CA2483980C - Non-invasive delivery of polypeptides through the blood-brain barrier, and in vivo selection of endocytotic ligands - Google Patents
Non-invasive delivery of polypeptides through the blood-brain barrier, and in vivo selection of endocytotic ligands Download PDFInfo
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- Veterinary Medicine (AREA)
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- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
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- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Physics & Mathematics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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AUPS1935A AUPS193502A0 (en) | 2002-04-26 | 2002-04-26 | Molecules that mediate internalisation in cells |
AUPS1935 | 2002-04-26 | ||
US10/188,184 | 2002-07-02 | ||
US10/188,184 US20030083299A1 (en) | 2000-11-04 | 2002-07-02 | Non-invasive delivery of polypeptides through the blood-brain barrier |
PCT/IB2003/002371 WO2003091387A2 (en) | 2002-04-26 | 2003-04-28 | Non-invasive delivery of polypeptides through the blood-brain barrier, and in vivo selection of endocytotic ligands |
Publications (2)
Publication Number | Publication Date |
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CA2483980A1 CA2483980A1 (en) | 2003-11-06 |
CA2483980C true CA2483980C (en) | 2013-07-16 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CA2483980A Expired - Fee Related CA2483980C (en) | 2002-04-26 | 2003-04-28 | Non-invasive delivery of polypeptides through the blood-brain barrier, and in vivo selection of endocytotic ligands |
Country Status (4)
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EP (1) | EP1503801A4 (ja) |
JP (2) | JP2005535580A (ja) |
CA (1) | CA2483980C (ja) |
WO (1) | WO2003091387A2 (ja) |
Families Citing this family (5)
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WO2006070290A2 (en) * | 2004-06-23 | 2006-07-06 | Ferguson Ian A | Agents and methods for early diagnosis and monitoring of alzheimer's disease and other neurological disorders |
EP1985311A4 (en) * | 2006-01-24 | 2011-04-13 | Univ Kagoshima | AGENTS FOR TARGETING A MEDICAMENT ON CEREBRAL NEURONS |
JP2011024499A (ja) * | 2009-07-27 | 2011-02-10 | Nec Soft Ltd | 核酸の製造方法、デリバリー対象物質を臓器特異的にデリバリー可能なデリバリー用タグ核酸およびその用途 |
US20130123647A1 (en) | 2011-05-03 | 2013-05-16 | The Research Foundation Of State University Of New York | Methods Useful in Optimizing the Treatment of Neuropathies and Targeting Tissues with Cosmetic Botulinum Injections |
CN113838541B (zh) * | 2021-09-29 | 2023-10-10 | 脸萌有限公司 | 设计配体分子的方法和装置 |
Family Cites Families (2)
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US6040172A (en) * | 1992-08-14 | 2000-03-21 | The Rockefeller University | Defective DNA viral vector comprising a neural tissue-specific promoter for in vivo expression of a gene |
US6770797B2 (en) * | 2001-06-01 | 2004-08-03 | Rhode Island Hospital | Non-Transgenic nonhuman model for Alzheimer's Disease using a AD7c-NTP nucleic acid |
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2003
- 2003-04-28 CA CA2483980A patent/CA2483980C/en not_active Expired - Fee Related
- 2003-04-28 JP JP2003587923A patent/JP2005535580A/ja active Pending
- 2003-04-28 WO PCT/IB2003/002371 patent/WO2003091387A2/en active Application Filing
- 2003-04-28 EP EP03727872A patent/EP1503801A4/en not_active Withdrawn
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2013
- 2013-01-23 JP JP2013010399A patent/JP2013136586A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP1503801A4 (en) | 2006-02-08 |
WO2003091387A2 (en) | 2003-11-06 |
WO2003091387A3 (en) | 2004-01-08 |
WO2003091387A9 (en) | 2004-02-26 |
JP2005535580A (ja) | 2005-11-24 |
JP2013136586A (ja) | 2013-07-11 |
CA2483980A1 (en) | 2003-11-06 |
EP1503801A2 (en) | 2005-02-09 |
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