CA2488006A1 - A human cell assay to determine effect of sample compounds on col2 enhancer expression - Google Patents

A human cell assay to determine effect of sample compounds on col2 enhancer expression Download PDF

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Publication number
CA2488006A1
CA2488006A1 CA002488006A CA2488006A CA2488006A1 CA 2488006 A1 CA2488006 A1 CA 2488006A1 CA 002488006 A CA002488006 A CA 002488006A CA 2488006 A CA2488006 A CA 2488006A CA 2488006 A1 CA2488006 A1 CA 2488006A1
Authority
CA
Canada
Prior art keywords
sox9
expression
test compound
activity
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002488006A
Other languages
English (en)
French (fr)
Inventor
Leonard Buckbinder
Jean Frances Schaefer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2488006A1 publication Critical patent/CA2488006A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA002488006A 2002-06-04 2003-05-26 A human cell assay to determine effect of sample compounds on col2 enhancer expression Abandoned CA2488006A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38615602P 2002-06-04 2002-06-04
US60/386,156 2002-06-04
PCT/IB2003/002256 WO2003102130A2 (en) 2002-06-04 2003-05-26 A human cell assay to determine effect of sample compounds on col2 enhancer expression

Publications (1)

Publication Number Publication Date
CA2488006A1 true CA2488006A1 (en) 2003-12-11

Family

ID=29712234

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002488006A Abandoned CA2488006A1 (en) 2002-06-04 2003-05-26 A human cell assay to determine effect of sample compounds on col2 enhancer expression

Country Status (7)

Country Link
EP (1) EP1576098A2 (ja)
JP (1) JP2006500915A (ja)
AU (1) AU2003233009A1 (ja)
BR (1) BR0311594A (ja)
CA (1) CA2488006A1 (ja)
MX (1) MXPA04012042A (ja)
WO (1) WO2003102130A2 (ja)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008049226A1 (en) * 2006-10-27 2008-05-02 The University Of Western Ontario Inhibition of sox9 function fn the treatment of proteogl ycan-associated pathophysiological conditions
KR102084227B1 (ko) * 2018-09-05 2020-03-03 (주)루젠에스씨아이 인간 형질전환 연골세포주 기반 연골질환 치료제 스크리닝 시스템

Also Published As

Publication number Publication date
MXPA04012042A (es) 2005-03-07
AU2003233009A8 (en) 2003-12-19
BR0311594A (pt) 2007-04-27
WO2003102130A3 (en) 2006-06-22
AU2003233009A1 (en) 2003-12-19
EP1576098A2 (en) 2005-09-21
JP2006500915A (ja) 2006-01-12
WO2003102130A2 (en) 2003-12-11

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued