CA2495487A1 - Combination of zd6474, an inhibitor of the vascular endothelial growth factor receptor, with radiotherapy in the treatment of cancer - Google Patents
Combination of zd6474, an inhibitor of the vascular endothelial growth factor receptor, with radiotherapy in the treatment of cancer Download PDFInfo
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- CA2495487A1 CA2495487A1 CA002495487A CA2495487A CA2495487A1 CA 2495487 A1 CA2495487 A1 CA 2495487A1 CA 002495487 A CA002495487 A CA 002495487A CA 2495487 A CA2495487 A CA 2495487A CA 2495487 A1 CA2495487 A1 CA 2495487A1
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- LRHBZJAIQBBNFI-UHFFFAOYSA-N ethyl 3-methoxy-4-[(1-methylpiperidin-4-yl)methoxy]benzoate Chemical compound COC1=CC(C(=O)OCC)=CC=C1OCC1CCN(C)CC1 LRHBZJAIQBBNFI-UHFFFAOYSA-N 0.000 description 1
- YKLVXLQPUAUIGF-UHFFFAOYSA-N ethyl 5-methoxy-4-[(1-methylpiperidin-4-yl)methoxy]-2-nitrobenzoate Chemical compound C1=C([N+]([O-])=O)C(C(=O)OCC)=CC(OC)=C1OCC1CCN(C)CC1 YKLVXLQPUAUIGF-UHFFFAOYSA-N 0.000 description 1
- FAMRKDQNMBBFBR-UHFFFAOYSA-N ethyl n-ethoxycarbonyliminocarbamate Chemical compound CCOC(=O)N=NC(=O)OCC FAMRKDQNMBBFBR-UHFFFAOYSA-N 0.000 description 1
- RUJPPJYDHHAEEK-UHFFFAOYSA-N ethyl piperidine-4-carboxylate Chemical compound CCOC(=O)C1CCNCC1 RUJPPJYDHHAEEK-UHFFFAOYSA-N 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
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- CAJIOLKERBQYCQ-UHFFFAOYSA-N n-(4-bromo-2-fluorophenyl)-6-methoxy-7-phenylmethoxyquinazolin-4-amine;hydrochloride Chemical compound Cl.N1=CN=C2C=C(OCC=3C=CC=CC=3)C(OC)=CC2=C1NC1=CC=C(Br)C=C1F CAJIOLKERBQYCQ-UHFFFAOYSA-N 0.000 description 1
- HTCPERSEGREUFC-UHFFFAOYSA-N n-desmethyl vandetanib Chemical compound N1=CN=C2C=C(OCC3CCNCC3)C(OC)=CC2=C1NC1=CC=C(Br)C=C1F HTCPERSEGREUFC-UHFFFAOYSA-N 0.000 description 1
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- 230000035790 physiological processes and functions Effects 0.000 description 1
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- 229920001184 polypeptide Polymers 0.000 description 1
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- 229950008882 polysorbate Drugs 0.000 description 1
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- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
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- 230000001737 promoting effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 150000003246 quinazolines Chemical class 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 108091008598 receptor tyrosine kinases Proteins 0.000 description 1
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- 230000011514 reflex Effects 0.000 description 1
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- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
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- 108091008601 sVEGFR Proteins 0.000 description 1
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- 229910052708 sodium Inorganic materials 0.000 description 1
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- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- CTEDVGRUGMPBHE-UHFFFAOYSA-N tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCC(CO)CC1 CTEDVGRUGMPBHE-UHFFFAOYSA-N 0.000 description 1
- DARTVAOOTJKHQW-UHFFFAOYSA-N tert-butyl 4-[(4-methylphenyl)sulfonyloxymethyl]piperidine-1-carboxylate Chemical compound C1=CC(C)=CC=C1S(=O)(=O)OCC1CCN(C(=O)OC(C)(C)C)CC1 DARTVAOOTJKHQW-UHFFFAOYSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
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- 231100000419 toxicity Toxicity 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- IMNIMPAHZVJRPE-UHFFFAOYSA-N triethylenediamine Chemical compound C1CN2CCN1CC2 IMNIMPAHZVJRPE-UHFFFAOYSA-N 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0218525A GB0218525D0 (en) | 2002-08-09 | 2002-08-09 | Combination therapy |
| GB0218525.4 | 2002-08-09 | ||
| GB0307560.3 | 2003-04-02 | ||
| GB0307560A GB0307560D0 (en) | 2003-04-02 | 2003-04-02 | Combination therapy |
| PCT/GB2003/003388 WO2004014383A1 (en) | 2002-08-09 | 2003-08-05 | Combination of zd6474, an inhibitor of the vascular endothelial growth factor receptor, with radiotherapy in the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2495487A1 true CA2495487A1 (en) | 2004-02-19 |
Family
ID=31716921
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002495487A Abandoned CA2495487A1 (en) | 2002-08-09 | 2003-08-05 | Combination of zd6474, an inhibitor of the vascular endothelial growth factor receptor, with radiotherapy in the treatment of cancer |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20050222183A1 (enExample) |
| EP (1) | EP1534287A1 (enExample) |
| JP (1) | JP2006502132A (enExample) |
| KR (1) | KR20050056190A (enExample) |
| CN (1) | CN1313094C (enExample) |
| AU (1) | AU2003249000B2 (enExample) |
| BR (1) | BR0313116A (enExample) |
| CA (1) | CA2495487A1 (enExample) |
| IL (1) | IL166522A0 (enExample) |
| MX (1) | MXPA05001458A (enExample) |
| NO (1) | NO20050450L (enExample) |
| NZ (1) | NZ537753A (enExample) |
| WO (1) | WO2004014383A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU769222B2 (en) | 1999-11-05 | 2004-01-22 | Genzyme Corporation | Quinazoline derivatives as VEGF inhibitors |
| GB0008269D0 (en) | 2000-04-05 | 2000-05-24 | Astrazeneca Ab | Combination chemotherapy |
| ES2267748T3 (es) * | 2000-04-07 | 2007-03-16 | Astrazeneca Ab | Compuestos de quinazolina. |
| GB0126879D0 (en) * | 2001-11-08 | 2002-01-02 | Astrazeneca Ab | Combination therapy |
| MXPA04007459A (es) * | 2002-02-01 | 2005-09-08 | Astrazeneca Ab | Compuestos de quinazolina. |
| GB0218526D0 (en) * | 2002-08-09 | 2002-09-18 | Astrazeneca Ab | Combination therapy |
| GB0223380D0 (en) * | 2002-10-09 | 2002-11-13 | Astrazeneca Ab | Combination therapy |
| EP1562955B1 (en) | 2002-11-04 | 2008-02-27 | Astrazeneca AB | Quinazoline derivatives as src tyrosine kinase inhibitors |
| PT1592423E (pt) * | 2003-02-13 | 2011-06-16 | Astrazeneca Ab | Terapia de combinação de zd6474 com 5-fu e/ou cpt-11 |
| GB0310401D0 (en) * | 2003-05-07 | 2003-06-11 | Astrazeneca Ab | Therapeutic agent |
| ATE478671T1 (de) * | 2003-07-10 | 2010-09-15 | Astrazeneca Ab | Verwendung des chinazolin-derivats zd6474 in kombination mit platinverbindungen und optional ionisierender strahlung bei der behandlung von erkrankungen im zusammenhang mit angiogenese und/oder erhöhter gefässpermeabilität |
| JP2008514577A (ja) * | 2004-09-27 | 2008-05-08 | アストラゼネカ アクチボラグ | Ｚｄ６４７４及びイマチニブを含んでなる組合せ |
| GB0424339D0 (en) * | 2004-11-03 | 2004-12-08 | Astrazeneca Ab | Combination therapy |
| GB0519879D0 (en) | 2005-09-30 | 2005-11-09 | Astrazeneca Ab | Chemical process |
| DK1971338T3 (da) * | 2005-12-22 | 2011-05-23 | Astrazeneca Ab | Kombination af ZD6474 og pemetrexed |
| JP4945133B2 (ja) * | 2006-01-19 | 2012-06-06 | 富士フイルムＲｉファーマ株式会社 | ４−フェノキシキナゾリン誘導体放射性化合物 |
| JP2010504949A (ja) * | 2006-09-29 | 2010-02-18 | アストラゼネカ アクチボラグ | Ｚｄ６４７４とベバシズマブの癌療法のための組合せ |
| US20080190689A1 (en) * | 2007-02-12 | 2008-08-14 | Ballard Ebbin C | Inserts for engine exhaust systems |
| WO2009118560A1 (en) * | 2008-03-28 | 2009-10-01 | Astrazeneca Ab | Combination therapy 038 |
| CN106317022A (zh) * | 2015-06-25 | 2017-01-11 | 中美华世通生物医药科技（武汉）有限公司 | 化合物的制备方法和用途 |
| CN106397401B (zh) * | 2016-08-30 | 2018-11-13 | 山东罗欣药业集团股份有限公司 | 一种抗癌药物的晶体化合物及其制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU769222B2 (en) * | 1999-11-05 | 2004-01-22 | Genzyme Corporation | Quinazoline derivatives as VEGF inhibitors |
-
2003
- 2003-08-05 KR KR1020057002082A patent/KR20050056190A/ko not_active Ceased
- 2003-08-05 CA CA002495487A patent/CA2495487A1/en not_active Abandoned
- 2003-08-05 EP EP03784247A patent/EP1534287A1/en not_active Withdrawn
- 2003-08-05 JP JP2004527017A patent/JP2006502132A/ja active Pending
- 2003-08-05 MX MXPA05001458A patent/MXPA05001458A/es unknown
- 2003-08-05 US US10/523,832 patent/US20050222183A1/en not_active Abandoned
- 2003-08-05 WO PCT/GB2003/003388 patent/WO2004014383A1/en not_active Ceased
- 2003-08-05 BR BR0313116-5A patent/BR0313116A/pt not_active IP Right Cessation
- 2003-08-05 AU AU2003249000A patent/AU2003249000B2/en not_active Ceased
- 2003-08-05 CN CNB038191016A patent/CN1313094C/zh not_active Expired - Fee Related
- 2003-08-05 NZ NZ537753A patent/NZ537753A/en unknown
-
2005
- 2005-01-26 IL IL16652205A patent/IL166522A0/xx unknown
- 2005-01-26 NO NO20050450A patent/NO20050450L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1674905A (zh) | 2005-09-28 |
| AU2003249000B2 (en) | 2007-04-05 |
| NO20050450L (no) | 2005-05-02 |
| NZ537753A (en) | 2008-04-30 |
| US20050222183A1 (en) | 2005-10-06 |
| JP2006502132A (ja) | 2006-01-19 |
| CN1313094C (zh) | 2007-05-02 |
| IL166522A0 (en) | 2006-01-15 |
| BR0313116A (pt) | 2005-07-05 |
| KR20050056190A (ko) | 2005-06-14 |
| WO2004014383A1 (en) | 2004-02-19 |
| EP1534287A1 (en) | 2005-06-01 |
| MXPA05001458A (es) | 2005-06-06 |
| AU2003249000A1 (en) | 2004-02-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |