ES2535484T3 - Material compuesto de polímero-hueso que se puede formar o configurar y método para su producción - Google Patents

Material compuesto de polímero-hueso que se puede formar o configurar y método para su producción Download PDF

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Publication number
ES2535484T3
ES2535484T3 ES03797000.1T ES03797000T ES2535484T3 ES 2535484 T3 ES2535484 T3 ES 2535484T3 ES 03797000 T ES03797000 T ES 03797000T ES 2535484 T3 ES2535484 T3 ES 2535484T3
Authority
ES
Spain
Prior art keywords
bone
osteoimplant
composite
particles
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES03797000.1T
Other languages
English (en)
Spanish (es)
Inventor
John M. Winterbottom
David Kaes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warsaw Orthopedic Inc
Original Assignee
Warsaw Orthopedic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warsaw Orthopedic Inc filed Critical Warsaw Orthopedic Inc
Application granted granted Critical
Publication of ES2535484T3 publication Critical patent/ES2535484T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/365—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A61L27/3847—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Botany (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Zoology (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Vascular Medicine (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Surgery (AREA)
  • Polymers & Plastics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Developmental Biology & Embryology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
ES03797000.1T 2002-12-12 2003-12-12 Material compuesto de polímero-hueso que se puede formar o configurar y método para su producción Expired - Lifetime ES2535484T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43296802P 2002-12-12 2002-12-12
US432968P 2002-12-12
PCT/US2003/039704 WO2004053112A1 (en) 2002-12-12 2003-12-12 Formable and settable polymer bone composite and method of production thereof

Publications (1)

Publication Number Publication Date
ES2535484T3 true ES2535484T3 (es) 2015-05-12

Family

ID=32508020

Family Applications (1)

Application Number Title Priority Date Filing Date
ES03797000.1T Expired - Lifetime ES2535484T3 (es) 2002-12-12 2003-12-12 Material compuesto de polímero-hueso que se puede formar o configurar y método para su producción

Country Status (9)

Country Link
US (2) US7291345B2 (enExample)
EP (1) EP1578957B1 (enExample)
JP (1) JP2006509539A (enExample)
KR (1) KR20050088380A (enExample)
AU (1) AU2003297929B8 (enExample)
CA (1) CA2510420A1 (enExample)
ES (1) ES2535484T3 (enExample)
NZ (1) NZ540697A (enExample)
WO (1) WO2004053112A1 (enExample)

Families Citing this family (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010032017A1 (en) * 1999-12-30 2001-10-18 Alfaro Arthur A. Intervertebral implants
US20030120274A1 (en) * 2000-10-20 2003-06-26 Morris John W. Implant retaining device
CA2430744C (en) 2000-12-08 2009-11-10 Osteotech, Inc. Implant for orthopedic applications
US8740987B2 (en) 2001-06-04 2014-06-03 Warsaw Orthopedic, Inc. Tissue-derived mesh for orthopedic regeneration
GB0116341D0 (en) * 2001-07-04 2001-08-29 Smith & Nephew Biodegradable polymer systems
US6855167B2 (en) * 2001-12-05 2005-02-15 Osteotech, Inc. Spinal intervertebral implant, interconnections for such implant and processes for making
GB0202233D0 (en) * 2002-01-31 2002-03-20 Smith & Nephew Bioresorbable polymers
US20040127563A1 (en) * 2002-03-22 2004-07-01 Deslauriers Richard J. Methods of performing medical procedures which promote bone growth, compositions which promote bone growth, and methods of making such compositions
JP2006501884A (ja) * 2002-08-12 2006-01-19 オステオテック，インコーポレイテッド 骨−ポリマー複合材料の合成
CA2496364A1 (en) * 2002-08-20 2004-03-04 Exactech, Inc. Composition for the carrying and delivery of bone growth inducing material and methods for producing and applying the composition
US20050251267A1 (en) * 2004-05-04 2005-11-10 John Winterbottom Cell permeable structural implant
AU2003297929B8 (en) * 2002-12-12 2009-06-11 Warsaw Orthopedic, Inc. Formable and settable polymer bone composite and method of production thereof
US9107751B2 (en) * 2002-12-12 2015-08-18 Warsaw Orthopedic, Inc. Injectable and moldable bone substitute materials
US7985414B2 (en) * 2003-02-04 2011-07-26 Warsaw Orthopedic, Inc. Polyurethanes for osteoimplants
KR101110759B1 (ko) 2003-02-04 2012-03-13 오스테오테크, 인코포레이티드 골임플란트용 폴리우레탄
US20040260398A1 (en) * 2003-02-10 2004-12-23 Kelman David C. Resorbable devices
US7887544B2 (en) * 2003-03-10 2011-02-15 Tornier Sas Ancillary tool for positioning a glenoid implant
FR2859099B1 (fr) * 2003-08-25 2006-01-06 Tornier Sa Composant glenoidien de prothese d'epaule et prothese totale d'epaule incorporant un tel composant
US7141354B2 (en) * 2003-09-30 2006-11-28 Dai Nippon Printing Co., Ltd. Photo radical generator, photo sensitive resin composition and article
FR2863865B1 (fr) * 2003-12-19 2006-10-06 Tornier Sa Prothese d'epaule ou de hanche et son procede de montage
GB0329654D0 (en) * 2003-12-23 2004-01-28 Smith & Nephew Tunable segmented polyacetal
US20070231788A1 (en) * 2003-12-31 2007-10-04 Keyvan Behnam Method for In Vitro Assay of Demineralized Bone Matrix
CA2535169A1 (en) 2003-12-31 2005-07-21 Osteotech, Inc. Improved bone matrix compositions and methods
US8012210B2 (en) 2004-01-16 2011-09-06 Warsaw Orthopedic, Inc. Implant frames for use with settable materials and related methods of use
EP1708651A4 (en) 2004-01-27 2011-11-02 Osteotech Inc STABILIZED BONE PROOF
JP2007519492A (ja) * 2004-01-30 2007-07-19 オステオテック，インコーポレイテッド 脊椎融合のための積み重ねインプラント
WO2005094553A2 (en) 2004-03-24 2005-10-13 Doctor's Research Group, Inc. Compositions for promoting bone growth and methods thereof
US7678150B2 (en) 2004-06-15 2010-03-16 Tornier Sas Total shoulder prosthesis of an inverted type
FR2871371B1 (fr) * 2004-06-15 2007-04-06 Tornier Sas Composant glenoidien de prothese d'epaule, jeu d'elements constitutifs d'un tel composant et prothese totale d'epaule incorporant un tel composant
US8303665B2 (en) 2004-06-15 2012-11-06 Tornier Sas Glenoidal component, set of such components and shoulder prosthesis incorporating such a glenoidal component
FR2872025B1 (fr) 2004-06-28 2006-08-25 Tornier Sas Prothese d'epaule ou de hanche
CA2619571A1 (en) * 2005-08-18 2007-02-22 Smith & Nephew, Plc High strength devices and composites
US9763788B2 (en) 2005-09-09 2017-09-19 Board Of Trustees Of The University Of Arkansas Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same
US8936805B2 (en) 2005-09-09 2015-01-20 Board Of Trustees Of The University Of Arkansas Bone regeneration using biodegradable polymeric nanocomposite materials and applications of the same
WO2007030752A2 (en) * 2005-09-09 2007-03-15 University Of Arkansas At Little Rock System and method for tissue generation and bone regeneration
US8911759B2 (en) * 2005-11-01 2014-12-16 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
WO2007067624A2 (en) * 2005-12-06 2007-06-14 Tyco Healthcare Group Lp Bioabsorbable compounds and compositions containing them
CA2637606C (en) * 2006-01-19 2013-03-19 Osteotech, Inc. Porous osteoimplant
WO2007103276A2 (en) 2006-03-03 2007-09-13 Smith & Nephew, Inc. Systems and methods for delivering a medicament
US20070207182A1 (en) 2006-03-06 2007-09-06 Jan Weber Medical devices having electrically aligned elongated particles
WO2007109291A2 (en) * 2006-03-21 2007-09-27 Axiom Orthopaedics, Inc. Non-spherical articulating surfaces in shoulder and hip prosthesis
EP1996124B1 (en) * 2006-03-21 2019-10-30 Tornier, Inc. Femoral and humeral stem components sytem for orthopedic joint reconstruction
US9474619B2 (en) * 2006-03-21 2016-10-25 Tornier, Inc. Glenoid component with improved fixation stability
US20070269544A1 (en) * 2006-03-29 2007-11-22 Sdgi Holdings, Inc. Devices and methods for contouring a shape of an implant that is positioned within a patient
ES2376222T3 (es) * 2006-03-30 2012-03-12 Mark Clarke Construcciones óseas tridimensionales mineralizadas.
FR2899790B1 (fr) * 2006-04-13 2008-06-13 Tornier Sas Composant glenoidien pour prothese totale d'epaule, jeu de tels composants, et prothese totale d'epaule comprenant un tel composant
FR2900045B1 (fr) * 2006-04-21 2009-01-16 Tornier Sas Prothese d'epaule ou de hanche
US20100209470A1 (en) * 2006-05-01 2010-08-19 Warsaw Orthopedic, Inc. An Indiana Corporation Demineralized bone matrix devices
US8506983B2 (en) * 2006-05-01 2013-08-13 Warsaw Orthopedic, Inc. Bone filler material
EP3047860B1 (en) 2006-07-20 2024-08-28 OrbusNeich Medical Pte. Ltd. Bioabsorbable polymeric composition for a medical device
US8637064B2 (en) * 2006-09-20 2014-01-28 Warsaw Orthopedic, Inc. Compression molding method for making biomaterial composites
US7959942B2 (en) 2006-10-20 2011-06-14 Orbusneich Medical, Inc. Bioabsorbable medical device with coating
EP2073754A4 (en) 2006-10-20 2012-09-26 Orbusneich Medical Inc BIOABSORBABLE POLYMER COMPOSITION AND MEDICAL DEVICE BACKGROUND
US8722783B2 (en) * 2006-11-30 2014-05-13 Smith & Nephew, Inc. Fiber reinforced composite material
US20090287309A1 (en) 2007-01-30 2009-11-19 Tornier Sas Intra-articular joint replacement
FR2911773B1 (fr) 2007-01-30 2009-03-27 Tornier Sas Methode et ensemble d'instrumentation chirurgicale pour poser une prothese totale d'epaule inversee,et prothese correspondante
EP2114310B1 (en) * 2007-02-12 2016-01-06 Warsaw Orthopedic, Inc. Joint revision implant
AU2008240418B2 (en) 2007-04-18 2013-08-15 Smith & Nephew Plc Expansion moulding of shape memory polymers
EP2142227B1 (en) 2007-04-19 2012-02-29 Smith & Nephew, Inc. Multi-modal shape memory polymers
ATE505220T1 (de) 2007-04-19 2011-04-15 Smith & Nephew Inc Graft-fixierung
WO2008157492A2 (en) 2007-06-15 2008-12-24 Osteotech, Inc. Osteoinductive demineralized cancellous bone
EP2167148B1 (en) * 2007-06-15 2017-12-27 Warsaw Orthopedic, Inc. Method of treating tissue
AU2008265850B2 (en) 2007-06-15 2014-06-26 Warsaw Orthopedic, Inc. Bone matrix compositions and methods
US9554920B2 (en) * 2007-06-15 2017-01-31 Warsaw Orthopedic, Inc. Bone matrix compositions having nanoscale textured surfaces
US20110054408A1 (en) * 2007-07-10 2011-03-03 Guobao Wei Delivery systems, devices, tools, and methods of use
WO2009009684A1 (en) * 2007-07-10 2009-01-15 Osteotech, Inc. Delivery system
EP2197508B1 (en) 2007-09-06 2014-12-10 Boston Scientific Limited Medical devices containing silicate and carbon particles
ES2446544T3 (es) * 2007-10-19 2014-03-10 Warsaw Orthopedic, Inc. Composiciones de matrices óseas desmineralizadas y métodos
WO2009073068A2 (en) * 2007-11-30 2009-06-11 The Govt. Of U.S.A. As Represented By The Secretary Of The Department Of Health And Human Services Bone scaffolds, injectable bone repair materials and methods for bone repair
GB2457756A (en) * 2008-01-09 2009-09-02 Univ Aberdeen Bioceramic calcium phosphosilicate compositions
US8685432B2 (en) * 2008-03-25 2014-04-01 University Of Utah Research Foundation Controlled release tissue graft combination biomaterials
AU2009228114A1 (en) * 2008-03-28 2009-10-01 Warsaw Orthopedic, Inc. Bone anchors for orthopedic applications
CA2742047A1 (en) 2008-10-24 2010-04-29 Warsaw Orthopedic, Inc. Compositions and methods for promoting bone formation
WO2012134540A2 (en) 2010-10-22 2012-10-04 Vanderbilt University Injectable synthetic pur composite
EP2358408A2 (en) * 2008-10-30 2011-08-24 Osteotech, Inc., Bone/polyurethane composites and methods thereof
US9011537B2 (en) * 2009-02-12 2015-04-21 Warsaw Orthopedic, Inc. Delivery system cartridge
KR101139660B1 (ko) * 2009-06-15 2012-05-14 한스바이오메드 주식회사 탈회골(ｄｂｍ)을 포함하는 골 충진재의 제조방법
US8784499B2 (en) * 2010-03-25 2014-07-22 Lifecell Corporation Preparation of regenerative tissue scaffolds
US20110243913A1 (en) * 2010-04-06 2011-10-06 Orthovita, Inc. Biomaterial Compositions and Methods of Use
US9408652B2 (en) 2010-04-27 2016-08-09 Tornier Sas Intra-articular joint replacement and method
ES2762118T3 (es) * 2010-08-10 2020-05-22 Lifecell Corp Andamiajes tisulares regenerativos
CA2809606C (en) 2010-08-26 2020-12-01 University Of Louisville Research Foundation, Inc. Compositions and methods for treating bone defects
FR2966343B1 (fr) 2010-10-22 2012-12-07 Tornier Sa Jeu de composants glenoidiens d'une prothese d'epaule
US8926710B2 (en) 2010-10-25 2015-01-06 Warsaw Orthopedic, Inc. Osteoinductive bone graft injectable cement
WO2012062360A1 (en) 2010-11-10 2012-05-18 Stryker Trauma Gmbh Polymeric bone foam composition and method
US8637067B1 (en) 2011-03-10 2014-01-28 Lifecell Corporation Elastic tissue matrix derived hydrogel
CA3057353C (en) 2011-09-09 2022-07-26 Abyrx, Inc. Absorbable multi-putty bone cements and hemostatic compositions and methods of use
WO2013055889A2 (en) 2011-10-14 2013-04-18 Innovative Surface Technologies, Inc. Implantable scaffolds and methods of use
US9549805B2 (en) 2011-12-20 2017-01-24 Lifecell Corporation Flowable tissue products
EP3549615B1 (en) 2011-12-20 2020-12-16 LifeCell Corporation Sheet tissue products
AU2013212592B2 (en) 2012-01-24 2016-06-30 Lifecell Corporation Elongated tissue matrices
BR112014026088B1 (pt) 2012-04-24 2019-11-05 Lifecell Corp produto de tratamento de tecidos
US10207027B2 (en) 2012-06-11 2019-02-19 Globus Medical, Inc. Bioactive bone graft substitutes
US9889235B2 (en) 2013-02-05 2018-02-13 University Of Utah Research Foundation Implantable devices for bone or joint defects
AU2014227561C1 (en) 2013-03-15 2017-12-14 Cook Biotech Incorporated ECM implant compositions and methods
US10046090B2 (en) 2013-10-08 2018-08-14 Vivorte, Inc. Processed bone particle compositions and related methods
US9486483B2 (en) 2013-10-18 2016-11-08 Globus Medical, Inc. Bone grafts including osteogenic stem cells, and methods relating to the same
US9539286B2 (en) 2013-10-18 2017-01-10 Globus Medical, Inc. Bone grafts including osteogenic stem cells, and methods relating to the same
US9827349B1 (en) 2013-11-26 2017-11-28 Abyrx Inc. Settable surgical implants and their packaging
US9579421B2 (en) 2014-02-07 2017-02-28 Globus Medical Inc. Bone grafts and methods of making and using bone grafts
US9463264B2 (en) 2014-02-11 2016-10-11 Globus Medical, Inc. Bone grafts and methods of making and using bone grafts
US10531957B2 (en) 2015-05-21 2020-01-14 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
US10016529B2 (en) 2015-06-10 2018-07-10 Globus Medical, Inc. Biomaterial compositions, implants, and methods of making the same
US11426489B2 (en) 2015-06-10 2022-08-30 Globus Medical, Inc. Biomaterial compositions, implants, and methods of making the same
US10549011B2 (en) * 2015-10-26 2020-02-04 Osteolife Biomedical, Llc Bone putty and gel systems and methods
US20170128633A1 (en) 2015-11-10 2017-05-11 Theodore Malinin Bioactive Implants and Methods of Making and Using
DE102016107223B4 (de) * 2016-04-19 2018-05-24 Karl Leibinger Medizintechnik Gmbh & Co. Kg Hybridimplantat aus einem Kompositmaterial
CA3027490C (en) 2016-06-13 2021-08-10 Lifenet Health Demineralized bone fibers and preparation thereof
FR3053239B1 (fr) 2016-06-30 2022-02-25 Teknimed Susbtitut osseux et systeme d'injection autonome
US10743996B2 (en) 2017-03-24 2020-08-18 Robert L. Bundy Amnion putty for cartilage repair
US12311076B1 (en) 2018-06-07 2025-05-27 Seaspine, Inc. Demineralized bone matrix composition with enhanced osteoinductivity and osteoconductivity
WO2021035795A1 (zh) * 2019-08-31 2021-03-04 深圳市立心科学有限公司 可塑形的人工骨复合材料及其制备方法
US11896736B2 (en) 2020-07-13 2024-02-13 Globus Medical, Inc Biomaterial implants and methods of making the same

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3919773A (en) * 1973-12-20 1975-11-18 Sybron Corp Direct moldable implant material
US3892649A (en) * 1974-05-13 1975-07-01 Us Navy Electrodeposition of bone within a plastic matrix
US3949073A (en) * 1974-11-18 1976-04-06 The Board Of Trustees Of Leland Stanford Junior University Process for augmenting connective mammalian tissue with in situ polymerizable native collagen solution
US4183874A (en) * 1976-04-30 1980-01-15 Union Carbide Corporation Silane end-capped polyarylene shaped articles and mixed resins
NL8304066A (nl) 1983-11-28 1985-06-17 Hoogovens Groep Bv Werkwijze voor het bereiden van kooks.
US4551156A (en) * 1984-01-16 1985-11-05 Standard Oil Company Permselective membrane compositions for gas separations and process for the separation of gases therewith
US4637931A (en) * 1984-10-09 1987-01-20 The United States Of America As Represented By The Secretary Of The Army Polyactic-polyglycolic acid copolymer combined with decalcified freeze-dried bone for use as a bone repair material
US4595713A (en) 1985-01-22 1986-06-17 Hexcel Corporation Medical putty for tissue augmentation
US4645503A (en) * 1985-08-27 1987-02-24 Orthomatrix Inc. Moldable bone-implant material
US4783504A (en) * 1986-02-28 1988-11-08 Shell Oil Company Hot melt adhesive containing a silane grafted hydrogenated block polymer
US6311690B1 (en) * 1986-03-27 2001-11-06 Gensci Orthobiologics, Inc. Bone repair material and delayed drug delivery system
US5736372A (en) * 1986-11-20 1998-04-07 Massachusetts Institute Of Technology Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure
US5306311A (en) * 1987-07-20 1994-04-26 Regen Corporation Prosthetic articular cartilage
US5162445A (en) * 1988-05-27 1992-11-10 Exxon Chemical Patents Inc. Para-alkylstyrene/isoolefin copolymers and functionalized copolymers thereof
DE3826915A1 (de) * 1988-08-09 1990-02-15 Henkel Kgaa Neue werkstoffe fuer den knochenersatz und knochen- bzw. prothesenverbund
US5246782A (en) * 1990-12-10 1993-09-21 The Dow Chemical Company Laminates of polymers having perfluorocyclobutane rings and polymers containing perfluorocyclobutane rings
US5324519A (en) * 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
JP2683442B2 (ja) * 1990-08-21 1997-11-26 ポリプラスチックス株式会社 ポリアリーレンサルファイド樹脂組成物及びその製造法
US5333626A (en) * 1991-12-31 1994-08-02 Cryolife, Inc. Preparation of bone for transplantation
US5513662A (en) * 1991-12-31 1996-05-07 Osteotech, Inc. Preparation of bone for transplantation
US5468544A (en) * 1993-11-15 1995-11-21 The Trustees Of The University Of Pennsylvania Composite materials using bone bioactive glass and ceramic fibers
US5626861A (en) * 1994-04-01 1997-05-06 Massachusetts Institute Of Technology Polymeric-hydroxyapatite bone composite
AU3795395A (en) * 1994-11-30 1996-06-06 Ethicon Inc. Hard tissue bone cements and substitutes
US6376573B1 (en) * 1994-12-21 2002-04-23 Interpore International Porous biomaterials and methods for their manufacture
US5606000A (en) * 1995-02-06 1997-02-25 National Chemical Laboratory Silicon containing polyarylates
CA2270599C (en) 1996-11-05 2005-06-14 Challenge Bioproducts Co., Ltd. Chemical modification of biomedical materials with genipin
US20020098222A1 (en) * 1997-03-13 2002-07-25 John F. Wironen Bone paste
US5948386A (en) * 1997-03-14 1999-09-07 The Curators Of The University Of Missouri Conjugate and method for forming aminomethyl phosphorus conjugates
US5846484A (en) * 1997-03-20 1998-12-08 Osteotech, Inc. Pressure flow system and method for treating a fluid permeable workpiece such as a bone
US5837752A (en) * 1997-07-17 1998-11-17 Massachusetts Institute Of Technology Semi-interpenetrating polymer networks
US5910315A (en) * 1997-07-18 1999-06-08 Stevenson; Sharon Allograft tissue material for filling spinal fusion cages or related surgical spaces
US6309659B1 (en) * 1997-09-02 2001-10-30 Gensci Orthobiologics, Inc. Reverse phase connective tissue repair composition
US6399693B1 (en) * 1997-10-23 2002-06-04 Univ. Of Florida Research Foundation Bioactive composites comprising silane functionalized polyaryl polymers
US6027744A (en) * 1998-04-24 2000-02-22 University Of Massachusetts Medical Center Guided development and support of hydrogel-cell compositions
US6406498B1 (en) * 1998-09-04 2002-06-18 Bionx Implants Oy Bioactive, bioabsorbable surgical composite material
US6132468A (en) * 1998-09-10 2000-10-17 Mansmann; Kevin A. Arthroscopic replacement of cartilage using flexible inflatable envelopes
US6165486A (en) * 1998-11-19 2000-12-26 Carnegie Mellon University Biocompatible compositions and methods of using same
US6294187B1 (en) * 1999-02-23 2001-09-25 Osteotech, Inc. Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same
US6696073B2 (en) * 1999-02-23 2004-02-24 Osteotech, Inc. Shaped load-bearing osteoimplant and methods of making same
WO2001012240A1 (en) * 1999-08-17 2001-02-22 Taki Chemical Co., Ltd. Biological materials
US6352667B1 (en) * 1999-08-24 2002-03-05 Absorbable Polymer Technologies, Inc. Method of making biodegradable polymeric implants
US6183498B1 (en) * 1999-09-20 2001-02-06 Devore Dale P. Methods and products for sealing a fluid leak in a tissue
EP1142596A1 (en) * 2000-04-03 2001-10-10 Universiteit Gent Compositions of crosslinkable prepolymers for use in therapeutically active biodegradable implants
US6340477B1 (en) * 2000-04-27 2002-01-22 Lifenet Bone matrix composition and methods for making and using same
DE60101967T2 (de) * 2000-07-03 2004-07-22 Osteotech, Inc. Knochenbildendes implantat aus knochen
US6432436B1 (en) * 2000-10-03 2002-08-13 Musculoskeletal Transplant Foundation Partially demineralized cortical bone constructs
CA2430744C (en) * 2000-12-08 2009-11-10 Osteotech, Inc. Implant for orthopedic applications
US20030045942A1 (en) * 2001-09-05 2003-03-06 Lai Wen-Fu T. Regenerative bone implants
US20030180344A1 (en) * 2002-02-05 2003-09-25 Cambridge Scientific, Inc. Bioresorbable osteoconductive compositions for bone regeneration
WO2003073912A2 (en) * 2002-02-28 2003-09-12 Wm. Marsh Rice University Pre-fabricated tissue-engineered plug
US7166133B2 (en) * 2002-06-13 2007-01-23 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being
AU2002950340A0 (en) * 2002-07-23 2002-09-12 Commonwealth Scientific And Industrial Research Organisation Biodegradable polyurethane/urea compositions
JP2006501884A (ja) * 2002-08-12 2006-01-19 オステオテック，インコーポレイテッド 骨−ポリマー複合材料の合成
AU2003277325A1 (en) * 2002-10-08 2004-05-04 Osteotech, Inc. Coupling agents for orthopedic biomaterials
AU2003297929B8 (en) * 2002-12-12 2009-06-11 Warsaw Orthopedic, Inc. Formable and settable polymer bone composite and method of production thereof
US20050281856A1 (en) * 2004-05-10 2005-12-22 Mcglohorn Jonathan Implantable biostructure comprising an osteoconductive member and an osteoinductive material

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