CA2504226A1 - Histone deacetylase inhibitors for treating degenerative diseases of the eye - Google Patents
Histone deacetylase inhibitors for treating degenerative diseases of the eye Download PDFInfo
- Publication number
- CA2504226A1 CA2504226A1 CA002504226A CA2504226A CA2504226A1 CA 2504226 A1 CA2504226 A1 CA 2504226A1 CA 002504226 A CA002504226 A CA 002504226A CA 2504226 A CA2504226 A CA 2504226A CA 2504226 A1 CA2504226 A1 CA 2504226A1
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- CA
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- Prior art keywords
- retinal
- vol
- disease
- eye
- glaucoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
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- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| US42557602P | 2002-11-12 | 2002-11-12 | |
| US60/425,576 | 2002-11-12 | ||
| PCT/US2003/033873 WO2004043348A2 (en) | 2002-11-12 | 2003-10-27 | Histone deacetylase inhibitors for treating degenerative diseases of the eye |
Publications (1)
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| CA2504226A1 true CA2504226A1 (en) | 2004-05-27 |
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| CA002504226A Abandoned CA2504226A1 (en) | 2002-11-12 | 2003-10-27 | Histone deacetylase inhibitors for treating degenerative diseases of the eye |
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| Country | Link |
|---|---|
| US (2) | US20040092431A1 (enExample) |
| EP (1) | EP1562592A4 (enExample) |
| JP (1) | JP2006508120A (enExample) |
| KR (1) | KR20050074547A (enExample) |
| CN (1) | CN1711086A (enExample) |
| AU (1) | AU2003286686B2 (enExample) |
| BR (1) | BR0316163A (enExample) |
| CA (1) | CA2504226A1 (enExample) |
| MX (1) | MXPA05004738A (enExample) |
| RU (1) | RU2324483C2 (enExample) |
| WO (1) | WO2004043348A2 (enExample) |
| ZA (1) | ZA200503230B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7250514B1 (en) | 2002-10-21 | 2007-07-31 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| CA2504460A1 (en) * | 2002-11-12 | 2004-05-27 | Peter G. Klimko | Histone deacetylase inhibitors for the treatment of ocular neovascular or edematous disorders and diseases |
| US20080004311A1 (en) * | 2002-11-12 | 2008-01-03 | Alcon, Inc. | Histone deacetylase inhibitors for treating degenerative diseases of the eye |
| CN1711086A (zh) * | 2002-11-12 | 2005-12-21 | 爱尔康公司 | 用于治疗眼的退化性疾病的组蛋白脱乙酰酶抑制剂 |
| US7169801B2 (en) | 2003-03-17 | 2007-01-30 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US20050197336A1 (en) * | 2004-03-08 | 2005-09-08 | Miikana Therapeutics Corporation | Inhibitors of histone deacetylase |
| US7345043B2 (en) * | 2004-04-01 | 2008-03-18 | Miikana Therapeutics | Inhibitors of histone deacetylase |
| GB2417682A (en) * | 2004-08-18 | 2006-03-08 | Univ East Anglia | Histone deacetylse inhibitor for treating connective tissue disorders |
| US7642275B2 (en) | 2004-12-16 | 2010-01-05 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| JP2008530136A (ja) | 2005-02-14 | 2008-08-07 | ミイカナ セラピューティクス インコーポレイテッド | ヒストンデアセチラーゼの阻害剤として有用な縮合複素環化合物 |
| US7642253B2 (en) | 2005-05-11 | 2010-01-05 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| AU2006270322A1 (en) | 2005-07-14 | 2007-01-25 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| AU2006272497B2 (en) * | 2005-07-27 | 2012-07-19 | University Of Florida Research Foundation, Inc. | Small compounds that correct protein misfolding and uses thereof |
| CN101646651A (zh) | 2007-03-28 | 2010-02-10 | 参天制药株式会社 | 具有脲结构的新型吡啶羧酸（2-氨基苯基）酰胺衍生物 |
| JP2008266321A (ja) * | 2007-03-28 | 2008-11-06 | Santen Pharmaceut Co Ltd | フェニレンジアミン誘導体を有効成分とする眼圧下降剤 |
| CA2680838A1 (en) * | 2007-03-28 | 2008-10-16 | Santen Pharmaceutical Co., Ltd. | Intraocular pressure-lowering agent comprising compound having histone deacetylase inhibitory effect as active ingredient |
| US8198271B2 (en) | 2008-05-23 | 2012-06-12 | Santen Pharmaceutical Co., Ltd. | Thiophenediamine derivative having urea structure |
| PT2575467T (pt) * | 2010-05-27 | 2016-10-14 | Univ Colorado Regents | Compostos macrocíclicos úteis como inibidores de histona desacetilases |
| CN107362148B (zh) * | 2017-07-27 | 2020-04-21 | 东曜药业有限公司 | 一种治疗肿瘤的药物组合物及其制备方法和应用 |
| CA3182426A1 (en) * | 2020-06-11 | 2021-12-16 | Andrei V. Tkatchenko | Methods and compositions for preventing and treating myopia with trichostatin a, a histone deacetylase (hdac) inhibitor, and derivatives thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2534580A1 (fr) * | 1982-10-13 | 1984-04-20 | Synthelabo | Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent |
| US5151444B1 (en) * | 1987-09-18 | 1999-07-06 | R Tech Ueno Ltd | Ocular hypotensive agents |
| US5296504A (en) * | 1988-09-06 | 1994-03-22 | Kabi Pharmacia | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| US5321128A (en) * | 1988-09-06 | 1994-06-14 | Kabi Pharmacia Ab | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| ES2213504T1 (es) * | 1988-09-06 | 2004-09-01 | Pfizer Health Ab | Derivados de prostaglandina para el tratamiento del glaucoma o hipertension ocular. |
| US5464866A (en) * | 1992-08-17 | 1995-11-07 | Alcon Laboratories, Inc. | Substituted hydrindanes for the treatment of angiogenesis-dependent diseases |
| US5352708A (en) * | 1992-09-21 | 1994-10-04 | Allergan, Inc. | Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
| US5688819A (en) * | 1992-09-21 | 1997-11-18 | Allergan | Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
| US5510383A (en) * | 1993-08-03 | 1996-04-23 | Alcon Laboratories, Inc. | Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension |
| US5681854A (en) * | 1995-11-22 | 1997-10-28 | Alcon Laboratories, Inc. | Use of aliphatic carboxylic acid derivatives in ophthalmic disorders |
| JP2003520183A (ja) * | 1997-10-06 | 2003-07-02 | アメリカン・サイアナミド・カンパニー | マトリクス金属プロテイナーゼおよびｔａｃｅ阻害薬としてのオルト−スルホンアミド二環式ヘテロアリールヒドロキサム酸の製造および使用 |
| AUPP505798A0 (en) * | 1998-08-04 | 1998-08-27 | Fujisawa Pharmaceutical Co., Ltd. | Novel compound fr225497 substance |
| JP2004516328A (ja) * | 2000-12-22 | 2004-06-03 | ヒャン ウー リー | アピシジン誘導体、その合成方法、及び該誘導体を含む抗癌剤組成物 |
| US6905669B2 (en) * | 2001-04-24 | 2005-06-14 | Supergen, Inc. | Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase |
| US7154002B1 (en) * | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7250514B1 (en) * | 2002-10-21 | 2007-07-31 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US20080004311A1 (en) * | 2002-11-12 | 2008-01-03 | Alcon, Inc. | Histone deacetylase inhibitors for treating degenerative diseases of the eye |
| CN1711086A (zh) * | 2002-11-12 | 2005-12-21 | 爱尔康公司 | 用于治疗眼的退化性疾病的组蛋白脱乙酰酶抑制剂 |
| US8034768B2 (en) * | 2007-06-22 | 2011-10-11 | Board Of Regents, The University Of Texas System | Composition and method for the treatment of diseases affected by histone deacetylase inhibitors |
-
2003
- 2003-10-27 CN CNA2003801029350A patent/CN1711086A/zh active Pending
- 2003-10-27 AU AU2003286686A patent/AU2003286686B2/en not_active Ceased
- 2003-10-27 KR KR1020057008066A patent/KR20050074547A/ko not_active Ceased
- 2003-10-27 BR BR0316163-3A patent/BR0316163A/pt not_active IP Right Cessation
- 2003-10-27 US US10/694,309 patent/US20040092431A1/en not_active Abandoned
- 2003-10-27 RU RU2005118108/14A patent/RU2324483C2/ru not_active IP Right Cessation
- 2003-10-27 CA CA002504226A patent/CA2504226A1/en not_active Abandoned
- 2003-10-27 MX MXPA05004738A patent/MXPA05004738A/es active IP Right Grant
- 2003-10-27 EP EP03777895A patent/EP1562592A4/en not_active Withdrawn
- 2003-10-27 JP JP2004551572A patent/JP2006508120A/ja not_active Withdrawn
- 2003-10-27 WO PCT/US2003/033873 patent/WO2004043348A2/en not_active Ceased
- 2003-10-27 US US10/531,747 patent/US20070088045A1/en not_active Abandoned
-
2005
- 2005-04-21 ZA ZA200503230A patent/ZA200503230B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003286686A1 (en) | 2004-06-03 |
| US20070088045A1 (en) | 2007-04-19 |
| ZA200503230B (en) | 2006-06-28 |
| EP1562592A2 (en) | 2005-08-17 |
| CN1711086A (zh) | 2005-12-21 |
| BR0316163A (pt) | 2005-09-27 |
| JP2006508120A (ja) | 2006-03-09 |
| WO2004043348A2 (en) | 2004-05-27 |
| RU2005118108A (ru) | 2006-01-20 |
| US20040092431A1 (en) | 2004-05-13 |
| RU2324483C2 (ru) | 2008-05-20 |
| EP1562592A4 (en) | 2009-01-21 |
| AU2003286686B2 (en) | 2009-07-16 |
| WO2004043348A3 (en) | 2004-07-15 |
| KR20050074547A (ko) | 2005-07-18 |
| MXPA05004738A (es) | 2005-08-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 20121029 |