CA2493373A1 - Urea-substituted and urethane-substituted acylureas, methods for the production thereof and their use as medicaments - Google Patents
Urea-substituted and urethane-substituted acylureas, methods for the production thereof and their use as medicaments Download PDFInfo
- Publication number
- CA2493373A1 CA2493373A1 CA002493373A CA2493373A CA2493373A1 CA 2493373 A1 CA2493373 A1 CA 2493373A1 CA 002493373 A CA002493373 A CA 002493373A CA 2493373 A CA2493373 A CA 2493373A CA 2493373 A1 CA2493373 A1 CA 2493373A1
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- CA
- Canada
- Prior art keywords
- alkyl
- alkenyl
- phenyl
- substituted
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 239000003814 drug Substances 0.000 title claims description 12
- 150000007945 N-acyl ureas Chemical class 0.000 title abstract description 4
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- 150000003839 salts Chemical class 0.000 claims abstract description 19
- 230000003178 anti-diabetic effect Effects 0.000 claims abstract description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 72
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 55
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 51
- 125000000217 alkyl group Chemical group 0.000 claims description 48
- 239000000556 agonist Substances 0.000 claims description 33
- 125000000623 heterocyclic group Chemical group 0.000 claims description 33
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- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 30
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims description 29
- 125000003342 alkenyl group Chemical group 0.000 claims description 27
- 239000000203 mixture Substances 0.000 claims description 27
- 125000003118 aryl group Chemical group 0.000 claims description 26
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 25
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 20
- 229910052760 oxygen Inorganic materials 0.000 claims description 20
- 229910052717 sulfur Inorganic materials 0.000 claims description 20
- 125000005842 heteroatom Chemical group 0.000 claims description 16
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 15
- 125000000304 alkynyl group Chemical group 0.000 claims description 14
- 125000004404 heteroalkyl group Chemical group 0.000 claims description 14
- 125000004076 pyridyl group Chemical group 0.000 claims description 14
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- DNDCVAGJPBKION-DOPDSADYSA-N bombesin Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC=1NC2=CC=CC=C2C=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1NC(=O)CC1)C(C)C)C1=CN=CN1 DNDCVAGJPBKION-DOPDSADYSA-N 0.000 claims description 2
- OZVBMTJYIDMWIL-AYFBDAFISA-N bromocriptine Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=C(Br)NC3=C1 OZVBMTJYIDMWIL-AYFBDAFISA-N 0.000 claims description 2
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- SLZIZIJTGAYEKK-CIJSCKBQSA-N molport-023-220-247 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CN)[C@@H](C)O)C1=CNC=N1 SLZIZIJTGAYEKK-CIJSCKBQSA-N 0.000 claims description 2
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Classifications
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
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- C07C275/48—Y being a hydrogen or a carbon atom
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-
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10231371 | 2002-07-11 | ||
| DE10231371.7 | 2002-07-11 | ||
| PCT/EP2003/006934 WO2004007437A1 (de) | 2002-07-11 | 2003-06-30 | Harnstoff- und urethan-substituierte acylharnstoffe, verfahren zu deren herstellung und deren verwendung als arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2493373A1 true CA2493373A1 (en) | 2004-01-22 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002493373A Abandoned CA2493373A1 (en) | 2002-07-11 | 2003-06-30 | Urea-substituted and urethane-substituted acylureas, methods for the production thereof and their use as medicaments |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1523471B1 (enExample) |
| JP (1) | JP4374428B2 (enExample) |
| AT (1) | ATE443041T1 (enExample) |
| AU (1) | AU2003281027A1 (enExample) |
| BR (1) | BR0312593A (enExample) |
| CA (1) | CA2493373A1 (enExample) |
| DE (1) | DE50311923D1 (enExample) |
| IL (1) | IL166057A0 (enExample) |
| MX (1) | MXPA05000055A (enExample) |
| TW (1) | TW200407282A (enExample) |
| WO (1) | WO2004007437A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10306502B4 (de) * | 2003-02-17 | 2005-03-17 | Aventis Pharma Deutschland Gmbh | Substituierte 3-(Benzoylureido)-thiophenderivate und sie enthaltende Arzneimittel |
| DE10309929B4 (de) * | 2003-03-07 | 2006-02-23 | Sanofi-Aventis Deutschland Gmbh | Substituierte Benzoylureidopyridyl-piperidin- und -pyrrolidin-carbonsäurederivate, Verfahren zu deren Herstellung und deren Verwendung |
| US7501440B2 (en) | 2003-03-07 | 2009-03-10 | Sanofi-Aventis Deutschland Gmbh | Substituted benzoylureidopyridylpiperidine-and-pyrrolidinecarboxylic acid derivatives, processes for preparing them and their use |
| FR2884516B1 (fr) * | 2005-04-15 | 2007-06-22 | Cerep Sa | Antagonistes npy, preparation et utilisations |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| DE102007012284A1 (de) | 2007-03-16 | 2008-09-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| GB0706932D0 (en) * | 2007-04-10 | 2007-05-16 | Univ London Pharmacy | Ureylene derivatives |
| DE102007035334A1 (de) | 2007-07-27 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| DE102007035333A1 (de) | 2007-07-27 | 2009-01-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel |
| DE102007042154A1 (de) | 2007-09-05 | 2009-03-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Arylsulfonylaminomethyphosphonsäure-Derivate, deren Herstellung und deren Verwendung als Arzneimittel |
| FR2930552B1 (fr) * | 2008-04-24 | 2012-10-12 | Centre Nat Rech Scient | N-acylthiourees et n-acylurees inhibiteurs de la voie de signalisation des proteines hedgehog |
| FR2980477B1 (fr) * | 2011-09-23 | 2013-10-18 | Centre Nat Rech Scient | Nouveaux composes modulateurs de la voie de signalisation des proteines hedgehog, leurs formes marquees, et applications |
| US9060515B2 (en) * | 2011-12-21 | 2015-06-23 | Biota Europe Ltd. | Heterocyclic urea compounds |
| US10759749B2 (en) | 2016-08-31 | 2020-09-01 | Jcr Pharmaceuticals Co., Ltd. | Therapeutic agent for diabetes |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0116729B1 (en) * | 1983-01-24 | 1988-10-12 | Duphar International Research B.V | Benzoylurea compounds and pesticidal compositions comprisingsame |
| EP0167197B1 (en) * | 1984-07-05 | 1989-01-18 | Duphar International Research B.V | Benzoylurea compounds, and insecticidal and acaricidal compositions comprising same |
| EP0221847A3 (de) * | 1985-10-29 | 1988-03-23 | Ciba-Geigy Ag | Salze von Benzoylharnstoffen |
| JPS6434953A (en) * | 1987-07-30 | 1989-02-06 | Agro Kanesho Co Ltd | Benzoylurea based compound and acaricide and insecticide containing said compound as active ingredient |
| US6297269B1 (en) * | 1995-06-06 | 2001-10-02 | Pfizer Inc. | Substituted n-(indole-2-carbonyl-) amides and derivatives as glycogen phosphorylase inhibitors |
| JP3902313B2 (ja) * | 1998-01-14 | 2007-04-04 | 日本曹達株式会社 | 発色性染料および記録材料を使用する発色方法 |
| AR028253A1 (es) * | 2000-03-16 | 2003-04-30 | Pfizer Prod Inc | Inhibidores de la glucogeno fosforilasa |
| WO2001087845A2 (en) * | 2000-05-15 | 2001-11-22 | Fujisawa Pharmaceutical Co., Ltd. | N-containing heterocyclic compounds and their use as 5-ht antagonists |
| NZ523034A (en) * | 2000-06-09 | 2004-07-30 | Aventis Pharma Gmbh | Acylphenyl urea derivatives, methods for the production thereof and use thereof as a medicament |
| GB0021831D0 (en) * | 2000-09-06 | 2000-10-18 | Astrazeneca Ab | Chemical compounds |
| PE20021091A1 (es) * | 2001-05-25 | 2003-02-04 | Aventis Pharma Gmbh | Derivados de fenilurea sustituidos con carbonamida y procedimiento para su preparacion |
-
2003
- 2003-06-30 EP EP03740386A patent/EP1523471B1/de not_active Expired - Lifetime
- 2003-06-30 CA CA002493373A patent/CA2493373A1/en not_active Abandoned
- 2003-06-30 DE DE50311923T patent/DE50311923D1/de not_active Expired - Lifetime
- 2003-06-30 WO PCT/EP2003/006934 patent/WO2004007437A1/de not_active Ceased
- 2003-06-30 JP JP2004520438A patent/JP4374428B2/ja not_active Expired - Fee Related
- 2003-06-30 BR BR0312593-9A patent/BR0312593A/pt not_active IP Right Cessation
- 2003-06-30 MX MXPA05000055A patent/MXPA05000055A/es unknown
- 2003-06-30 AT AT03740386T patent/ATE443041T1/de not_active IP Right Cessation
- 2003-06-30 AU AU2003281027A patent/AU2003281027A1/en not_active Abandoned
- 2003-07-09 TW TW092118659A patent/TW200407282A/zh unknown
-
2004
- 2004-12-23 IL IL16605704A patent/IL166057A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE443041T1 (de) | 2009-10-15 |
| DE50311923D1 (de) | 2009-10-29 |
| WO2004007437A9 (de) | 2007-08-16 |
| EP1523471A1 (de) | 2005-04-20 |
| IL166057A0 (en) | 2006-01-15 |
| MXPA05000055A (es) | 2005-04-08 |
| JP2005532402A (ja) | 2005-10-27 |
| AU2003281027A1 (en) | 2004-02-02 |
| EP1523471B1 (de) | 2009-09-16 |
| BR0312593A (pt) | 2005-04-12 |
| WO2004007437A1 (de) | 2004-01-22 |
| JP4374428B2 (ja) | 2009-12-02 |
| TW200407282A (en) | 2004-05-16 |
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Legal Events
| Date | Code | Title | Description |
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| FZDE | Discontinued |