06-11 | Boston Scientific Scimed, Inc. | Prosthetic heart valves having fiber reinforced leaflets |
| US10716671B2 (en) * | 2015-07-02 | 2020-07-21 | Boston Scientific Scimed, Inc. | Prosthetic heart valve composed of composite fibers |
| WO2017019841A1 (en) | 2015-07-28 | 2017-02-02 | Trustees Of Tufts College | Polypeptide monoliths |
| WO2017123383A2 (en) | 2015-12-17 | 2017-07-20 | Trustees Of Tufts College | Silk-fibroin hydrogels, methods of forming, and uses thereof |
| CN105603622A (zh) * | 2015-12-28 | 2016-05-25 | 宝鸡金健数码针纺有限责任公司 | 一种中药针织面料的生产方法 |
| WO2017165889A2 (en) * | 2016-03-25 | 2017-09-28 | Biorez, Inc. | Complex braided scaffolds for improved tissue regeneration |
| US10368982B2 (en) | 2016-05-19 | 2019-08-06 | Boston Scientific Scimed, Inc. | Prosthetic valves, valve leaflets and related methods |
| WO2017204563A1 (ko) * | 2016-05-24 | 2017-11-30 | 주식회사 아모라이프사이언스 | 세포배양 지지체용 원사, 이를 포함하는 세포배양 지지체용 원단 |
| KR101856575B1 (ko) * | 2016-05-25 | 2018-06-19 | 주식회사 아모그린텍 | 세포배양 지지체용 원사 및 이를 포함하는 원단 |
| US11248313B2 (en) | 2016-08-01 | 2022-02-15 | Trustees Of Tufts College | Biomimetic mechanical tension driven fabrication of nanofibrillar architecture |
| EP3615097A1 (en) | 2017-04-25 | 2020-03-04 | Boston Scientific Scimed, Inc. | Biocompatible polyisobutylene-fiber composite materials and methods |
| US11992686B2 (en) | 2018-03-16 | 2024-05-28 | The Regents Of The University Of California | Flexible spinal cord stimulators for pain and trauma management through neuromodulation |
| US12245935B2 (en) | 2019-11-26 | 2025-03-11 | Boston Scientific Limited | Composite web-polymer heart valve |
| WO2022147483A2 (en) * | 2020-12-31 | 2022-07-07 | Trustees Of Tufts College | Silk-based articles having decreased water uptake and improved mechanical properties, and methods of making and using the same |
| DE102023205151A1 (de) * | 2023-06-01 | 2024-12-05 | Volkswagen Aktiengesellschaft | Biomaterial umfassend bakterielle Cellulosefasern |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE367138A (enExample) * | 1930-02-03 | |||
| US4141207A (en) * | 1977-09-02 | 1979-02-27 | Shigesaburo Mizushima | Process for producing curl shrunk silk yarn |
| US5245012A (en) | 1990-04-19 | 1993-09-14 | The United States Of America As Represented By The Secretary Of The Army | Method to achieve solubilization of spider silk proteins |
| US5252285A (en) | 1992-01-27 | 1993-10-12 | E. I. Du Pont De Nemours And Company | Process for making silk fibroin fibers |
| JPH05228204A (ja) * | 1992-02-19 | 1993-09-07 | Pola Chem Ind Inc | 創傷被覆材及びその製造方法 |
| JPH0931798A (ja) | 1995-07-07 | 1997-02-04 | Toru Takada | シルク・ビロード布地又は編地とその製造方法 |
| IL123398A0 (en) | 1995-08-22 | 1998-09-24 | Agricola Tech Inc | Cloning methods for high strength spider silk proteins |
| JP2997758B2 (ja) * | 1996-01-23 | 2000-01-11 | 農林水産省蚕糸・昆虫農業技術研究所長 | 創傷被覆材 |
| JP3023431B2 (ja) * | 1996-02-23 | 2000-03-21 | 株式会社山嘉精練 | 先染絹生糸を用いる織編物の製造方法及びそれによって製造された織編物 |
| US6175053B1 (en) | 1997-06-18 | 2001-01-16 | Japan As Represented By Director General Of National Institute Of Sericultural And Entomological Science Ministry Of Agriculture, Forrestry And Fisheries | Wound dressing material containing silk fibroin and sericin as main component and method for preparing same |
| GB9912240D0 (en) * | 1999-05-27 | 1999-07-28 | Smith & Nephew | Implantable medical devices |
| IT1316885B1 (it) * | 2000-10-02 | 2003-05-13 | Consorzio Per Gli Studi Uni | Procedimento per la preparazione di un tessuto non tessuto in fibroinadi seta. |
-
2004
- 2004-03-11 EP EP04719844A patent/EP1601826B1/en not_active Expired - Lifetime
- 2004-03-11 ES ES11171347T patent/ES2424313T3/es not_active Expired - Lifetime
- 2004-03-11 ES ES04719844T patent/ES2368843T3/es not_active Expired - Lifetime
- 2004-03-11 PT PT111908455T patent/PT2426241E/pt unknown
- 2004-03-11 JP JP2006507132A patent/JP4815554B2/ja not_active Expired - Fee Related
- 2004-03-11 PT PT111713475T patent/PT2374919E/pt unknown
- 2004-03-11 PL PL11190845T patent/PL2426241T3/pl unknown
- 2004-03-11 CA CA2518509A patent/CA2518509C/en not_active Expired - Fee Related
- 2004-03-11 EP EP11171347.5A patent/EP2374919B9/en not_active Expired - Lifetime
- 2004-03-11 EP EP11190845.5A patent/EP2426241B9/en not_active Expired - Lifetime
- 2004-03-11 PT PT04719844T patent/PT1601826E/pt unknown
- 2004-03-11 DK DK04719844.5T patent/DK1601826T3/da active
- 2004-03-11 PL PL11171347T patent/PL2374919T3/pl unknown
- 2004-03-11 ES ES11190845T patent/ES2425101T3/es not_active Expired - Lifetime
- 2004-03-11 DK DK11171347.5T patent/DK2374919T3/da active
- 2004-03-11 AT AT04719844T patent/ATE514805T1/de active
- 2004-03-11 WO PCT/US2004/007647 patent/WO2004080346A2/en not_active Ceased
-
2011
- 2011-02-16 JP JP2011030342A patent/JP2011147790A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1601826B1 (en) | 2011-06-29 |
| PT2426241E (pt) | 2013-08-30 |
| EP2426241B9 (en) | 2013-10-23 |
| EP1601826A2 (en) | 2005-12-07 |
| CA2518509A1 (en) | 2004-09-23 |
| ES2368843T3 (es) | 2011-11-22 |
| WO2004080346A9 (en) | 2005-02-17 |
| EP2374919B1 (en) | 2013-05-08 |
| PL2374919T3 (pl) | 2013-10-31 |
| EP2426241B1 (en) | 2013-05-22 |
| WO2004080346A2 (en) | 2004-09-23 |
| PT2374919E (pt) | 2013-08-26 |
| EP2374919A1 (en) | 2011-10-12 |
| DK2374919T3 (da) | 2013-08-05 |
| DK1601826T3 (da) | 2011-10-24 |
| ES2424313T3 (es) | 2013-10-01 |
| JP2011147790A (ja) | 2011-08-04 |
| EP2374919B9 (en) | 2013-10-23 |
| WO2004080346A3 (en) | 2004-12-09 |
| PL2426241T3 (pl) | 2013-10-31 |
| JP2006519664A (ja) | 2006-08-31 |
| EP1601826A4 (en) | 2010-01-06 |
| EP2426241A1 (en) | 2012-03-07 |
| ATE514805T1 (de) | 2011-07-15 |
| PT1601826E (pt) | 2011-10-11 |
| ES2425101T3 (es) | 2013-10-11 |
| JP4815554B2 (ja) | 2011-11-16 |
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| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20190311 |