CA2500120A1 - Prpsc -interacting molecules and uses thereof - Google Patents
Prpsc -interacting molecules and uses thereof Download PDFInfo
- Publication number
- CA2500120A1 CA2500120A1 CA002500120A CA2500120A CA2500120A1 CA 2500120 A1 CA2500120 A1 CA 2500120A1 CA 002500120 A CA002500120 A CA 002500120A CA 2500120 A CA2500120 A CA 2500120A CA 2500120 A1 CA2500120 A1 CA 2500120A1
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- Prior art keywords
- peptide
- prp
- motif
- prps
- yyx
- Prior art date
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2469/00—Immunoassays for the detection of microorganisms
- G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2828—Prion diseases
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/256,538 US20040072236A1 (en) | 2002-09-27 | 2002-09-27 | PrPSc -interacting molecules and uses thereof |
| US10/256,538 | 2002-09-27 | ||
| PCT/US2003/030273 WO2004029072A2 (en) | 2002-09-27 | 2003-09-25 | PrPsc -INTERACTING MOLECULES AND USES THEREOF |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2500120A1 true CA2500120A1 (en) | 2004-04-08 |
Family
ID=32041771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002500120A Abandoned CA2500120A1 (en) | 2002-09-27 | 2003-09-26 | Prpsc -interacting molecules and uses thereof |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20040072236A1 (show.php) |
| EP (1) | EP1575989B1 (show.php) |
| JP (1) | JP4533750B2 (show.php) |
| AT (1) | ATE467124T1 (show.php) |
| CA (1) | CA2500120A1 (show.php) |
| DE (1) | DE60332488D1 (show.php) |
| WO (1) | WO2004029072A2 (show.php) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US7041807B1 (en) | 1999-06-23 | 2006-05-09 | Caprion Pharmaceuticals, Inc. | Antibodies to a YYX epitope of a mammalian prion protein |
| JP4235544B2 (ja) | 2001-05-31 | 2009-03-11 | アドライフ インコーポレーティッド | 欠陥折畳み蛋白質センサー方法 |
| US20050026165A1 (en) | 2001-05-31 | 2005-02-03 | Cindy Orser | Detection of conformationally altered proteins and prions |
| US20040072236A1 (en) | 2002-09-27 | 2004-04-15 | Neil Cashman | PrPSc -interacting molecules and uses thereof |
| EP1616036A4 (en) * | 2003-04-14 | 2007-03-21 | Pathogen Removal And Diagnosti | PROCESS FOR IDENTIFYING LIGANDS SPECIFIC TO STRUCTURAL FORMS OF PROTEINS |
| US7439041B2 (en) | 2003-08-13 | 2008-10-21 | Novartis Vaccines And Diagnostics, Inc. | Prion-specific peptide reagents |
| US20060035242A1 (en) * | 2004-08-13 | 2006-02-16 | Michelitsch Melissa D | Prion-specific peptide reagents |
| US20060057671A1 (en) * | 2004-09-10 | 2006-03-16 | Orser Cindy S | Immobilized probes and methods of detecting conformationally altered prion proteins |
| US7328063B2 (en) * | 2004-11-30 | 2008-02-05 | Cardiac Pacemakers, Inc. | Method and apparatus for arrhythmia classification using atrial signal mapping |
| WO2006076683A2 (en) * | 2005-01-13 | 2006-07-20 | Novartis Vaccines And Diagnostics Inc. | Isolation and detection of pathogenic prions |
| EP1848831A4 (en) * | 2005-01-13 | 2008-11-05 | Novartis Vaccines & Diagnostic | ELISA TESTS USING PRION-SPECIFIC PEPTIDE REAGENT |
| EP1853915B1 (en) * | 2005-02-15 | 2011-10-12 | Adlyfe, Inc. | Method for detecting misfolded proteins and prions |
| WO2007030804A1 (en) * | 2005-09-09 | 2007-03-15 | Novartis Ag | Prion-specific peptoid reagents |
| JP4769925B2 (ja) * | 2006-03-15 | 2011-09-07 | 国立大学法人東北大学 | 異常型プリオン蛋白質の濃縮方法、および除去方法 |
| BRPI0714930A2 (pt) * | 2006-07-28 | 2013-05-21 | Adlyfe Inc | sondas peptÍdicas para fins diagnàsticos e terapÊuticos |
| US7601506B2 (en) * | 2006-07-28 | 2009-10-13 | Idexx Laboratories, Inc. | Identification of leucocytes bearing diagnostic markers for transmissible spongiform encephalopathies |
| WO2008083972A2 (en) * | 2007-01-12 | 2008-07-17 | Alicon Ag | Method for removing prion protein |
| US9056918B2 (en) * | 2008-04-25 | 2015-06-16 | University Of Saskatchewan | Prion epitopes and methods of use thereof |
| BRPI0910550A2 (pt) * | 2008-04-30 | 2015-09-29 | Novartis Ag | ensaio para confôrmeros patogênicos |
| US20120009209A1 (en) * | 2010-06-10 | 2012-01-12 | The Regents Of The University Of California | Enrichment and purification of infectious prion proteins |
| WO2012037095A1 (en) * | 2010-09-13 | 2012-03-22 | Abbott Laboratories | A highly sensitive monoclonal antibody residual detection assay |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI90990C (fi) * | 1984-12-18 | 1994-04-25 | Boehringer Ingelheim Int | Rekombinantti-DNA-molekyyli, transformoitu isäntäorganismi ja menetelmä interferonin valmistamiseksi |
| EP0647849A3 (en) | 1986-04-30 | 1996-05-15 | Igen Inc | Detection of the presence of analytes in a sample. |
| SU1529119A1 (ru) | 1987-04-20 | 1989-12-15 | Белорусский научно-исследовательский институт эпидемиологии и микробиологии | Способ определени нейровирусов в спинномозговой жидкости |
| US4806627A (en) * | 1987-05-29 | 1989-02-21 | Research Foundation Of Mental Hygiene Inc. | Hybrid cell lines producing monoclonal antibodies dircted against scrapie-associated fibril proteins |
| AU9028791A (en) | 1990-10-05 | 1992-04-28 | President And Fellows Of Harvard College | Detection and isolation of ligands |
| EP0619841B1 (en) | 1990-10-30 | 1998-07-08 | La Jolla Cancer Research Foundation | T-cadherin adhesion molecule |
| US5773572A (en) * | 1991-12-03 | 1998-06-30 | Proteus Molecular Design Limited | Fragments of prion proteins |
| US5597725A (en) * | 1992-04-17 | 1997-01-28 | Doheny Eye Institute | Cadherin-specific antibodies and hybridoma cell lines |
| US5646250A (en) * | 1992-04-17 | 1997-07-08 | Doheny Eye Institute | Cadherin polypeptides |
| EP0604603A4 (en) * | 1992-04-17 | 1996-09-25 | Doheny Eye Inst | ELEMENTS AND METHODS FOR THE PRODUCTION OF CADHERINES. |
| WO1993023432A1 (en) | 1992-05-15 | 1993-11-25 | New York University | Soluble prion polypeptides, and methods for detecting and purifying thereof |
| US5276059A (en) | 1992-07-10 | 1994-01-04 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibition of diseases associated with amyloid formation |
| US5643781A (en) * | 1992-12-29 | 1997-07-01 | Doheny Eye Institute | DNA encoding protocadherin-42 |
| US5798224A (en) | 1992-12-29 | 1998-08-25 | Doheny Eye Institute | Nucleic acids encoding protocadherin |
| US5679530A (en) | 1995-04-12 | 1997-10-21 | Ludwig Institute For Cancer Research | Isolated protein having molecular weight of from about 55 kilodaltons to about 65 kilodaltons (SDS-page) which binds to prion protein |
| US5948763A (en) * | 1995-06-07 | 1999-09-07 | New York University | Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits |
| AU707484B2 (en) | 1995-09-14 | 1999-07-08 | Regents Of The University Of California, The | Antibodies specific for native PrPsc |
| US5750361A (en) * | 1995-11-02 | 1998-05-12 | The Regents Of The University Of California | Formation and use of prion protein (PRP) complexes |
| US6451541B1 (en) * | 1996-05-14 | 2002-09-17 | Ernst-Ludwig Winnacker | Chaperones capable of binding to prion proteins and distinguishing the isoforms PrPc and PrPsc |
| WO1997045746A2 (en) * | 1996-05-29 | 1997-12-04 | Mcgill University | Prion protein binding proteins and uses thereof |
| EP0861900A1 (en) | 1997-02-21 | 1998-09-02 | Erziehungsdirektion Of The Canton Zurich | Immunological detection of prions |
| US5891641A (en) * | 1997-02-21 | 1999-04-06 | The Regents Of The University Of California | Assay for disease related conformation of a protein |
| DE19741607A1 (de) | 1997-09-20 | 1999-03-25 | Prionics Ag | Synthetische Polypeptide zur Diagnose und Therapie von Prionerkrankungen |
| US6165784A (en) | 1997-10-14 | 2000-12-26 | The United States Of America As Represented By The Secretary Of Agriculture | Antibodies for the detection of prion protein as an indication of transmissible spongiform encephalopathies |
| DE1057022T1 (de) | 1998-02-20 | 2001-10-25 | The Regents Of The University Of California, Oakland | Assay für spezifische stämme von mit mehreren krankheiten zusammenhängenden proteinkonformationen |
| US6211149B1 (en) * | 1998-08-03 | 2001-04-03 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibitors of formation of protease resistant prion protein |
| GB2348203B (en) * | 1998-11-04 | 2002-06-19 | Imp College Innovations Ltd | Solube beta-forms of prion proteins, methods of preparation and use |
| JP2003521477A (ja) * | 1999-06-23 | 2003-07-15 | カプリオン ファーマシューティカルズ インコーポレーティッド | プリオン蛋白質ペプチドおよびその使用 |
| CA2376914A1 (en) * | 1999-06-29 | 2001-01-04 | Mcgill University | Prion protein binding proteins and uses thereof |
| EP1272509A2 (en) * | 2000-04-05 | 2003-01-08 | V.I. Technologies, Inc. | Prion-binding peptidic ligands and methods of using same |
| DE10230141B4 (de) * | 2002-07-04 | 2004-07-15 | Priontype Gmbh | Verfahren und Kit zur Anreicherung und zum Nachweis von veränderten Prion-Proteinen (PrPSc) |
| US20040072236A1 (en) | 2002-09-27 | 2004-04-15 | Neil Cashman | PrPSc -interacting molecules and uses thereof |
-
2002
- 2002-09-27 US US10/256,538 patent/US20040072236A1/en not_active Abandoned
-
2003
- 2003-09-25 WO PCT/US2003/030273 patent/WO2004029072A2/en not_active Ceased
- 2003-09-26 EP EP03754894A patent/EP1575989B1/en not_active Expired - Lifetime
- 2003-09-26 AT AT03754894T patent/ATE467124T1/de not_active IP Right Cessation
- 2003-09-26 JP JP2004539916A patent/JP4533750B2/ja not_active Expired - Fee Related
- 2003-09-26 DE DE60332488T patent/DE60332488D1/de not_active Expired - Lifetime
- 2003-09-26 CA CA002500120A patent/CA2500120A1/en not_active Abandoned
-
2006
- 2006-01-27 US US11/342,208 patent/US7435540B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7435540B2 (en) | 2008-10-14 |
| DE60332488D1 (de) | 2010-06-17 |
| WO2004029072A3 (en) | 2005-12-15 |
| JP4533750B2 (ja) | 2010-09-01 |
| JP2006507484A (ja) | 2006-03-02 |
| US20040072236A1 (en) | 2004-04-15 |
| WO2004029072A2 (en) | 2004-04-08 |
| EP1575989A2 (en) | 2005-09-21 |
| EP1575989A4 (en) | 2007-05-16 |
| EP1575989B1 (en) | 2010-05-05 |
| ATE467124T1 (de) | 2010-05-15 |
| AU2003272695A1 (en) | 2004-04-19 |
| US20060183156A1 (en) | 2006-08-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20130819 |