CA2490724C - Method for the diagnosis and prognosis of malignant diseases - Google Patents
Method for the diagnosis and prognosis of malignant diseases Download PDFInfo
- Publication number
- CA2490724C CA2490724C CA2490724A CA2490724A CA2490724C CA 2490724 C CA2490724 C CA 2490724C CA 2490724 A CA2490724 A CA 2490724A CA 2490724 A CA2490724 A CA 2490724A CA 2490724 C CA2490724 C CA 2490724C
- Authority
- CA
- Canada
- Prior art keywords
- nucleolin
- cell
- cells
- plasma membrane
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Hospice & Palliative Care (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/118,854 | 2002-04-08 | ||
US10/118,854 US7541150B2 (en) | 2002-04-08 | 2002-04-08 | Method for the diagnosis and prognosis of malignant diseases |
PCT/US2003/010745 WO2003086174A2 (en) | 2002-04-08 | 2003-04-08 | A new method for the diagnosis and prognosis of malignant diseases |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2490724A1 CA2490724A1 (en) | 2003-10-23 |
CA2490724C true CA2490724C (en) | 2010-12-21 |
Family
ID=28789881
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2490724A Expired - Fee Related CA2490724C (en) | 2002-04-08 | 2003-04-08 | Method for the diagnosis and prognosis of malignant diseases |
Country Status (10)
Country | Link |
---|---|
US (1) | US7541150B2 (ja) |
EP (1) | EP1492440B8 (ja) |
JP (3) | JP4841109B2 (ja) |
AT (1) | ATE398138T1 (ja) |
AU (1) | AU2003234694B8 (ja) |
CA (1) | CA2490724C (ja) |
DE (1) | DE60321552D1 (ja) |
DK (1) | DK1492440T3 (ja) |
ES (1) | ES2307936T3 (ja) |
WO (1) | WO2003086174A2 (ja) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110178161A1 (en) * | 1999-04-08 | 2011-07-21 | Antisoma Research Limited | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
US7960540B2 (en) * | 1999-04-08 | 2011-06-14 | Advanced Cancer Therapeutics, Llc | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
US8114850B2 (en) * | 1999-04-08 | 2012-02-14 | Advanced Cancer Therapeutics, Llc | Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin |
CA2370000A1 (en) * | 1999-04-08 | 2000-10-19 | Uab Research Foundation | Antiproliferative activity of g-righ oligonucleotides and method of using same to bind to nucleolin |
CA2476764A1 (en) * | 2002-02-19 | 2003-08-28 | Syntherica Corporation | Compositions and methods for surrogate antibody modulation of an immune response and transport |
US7544767B2 (en) * | 2002-04-05 | 2009-06-09 | Burnham Institute For Medical Research | HMGN2 peptides and related molecules that selectively home to tumor blood vessels and tumor cells |
US7541150B2 (en) | 2002-04-08 | 2009-06-02 | University Of Louisville Research Foundation, Inc | Method for the diagnosis and prognosis of malignant diseases |
US7357928B2 (en) | 2002-04-08 | 2008-04-15 | University Of Louisville Research Foundation, Inc. | Method for the diagnosis and prognosis of malignant diseases |
US20040132049A1 (en) * | 2002-06-26 | 2004-07-08 | Bates Paula J. | Method for the detection of apoptosis |
US7858323B2 (en) * | 2004-06-09 | 2010-12-28 | The Regents Of The University Of Michigan | Phage microarray profiling of the humoral response to disease |
CN1969189B (zh) * | 2004-06-14 | 2012-03-21 | 协和梅迪克斯株式会社 | 非特异性反应被抑制的可溶性白介素-2受体免疫学测定方法和试剂 |
US20060073534A1 (en) * | 2004-10-05 | 2006-04-06 | The University Of Georgia Research Foundation, Inc | Method for cleaving and deglycosylating antibodies to promote ligand binding |
CN102539734B (zh) * | 2005-05-12 | 2016-02-03 | 清华大学 | 核仁素辅助的癌症诊断与治疗方法 |
AU2008287426B2 (en) * | 2007-08-10 | 2014-06-26 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
US8680019B2 (en) * | 2007-08-10 | 2014-03-25 | Protelica, Inc. | Universal fibronectin Type III binding-domain libraries |
US8470966B2 (en) | 2007-08-10 | 2013-06-25 | Protelica, Inc. | Universal fibronectin type III binding-domain libraries |
US20090131351A1 (en) * | 2007-11-16 | 2009-05-21 | Antisoma Research Limited | Methods, compositions, and kits for modulating tumor cell proliferation |
US20090226914A1 (en) * | 2007-12-31 | 2009-09-10 | Bates Paula J | Methods and products to target, capture and characterize stem cells |
CN102770529B (zh) | 2009-11-17 | 2018-06-05 | Musc研究发展基金会 | 针对人核仁素的人单克隆抗体 |
CN101782573B (zh) * | 2010-01-11 | 2014-09-10 | 天津师范大学 | 检测重金属胁迫下核仁c23蛋白质定位的免疫荧光方法 |
EP3450979A3 (en) | 2010-03-17 | 2019-04-24 | The Regents of The University of Michigan | Using phage epitopes to profile the immune response |
WO2011120015A2 (en) * | 2010-03-26 | 2011-09-29 | Armune Biosciences, Inc. | Method and system of particle-coupled phage epitope |
ES2572915T3 (es) | 2011-06-02 | 2016-06-03 | The University Of Louisville Research Foundation, Inc. | Nanopartículas conjugadas a un agente antinucleolina |
US20130023479A1 (en) | 2011-07-22 | 2013-01-24 | Protgen Ltd. | Use of nucleolin as a biomarker for lymphangiogenesis in cancer prognosis and therapy |
US10857237B2 (en) | 2015-05-05 | 2020-12-08 | University Of Louisville Research Foundation, Inc. | Anti-nucleolin agent-conjugated nanoparticles as radio-sensitizers and MRI and/or X-ray contrast agents |
RU2728964C2 (ru) | 2016-02-19 | 2020-08-03 | Сива Корпорейшн | Способ и композиция для лечения рака, уничтожения метастатических раковых клеток и профилактики метастазов рака, используя антитела к конечным продуктам повышенного гликирования ( AGE) |
WO2017181049A1 (en) * | 2016-04-15 | 2017-10-19 | Charlestonpharma, Llc | Anti-nucleolin agents |
US20190192686A1 (en) | 2016-08-02 | 2019-06-27 | The University Of Louisville Research Foundation, | Targeted nanodroplet emulsions for treating cancer |
JP2020515634A (ja) * | 2017-03-20 | 2020-05-28 | キャンサー、セラピューティックス、ラボラトリーズ、インコーポレイテッドCancer Therapeutics Laboratories, Inc. | 腫瘍壊死を標的とする組成物及び方法 |
US20230181769A1 (en) | 2019-09-10 | 2023-06-15 | University Of Louisville Research Foundation, Inc. | Anti-nucleolin agent-peg-conjugated nanoparticles |
CN115135665A (zh) * | 2019-12-30 | 2022-09-30 | 俄亥俄州国家创新基金会 | 包含细胞穿透肽的环状蛋白 |
US20210299156A1 (en) | 2020-03-28 | 2021-09-30 | Qualigen Inc. | Methods of inhibiting or treating coronavirus infection, and methods for delivering an anti-nucleolin agent |
Family Cites Families (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4522811A (en) * | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
US4474892A (en) * | 1983-02-16 | 1984-10-02 | Board Of Trustees Of The Leland Stanford Junior University | Two-site immunoassays using monoclonal antibodies of different classes or subclasses and test kits for performing same |
US5169774A (en) * | 1984-02-08 | 1992-12-08 | Cetus Oncology Corporation | Monoclonal anti-human breast cancer antibodies |
US4665897A (en) * | 1984-05-25 | 1987-05-19 | Lemelson Jerome H | Composition and method for detecting and treating cancer |
US4987071A (en) * | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
US5223427A (en) * | 1987-03-31 | 1993-06-29 | The Scripps Research Institute | Hybridomas producing monoclonal antibodies reactive with human tissue-factor glycoprotein heavy chain |
GB8823869D0 (en) * | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US5192660A (en) * | 1989-04-24 | 1993-03-09 | The United States Of America As Represented By The Department Of Health And Human Services | ELISA methods for the determination of human platelet derived growth factor (PDGF) dimer forms present in human tissues and fluids |
AU635008B2 (en) * | 1989-12-13 | 1993-03-11 | Genelabs Diagnostics Pte Ltd | Analytical apparatus and method for automated blot assay |
US5770429A (en) * | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5736348A (en) * | 1990-11-28 | 1998-04-07 | Fundacao Oswaldo Cruz (Fiocruz) | Method for the immunological diagnosis of Chagas' Disease using recombinant antigens |
JPH05244988A (ja) * | 1992-03-04 | 1993-09-24 | Green Cross Corp:The | 抗組織因子モノクローナル抗体、及びこれによる免疫抑制剤 |
ES2247204T3 (es) | 1994-01-31 | 2006-03-01 | Trustees Of Boston University | Bancos de anticuerpos policlonales. |
JPH07242566A (ja) | 1994-03-01 | 1995-09-19 | Kirin Brewery Co Ltd | 免疫抑制剤 |
US6096532A (en) * | 1995-06-07 | 2000-08-01 | Aastrom Biosciences, Inc. | Processor apparatus for use in a system for maintaining and growing biological cells |
US5567660A (en) * | 1995-09-13 | 1996-10-22 | Taiwan Semiconductor Manufacturing Company Ltd | Spin-on-glass planarization by a new stagnant coating method |
CA2240494C (en) | 1995-12-15 | 2007-03-13 | Lloyd G. Mitchell | Therapeutic molecules generated by trans-splicing |
US6048703A (en) * | 1996-11-15 | 2000-04-11 | Cephalon, Inc. | Methods for detecting cell apoptosis |
KR20080059467A (ko) | 1996-12-03 | 2008-06-27 | 아브게닉스, 인크. | 복수의 vh 및 vk 부위를 함유하는 사람 면역글로불린유전자좌를 갖는 형질전환된 포유류 및 이로부터 생성된항체 |
CA2284084A1 (en) | 1997-03-12 | 1998-09-17 | Institut Pasteur | A novel cell surface receptor for hiv retroviruses, therapeutic and diagnostic uses |
JP2001523977A (ja) * | 1997-06-05 | 2001-11-27 | ザ ユニバーシティ オブ テキサス システム ボード オブ リージェンツ | Apaf−1、ced−4ヒト相同体、カスパーゼ−3の活性化因子 |
CA2293632C (en) * | 1997-06-12 | 2011-11-29 | Research Corporation Technologies, Inc. | Artificial antibody polypeptides |
US6339075B1 (en) * | 1997-06-30 | 2002-01-15 | The University Of British Columbia | Use of dextran and other polysaccharides to improve mucus clearance |
AU6053898A (en) | 1997-08-04 | 1999-02-22 | Burnham Institute, The | A cell-free system of mitochondria-dependent apoptosis, and methods of use ther eof |
US6325785B1 (en) * | 1997-08-14 | 2001-12-04 | Sherwood Services Ag | Sputum trap manifold with nested caps |
US5925334A (en) * | 1997-08-27 | 1999-07-20 | Rubin; Bruce K. | Use of surface active agents to promote mucus clearance |
US5932475A (en) * | 1997-12-12 | 1999-08-03 | Incyte Pharmaceuticals, Inc. | Human nucleolin-like protein |
US6506559B1 (en) * | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
US6306404B1 (en) * | 1998-07-14 | 2001-10-23 | American Cyanamid Company | Adjuvant and vaccine compositions containing monophosphoryl lipid A |
AU6162999A (en) * | 1998-09-24 | 2000-04-10 | Promega Corporation | Apoptosis marker antibodies and methods of use |
CA2370000A1 (en) * | 1999-04-08 | 2000-10-19 | Uab Research Foundation | Antiproliferative activity of g-righ oligonucleotides and method of using same to bind to nucleolin |
WO2000063250A1 (en) | 1999-04-15 | 2000-10-26 | Merck Frosst Canada & Co. | Antibodies that recognize app cleaved by caspases and methods of use |
US6165786A (en) | 1999-11-03 | 2000-12-26 | Isis Pharmaceuticals, Inc. | Antisense modulation of nucleolin expression |
EP1229328B1 (en) | 1999-11-08 | 2007-06-20 | Eisai Co., Ltd. | Method of detecting cell death using cytochrome C. |
JP2001213804A (ja) * | 2000-01-31 | 2001-08-07 | Chugai Pharmaceut Co Ltd | 抗組織因子抗体の複合体 |
AU2001245793A1 (en) | 2000-03-16 | 2001-09-24 | Cold Spring Harbor Laboratory | Methods and compositions for rna interference |
DK1309726T4 (en) | 2000-03-30 | 2019-01-28 | Whitehead Inst Biomedical Res | RNA Sequence-Specific Mediators of RNA Interference |
JP2004505894A (ja) | 2000-06-02 | 2004-02-26 | ユニバーシティー オブ コネティカット ヘルス センター | 免疫療法のためのα(2)マクログロブリンと抗原分子との複合体 |
US20020028488A1 (en) * | 2000-06-19 | 2002-03-07 | Sujay Singh | Transgenic avian species for making human and chimeric antibodies |
DE10037861A1 (de) | 2000-08-01 | 2002-02-14 | Max Delbrueck Centrum | Mittel zur Therapie maligner Erkrankungen |
AU2001284703B2 (en) | 2000-08-03 | 2007-03-22 | Therapeutic Human Polyclonals Inc. | Production of humanized antibodies in transgenic animals |
DE10059821A1 (de) | 2000-12-01 | 2002-06-13 | Clariant Gmbh | Tensidfreie kosmetische, dermatologische und pharmazeutische Mittel |
JP3676991B2 (ja) | 2001-07-05 | 2005-07-27 | 松下電器産業株式会社 | 無線通信装置及び無線通信方法 |
US20050130117A1 (en) | 2001-10-03 | 2005-06-16 | Davis Cong L. | Modulators of lymphocyte activation and migration |
WO2003087124A2 (en) | 2002-04-05 | 2003-10-23 | The Burnham Institute | Hmgn2 peptides and related melecules that selectively home to tumor blood vessels and tumor cells |
US7541150B2 (en) | 2002-04-08 | 2009-06-02 | University Of Louisville Research Foundation, Inc | Method for the diagnosis and prognosis of malignant diseases |
US7357928B2 (en) | 2002-04-08 | 2008-04-15 | University Of Louisville Research Foundation, Inc. | Method for the diagnosis and prognosis of malignant diseases |
US20040132049A1 (en) | 2002-06-26 | 2004-07-08 | Bates Paula J. | Method for the detection of apoptosis |
-
2002
- 2002-04-08 US US10/118,854 patent/US7541150B2/en not_active Expired - Fee Related
-
2003
- 2003-04-08 JP JP2003583205A patent/JP4841109B2/ja not_active Expired - Fee Related
- 2003-04-08 ES ES03728350T patent/ES2307936T3/es not_active Expired - Lifetime
- 2003-04-08 AU AU2003234694A patent/AU2003234694B8/en not_active Ceased
- 2003-04-08 DK DK03728350T patent/DK1492440T3/da active
- 2003-04-08 WO PCT/US2003/010745 patent/WO2003086174A2/en active Application Filing
- 2003-04-08 CA CA2490724A patent/CA2490724C/en not_active Expired - Fee Related
- 2003-04-08 EP EP03728350A patent/EP1492440B8/en not_active Expired - Lifetime
- 2003-04-08 DE DE60321552T patent/DE60321552D1/de not_active Expired - Lifetime
- 2003-04-08 AT AT03728350T patent/ATE398138T1/de not_active IP Right Cessation
-
2011
- 2011-06-07 JP JP2011127396A patent/JP2011246467A/ja active Pending
-
2012
- 2012-12-06 JP JP2012266961A patent/JP5712198B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US7541150B2 (en) | 2009-06-02 |
EP1492440A4 (en) | 2005-08-24 |
US20030194754A1 (en) | 2003-10-16 |
WO2003086174A3 (en) | 2004-09-23 |
JP2013100295A (ja) | 2013-05-23 |
JP5712198B2 (ja) | 2015-05-07 |
EP1492440B8 (en) | 2008-07-16 |
DE60321552D1 (de) | 2008-07-24 |
WO2003086174A2 (en) | 2003-10-23 |
CA2490724A1 (en) | 2003-10-23 |
JP2011246467A (ja) | 2011-12-08 |
EP1492440B1 (en) | 2008-06-11 |
JP2005526968A (ja) | 2005-09-08 |
EP1492440A2 (en) | 2005-01-05 |
DK1492440T3 (da) | 2008-09-22 |
ATE398138T1 (de) | 2008-07-15 |
AU2003234694A1 (en) | 2003-10-27 |
ES2307936T3 (es) | 2008-12-01 |
JP4841109B2 (ja) | 2011-12-21 |
AU2003234694B2 (en) | 2008-05-15 |
AU2003234694B8 (en) | 2008-10-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2490724C (en) | Method for the diagnosis and prognosis of malignant diseases | |
AU2004279837B2 (en) | A method for the treatment of malignant diseases by inhibiting nucleolin | |
US20110065121A1 (en) | Method for the detection of apoptosis | |
CN106415269B (zh) | 直接免疫组织化学测定 | |
JP4868152B2 (ja) | 癌細胞の悪性度判定法 | |
US20120129168A1 (en) | Tumor marker and use thereof | |
KR20230140746A (ko) | 암전이의 검출용 신규 바이오마커 | |
JP2014534432A (ja) | 乳癌用の予測バイオマーカ | |
PRECISION | DEPENDENCE OF DNA-ANEUPLOIDY DETECTION IN GRADE I UROTHELIAL CARCINOMAS FROM PRECISION OF MEASUREMENTS AND ALGORITHMS OF INTERPRETATION | |
Pereira et al. | Diffuse immunoexpression of RET oncoprotien represents a supplementary evidence for the differential diagnosis of papillary carcinoma of the thyroid | |
JP2012240942A (ja) | 抗atbf1抗体及びその用途 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20200831 |
|
MKLA | Lapsed |
Effective date: 20200831 |