CA2510420A1 - Formable and settable polymer bone composite and method of production thereof - Google Patents
Formable and settable polymer bone composite and method of production thereof Download PDFInfo
- Publication number
- CA2510420A1 CA2510420A1 CA002510420A CA2510420A CA2510420A1 CA 2510420 A1 CA2510420 A1 CA 2510420A1 CA 002510420 A CA002510420 A CA 002510420A CA 2510420 A CA2510420 A CA 2510420A CA 2510420 A1 CA2510420 A1 CA 2510420A1
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- Prior art keywords
- bone
- composite
- polymer
- osteoimplant
- poly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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| PCT/US2003/039704 WO2004053112A1 (en) | 2002-12-12 | 2003-12-12 | Formable and settable polymer bone composite and method of production thereof |
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Families Citing this family (113)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001049220A1 (en) * | 1999-12-30 | 2001-07-12 | Osteotech, Inc. | Intervertebral implants |
| US20030120274A1 (en) * | 2000-10-20 | 2003-06-26 | Morris John W. | Implant retaining device |
| ES2326467T3 (es) | 2000-12-08 | 2009-10-13 | Osteotech, Inc. | Implante para aplicaciones ortopedicas. |
| GB0116341D0 (en) * | 2001-07-04 | 2001-08-29 | Smith & Nephew | Biodegradable polymer systems |
| US6855167B2 (en) * | 2001-12-05 | 2005-02-15 | Osteotech, Inc. | Spinal intervertebral implant, interconnections for such implant and processes for making |
| GB0202233D0 (en) * | 2002-01-31 | 2002-03-20 | Smith & Nephew | Bioresorbable polymers |
| US7964207B2 (en) * | 2002-03-22 | 2011-06-21 | Doctor's Research Group, Inc. | Methods of performing medical procedures that promote bone growth, method of making compositions that promote bone growth, and apparatus for use in such methods |
| US20040127563A1 (en) * | 2002-03-22 | 2004-07-01 | Deslauriers Richard J. | Methods of performing medical procedures which promote bone growth, compositions which promote bone growth, and methods of making such compositions |
| US8771719B2 (en) * | 2002-08-12 | 2014-07-08 | Warsaw Orthopedic, Inc. | Synthesis of a bone-polymer composite material |
| WO2004017915A2 (en) * | 2002-08-20 | 2004-03-04 | Exactech, Inc. | Composition for the carrying and delivery of bone growth inducing material and methods for producing and applying the composition |
| JP2006509539A (ja) * | 2002-12-12 | 2006-03-23 | オステオテック，インコーポレイテッド | 形成可能かつ硬化可能なポリマー骨複合体およびその生成方法 |
| US20050251267A1 (en) * | 2004-05-04 | 2005-11-10 | John Winterbottom | Cell permeable structural implant |
| US7985414B2 (en) * | 2003-02-04 | 2011-07-26 | Warsaw Orthopedic, Inc. | Polyurethanes for osteoimplants |
| EP1589962B1 (en) * | 2003-02-04 | 2015-04-08 | Warsaw Orthopedic, Inc. | Polyurethanes for osteoimplants |
| US20040260398A1 (en) * | 2003-02-10 | 2004-12-23 | Kelman David C. | Resorbable devices |
| US7887544B2 (en) * | 2003-03-10 | 2011-02-15 | Tornier Sas | Ancillary tool for positioning a glenoid implant |
| FR2859099B1 (fr) * | 2003-08-25 | 2006-01-06 | Tornier Sa | Composant glenoidien de prothese d'epaule et prothese totale d'epaule incorporant un tel composant |
| US7141354B2 (en) * | 2003-09-30 | 2006-11-28 | Dai Nippon Printing Co., Ltd. | Photo radical generator, photo sensitive resin composition and article |
| WO2005062868A2 (en) | 2003-12-19 | 2005-07-14 | Osteotech, Inc. | Tissue-derived mesh for orthopedic regeneration |
| FR2863865B1 (fr) * | 2003-12-19 | 2006-10-06 | Tornier Sa | Prothese d'epaule ou de hanche et son procede de montage |
| GB0329654D0 (en) * | 2003-12-23 | 2004-01-28 | Smith & Nephew | Tunable segmented polyacetal |
| WO2005065396A2 (en) * | 2003-12-31 | 2005-07-21 | Osteotech, Inc. | Improved bone matrix compositions and methods |
| US8734525B2 (en) * | 2003-12-31 | 2014-05-27 | Warsaw Orthopedic, Inc. | Osteoinductive demineralized cancellous bone |
| US20070231788A1 (en) * | 2003-12-31 | 2007-10-04 | Keyvan Behnam | Method for In Vitro Assay of Demineralized Bone Matrix |
| US8012210B2 (en) | 2004-01-16 | 2011-09-06 | Warsaw Orthopedic, Inc. | Implant frames for use with settable materials and related methods of use |
| NZ579516A (en) | 2004-01-27 | 2011-01-28 | Osteotech Inc | Stabilized bone graft |
| WO2005074850A1 (en) * | 2004-01-30 | 2005-08-18 | Osteotech, Inc. | Stacking implants for spinal fusion |
| FR2871371B1 (fr) * | 2004-06-15 | 2007-04-06 | Tornier Sas | Composant glenoidien de prothese d'epaule, jeu d'elements constitutifs d'un tel composant et prothese totale d'epaule incorporant un tel composant |
| EP1607069B1 (fr) | 2004-06-15 | 2009-12-23 | Tornier | Prothese totale d'epaule de type inverse |
| US8303665B2 (en) | 2004-06-15 | 2012-11-06 | Tornier Sas | Glenoidal component, set of such components and shoulder prosthesis incorporating such a glenoidal component |
| FR2872025B1 (fr) | 2004-06-28 | 2006-08-25 | Tornier Sas | Prothese d'epaule ou de hanche |
| EP1922091A2 (en) * | 2005-08-18 | 2008-05-21 | Smith & Nephew, PLC | High strength devices and composites |
| WO2007030752A2 (en) * | 2005-09-09 | 2007-03-15 | University Of Arkansas At Little Rock | System and method for tissue generation and bone regeneration |
| US9763788B2 (en) | 2005-09-09 | 2017-09-19 | Board Of Trustees Of The University Of Arkansas | Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same |
| US8936805B2 (en) | 2005-09-09 | 2015-01-20 | Board Of Trustees Of The University Of Arkansas | Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same |
| CN101365499A (zh) | 2005-11-01 | 2009-02-11 | 骨骼技术股份有限公司 | 骨基质组合物和方法 |
| AU2006321914B2 (en) * | 2005-12-06 | 2012-01-19 | Covidien Lp | Bioabsorbable compounds and compositions containing them |
| AU2007207495A1 (en) * | 2006-01-19 | 2007-07-26 | Warsaw Orthopedic, Inc. | Porous osteoimplant |
| EP1976460A4 (en) | 2006-01-19 | 2012-06-20 | Warsaw Orthopedic Inc | INJECTABLE AND FORMABLE BONE REPLACEMENT MATERIALS |
| WO2007103276A2 (en) | 2006-03-03 | 2007-09-13 | Smith & Nephew, Inc. | Systems and methods for delivering a medicament |
| US20070207182A1 (en) | 2006-03-06 | 2007-09-06 | Jan Weber | Medical devices having electrically aligned elongated particles |
| EP1996125B1 (en) * | 2006-03-21 | 2013-05-15 | Tornier, Inc. | Glenoid component with improved fixation stability |
| EP1996124B1 (en) | 2006-03-21 | 2019-10-30 | Tornier, Inc. | Femoral and humeral stem components sytem for orthopedic joint reconstruction |
| US9433507B2 (en) * | 2006-03-21 | 2016-09-06 | Tornier, Inc. | Non-spherical articulating surfaces in shoulder and hip replacement |
| US20070269544A1 (en) * | 2006-03-29 | 2007-11-22 | Sdgi Holdings, Inc. | Devices and methods for contouring a shape of an implant that is positioned within a patient |
| EP2013730B1 (en) * | 2006-03-30 | 2011-11-02 | Mark Clarke | Mineralized three-dimensional bone constructs |
| FR2899790B1 (fr) * | 2006-04-13 | 2008-06-13 | Tornier Sas | Composant glenoidien pour prothese totale d'epaule, jeu de tels composants, et prothese totale d'epaule comprenant un tel composant |
| FR2900045B1 (fr) * | 2006-04-21 | 2009-01-16 | Tornier Sas | Prothese d'epaule ou de hanche |
| US20100209470A1 (en) * | 2006-05-01 | 2010-08-19 | Warsaw Orthopedic, Inc. An Indiana Corporation | Demineralized bone matrix devices |
| US8506983B2 (en) * | 2006-05-01 | 2013-08-13 | Warsaw Orthopedic, Inc. | Bone filler material |
| CN103122132B (zh) | 2006-07-20 | 2016-03-16 | 奥巴斯尼茨医学公司 | 用于医疗器械的可生物吸收聚合物组合物 |
| US8637064B2 (en) | 2006-09-20 | 2014-01-28 | Warsaw Orthopedic, Inc. | Compression molding method for making biomaterial composites |
| CN101631513B (zh) | 2006-10-20 | 2013-06-05 | 奥巴斯尼茨医学公司 | 可生物吸收的聚合物组合物和医疗设备 |
| US7959942B2 (en) | 2006-10-20 | 2011-06-14 | Orbusneich Medical, Inc. | Bioabsorbable medical device with coating |
| AU2007325001B2 (en) * | 2006-11-30 | 2014-04-10 | Smith & Nephew, Inc. | Fiber reinforced composite material |
| FR2911773B1 (fr) | 2007-01-30 | 2009-03-27 | Tornier Sas | Methode et ensemble d'instrumentation chirurgicale pour poser une prothese totale d'epaule inversee,et prothese correspondante |
| US20090287309A1 (en) | 2007-01-30 | 2009-11-19 | Tornier Sas | Intra-articular joint replacement |
| WO2008100856A2 (en) * | 2007-02-12 | 2008-08-21 | Osteotech, Inc. | Joint revision implant |
| JP5416090B2 (ja) | 2007-04-18 | 2014-02-12 | スミス アンド ネフュー ピーエルシー | 形状記憶ポリマーの膨張成形 |
| ATE505220T1 (de) | 2007-04-19 | 2011-04-15 | Smith & Nephew Inc | Graft-fixierung |
| WO2008131197A1 (en) | 2007-04-19 | 2008-10-30 | Smith & Nephew, Inc. | Multi-modal shape memory polymers |
| US9554920B2 (en) * | 2007-06-15 | 2017-01-31 | Warsaw Orthopedic, Inc. | Bone matrix compositions having nanoscale textured surfaces |
| CA2690457C (en) | 2007-06-15 | 2018-02-20 | Osteotech, Inc. | Bone matrix compositions and methods |
| EP2167148B1 (en) * | 2007-06-15 | 2017-12-27 | Warsaw Orthopedic, Inc. | Method of treating tissue |
| US20110054408A1 (en) * | 2007-07-10 | 2011-03-03 | Guobao Wei | Delivery systems, devices, tools, and methods of use |
| WO2009009684A1 (en) | 2007-07-10 | 2009-01-15 | Osteotech, Inc. | Delivery system |
| EP2197508B1 (en) | 2007-09-06 | 2014-12-10 | Boston Scientific Limited | Medical devices containing silicate and carbon particles |
| WO2009052492A2 (en) | 2007-10-19 | 2009-04-23 | Osteotech, Inc. | Demineralized bone matrix compositions and methods |
| US20100272693A1 (en) * | 2007-11-30 | 2010-10-28 | Eunah Lee | Bone scaffolds, injectable bone repair materials and methods for bone repair |
| GB2457756A (en) | 2008-01-09 | 2009-09-02 | Univ Aberdeen | Bioceramic calcium phosphosilicate compositions |
| US8685432B2 (en) * | 2008-03-25 | 2014-04-01 | University Of Utah Research Foundation | Controlled release tissue graft combination biomaterials |
| AU2009228114A1 (en) * | 2008-03-28 | 2009-10-01 | Warsaw Orthopedic, Inc. | Bone anchors for orthopedic applications |
| JP2012506733A (ja) | 2008-10-24 | 2012-03-22 | ウォーソー・オーソペディック・インコーポレーテッド | 骨形成を促進するための組成物および方法 |
| WO2012134540A2 (en) | 2010-10-22 | 2012-10-04 | Vanderbilt University | Injectable synthetic pur composite |
| WO2010059389A2 (en) * | 2008-10-30 | 2010-05-27 | Osteotech, Inc. | Bone/polyurethane composites and methods thereof |
| WO2010093950A1 (en) * | 2009-02-12 | 2010-08-19 | Osteotech, Inc. | Delivery system cartridge |
| KR101139660B1 (ko) * | 2009-06-15 | 2012-05-14 | 한스바이오메드 주식회사 | 탈회골(ｄｂｍ)을 포함하는 골 충진재의 제조방법 |
| EP2550028B1 (en) * | 2010-03-25 | 2018-03-07 | Lifecell Corporation | Preparation of regenerative tissue scaffolds |
| US20110243913A1 (en) * | 2010-04-06 | 2011-10-06 | Orthovita, Inc. | Biomaterial Compositions and Methods of Use |
| US9408652B2 (en) | 2010-04-27 | 2016-08-09 | Tornier Sas | Intra-articular joint replacement and method |
| ES2662331T3 (es) * | 2010-08-10 | 2018-04-06 | Lifecell Corporation | Matrices tisulares regenerativas |
| US9072720B2 (en) | 2010-08-26 | 2015-07-07 | University Of Louisville Research Foundation, Inc. | Compositions and methods for treating bone defects |
| FR2966343B1 (fr) | 2010-10-22 | 2012-12-07 | Tornier Sa | Jeu de composants glenoidiens d'une prothese d'epaule |
| US8926710B2 (en) | 2010-10-25 | 2015-01-06 | Warsaw Orthopedic, Inc. | Osteoinductive bone graft injectable cement |
| EP2637983B1 (en) | 2010-11-10 | 2018-12-26 | Stryker European Holdings I, LLC | Process for the preparation of a polymeric bone foam |
| US8637067B1 (en) | 2011-03-10 | 2014-01-28 | Lifecell Corporation | Elastic tissue matrix derived hydrogel |
| EP2753371B1 (en) | 2011-09-09 | 2021-08-04 | Abyrx, Inc. | Absorbable multi-putty bone cements and hemostatic compositions and methods of use |
| WO2013055889A2 (en) | 2011-10-14 | 2013-04-18 | Innovative Surface Technologies, Inc. | Implantable scaffolds and methods of use |
| ES2726105T3 (es) | 2011-12-20 | 2019-10-01 | Lifecell Corp | Productos de tejido fluidizable |
| EP3549615B1 (en) | 2011-12-20 | 2020-12-16 | LifeCell Corporation | Sheet tissue products |
| AU2013212592B2 (en) | 2012-01-24 | 2016-06-30 | Lifecell Corporation | Elongated tissue matrices |
| WO2013162997A1 (en) | 2012-04-24 | 2013-10-31 | Lifecell Corporation | Functionalized tissue matrices |
| US10207027B2 (en) | 2012-06-11 | 2019-02-19 | Globus Medical, Inc. | Bioactive bone graft substitutes |
| WO2014123978A2 (en) | 2013-02-05 | 2014-08-14 | University Of Utah Research Foundation | Implantable devices for bone or joint defects |
| AU2014227561C1 (en) | 2013-03-15 | 2017-12-14 | Cook Biotech Incorporated | ECM implant compositions and methods |
| AU2014331971B2 (en) | 2013-10-08 | 2018-07-19 | Vivorte, Inc. | Processed bone particle compositions and related methods |
| US9539286B2 (en) | 2013-10-18 | 2017-01-10 | Globus Medical, Inc. | Bone grafts including osteogenic stem cells, and methods relating to the same |
| US9486483B2 (en) | 2013-10-18 | 2016-11-08 | Globus Medical, Inc. | Bone grafts including osteogenic stem cells, and methods relating to the same |
| US9827349B1 (en) | 2013-11-26 | 2017-11-28 | Abyrx Inc. | Settable surgical implants and their packaging |
| US9579421B2 (en) | 2014-02-07 | 2017-02-28 | Globus Medical Inc. | Bone grafts and methods of making and using bone grafts |
| US9463264B2 (en) | 2014-02-11 | 2016-10-11 | Globus Medical, Inc. | Bone grafts and methods of making and using bone grafts |
| WO2016187413A1 (en) | 2015-05-21 | 2016-11-24 | Musculoskeletal Transplant Foundation | Modified demineralized cortical bone fibers |
| US10016529B2 (en) | 2015-06-10 | 2018-07-10 | Globus Medical, Inc. | Biomaterial compositions, implants, and methods of making the same |
| US11426489B2 (en) | 2015-06-10 | 2022-08-30 | Globus Medical, Inc. | Biomaterial compositions, implants, and methods of making the same |
| US10549011B2 (en) * | 2015-10-26 | 2020-02-04 | Osteolife Biomedical, Llc | Bone putty and gel systems and methods |
| US20170128633A1 (en) | 2015-11-10 | 2017-05-11 | Theodore Malinin | Bioactive Implants and Methods of Making and Using |
| DE102016107223B4 (de) * | 2016-04-19 | 2018-05-24 | Karl Leibinger Medizintechnik Gmbh & Co. Kg | Hybridimplantat aus einem Kompositmaterial |
| US11033656B2 (en) | 2016-06-13 | 2021-06-15 | Lifenet Health | Demineralized bone fibers and preparation thereof |
| FR3053239B1 (fr) | 2016-06-30 | 2022-02-25 | Teknimed | Susbtitut osseux et systeme d'injection autonome |
| US10743996B2 (en) | 2017-03-24 | 2020-08-18 | Robert L. Bundy | Amnion putty for cartilage repair |
| US12311076B1 (en) | 2018-06-07 | 2025-05-27 | Seaspine, Inc. | Demineralized bone matrix composition with enhanced osteoinductivity and osteoconductivity |
| WO2021035795A1 (zh) * | 2019-08-31 | 2021-03-04 | 深圳市立心科学有限公司 | 可塑形的人工骨复合材料及其制备方法 |
| US11896736B2 (en) | 2020-07-13 | 2024-02-13 | Globus Medical, Inc | Biomaterial implants and methods of making the same |
Family Cites Families (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3919773A (en) | 1973-12-20 | 1975-11-18 | Sybron Corp | Direct moldable implant material |
| US3892649A (en) | 1974-05-13 | 1975-07-01 | Us Navy | Electrodeposition of bone within a plastic matrix |
| US3949073A (en) | 1974-11-18 | 1976-04-06 | The Board Of Trustees Of Leland Stanford Junior University | Process for augmenting connective mammalian tissue with in situ polymerizable native collagen solution |
| US4183874A (en) | 1976-04-30 | 1980-01-15 | Union Carbide Corporation | Silane end-capped polyarylene shaped articles and mixed resins |
| NL8304066A (nl) | 1983-11-28 | 1985-06-17 | Hoogovens Groep Bv | Werkwijze voor het bereiden van kooks. |
| US4551156A (en) | 1984-01-16 | 1985-11-05 | Standard Oil Company | Permselective membrane compositions for gas separations and process for the separation of gases therewith |
| US4637931A (en) * | 1984-10-09 | 1987-01-20 | The United States Of America As Represented By The Secretary Of The Army | Polyactic-polyglycolic acid copolymer combined with decalcified freeze-dried bone for use as a bone repair material |
| US4595713A (en) | 1985-01-22 | 1986-06-17 | Hexcel Corporation | Medical putty for tissue augmentation |
| US4645503A (en) | 1985-08-27 | 1987-02-24 | Orthomatrix Inc. | Moldable bone-implant material |
| US4783504A (en) | 1986-02-28 | 1988-11-08 | Shell Oil Company | Hot melt adhesive containing a silane grafted hydrogenated block polymer |
| US6311690B1 (en) * | 1986-03-27 | 2001-11-06 | Gensci Orthobiologics, Inc. | Bone repair material and delayed drug delivery system |
| US5736372A (en) | 1986-11-20 | 1998-04-07 | Massachusetts Institute Of Technology | Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure |
| US5306311A (en) | 1987-07-20 | 1994-04-26 | Regen Corporation | Prosthetic articular cartilage |
| US5162445A (en) | 1988-05-27 | 1992-11-10 | Exxon Chemical Patents Inc. | Para-alkylstyrene/isoolefin copolymers and functionalized copolymers thereof |
| DE3826915A1 (de) | 1988-08-09 | 1990-02-15 | Henkel Kgaa | Neue werkstoffe fuer den knochenersatz und knochen- bzw. prothesenverbund |
| US5246782A (en) | 1990-12-10 | 1993-09-21 | The Dow Chemical Company | Laminates of polymers having perfluorocyclobutane rings and polymers containing perfluorocyclobutane rings |
| US5324519A (en) | 1989-07-24 | 1994-06-28 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
| JP2683442B2 (ja) | 1990-08-21 | 1997-11-26 | ポリプラスチックス株式会社 | ポリアリーレンサルファイド樹脂組成物及びその製造法 |
| US5513662A (en) | 1991-12-31 | 1996-05-07 | Osteotech, Inc. | Preparation of bone for transplantation |
| US5333626A (en) | 1991-12-31 | 1994-08-02 | Cryolife, Inc. | Preparation of bone for transplantation |
| US5468544A (en) | 1993-11-15 | 1995-11-21 | The Trustees Of The University Of Pennsylvania | Composite materials using bone bioactive glass and ceramic fibers |
| US5626861A (en) | 1994-04-01 | 1997-05-06 | Massachusetts Institute Of Technology | Polymeric-hydroxyapatite bone composite |
| AU3795395A (en) | 1994-11-30 | 1996-06-06 | Ethicon Inc. | Hard tissue bone cements and substitutes |
| US6376573B1 (en) | 1994-12-21 | 2002-04-23 | Interpore International | Porous biomaterials and methods for their manufacture |
| US5606000A (en) | 1995-02-06 | 1997-02-25 | National Chemical Laboratory | Silicon containing polyarylates |
| WO1998019718A1 (en) | 1996-11-05 | 1998-05-14 | Challenge Bioproducts Co., Ltd. | Chemical modification of biomedical materials with genipin |
| US20020098222A1 (en) | 1997-03-13 | 2002-07-25 | John F. Wironen | Bone paste |
| US5948386A (en) | 1997-03-14 | 1999-09-07 | The Curators Of The University Of Missouri | Conjugate and method for forming aminomethyl phosphorus conjugates |
| US5846484A (en) | 1997-03-20 | 1998-12-08 | Osteotech, Inc. | Pressure flow system and method for treating a fluid permeable workpiece such as a bone |
| US5837752A (en) | 1997-07-17 | 1998-11-17 | Massachusetts Institute Of Technology | Semi-interpenetrating polymer networks |
| US5910315A (en) * | 1997-07-18 | 1999-06-08 | Stevenson; Sharon | Allograft tissue material for filling spinal fusion cages or related surgical spaces |
| US6309659B1 (en) * | 1997-09-02 | 2001-10-30 | Gensci Orthobiologics, Inc. | Reverse phase connective tissue repair composition |
| US6399693B1 (en) | 1997-10-23 | 2002-06-04 | Univ. Of Florida Research Foundation | Bioactive composites comprising silane functionalized polyaryl polymers |
| US6027744A (en) | 1998-04-24 | 2000-02-22 | University Of Massachusetts Medical Center | Guided development and support of hydrogel-cell compositions |
| US6406498B1 (en) | 1998-09-04 | 2002-06-18 | Bionx Implants Oy | Bioactive, bioabsorbable surgical composite material |
| US6132468A (en) | 1998-09-10 | 2000-10-17 | Mansmann; Kevin A. | Arthroscopic replacement of cartilage using flexible inflatable envelopes |
| US6165486A (en) | 1998-11-19 | 2000-12-26 | Carnegie Mellon University | Biocompatible compositions and methods of using same |
| US6696073B2 (en) | 1999-02-23 | 2004-02-24 | Osteotech, Inc. | Shaped load-bearing osteoimplant and methods of making same |
| US6294187B1 (en) | 1999-02-23 | 2001-09-25 | Osteotech, Inc. | Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same |
| EP1121943B1 (en) | 1999-08-17 | 2007-07-04 | Taki Chemical Co., Ltd. | Biological materials |
| US6352667B1 (en) | 1999-08-24 | 2002-03-05 | Absorbable Polymer Technologies, Inc. | Method of making biodegradable polymeric implants |
| US6183498B1 (en) | 1999-09-20 | 2001-02-06 | Devore Dale P. | Methods and products for sealing a fluid leak in a tissue |
| EP1142596A1 (en) | 2000-04-03 | 2001-10-10 | Universiteit Gent | Compositions of crosslinkable prepolymers for use in therapeutically active biodegradable implants |
| US6340477B1 (en) * | 2000-04-27 | 2002-01-22 | Lifenet | Bone matrix composition and methods for making and using same |
| TR200400527T4 (tr) * | 2000-07-03 | 2004-07-21 | Osteotech Inc. | Kemikten türetilmiş osteojenik implantlar |
| US6432436B1 (en) | 2000-10-03 | 2002-08-13 | Musculoskeletal Transplant Foundation | Partially demineralized cortical bone constructs |
| ES2326467T3 (es) | 2000-12-08 | 2009-10-13 | Osteotech, Inc. | Implante para aplicaciones ortopedicas. |
| US20030045942A1 (en) | 2001-09-05 | 2003-03-06 | Lai Wen-Fu T. | Regenerative bone implants |
| CA2475110C (en) | 2002-02-05 | 2010-03-23 | Cambridge Scientific, Inc. | Bioresorbable osteoconductive compositions for bone regeneration |
| EP1478304A4 (en) | 2002-02-28 | 2006-02-15 | Univ Wm Marsh Rice | PREFABRICATED PLOT BASED ON FABRICS |
| US7166133B2 (en) | 2002-06-13 | 2007-01-23 | Kensey Nash Corporation | Devices and methods for treating defects in the tissue of a living being |
| AU2002950340A0 (en) | 2002-07-23 | 2002-09-12 | Commonwealth Scientific And Industrial Research Organisation | Biodegradable polyurethane/urea compositions |
| US8771719B2 (en) | 2002-08-12 | 2014-07-08 | Warsaw Orthopedic, Inc. | Synthesis of a bone-polymer composite material |
| CA2501822C (en) | 2002-10-08 | 2012-02-21 | Osteotech, Inc. | Coupling agents for orthopedic biomaterials |
| JP2006509539A (ja) * | 2002-12-12 | 2006-03-23 | オステオテック，インコーポレイテッド | 形成可能かつ硬化可能なポリマー骨複合体およびその生成方法 |
| WO2005110437A2 (en) | 2004-05-10 | 2005-11-24 | Therics, Inc. | Implantable biostructure comprising an osteoconductive member and an osteoinductive material |
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2003
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- 2003-12-12 NZ NZ540697A patent/NZ540697A/en not_active IP Right Cessation
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- 2003-12-12 AU AU2003297929A patent/AU2003297929B8/en not_active Ceased
- 2003-12-12 US US10/735,135 patent/US7291345B2/en not_active Expired - Lifetime
- 2003-12-12 ES ES03797000.1T patent/ES2535484T3/es not_active Expired - Lifetime
- 2003-12-12 KR KR1020057010762A patent/KR20050088380A/ko not_active Ceased
- 2003-12-12 EP EP03797000.1A patent/EP1578957B1/en not_active Expired - Lifetime
- 2003-12-12 CA CA002510420A patent/CA2510420A1/en not_active Abandoned
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2007
- 2007-11-05 US US11/934,980 patent/US9308292B2/en not_active Expired - Fee Related
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| EP1578957B1 (en) | 2015-04-15 |
| US20080063684A1 (en) | 2008-03-13 |
| KR20050088380A (ko) | 2005-09-05 |
| US9308292B2 (en) | 2016-04-12 |
| NZ540697A (en) | 2008-05-30 |
| WO2004053112A1 (en) | 2004-06-24 |
| US7291345B2 (en) | 2007-11-06 |
| ES2535484T3 (es) | 2015-05-12 |
| EP1578957A4 (en) | 2008-09-03 |
| US20050008672A1 (en) | 2005-01-13 |
| AU2003297929B2 (en) | 2009-02-12 |
| JP2006509539A (ja) | 2006-03-23 |
| EP1578957A1 (en) | 2005-09-28 |
| AU2003297929B8 (en) | 2009-06-11 |
| AU2003297929A1 (en) | 2004-06-30 |
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