CA2485847C - Glucan-based vaccines - Google Patents
Glucan-based vaccines Download PDFInfo
- Publication number
- CA2485847C CA2485847C CA2485847A CA2485847A CA2485847C CA 2485847 C CA2485847 C CA 2485847C CA 2485847 A CA2485847 A CA 2485847A CA 2485847 A CA2485847 A CA 2485847A CA 2485847 C CA2485847 C CA 2485847C
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- glucan
- beta
- fungal
- antigen
- antibodies
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Landscapes
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| US7507724B2 (en) * | 2001-01-16 | 2009-03-24 | Sloan-Kettering Institute For Cancer Research | Therapy-enhancing glucan |
| US7906492B2 (en) | 2001-01-16 | 2011-03-15 | Sloan-Kettering Institute For Cancer Research | Therapy-enhancing glucan |
| US8071552B2 (en) * | 2004-04-05 | 2011-12-06 | Universite Bordeaux 2 | Peptides and peptidomimetics binding to CD23 |
| GB0420466D0 (en) * | 2004-09-14 | 2004-10-20 | Cassone Antonio | Anti-glucan antibodies |
| PL2878307T3 (pl) | 2005-06-27 | 2020-01-31 | Glaxosmithkline Biologicals S.A. | Kompozycja immunogenna |
| WO2007084661A2 (en) * | 2006-01-17 | 2007-07-26 | Sloan-Kettering Institute For Cancer Research | Therapy-enhancing glucan |
| US8323644B2 (en) * | 2006-01-17 | 2012-12-04 | Sloan-Kettering Institute For Cancer Research | Therapy-enhancing glucan |
| US20090053221A1 (en) * | 2006-01-17 | 2009-02-26 | Cheung Nai-Kong V | Immune response enhancing glucan |
| WO2007127668A2 (en) * | 2006-04-26 | 2007-11-08 | Wyeth | Novel processes for coating container means which inhibit precipitation of polysaccharide-protein conjugate formulations |
| WO2009134891A2 (en) * | 2008-04-29 | 2009-11-05 | Immunexcite, Inc. | Immunomodulating compositions and methods of use thereof |
| US9457047B2 (en) | 2006-11-06 | 2016-10-04 | Whitehead Institute | Immunomodulating compositions and methods of use thereof |
| ES2397186T3 (es) * | 2006-11-06 | 2013-03-05 | Whitehead Institute | Composiciones inmunomoduladoras y métodos para su uso |
| AU2013203785B2 (en) * | 2006-11-06 | 2016-11-17 | Immunexcite, Inc. | Immunomodulating compositions and methods of use thereof |
| JP4687644B2 (ja) | 2006-12-22 | 2011-05-25 | 富士ゼロックス株式会社 | 画像処理装置、画像読取装置及び画像形成装置 |
| US9439954B2 (en) | 2007-11-26 | 2016-09-13 | Glaxosmithkline Biologicals Sa | Conjugated beta-1,3-linked glucans |
| CA2706617A1 (en) † | 2007-11-26 | 2009-06-25 | Novartis Ag | Adjuvanted glucans |
| US20110236489A1 (en) | 2008-09-18 | 2011-09-29 | Novartis Ag | Vaccine adjuvant combinations |
| NL1036661C2 (en) | 2009-03-04 | 2010-09-07 | Serrix B V | Anti-fungal compounds & compositions. |
| JP2012520289A (ja) * | 2009-03-10 | 2012-09-06 | パルメッド テバ リミテッド | 新規なコプリヌス・コマトゥスおよびトレメッラ・メセンテリカキノコ菌株、それらの生産物および抽出物、ならびにそれらを含む組成物 |
| CN102740882A (zh) | 2009-08-27 | 2012-10-17 | 诺华有限公司 | 含有铝、寡核苷酸和聚阳离子的佐剂 |
| ES2443952T3 (es) | 2009-09-02 | 2014-02-21 | Novartis Ag | Composiciones inmunógenas que incluyen moduladores de la actividad de TLR |
| WO2011035205A2 (en) | 2009-09-18 | 2011-03-24 | Calmune Corporation | Antibodies against candida, collections thereof and methods of use |
| EA201291091A1 (ru) * | 2010-05-14 | 2013-05-30 | Олтек, Инк. | Компоненты клеточной стенки дрожжей и их обнаружение |
| CN105999275A (zh) | 2010-09-01 | 2016-10-12 | 诺华有限公司 | 免疫增强剂吸附不溶性金属离子 |
| US9618508B2 (en) | 2010-12-14 | 2017-04-11 | Glaxosmithkline Biologicals Sa | Flow cytometry analysis of materials adsorbed to metal salts |
| US20140112950A1 (en) | 2011-03-02 | 2014-04-24 | Manmohan Singh | Combination vaccines with lower doses of antigen and/or adjuvant |
| US9149541B2 (en) | 2011-07-08 | 2015-10-06 | Novartis Ag | Tyrosine ligation process |
| JP6170932B2 (ja) | 2011-11-07 | 2017-07-26 | ノバルティス アーゲー | spr0096抗原およびspr2021抗原を含むキャリア分子 |
| HRP20161354T1 (hr) | 2012-03-07 | 2016-12-02 | Glaxosmithkline Biologicals Sa | Argininske soli agonista tlr7 |
| JP2015510872A (ja) | 2012-03-07 | 2015-04-13 | ノバルティス アーゲー | Streptococcuspneumoniae抗原の増強された製剤 |
| US9375471B2 (en) | 2012-03-08 | 2016-06-28 | Glaxosmithkline Biologicals Sa | Adjuvanted formulations of booster vaccines |
| US10092646B2 (en) * | 2012-04-30 | 2018-10-09 | Biothera, Inc. | Compositions and methods for beta-glucan immunotherapy |
| TR201807340T4 (tr) | 2013-02-01 | 2018-06-21 | Glaxosmithkline Biologicals Sa | Çan benzeri reseptör agonistleri içeren immünolojik kompozisyonların intradermal yoldan verilmesi. |
| CN103083663B (zh) * | 2013-02-04 | 2014-12-10 | 江苏省农业科学院 | 一种免疫增强剂、灭活疫苗及其制备方法 |
| US20160017062A1 (en) | 2013-03-12 | 2016-01-21 | Wellstat Vaccines, Llc | Antibodies targeted to fungal cell wall polysaccharides |
| CN105593238B (zh) | 2013-07-11 | 2020-09-08 | 诺华股份有限公司 | 使用微生物转谷氨酰胺酶进行赖氨酸特异性化学酶法蛋白质修饰 |
| US9885726B2 (en) * | 2013-12-05 | 2018-02-06 | Biothera, Inc. | β-glucan assay methods |
| ES2857557T3 (es) * | 2015-01-26 | 2021-09-29 | Kaleido Biosciences Inc | Compuestos terapéuticos de glicano y métodos relacionados de los mismos |
| CN104771498A (zh) * | 2015-03-13 | 2015-07-15 | 臧海阳 | 一种治疗热毒蕴结型痄腮的中药组合物 |
| US11815435B2 (en) | 2017-02-24 | 2023-11-14 | Hibercell, Inc. | Beta glucan immunopharmacodynamics |
| KR102795692B1 (ko) * | 2018-01-19 | 2025-04-16 | 밀테니 비오텍 비.브이. & 씨오. 케이지 | 키메라 항원 수용체를 발현하는 조절 t 세포 |
| US11701417B2 (en) * | 2019-03-27 | 2023-07-18 | West Virginia University | Vaccine formulation to protect against pertussis |
| WO2023002252A1 (en) | 2021-07-21 | 2023-01-26 | Bioatlantis Limited | Composition comprising beta-glucans and alpha-fucans for improving gut health and animal performance and methods of making the same |
| AU2023225283A1 (en) | 2022-02-28 | 2024-08-22 | Tridem Bioscience Gmbh & Co Kg | A CONJUGATE CONSISTING OF OR COMPRISING AT LEAST A ß-GLUCAN OR A MANNAN. |
| EP4486387A1 (en) | 2022-02-28 | 2025-01-08 | Tridem Bioscience GmbH & Co KG | A conjugate consisting of or comprising at least a ss-glucan or a mannan |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE466289B (sv) * | 1984-09-19 | 1992-01-27 | James Hoffman | Makrofagstimulerande komposition jaemte foerfarande foer dess framstaellning |
| JPS6383012A (ja) * | 1986-09-26 | 1988-04-13 | Nonogawa Shoji:Kk | 化粧料 |
| JPH05503952A (ja) * | 1989-09-08 | 1993-06-24 | アルファ ベータ テクノロジー,インコーポレイティッド | 可溶性グルカン類の製造方法 |
| EP0471954A3 (en) | 1990-08-13 | 1993-03-03 | American Cyanamid Company | Immunogenic conjugates of nontoxic oligosaccharide derived from bordetella pertussis lipooligosaccharide |
| US5153312A (en) * | 1990-09-28 | 1992-10-06 | American Cyanamid Company | Oligosaccharide conjugate vaccines |
| ATE280235T1 (de) * | 1993-03-05 | 2004-11-15 | Wyeth Corp | Plasmid zur herstellung von crm-protein und diphtherie-toxin |
| CN1094288A (zh) * | 1993-04-23 | 1994-11-02 | 福建省微生物研究所 | 利用红色诺卡氏菌制造细胞壁骨架粉末的方法 |
| NO300692B1 (no) | 1994-04-29 | 1997-07-07 | Biotec Mackzymal As | Solubilisert forgrenet ß-1,3-glukan og anvendelse derav samt anvendelse av usolubilisert forgrenet ß-1,3-glukan |
| US6309642B1 (en) * | 1997-04-28 | 2001-10-30 | The Research And Development Institute, Inc. | Peptides which mimic candida carbohydrate epitopes and their use in a vaccine |
| AUPN166195A0 (en) * | 1995-03-13 | 1995-04-06 | Norvet Research Pty Limited | Process for glucan extraction |
| JPH09309842A (ja) * | 1996-05-20 | 1997-12-02 | Kureha Chem Ind Co Ltd | 新規な生理活性物質、その製造方法及び医薬組成物 |
| AU760669B2 (en) * | 1998-04-28 | 2003-05-22 | Galenica Pharmaceuticals, Inc. | Polysaccharide-antigen conjugates |
| US6248329B1 (en) * | 1998-06-01 | 2001-06-19 | Ramaswamy Chandrashekar | Parasitic helminth cuticlin nucleic acid molecules and uses thereof |
| GB9925559D0 (en) * | 1999-10-28 | 1999-12-29 | Smithkline Beecham Biolog | Novel method |
| JP4230635B2 (ja) | 2000-02-29 | 2009-02-25 | 富士フイルム株式会社 | デジタルカメラ |
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- 2003-05-15 DE DE60336027T patent/DE60336027D1/de not_active Expired - Lifetime
- 2003-05-15 SI SI200331275T patent/SI1506009T1/sl unknown
- 2003-05-15 PT PT03730424T patent/PT1506009E/pt unknown
- 2003-05-15 US US10/514,483 patent/US20050208079A1/en not_active Abandoned
- 2003-05-15 CA CA2830619A patent/CA2830619A1/en not_active Abandoned
- 2003-05-15 AT AT07075796T patent/ATE497781T1/de not_active IP Right Cessation
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| JP2005535298A (ja) | 2005-11-24 |
| US7824688B2 (en) | 2010-11-02 |
| JP2010131017A (ja) | 2010-06-17 |
| JP2012224636A (ja) | 2012-11-15 |
| CY1108234T1 (el) | 2014-02-12 |
| US20050208079A1 (en) | 2005-09-22 |
| PT1506009E (pt) | 2008-08-14 |
| HK1069125A1 (en) | 2005-05-13 |
| ATE497781T1 (de) | 2011-02-15 |
| ATE395080T1 (de) | 2008-05-15 |
| US20130171187A1 (en) | 2013-07-04 |
| CA2485847A1 (en) | 2003-11-27 |
| US20110059120A1 (en) | 2011-03-10 |
| DK1506009T3 (da) | 2008-09-01 |
| WO2003097091A3 (en) | 2004-03-04 |
| HK1114335A1 (en) | 2008-10-31 |
| GB0211118D0 (en) | 2002-06-26 |
| AU2003241104A1 (en) | 2003-12-02 |
| EP1891970B1 (en) | 2011-02-09 |
| SI1506009T1 (sl) | 2008-10-31 |
| DE60320979D1 (de) | 2008-06-26 |
| ES2306871T3 (es) | 2008-11-16 |
| EP1506009B1 (en) | 2008-05-14 |
| US8679506B2 (en) | 2014-03-25 |
| WO2003097091A2 (en) | 2003-11-27 |
| CA2830619A1 (en) | 2003-11-27 |
| EP1506009A2 (en) | 2005-02-16 |
| DE60336027D1 (de) | 2011-03-24 |
| JP5684758B2 (ja) | 2015-03-18 |
| US8398990B2 (en) | 2013-03-19 |
| US20070141088A1 (en) | 2007-06-21 |
| EP1891970A1 (en) | 2008-02-27 |
| JP5110767B2 (ja) | 2012-12-26 |
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