CA2497572C - Akt inhibitors, pharmaceutical compositions, and uses thereof - Google Patents
Akt inhibitors, pharmaceutical compositions, and uses thereof Download PDFInfo
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- CA2497572C CA2497572C CA2497572A CA2497572A CA2497572C CA 2497572 C CA2497572 C CA 2497572C CA 2497572 A CA2497572 A CA 2497572A CA 2497572 A CA2497572 A CA 2497572A CA 2497572 C CA2497572 C CA 2497572C
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- compound
- pharmaceutically acceptable
- acceptable salt
- disease
- akt
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Classifications
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- C07C43/02—Ethers
- C07C43/18—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C43/196—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring containing hydroxy or O-metal groups
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- A—HUMAN NECESSITIES
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- A61P11/08—Bronchodilators
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
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Landscapes
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- Pain & Pain Management (AREA)
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- Reproductive Health (AREA)
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- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US40723902P | 2002-09-03 | 2002-09-03 | |
| US60/407,239 | 2002-09-03 | ||
| PCT/US2003/027607 WO2004022569A1 (en) | 2002-09-03 | 2003-09-03 | Akt inhibitors, pharmaceutical compositions, and uses thereof |
Publications (2)
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| CA2497572A1 CA2497572A1 (en) | 2004-03-18 |
| CA2497572C true CA2497572C (en) | 2013-05-14 |
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| CA2497572A Expired - Fee Related CA2497572C (en) | 2002-09-03 | 2003-09-03 | Akt inhibitors, pharmaceutical compositions, and uses thereof |
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| US (1) | US7378403B2 (enExample) |
| EP (1) | EP1537129B1 (enExample) |
| JP (1) | JP4641796B2 (enExample) |
| AU (1) | AU2003270087B2 (enExample) |
| CA (1) | CA2497572C (enExample) |
| WO (1) | WO2004022569A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101632669B (zh) * | 2000-08-04 | 2011-05-18 | Dmi生物科学公司 | 二酮基哌嗪和包含它们的组合物的使用方法 |
| AU2003279761B2 (en) * | 2002-10-02 | 2009-11-12 | Luoxis Diagnostics, Inc. | Diagnosis and monitoring of diseases |
| KR20150080004A (ko) | 2003-05-15 | 2015-07-08 | 앰피오 파마슈티컬스 인코퍼레이티드 | Ｔ-세포 매개성 질환의 치료 방법 |
| WO2008070823A2 (en) * | 2006-12-07 | 2008-06-12 | University Of South Florida | Substrate-mimetic akt inhibitor |
| US20100048913A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
| WO2009146320A1 (en) | 2008-05-27 | 2009-12-03 | Dmi Life Sciences, Inc. | Therapeutic methods and compounds |
| EP2393827B1 (en) | 2009-02-05 | 2015-10-07 | Tokai Pharmaceuticals, Inc. | Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens |
| JP2013537195A (ja) | 2010-09-07 | 2013-09-30 | ディエムアイ アクイジション コーポレイション | 疾患の治療 |
| AU2012323305B2 (en) | 2011-10-10 | 2017-07-27 | Ampio Pharmaceuticals, Inc. | Treatment of degenerative joint disease |
| BR112014007657A2 (pt) | 2011-10-10 | 2017-04-11 | Ampio Pharmaceuticals Inc | dispositivos médicos implantáveis com tolerância imune aperfeiçoada e métodos para produção e implantação |
| MX355446B (es) | 2011-10-28 | 2018-04-18 | Ampio Pharmaceuticals Inc | Tratamiento de rinitis. |
| SG11201507093WA (en) | 2013-03-14 | 2015-10-29 | Univ Maryland Baltimore Office Of Technology Transfer | Androgen receptor down-regulating agents and uses thereof |
| BR112015020469A2 (pt) | 2013-03-15 | 2020-01-28 | Ampio Pharmaceuticals Inc | Usos de da-dkp, composição e método para fornecimento de células-tronco a umindivíduo |
| SG11201600525XA (en) | 2013-08-12 | 2016-02-26 | Tokai Pharmaceuticals Inc | Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies |
| US10526660B2 (en) | 2013-09-12 | 2020-01-07 | Dana-Farber Cancer Institute, Inc. | Methods for evaluating and treating Waldenstrom's macroglobulinemia |
| CA2958080A1 (en) | 2014-08-18 | 2016-02-25 | Ampio Pharmaceuticals, Inc. | Treatment of joint conditions |
| HK1246669A1 (zh) | 2015-06-22 | 2018-09-14 | Ampio Pharmaceuticals, Inc. | 人血清白蛋白低分子量组分在疾病治疗中的应用 |
| WO2021118924A2 (en) | 2019-12-12 | 2021-06-17 | Ting Therapeutics Llc | Compositions and methods for the prevention and treatment of hearing loss |
| CN111704546A (zh) * | 2020-06-30 | 2020-09-25 | 海南师范大学 | 一种含氧环己烷衍生物及其制备方法与应用 |
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| US4585762A (en) * | 1982-07-30 | 1986-04-29 | Fujisawa Pharmaceutical Co., Ltd. | Phospholipid derivatives, processes for use thereof and pharmaceutical composition of the same |
| JPS59187786A (ja) * | 1983-04-11 | 1984-10-24 | Meito Sangyo Kk | 酵素法リン脂質二級アルコ−ル誘導体の製法 |
| EP0122151B1 (en) * | 1983-04-11 | 1989-02-15 | Meito Sangyo Kabushiki Kaisha | Production of primary or secondary alcohol derivatives of phospholipids by the enzymatic technique |
| US5227508A (en) | 1992-01-24 | 1993-07-13 | Mayo Foundation For Medical Education And Research | 3-deoxy-3-substituted analogs of phosphatidylinositol |
| AU4427199A (en) * | 1998-06-26 | 2000-01-17 | Georgetown University | Inhibitors of phosphatidyl (myo)-inositol cycle |
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Also Published As
| Publication number | Publication date |
|---|---|
| EP1537129B1 (en) | 2013-11-06 |
| WO2004022569A9 (en) | 2004-06-10 |
| JP2005537329A (ja) | 2005-12-08 |
| EP1537129A1 (en) | 2005-06-08 |
| AU2003270087A1 (en) | 2004-03-29 |
| AU2003270087B2 (en) | 2009-04-23 |
| WO2004022569A1 (en) | 2004-03-18 |
| US7378403B2 (en) | 2008-05-27 |
| US20050272708A1 (en) | 2005-12-08 |
| CA2497572A1 (en) | 2004-03-18 |
| JP4641796B2 (ja) | 2011-03-02 |
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| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20180904 |