RU2324483C2 - Ингибиторы гистондеацетилазы для лечения дегенеративных заболеваний глаз - Google Patents
Ингибиторы гистондеацетилазы для лечения дегенеративных заболеваний глаз Download PDFInfo
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- RU2324483C2 RU2324483C2 RU2005118108/14A RU2005118108A RU2324483C2 RU 2324483 C2 RU2324483 C2 RU 2324483C2 RU 2005118108/14 A RU2005118108/14 A RU 2005118108/14A RU 2005118108 A RU2005118108 A RU 2005118108A RU 2324483 C2 RU2324483 C2 RU 2324483C2
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A—HUMAN NECESSITIES
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61P27/00—Drugs for disorders of the senses
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- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| RU2565076C2 (ru) * | 2010-05-27 | 2015-10-20 | Дзе Риджентс Оф Дзе Юниверсити Оф Колорадо, Э Боди Корпорейт | Макроциклические соединения, применимые в качестве ингибиторов гистондеацетилаз |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7250514B1 (en) | 2002-10-21 | 2007-07-31 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| AU2003286686B2 (en) * | 2002-11-12 | 2009-07-16 | Alcon, Inc. | Histone deacetylase inhibitors for treating degenerative diseases of the eye |
| RU2352337C2 (ru) * | 2002-11-12 | 2009-04-20 | Алькон, Инк. | Ингибиторы гистондеацетилазы для лечения офтальмологических неоваскулярных нарушений и заболеваний |
| US20080004311A1 (en) * | 2002-11-12 | 2008-01-03 | Alcon, Inc. | Histone deacetylase inhibitors for treating degenerative diseases of the eye |
| US7375228B2 (en) | 2003-03-17 | 2008-05-20 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US20050197336A1 (en) * | 2004-03-08 | 2005-09-08 | Miikana Therapeutics Corporation | Inhibitors of histone deacetylase |
| US7345043B2 (en) * | 2004-04-01 | 2008-03-18 | Miikana Therapeutics | Inhibitors of histone deacetylase |
| GB2417682A (en) * | 2004-08-18 | 2006-03-08 | Univ East Anglia | Histone deacetylse inhibitor for treating connective tissue disorders |
| WO2006066133A2 (en) | 2004-12-16 | 2006-06-22 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| JP2008530136A (ja) | 2005-02-14 | 2008-08-07 | ミイカナ セラピューティクス インコーポレイテッド | ヒストンデアセチラーゼの阻害剤として有用な縮合複素環化合物 |
| JP2008540574A (ja) | 2005-05-11 | 2008-11-20 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
| AU2006270322A1 (en) | 2005-07-14 | 2007-01-25 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| EP2374451A3 (en) * | 2005-07-27 | 2012-01-25 | University of Florida Research Foundation, Inc. | Histone deacetylase inhibitors (HDAC) that correct protein misfolding and uses thereof |
| WO2008117861A1 (ja) * | 2007-03-28 | 2008-10-02 | Santen Pharmaceutical Co., Ltd. | フェニレンジアミン誘導体を有効成分とする眼圧下降剤 |
| EP2135620A4 (en) * | 2007-03-28 | 2010-12-29 | Santen Pharmaceutical Co Ltd | AGAINST OKULAR HYPOTONIA CONNECTED TO HISTONE DEACETYLASE INHIBITION AS AN ACTIVE SUBSTANCE |
| WO2008117862A1 (ja) | 2007-03-28 | 2008-10-02 | Santen Pharmaceutical Co., Ltd. | ウレア構造を有する新規ピリジンカルボン酸（２－アミノフェニル）アミド誘導体 |
| CA2724357A1 (en) * | 2008-05-23 | 2009-11-26 | Santen Pharmaceutical Co., Ltd. | Novel thiophenediamine derivative having urea structure |
| CN107362148B (zh) * | 2017-07-27 | 2020-04-21 | 东曜药业有限公司 | 一种治疗肿瘤的药物组合物及其制备方法和应用 |
| WO2021252628A1 (en) * | 2020-06-11 | 2021-12-16 | The Trustees Of Columbia University In The City Of New York | Methods and compositions for preventing and treating myopia with trichostatin a, a histone deacetylase (hdac) inhibitor, and derivatives thereof |
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| RU2000111469A (ru) * | 1997-10-06 | 2002-02-27 | Американ Цианамид Компани | Получение и применение орто-сульфонамидобициклических гетероарильных гидроксамовых кислот в качестве ингибиторов металлопротеиназ матрикса и тасе (tnf-альфа-превращающего фермента) |
| KR20020051859A (ko) * | 2000-12-22 | 2002-06-29 | 이향우 | 애피시딘 유도체, 이의 합성방법 및 이를 포함하는 항암제조성물 |
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|---|---|---|---|---|
| FR2534580A1 (fr) * | 1982-10-13 | 1984-04-20 | Synthelabo | Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent |
| US5151444B1 (en) * | 1987-09-18 | 1999-07-06 | R Tech Ueno Ltd | Ocular hypotensive agents |
| US5321128A (en) * | 1988-09-06 | 1994-06-14 | Kabi Pharmacia Ab | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| ES2193901T1 (es) * | 1988-09-06 | 2003-11-16 | Pharmacia Ab | Derivados de prostaglandina para el tratamiento de glaucoma o hipertension ocular. |
| US5296504A (en) * | 1988-09-06 | 1994-03-22 | Kabi Pharmacia | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| US5464866A (en) * | 1992-08-17 | 1995-11-07 | Alcon Laboratories, Inc. | Substituted hydrindanes for the treatment of angiogenesis-dependent diseases |
| US5688819A (en) * | 1992-09-21 | 1997-11-18 | Allergan | Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
| US5352708A (en) * | 1992-09-21 | 1994-10-04 | Allergan, Inc. | Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
| US5510383A (en) * | 1993-08-03 | 1996-04-23 | Alcon Laboratories, Inc. | Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension |
| US5681854A (en) * | 1995-11-22 | 1997-10-28 | Alcon Laboratories, Inc. | Use of aliphatic carboxylic acid derivatives in ophthalmic disorders |
| RU2202546C2 (ru) * | 1997-10-06 | 2003-04-20 | Американ Цианамид Компани | ПОЛУЧЕНИЕ И ПРИМЕНЕНИЕ ОРТО-СУЛЬФОНАМИДОБИЦИКЛИЧЕСКИХ ГЕТЕРОАРИЛЬНЫХ ГИДРОКСАМОВЫХ КИСЛОТ В КАЧЕСТВЕ ИНГИБИТОРОВ МЕТАЛЛОПРОТЕИНАЗ МАТРИКСА И ТАСЕ (TNF-α-ПРЕВРАЩАЮЩЕГО ФЕРМЕНТА) |
| AUPP505798A0 (en) * | 1998-08-04 | 1998-08-27 | Fujisawa Pharmaceutical Co., Ltd. | Novel compound fr225497 substance |
| US6905669B2 (en) * | 2001-04-24 | 2005-06-14 | Supergen, Inc. | Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase |
| US7154002B1 (en) * | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7250514B1 (en) * | 2002-10-21 | 2007-07-31 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US20080004311A1 (en) * | 2002-11-12 | 2008-01-03 | Alcon, Inc. | Histone deacetylase inhibitors for treating degenerative diseases of the eye |
| AU2003286686B2 (en) * | 2002-11-12 | 2009-07-16 | Alcon, Inc. | Histone deacetylase inhibitors for treating degenerative diseases of the eye |
| US8034768B2 (en) * | 2007-06-22 | 2011-10-11 | Board Of Regents, The University Of Texas System | Composition and method for the treatment of diseases affected by histone deacetylase inhibitors |
-
2003
- 2003-10-27 AU AU2003286686A patent/AU2003286686B2/en not_active Ceased
- 2003-10-27 US US10/694,309 patent/US20040092431A1/en not_active Abandoned
- 2003-10-27 CN CNA2003801029350A patent/CN1711086A/zh active Pending
- 2003-10-27 EP EP03777895A patent/EP1562592A4/en not_active Withdrawn
- 2003-10-27 RU RU2005118108/14A patent/RU2324483C2/ru not_active IP Right Cessation
- 2003-10-27 BR BR0316163-3A patent/BR0316163A/pt not_active IP Right Cessation
- 2003-10-27 WO PCT/US2003/033873 patent/WO2004043348A2/en not_active Ceased
- 2003-10-27 CA CA002504226A patent/CA2504226A1/en not_active Abandoned
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- 2003-10-27 MX MXPA05004738A patent/MXPA05004738A/es active IP Right Grant
- 2003-10-27 KR KR1020057008066A patent/KR20050074547A/ko not_active Ceased
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| RU2000111469A (ru) * | 1997-10-06 | 2002-02-27 | Американ Цианамид Компани | Получение и применение орто-сульфонамидобициклических гетероарильных гидроксамовых кислот в качестве ингибиторов металлопротеиназ матрикса и тасе (tnf-альфа-превращающего фермента) |
| KR20020051859A (ko) * | 2000-12-22 | 2002-06-29 | 이향우 | 애피시딘 유도체, 이의 합성방법 및 이를 포함하는 항암제조성물 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2565076C2 (ru) * | 2010-05-27 | 2015-10-20 | Дзе Риджентс Оф Дзе Юниверсити Оф Колорадо, Э Боди Корпорейт | Макроциклические соединения, применимые в качестве ингибиторов гистондеацетилаз |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2005118108A (ru) | 2006-01-20 |
| BR0316163A (pt) | 2005-09-27 |
| ZA200503230B (en) | 2006-06-28 |
| JP2006508120A (ja) | 2006-03-09 |
| AU2003286686B2 (en) | 2009-07-16 |
| CN1711086A (zh) | 2005-12-21 |
| MXPA05004738A (es) | 2005-08-03 |
| KR20050074547A (ko) | 2005-07-18 |
| EP1562592A2 (en) | 2005-08-17 |
| EP1562592A4 (en) | 2009-01-21 |
| WO2004043348A3 (en) | 2004-07-15 |
| AU2003286686A1 (en) | 2004-06-03 |
| CA2504226A1 (en) | 2004-05-27 |
| US20040092431A1 (en) | 2004-05-13 |
| WO2004043348A2 (en) | 2004-05-27 |
| US20070088045A1 (en) | 2007-04-19 |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20111028 |