CA2504226A1 - Histone deacetylase inhibitors for treating degenerative diseases of the eye - Google Patents
Histone deacetylase inhibitors for treating degenerative diseases of the eye Download PDFInfo
- Publication number
- CA2504226A1 CA2504226A1 CA002504226A CA2504226A CA2504226A1 CA 2504226 A1 CA2504226 A1 CA 2504226A1 CA 002504226 A CA002504226 A CA 002504226A CA 2504226 A CA2504226 A CA 2504226A CA 2504226 A1 CA2504226 A1 CA 2504226A1
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- CA
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- Prior art keywords
- retinal
- vol
- disease
- eye
- glaucoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
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- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42557602P | 2002-11-12 | 2002-11-12 | |
| US60/425,576 | 2002-11-12 | ||
| PCT/US2003/033873 WO2004043348A2 (en) | 2002-11-12 | 2003-10-27 | Histone deacetylase inhibitors for treating degenerative diseases of the eye |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2504226A1 true CA2504226A1 (en) | 2004-05-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002504226A Abandoned CA2504226A1 (en) | 2002-11-12 | 2003-10-27 | Histone deacetylase inhibitors for treating degenerative diseases of the eye |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20040092431A1 (enExample) |
| EP (1) | EP1562592A4 (enExample) |
| JP (1) | JP2006508120A (enExample) |
| KR (1) | KR20050074547A (enExample) |
| CN (1) | CN1711086A (enExample) |
| AU (1) | AU2003286686B2 (enExample) |
| BR (1) | BR0316163A (enExample) |
| CA (1) | CA2504226A1 (enExample) |
| MX (1) | MXPA05004738A (enExample) |
| RU (1) | RU2324483C2 (enExample) |
| WO (1) | WO2004043348A2 (enExample) |
| ZA (1) | ZA200503230B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7250514B1 (en) | 2002-10-21 | 2007-07-31 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US20080004311A1 (en) * | 2002-11-12 | 2008-01-03 | Alcon, Inc. | Histone deacetylase inhibitors for treating degenerative diseases of the eye |
| US20040092431A1 (en) * | 2002-11-12 | 2004-05-13 | Hellberg Peggy E. | Histone deacetylase inhibitors for treating degenerative diseases of the eye |
| BR0316206A (pt) * | 2002-11-12 | 2005-09-27 | Alcon Inc | Uso inibidores de histona desacetilase para o tratamento de distúrbios e de doenças oculares neovasculares ou edematosos |
| US7375228B2 (en) | 2003-03-17 | 2008-05-20 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US20050197336A1 (en) * | 2004-03-08 | 2005-09-08 | Miikana Therapeutics Corporation | Inhibitors of histone deacetylase |
| US7345043B2 (en) * | 2004-04-01 | 2008-03-18 | Miikana Therapeutics | Inhibitors of histone deacetylase |
| GB2417682A (en) * | 2004-08-18 | 2006-03-08 | Univ East Anglia | Histone deacetylse inhibitor for treating connective tissue disorders |
| US7642275B2 (en) | 2004-12-16 | 2010-01-05 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| JP2008530136A (ja) | 2005-02-14 | 2008-08-07 | ミイカナ セラピューティクス インコーポレイテッド | ヒストンデアセチラーゼの阻害剤として有用な縮合複素環化合物 |
| JP2008540574A (ja) | 2005-05-11 | 2008-11-20 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
| CA2615105A1 (en) | 2005-07-14 | 2007-01-25 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| CN101267779A (zh) * | 2005-07-27 | 2008-09-17 | 福罗里达大学研究基金会有限公司 | 使用热休克治疗眼睛疾病 |
| WO2008117861A1 (ja) * | 2007-03-28 | 2008-10-02 | Santen Pharmaceutical Co., Ltd. | フェニレンジアミン誘導体を有効成分とする眼圧下降剤 |
| WO2008123395A1 (ja) * | 2007-03-28 | 2008-10-16 | Santen Pharmaceutical Co., Ltd. | ヒストン脱アセチル化酵素阻害作用を有する化合物を有効成分として含有する眼圧下降剤 |
| US8012972B2 (en) | 2007-03-28 | 2011-09-06 | Santen Pharmaceutical Co., Ltd. | Pyridinecarboxylic acid (2-aminophenyl) amide derivative having urea structure |
| US8198271B2 (en) | 2008-05-23 | 2012-06-12 | Santen Pharmaceutical Co., Ltd. | Thiophenediamine derivative having urea structure |
| PL2575467T3 (pl) * | 2010-05-27 | 2017-10-31 | Univ Colorado Regents | Związki makrocykliczne użyteczne jako inhibitory deacetylaz histonowych |
| CN107362148B (zh) * | 2017-07-27 | 2020-04-21 | 东曜药业有限公司 | 一种治疗肿瘤的药物组合物及其制备方法和应用 |
| KR20230051153A (ko) * | 2020-06-11 | 2023-04-17 | 더 트러스티스 오브 콜롬비아 유니버시티 인 더 시티 오브 뉴욕 | 히스톤 데아세틸레이스(hdac) 저해제인 트라이코스타틴 a 및 이의 유도체를 이용한 근시의 예방 및 치료를 위한 방법 및 조성물 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2534580A1 (fr) * | 1982-10-13 | 1984-04-20 | Synthelabo | Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent |
| US5151444B1 (en) * | 1987-09-18 | 1999-07-06 | R Tech Ueno Ltd | Ocular hypotensive agents |
| US5296504A (en) * | 1988-09-06 | 1994-03-22 | Kabi Pharmacia | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| US5321128A (en) * | 1988-09-06 | 1994-06-14 | Kabi Pharmacia Ab | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| DE68929435T2 (de) * | 1988-09-06 | 2003-07-17 | Pharmacia Ab, Stockholm | Prostaglandinderivate zur Behandlung des grünen Stars oder einer okularen Hypertension |
| US5464866A (en) * | 1992-08-17 | 1995-11-07 | Alcon Laboratories, Inc. | Substituted hydrindanes for the treatment of angiogenesis-dependent diseases |
| US5352708A (en) * | 1992-09-21 | 1994-10-04 | Allergan, Inc. | Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
| US5688819A (en) * | 1992-09-21 | 1997-11-18 | Allergan | Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
| US5510383A (en) * | 1993-08-03 | 1996-04-23 | Alcon Laboratories, Inc. | Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension |
| US5681854A (en) * | 1995-11-22 | 1997-10-28 | Alcon Laboratories, Inc. | Use of aliphatic carboxylic acid derivatives in ophthalmic disorders |
| CN1138760C (zh) * | 1997-10-06 | 2004-02-18 | 惠氏控股公司 | 作为基质金属蛋白酶和tace抑制剂的邻亚磺酰氨基二环杂芳基异羟肟酸的制备和用途 |
| AUPP505798A0 (en) * | 1998-08-04 | 1998-08-27 | Fujisawa Pharmaceutical Co., Ltd. | Novel compound fr225497 substance |
| WO2002051846A1 (en) * | 2000-12-22 | 2002-07-04 | Zee, Ok Pyo | Apicidin-derivatives, their synthetic methods, and antitumor compositions containing the same |
| US6905669B2 (en) * | 2001-04-24 | 2005-06-14 | Supergen, Inc. | Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase |
| US7154002B1 (en) * | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7250514B1 (en) * | 2002-10-21 | 2007-07-31 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US20040092431A1 (en) * | 2002-11-12 | 2004-05-13 | Hellberg Peggy E. | Histone deacetylase inhibitors for treating degenerative diseases of the eye |
| US20080004311A1 (en) * | 2002-11-12 | 2008-01-03 | Alcon, Inc. | Histone deacetylase inhibitors for treating degenerative diseases of the eye |
| US8034768B2 (en) * | 2007-06-22 | 2011-10-11 | Board Of Regents, The University Of Texas System | Composition and method for the treatment of diseases affected by histone deacetylase inhibitors |
-
2003
- 2003-10-27 US US10/694,309 patent/US20040092431A1/en not_active Abandoned
- 2003-10-27 MX MXPA05004738A patent/MXPA05004738A/es active IP Right Grant
- 2003-10-27 JP JP2004551572A patent/JP2006508120A/ja not_active Withdrawn
- 2003-10-27 CA CA002504226A patent/CA2504226A1/en not_active Abandoned
- 2003-10-27 RU RU2005118108/14A patent/RU2324483C2/ru not_active IP Right Cessation
- 2003-10-27 CN CNA2003801029350A patent/CN1711086A/zh active Pending
- 2003-10-27 AU AU2003286686A patent/AU2003286686B2/en not_active Ceased
- 2003-10-27 EP EP03777895A patent/EP1562592A4/en not_active Withdrawn
- 2003-10-27 WO PCT/US2003/033873 patent/WO2004043348A2/en not_active Ceased
- 2003-10-27 KR KR1020057008066A patent/KR20050074547A/ko not_active Ceased
- 2003-10-27 US US10/531,747 patent/US20070088045A1/en not_active Abandoned
- 2003-10-27 BR BR0316163-3A patent/BR0316163A/pt not_active IP Right Cessation
-
2005
- 2005-04-21 ZA ZA200503230A patent/ZA200503230B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003286686A1 (en) | 2004-06-03 |
| BR0316163A (pt) | 2005-09-27 |
| WO2004043348A2 (en) | 2004-05-27 |
| WO2004043348A3 (en) | 2004-07-15 |
| KR20050074547A (ko) | 2005-07-18 |
| EP1562592A2 (en) | 2005-08-17 |
| RU2005118108A (ru) | 2006-01-20 |
| JP2006508120A (ja) | 2006-03-09 |
| US20040092431A1 (en) | 2004-05-13 |
| US20070088045A1 (en) | 2007-04-19 |
| EP1562592A4 (en) | 2009-01-21 |
| MXPA05004738A (es) | 2005-08-03 |
| ZA200503230B (en) | 2006-06-28 |
| AU2003286686B2 (en) | 2009-07-16 |
| RU2324483C2 (ru) | 2008-05-20 |
| CN1711086A (zh) | 2005-12-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 20121029 |