CA2493375C - Biodegradable phase separated segmented multi block co-polymers - Google Patents

Biodegradable phase separated segmented multi block co-polymers Download PDF

Info

Publication number
CA2493375C
CA2493375C CA2493375A CA2493375A CA2493375C CA 2493375 C CA2493375 C CA 2493375C CA 2493375 A CA2493375 A CA 2493375A CA 2493375 A CA2493375 A CA 2493375A CA 2493375 C CA2493375 C CA 2493375C
Authority
CA
Canada
Prior art keywords
prepolymer
copolymer according
copolymer
chain
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2493375A
Other languages
English (en)
French (fr)
Other versions
CA2493375A1 (en
Inventor
Catharina Everdina Hissink
Ronald Meyboom
Theodorus Adrianus Cornelius Flipsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Innocore Technologies Holding BV
Original Assignee
Innocore Technologies BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innocore Technologies BV filed Critical Innocore Technologies BV
Publication of CA2493375A1 publication Critical patent/CA2493375A1/en
Application granted granted Critical
Publication of CA2493375C publication Critical patent/CA2493375C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
    • C08G18/4266—Polycondensates having carboxylic or carbonic ester groups in the main chain prepared from hydroxycarboxylic acids and/or lactones
    • C08G18/4269—Lactones
    • C08G18/4277—Caprolactone and/or substituted caprolactone
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
    • C08G18/4266—Polycondensates having carboxylic or carbonic ester groups in the main chain prepared from hydroxycarboxylic acids and/or lactones
    • C08G18/428—Lactides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/60—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from the reaction of a mixture of hydroxy carboxylic acids, polycarboxylic acids and polyhydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/64—Polyesters containing both carboxylic ester groups and carbonate groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2230/00—Compositions for preparing biodegradable polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Materials For Medical Uses (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Medicinal Preparation (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
CA2493375A 2002-07-16 2003-07-16 Biodegradable phase separated segmented multi block co-polymers Expired - Lifetime CA2493375C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02077878.3 2002-07-16
EP02077878A EP1382628A1 (en) 2002-07-16 2002-07-16 Biodegradable phase separated segmented/block co-polyesters
PCT/NL2003/000519 WO2004007588A1 (en) 2002-07-16 2003-07-16 Biodegradable phase separated segmented multi block co-polymers

Publications (2)

Publication Number Publication Date
CA2493375A1 CA2493375A1 (en) 2004-01-22
CA2493375C true CA2493375C (en) 2012-01-03

Family

ID=29762686

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2493375A Expired - Lifetime CA2493375C (en) 2002-07-16 2003-07-16 Biodegradable phase separated segmented multi block co-polymers

Country Status (10)

Country Link
US (1) US8674033B2 (cg-RX-API-DMAC10.html)
EP (2) EP1382628A1 (cg-RX-API-DMAC10.html)
JP (1) JP2005533148A (cg-RX-API-DMAC10.html)
CN (1) CN1675281B (cg-RX-API-DMAC10.html)
AT (1) ATE394439T1 (cg-RX-API-DMAC10.html)
AU (1) AU2003247231B2 (cg-RX-API-DMAC10.html)
CA (1) CA2493375C (cg-RX-API-DMAC10.html)
DE (1) DE60320819D1 (cg-RX-API-DMAC10.html)
ES (1) ES2305512T3 (cg-RX-API-DMAC10.html)
WO (1) WO2004007588A1 (cg-RX-API-DMAC10.html)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8685431B2 (en) * 2004-03-16 2014-04-01 Advanced Cardiovascular Systems, Inc. Biologically absorbable coatings for implantable devices based on copolymers having ester bonds and methods for fabricating the same
JP4621885B2 (ja) * 2004-05-07 2011-01-26 独立行政法人物質・材料研究機構 ポリリンゴ酸共重合体の製造方法
US8357391B2 (en) * 2004-07-30 2013-01-22 Advanced Cardiovascular Systems, Inc. Coatings for implantable devices comprising poly (hydroxy-alkanoates) and diacid linkages
US7655735B2 (en) 2004-08-02 2010-02-02 Samyang Corporation Biodegradable multi-block polymeric composition capable of sol-gel transition and pharmaceutical composition comprising the same
WO2006100844A1 (ja) * 2005-03-18 2006-09-28 Mitsui Chemicals, Inc. 生分解性を有する水環境応答型ポリマー、その製造方法および水崩壊性材料
DE102005033101A1 (de) * 2005-07-15 2007-01-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Resorbierbare Polyetherester und ihre Verwendung zur Herstellung von medizinischen Implantaten
US20070233219A1 (en) * 2006-02-16 2007-10-04 Bilal Shafi Polymeric heart restraint
US9028859B2 (en) * 2006-07-07 2015-05-12 Advanced Cardiovascular Systems, Inc. Phase-separated block copolymer coatings for implantable medical devices
EP3009477B1 (en) 2006-07-20 2024-01-24 Orbusneich Medical Pte. Ltd Bioabsorbable polymeric composition for a medical device
AU2007281035A1 (en) * 2006-08-02 2008-02-07 Polynovo Biomaterials Pty Ltd Biocompatible polymer compositions
GB0620685D0 (en) * 2006-10-18 2006-11-29 Controlled Therapeutics Sct Bioresorbable polymers
US7959942B2 (en) 2006-10-20 2011-06-14 Orbusneich Medical, Inc. Bioabsorbable medical device with coating
JP5593070B2 (ja) * 2006-10-20 2014-09-17 エリクシアー メディカル コーポレイション 管腔内人工装具および管腔内人工装具を被膜するための方法
CN101631513B (zh) 2006-10-20 2013-06-05 奥巴斯尼茨医学公司 可生物吸收的聚合物组合物和医疗设备
DE102006058755A1 (de) * 2006-12-08 2008-06-12 Gkss-Forschungszentrum Geesthacht Gmbh Verfahren zur Herstellung eines alternierenden Multiblockcopolymers mit Formgedächtnis
US8501290B2 (en) 2008-01-15 2013-08-06 Abbott Cardiovascular Systems Inc. Implantable medical devices fabricated from polyurethanes with biodegradable hard and soft blocks and blends thereof
WO2009097428A1 (en) 2008-01-29 2009-08-06 James Alexander Corporation Dispenser and process
US9259515B2 (en) 2008-04-10 2016-02-16 Abbott Cardiovascular Systems Inc. Implantable medical devices fabricated from polyurethanes with grafted radiopaque groups
US20090326642A1 (en) * 2008-06-25 2009-12-31 Yunbing Wang Implantable Medical Devices Fabricated From Radiopaque Polymers With High Fracture Toughness
WO2010101240A1 (ja) * 2009-03-06 2010-09-10 国立大学法人岡山大学 生分解性多孔質中空微粒子、その製造方法および用途
CN101531756B (zh) * 2009-04-16 2011-06-15 山东大学 一种水溶性聚乙二醇/聚乳酸多嵌段聚碳酸酯的制备方法
US9309347B2 (en) 2009-05-20 2016-04-12 Biomedical, Inc. Bioresorbable thermoset polyester/urethane elastomers
US8137396B2 (en) 2009-05-20 2012-03-20 480 Biomedical, Inc Medical implant
GB2475778B (en) * 2009-05-20 2013-03-13 Arsenal Medical Inc Medical implant
US8992601B2 (en) 2009-05-20 2015-03-31 480 Biomedical, Inc. Medical implants
US20110319987A1 (en) 2009-05-20 2011-12-29 Arsenal Medical Medical implant
MX338939B (es) * 2009-09-18 2016-05-06 Protherics Medicines Dev Ltd Polimeros de gelificación térmica reversa reconstituible.
US9155722B2 (en) * 2009-09-18 2015-10-13 Protherics Salt Lake City, Inc. Reconstitutable reverse thermal gelling polymers
WO2012005594A2 (en) * 2010-07-09 2012-01-12 Innocore Technologies B.V. Biodegradable phase separated segmented multi block co-polymers and release of biologically active polypeptides
WO2012133608A1 (ja) * 2011-03-30 2012-10-04 東レ株式会社 生分解性粒子、血管塞栓材料及び生分解性粒子の製造方法
JP6041802B2 (ja) 2011-06-03 2016-12-14 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
US20130005829A1 (en) * 2011-06-30 2013-01-03 Advanced Technologies And Regenerative Medicine, Llc. Segmented, epsilon-Caprolactone-Rich, Poly(epsilon-Caprolactone-co-p-Dioxanone) Copolymers for Medical Applications and Devices Therefrom
CA2842514C (en) * 2011-07-22 2018-12-18 Innocore Technologies B.V. Biodegradable, semi-crystalline, phase separated, thermoplastic multi-block copolymers for controlled release of biologically active compounds
JP2014528264A (ja) * 2011-09-30 2014-10-27 ソフラディム・プロダクション 軽重量メッシュの可逆性硬さ
JP5763565B2 (ja) 2012-02-02 2015-08-12 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
US20130236499A1 (en) * 2012-03-12 2013-09-12 Sasa Andjelic Segmented, Semicrystalline Poly(Lactide-co-epsilon-Caprolactone) Absorbable Copolymers
JP5812935B2 (ja) 2012-05-16 2015-11-17 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
JP6247216B2 (ja) 2012-09-10 2017-12-13 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
JP5620456B2 (ja) 2012-11-20 2014-11-05 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
JP6053482B2 (ja) 2012-11-30 2016-12-27 住友ゴム工業株式会社 注射器用ガスケットの製造方法
CN105722887B (zh) * 2012-12-06 2017-08-11 Lg化学株式会社 丙交酯共聚物以及包含该丙交酯共聚物的树脂组合物和膜
CN102977319B (zh) * 2012-12-17 2014-09-03 中国科学院长春应用化学研究所 可降解聚乳酸两嵌段共聚物、制备方法及其在改性聚乳酸中的应用
JP6105292B2 (ja) * 2013-01-07 2017-03-29 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
JP5816222B2 (ja) 2013-04-25 2015-11-18 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
CN103254411A (zh) * 2013-06-07 2013-08-21 北京理工大学 一种高分子量聚乳酸的直接缩聚扩链制备方法
JP5797239B2 (ja) 2013-06-11 2015-10-21 住友ゴム工業株式会社 立体形状物の表面改質方法及び注射器用ガスケット
CN105263995B (zh) 2013-06-20 2019-05-28 住友橡胶工业株式会社 表面改性方法和表面改性体
WO2015030550A1 (ko) * 2013-08-30 2015-03-05 주식회사 엘지화학 블록 공중합체
TWI535740B (zh) * 2013-08-30 2016-06-01 Ｌｇ化學股份有限公司 嵌段共聚物
JP5820489B2 (ja) 2014-01-06 2015-11-24 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
JP6338504B2 (ja) 2014-10-02 2018-06-06 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
EP3034534A1 (en) * 2014-12-17 2016-06-22 PURAC Biochem BV Substrates coated or bonded with a composition comprising a polyurethane
WO2016108242A1 (en) 2015-01-02 2016-07-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd Biodegradable polymer
JP6613692B2 (ja) 2015-08-03 2019-12-04 住友ゴム工業株式会社 表面改質方法及び表面改質弾性体
JP6551022B2 (ja) 2015-08-03 2019-07-31 住友ゴム工業株式会社 表面改質方法及び表面改質体
EP3576771B1 (en) * 2017-01-31 2022-03-09 Veru Inc. Compositions and methods for long term release of ganadotropin-releasing hormone (gnrh) antagonists
JP7142847B2 (ja) * 2017-05-29 2022-09-28 学校法人大阪医科薬科大学 半月板再生基材
JP7484167B2 (ja) * 2018-12-13 2024-05-16 東レ株式会社 医療用成形体、医療機器、神経再生誘導チューブ
CN109734869B (zh) * 2018-12-25 2021-05-11 广东工业大学 一种聚醚酯聚氨酯及其制备方法和应用
US20210017329A1 (en) * 2019-07-19 2021-01-21 Evonik Operations Gmbh Multi-block shape memory bioresorbable polymers
CA3156256A1 (en) 2019-10-01 2021-04-08 InnoCore Technologies Holding B.V. Biodegradable, phase separated, thermoplastic multi-block copolymer
CN111205445B (zh) * 2020-03-09 2021-07-16 成都颐合恒瑞医疗科技有限公司 一种双亲性嵌段共聚物、可吸收骨蜡及制法
WO2023023544A1 (en) * 2021-08-19 2023-02-23 Jabil Inc. Method of producing polycaprolactone powder by reprecipitation and subsequent use of same in additive manufacturing
JP7620957B2 (ja) * 2022-08-01 2025-01-24 Dic株式会社 ３－ヒドロキシ酪酸からなるコポリエステル及びその製造方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5066772A (en) * 1987-12-17 1991-11-19 Allied-Signal Inc. Medical devices fabricated totally or in part from copolymers of recurring units derived from cyclic carbonates and lactides
US5133739A (en) * 1990-02-06 1992-07-28 Ethicon, Inc. Segmented copolymers of ε-caprolactone and glycolide
DE4005415C2 (de) * 1990-02-21 1996-04-11 Boehringer Ingelheim Kg Verfahren zum Herstellen von Polyestern auf der Basis von Hydroxycarbonsäuren
NL9001984A (nl) * 1990-09-10 1992-04-01 Stamicarbon Werkwijze voor het produceren van een voorwerp van een copolymeer van lactide en epsilon-caprolacton voor medische toepassingen.
US5236444A (en) * 1992-10-27 1993-08-17 United States Surgical Corporation Absorbable polymers and surgical articles made therefrom
US5202413A (en) * 1993-02-16 1993-04-13 E. I. Du Pont De Nemours And Company Alternating (ABA)N polylactide block copolymers
KR960015447B1 (ko) * 1993-03-16 1996-11-14 주식회사 삼양사 의료용 생분해성 고분자
US6211249B1 (en) * 1997-07-11 2001-04-03 Life Medical Sciences, Inc. Polyester polyether block copolymers
WO1999042147A1 (en) 1998-02-23 1999-08-26 Massachusetts Institute Of Technology Biodegradable shape memory polymers
IL140049A0 (en) * 1998-06-05 2002-02-10 Polyganics Bv Biomedical polyurethane, its preparation and use
JP2003327814A (ja) * 2002-05-09 2003-11-19 Daicel Chem Ind Ltd 相溶性樹脂組成物

Also Published As

Publication number Publication date
ATE394439T1 (de) 2008-05-15
DE60320819D1 (de) 2008-06-19
ES2305512T3 (es) 2008-11-01
EP1551899A1 (en) 2005-07-13
JP2005533148A (ja) 2005-11-04
EP1551899B1 (en) 2008-05-07
US8674033B2 (en) 2014-03-18
CN1675281A (zh) 2005-09-28
WO2004007588A1 (en) 2004-01-22
CA2493375A1 (en) 2004-01-22
CN1675281B (zh) 2010-05-12
AU2003247231A1 (en) 2004-02-02
EP1382628A1 (en) 2004-01-21
AU2003247231B2 (en) 2008-07-31
US20070003592A1 (en) 2007-01-04

Similar Documents

Publication Publication Date Title
AU2003247231B2 (en) Biodegradable phase separated segmented multi block co-polymers
CA2804601C (en) Biodegradable phase separated segmented multi block co-polymers and release of biologically active polypeptides
CA2334110C (en) Biomedical polyurethane, its preparation and use
CA2294711C (en) Novel polymeric compositions
AU2007311654B2 (en) Bioresorbable polymers
US9433639B2 (en) Synthetic mechanical hemostatic composition, method of making and use thereof
Jamiolkowski et al. The Poly (a-Esters)

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20230717