CA2499245A1 - Procede et dispositif permettant de trier des particules - Google Patents
Procede et dispositif permettant de trier des particules Download PDFInfo
- Publication number
- CA2499245A1 CA2499245A1 CA002499245A CA2499245A CA2499245A1 CA 2499245 A1 CA2499245 A1 CA 2499245A1 CA 002499245 A CA002499245 A CA 002499245A CA 2499245 A CA2499245 A CA 2499245A CA 2499245 A1 CA2499245 A1 CA 2499245A1
- Authority
- CA
- Canada
- Prior art keywords
- cells
- sorting
- particles
- particle
- predetermined characteristic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- BCHIXGBGRHLSBE-UHFFFAOYSA-N (4-methyl-2-oxochromen-7-yl) dihydrogen phosphate Chemical compound C1=C(OP(O)(O)=O)C=CC2=C1OC(=O)C=C2C BCHIXGBGRHLSBE-UHFFFAOYSA-N 0.000 description 2
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- LYIIBVSRGJSHAV-UHFFFAOYSA-N 2-aminoacetaldehyde Chemical compound NCC=O LYIIBVSRGJSHAV-UHFFFAOYSA-N 0.000 description 1
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- 208000035143 Bacterial infection Diseases 0.000 description 1
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 208000026350 Inborn Genetic disease Diseases 0.000 description 1
- 208000024556 Mendelian disease Diseases 0.000 description 1
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- 230000005017 genetic modification Effects 0.000 description 1
- 235000013617 genetically modified food Nutrition 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
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- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- PNDZEEPOYCVIIY-UHFFFAOYSA-N indo-1 Chemical compound CC1=CC=C(N(CC(O)=O)CC(O)=O)C(OCCOC=2C(=CC=C(C=2)C=2N=C3[CH]C(=CC=C3C=2)C(O)=O)N(CC(O)=O)CC(O)=O)=C1 PNDZEEPOYCVIIY-UHFFFAOYSA-N 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
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- 239000003446 ligand Substances 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- FNEZBBILNYNQGC-UHFFFAOYSA-N methyl 2-(3,6-diamino-9h-xanthen-9-yl)benzoate Chemical compound COC(=O)C1=CC=CC=C1C1C2=CC=C(N)C=C2OC2=CC(N)=CC=C21 FNEZBBILNYNQGC-UHFFFAOYSA-N 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000002831 pharmacologic agent Substances 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
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- 238000007423 screening assay Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
- G01N15/1456—Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Electro-optical investigation, e.g. flow cytometers without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03B—SEPARATING SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS
- B03B5/00—Washing granular, powdered or lumpy materials; Wet separating
- B03B5/02—Washing granular, powdered or lumpy materials; Wet separating using shaken, pulsated or stirred beds as the principal means of separation
- B03B5/10—Washing granular, powdered or lumpy materials; Wet separating using shaken, pulsated or stirred beds as the principal means of separation on jigs
- B03B5/22—Washing granular, powdered or lumpy materials; Wet separating using shaken, pulsated or stirred beds as the principal means of separation on jigs using pulses generated by liquid injection
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
- B07C—POSTAL SORTING; SORTING INDIVIDUAL ARTICLES, OR BULK MATERIAL FIT TO BE SORTED PIECE-MEAL, e.g. BY PICKING
- B07C5/00—Sorting according to a characteristic or feature of the articles or material being sorted, e.g. by control effected by devices which detect or measure such characteristic or feature; Sorting by manually actuated devices, e.g. switches
- B07C5/34—Sorting according to other particular properties
-
- G01N15/149—
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
- G01N2015/1477—Multiparameters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
- G01N2015/1497—Particle shape
Abstract
La présente invention concerne un procédé et un dispositif permettant de trier des particules circulant à travers un système de canaux en circuit fermé de dimension capillaire. Le dispositif décrit dans cette invention comprend une bulle "à fonction soupape" destinée à produire, de manière sélective, une impulsion de pression pour séparer une particule présentant une caractéristique prédéterminée d'un flux de particules. Ce système de tri de particules peut également comprendre un tampon destiné à absorber l'impulsion de pression. Ce système de tri de particules peut également comprendre une multitude de modules de tri raccordés de manière rapprochée et qui sont combinés de manière à augmenter la vitesse de tri. Ledit système peut également comprendre un dispositif de tri à plusieurs étages pour permettre le tri en série de flux de particules, afin de réduire le taux d'erreurs.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41114302P | 2002-09-16 | 2002-09-16 | |
| US41105802P | 2002-09-16 | 2002-09-16 | |
| US60/411,143 | 2002-09-16 | ||
| US60/411,058 | 2002-09-16 | ||
| US10/329,008 US6976590B2 (en) | 2002-06-24 | 2002-12-23 | Method and apparatus for sorting particles |
| US10/329,008 | 2002-12-23 | ||
| PCT/US2003/029198 WO2004025266A2 (fr) | 2002-09-16 | 2003-09-16 | Procede et dispositif permettant de trier des particules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2499245A1 true CA2499245A1 (fr) | 2004-03-25 |
Family
ID=31999089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002499245A Abandoned CA2499245A1 (fr) | 2002-09-16 | 2003-09-16 | Procede et dispositif permettant de trier des particules |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1581350A4 (fr) |
| JP (1) | JP2005538727A (fr) |
| KR (1) | KR100990016B1 (fr) |
| AU (1) | AU2003270722A1 (fr) |
| BR (1) | BR0314268A (fr) |
| CA (1) | CA2499245A1 (fr) |
| WO (1) | WO2004025266A2 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110959112A (zh) * | 2017-08-04 | 2020-04-03 | 赛博泰仪器有限公司 | 微流体颗粒分析装置 |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4047336B2 (ja) * | 2005-02-08 | 2008-02-13 | 独立行政法人科学技術振興機構 | ゲル電極付セルソーターチップ |
| JP4509166B2 (ja) * | 2007-11-02 | 2010-07-21 | ソニー株式会社 | 微小粒子の測定方法、及び測定装置 |
| KR100940099B1 (ko) * | 2008-04-02 | 2010-02-02 | 한국기계연구원 | 암세포와 정상세포를 구별하기 위한 세포구별장치 및 그세포구별방법 |
| JP4661942B2 (ja) | 2008-05-13 | 2011-03-30 | ソニー株式会社 | マイクロチップとその流路構造 |
| JP2010226978A (ja) * | 2009-03-26 | 2010-10-14 | Mitsui Eng & Shipbuild Co Ltd | セルソータ |
| EP2462442A4 (fr) | 2009-08-06 | 2016-08-03 | Univ Cornell | Dispositif et procédé d'analyse moléculaire |
| KR101252829B1 (ko) * | 2009-10-06 | 2013-04-11 | 한국전자통신연구원 | 단일세포 분주용 어레이 장치 |
| US9815060B2 (en) | 2010-11-18 | 2017-11-14 | The Regents Of The University Of California | Method and device for high-throughput solution exchange for cell and particle suspensions |
| EP2641094B1 (fr) | 2010-11-18 | 2019-03-06 | The Regents of The University of California | Procédé d'échange de solutions à débit de traitement élevé pour cellules et particules en suspension |
| JP5720233B2 (ja) | 2010-12-17 | 2015-05-20 | ソニー株式会社 | マイクロチップ及び微小粒子分取装置 |
| EP2602608B1 (fr) * | 2011-12-07 | 2016-09-14 | Imec | Analyse et tri des cellules biologiques dans un écoulement |
| JP6169111B2 (ja) | 2012-02-29 | 2017-07-26 | フリューダイム・コーポレイション | マイクロ流体工学を利用した複数の単一細胞の捕捉及び処理の方法、システム、並びにデバイス |
| WO2013177206A2 (fr) | 2012-05-21 | 2013-11-28 | Fluidigm Corporation | Analyse de particules uniques de populations de particules |
| WO2014013802A1 (fr) | 2012-07-18 | 2014-01-23 | ソニー株式会社 | Dispositif d'isolation de microparticules, micropuce pour isolation de microparticules, et procédé associé |
| JP6036496B2 (ja) | 2012-07-24 | 2016-11-30 | ソニー株式会社 | 微小粒子分取方法 |
| JP5910412B2 (ja) | 2012-08-16 | 2016-04-27 | ソニー株式会社 | 微小粒子分取方法及び微小粒子分取用マイクロチップ |
| SG10201707485YA (en) | 2013-03-15 | 2017-10-30 | Fluidigm Corp | Methods and devices for analysis of defined multicellular combinations |
| JP2016527494A (ja) | 2013-07-05 | 2016-09-08 | ユニバーシティ オブ ワシントン スルー イッツ センター フォー コマーシャライゼーション | マイクロ流体アッセイのための方法、組成物およびシステム |
| EP3180600B1 (fr) | 2014-08-14 | 2021-06-02 | The Trustees Of The University Of Pennsylvania | Appareil et procédés permettant d'analyser des gouttelettes en utilisant des dispositifs microfluidiques |
| CN107209198B (zh) * | 2015-04-30 | 2019-07-19 | 惠普发展公司，有限责任合伙企业 | 目标成分定位和排出 |
| EP3978903A1 (fr) * | 2016-05-17 | 2022-04-06 | Sony Group Corporation | Appareil d'extraction de particules et procédé d'extraction de particules |
| CN108251291A (zh) * | 2016-12-29 | 2018-07-06 | 上海新微技术研发中心有限公司 | 一种细胞筛选装置和细胞筛选方法 |
| WO2019040599A1 (fr) * | 2017-08-22 | 2019-02-28 | Elegen Corporation | Suivi et codage de position dans des dispositifs microfluidiques |
| JP2020041881A (ja) * | 2018-09-10 | 2020-03-19 | ソニー株式会社 | 制御装置、該制御装置を用いた微小粒子分取装置及び微小粒子分取システム、並びに制御方法、及び制御プログラム |
| WO2021257068A1 (fr) * | 2020-06-17 | 2021-12-23 | Hewlett-Packard Development Company, L.P. | Détermination d'une erreur dans le passage détecté d'une population de particules cibles |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3574617D1 (de) * | 1984-09-11 | 1990-01-11 | Partec Ag | Verfahren und vorrichtung zur sortierung von mikroskopischen partikeln. |
| JPS63259466A (ja) * | 1987-04-16 | 1988-10-26 | Hitachi Ltd | 細胞分析装置 |
| JPH01170853A (ja) * | 1987-12-25 | 1989-07-05 | Hitachi Ltd | 細胞選別装置 |
| CA1328861C (fr) * | 1988-09-30 | 1994-04-26 | Occam Marine Technologies Ltd. | Separateur de particules agissant par application d'une force centrifuge a faible vitesse |
| HU203288B (en) * | 1989-04-01 | 1991-07-29 | Mta Mueszaki Kemiai Kutato Int | Apparatus for carrying out biocatalytic processes by means of biocatalyzer of solid phase |
| US5204884A (en) * | 1991-03-18 | 1993-04-20 | University Of Rochester | System for high-speed measurement and sorting of particles |
| DE69628016T2 (de) * | 1995-06-16 | 2004-04-01 | University Of Washington, Seattle | Miniaturisierte differentielle extraktionsvorrichtung und verfahren |
| JP3226012B2 (ja) * | 1995-11-17 | 2001-11-05 | 矢崎総業株式会社 | 培養液中微小物分離装置 |
| EP0925494B1 (fr) * | 1996-09-04 | 2001-12-19 | Scandinavian Micro Biodevices A/S | Systeme a microdebit pour separation et analyse de particules |
| US6221654B1 (en) * | 1996-09-25 | 2001-04-24 | California Institute Of Technology | Method and apparatus for analysis and sorting of polynucleotides based on size |
| CA2286601A1 (fr) * | 1997-05-16 | 1998-11-26 | Alberta Research Council | Systeme microfluidique et ses utilisations |
| IT1295939B1 (it) * | 1997-10-31 | 1999-05-28 | Giammaria Sitar | Dispositivo e metodo per la separazione di cellule umane od animali aventi densita' diverse da dispersioni cellulari che le contengono |
| US6592821B1 (en) * | 1999-05-17 | 2003-07-15 | Caliper Technologies Corp. | Focusing of microparticles in microfluidic systems |
| AU2001290879A1 (en) * | 2000-09-15 | 2002-03-26 | California Institute Of Technology | Microfabricated crossflow devices and methods |
-
2003
- 2003-09-16 CA CA002499245A patent/CA2499245A1/fr not_active Abandoned
- 2003-09-16 BR BR0314268-0A patent/BR0314268A/pt not_active IP Right Cessation
- 2003-09-16 AU AU2003270722A patent/AU2003270722A1/en not_active Abandoned
- 2003-09-16 WO PCT/US2003/029198 patent/WO2004025266A2/fr active Search and Examination
- 2003-09-16 KR KR1020057004433A patent/KR100990016B1/ko active IP Right Grant
- 2003-09-16 EP EP03752432A patent/EP1581350A4/fr not_active Withdrawn
- 2003-09-16 JP JP2004536583A patent/JP2005538727A/ja active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110959112A (zh) * | 2017-08-04 | 2020-04-03 | 赛博泰仪器有限公司 | 微流体颗粒分析装置 |
| CN110959112B (zh) * | 2017-08-04 | 2023-05-02 | 赛博泰仪器有限公司 | 微流体颗粒分析装置 |
Also Published As
| Publication number | Publication date |
|---|---|
| BR0314268A (pt) | 2005-07-26 |
| WO2004025266A2 (fr) | 2004-03-25 |
| KR20050047540A (ko) | 2005-05-20 |
| KR100990016B1 (ko) | 2010-10-26 |
| EP1581350A4 (fr) | 2009-09-23 |
| AU2003270722A1 (en) | 2004-04-30 |
| EP1581350A2 (fr) | 2005-10-05 |
| WO2004025266A3 (fr) | 2005-08-04 |
| JP2005538727A (ja) | 2005-12-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |