CA2490724C - Method for the diagnosis and prognosis of malignant diseases - Google Patents

Method for the diagnosis and prognosis of malignant diseases Download PDF

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Publication number
CA2490724C
CA2490724C CA2490724A CA2490724A CA2490724C CA 2490724 C CA2490724 C CA 2490724C CA 2490724 A CA2490724 A CA 2490724A CA 2490724 A CA2490724 A CA 2490724A CA 2490724 C CA2490724 C CA 2490724C
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CA
Canada
Prior art keywords
nucleolin
cell
cells
plasma membrane
antibody
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Expired - Fee Related
Application number
CA2490724A
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English (en)
French (fr)
Other versions
CA2490724A1 (en
Inventor
Paula J. Bates
Donald M. Miller
John O. Trent
Xiaohua Xu
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University of Louisville Research Foundation ULRF
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University of Louisville Research Foundation ULRF
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Publication of CA2490724A1 publication Critical patent/CA2490724A1/en
Application granted granted Critical
Publication of CA2490724C publication Critical patent/CA2490724C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
CA2490724A 2002-04-08 2003-04-08 Method for the diagnosis and prognosis of malignant diseases Expired - Fee Related CA2490724C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/118,854 2002-04-08
US10/118,854 US7541150B2 (en) 2002-04-08 2002-04-08 Method for the diagnosis and prognosis of malignant diseases
PCT/US2003/010745 WO2003086174A2 (en) 2002-04-08 2003-04-08 A new method for the diagnosis and prognosis of malignant diseases

Publications (2)

Publication Number Publication Date
CA2490724A1 CA2490724A1 (en) 2003-10-23
CA2490724C true CA2490724C (en) 2010-12-21

Family

ID=28789881

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2490724A Expired - Fee Related CA2490724C (en) 2002-04-08 2003-04-08 Method for the diagnosis and prognosis of malignant diseases

Country Status (10)

Country Link
US (1) US7541150B2 (ja)
EP (1) EP1492440B8 (ja)
JP (3) JP4841109B2 (ja)
AT (1) ATE398138T1 (ja)
AU (1) AU2003234694B8 (ja)
CA (1) CA2490724C (ja)
DE (1) DE60321552D1 (ja)
DK (1) DK1492440T3 (ja)
ES (1) ES2307936T3 (ja)
WO (1) WO2003086174A2 (ja)

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RU2728964C2 (ru) 2016-02-19 2020-08-03 Сива Корпорейшн Способ и композиция для лечения рака, уничтожения метастатических раковых клеток и профилактики метастазов рака, используя антитела к конечным продуктам повышенного гликирования ( AGE)
WO2017181049A1 (en) * 2016-04-15 2017-10-19 Charlestonpharma, Llc Anti-nucleolin agents
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JP2020515634A (ja) * 2017-03-20 2020-05-28 キャンサー、セラピューティックス、ラボラトリーズ、インコーポレイテッドCancer Therapeutics Laboratories, Inc. 腫瘍壊死を標的とする組成物及び方法
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Also Published As

Publication number Publication date
US7541150B2 (en) 2009-06-02
EP1492440A4 (en) 2005-08-24
US20030194754A1 (en) 2003-10-16
WO2003086174A3 (en) 2004-09-23
JP2013100295A (ja) 2013-05-23
JP5712198B2 (ja) 2015-05-07
EP1492440B8 (en) 2008-07-16
DE60321552D1 (de) 2008-07-24
WO2003086174A2 (en) 2003-10-23
CA2490724A1 (en) 2003-10-23
JP2011246467A (ja) 2011-12-08
EP1492440B1 (en) 2008-06-11
JP2005526968A (ja) 2005-09-08
EP1492440A2 (en) 2005-01-05
DK1492440T3 (da) 2008-09-22
ATE398138T1 (de) 2008-07-15
AU2003234694A1 (en) 2003-10-27
ES2307936T3 (es) 2008-12-01
JP4841109B2 (ja) 2011-12-21
AU2003234694B2 (en) 2008-05-15
AU2003234694B8 (en) 2008-10-23

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