CA2480790A1 - Use of antithrombin iii in treating acute lung injury - Google Patents
Use of antithrombin iii in treating acute lung injury Download PDFInfo
- Publication number
- CA2480790A1 CA2480790A1 CA002480790A CA2480790A CA2480790A1 CA 2480790 A1 CA2480790 A1 CA 2480790A1 CA 002480790 A CA002480790 A CA 002480790A CA 2480790 A CA2480790 A CA 2480790A CA 2480790 A1 CA2480790 A1 CA 2480790A1
- Authority
- CA
- Canada
- Prior art keywords
- atiii
- antithrombin iii
- lung injury
- lung
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 102000004411 Antithrombin III Human genes 0.000 title claims abstract description 78
- 108090000935 Antithrombin III Proteins 0.000 title claims abstract description 78
- 229960005348 antithrombin iii Drugs 0.000 title claims abstract description 78
- 206010069351 acute lung injury Diseases 0.000 title claims description 8
- 238000000034 method Methods 0.000 claims abstract description 21
- 208000004852 Lung Injury Diseases 0.000 claims abstract description 19
- 206010069363 Traumatic lung injury Diseases 0.000 claims abstract description 19
- 206010035664 Pneumonia Diseases 0.000 claims abstract description 16
- 231100000515 lung injury Toxicity 0.000 claims description 11
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 239000006199 nebulizer Substances 0.000 claims description 7
- 230000037396 body weight Effects 0.000 claims description 6
- 230000003612 virological effect Effects 0.000 claims description 5
- 230000004044 response Effects 0.000 claims description 4
- 239000000779 smoke Substances 0.000 claims description 4
- 241000589516 Pseudomonas Species 0.000 claims description 3
- 239000010425 asbestos Substances 0.000 claims description 3
- 229910052895 riebeckite Inorganic materials 0.000 claims description 3
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims description 2
- 208000019693 Lung disease Diseases 0.000 abstract description 17
- 230000006378 damage Effects 0.000 abstract description 10
- 239000000443 aerosol Substances 0.000 description 24
- 230000000694 effects Effects 0.000 description 13
- 241001494479 Pecora Species 0.000 description 11
- 208000021063 Respiratory fume inhalation disease Diseases 0.000 description 11
- 206010040047 Sepsis Diseases 0.000 description 10
- 238000011282 treatment Methods 0.000 description 10
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 9
- 239000011780 sodium chloride Substances 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 7
- 239000003937 drug carrier Substances 0.000 description 6
- 230000001154 acute effect Effects 0.000 description 5
- 239000007789 gas Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 230000002685 pulmonary effect Effects 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 238000004113 cell culture Methods 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 238000009472 formulation Methods 0.000 description 3
- 238000001990 intravenous administration Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000008267 milk Substances 0.000 description 3
- 210000004080 milk Anatomy 0.000 description 3
- 235000013336 milk Nutrition 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000003380 propellant Substances 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 230000009261 transgenic effect Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 241000283707 Capra Species 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 101000757319 Homo sapiens Antithrombin-III Proteins 0.000 description 2
- 208000029523 Interstitial Lung disease Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000002663 nebulization Methods 0.000 description 2
- 230000009826 neoplastic cell growth Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000000241 respiratory effect Effects 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 102000004895 Lipoproteins Human genes 0.000 description 1
- 108090001030 Lipoproteins Proteins 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 101150034459 Parpbp gene Proteins 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000004872 arterial blood pressure Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000009429 distress Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 210000001147 pulmonary artery Anatomy 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 230000007838 tissue remodeling Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 239000012808 vapor phase Substances 0.000 description 1
- 230000008728 vascular permeability Effects 0.000 description 1
- 230000002861 ventricular Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Zoology (AREA)
- Otolaryngology (AREA)
- Dispersion Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36899702P | 2002-04-01 | 2002-04-01 | |
| US60/368,997 | 2002-04-01 | ||
| PCT/US2003/009053 WO2003084476A2 (en) | 2002-04-01 | 2003-03-25 | Treatment of lung disorder |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2480790A1 true CA2480790A1 (en) | 2003-10-16 |
Family
ID=29420316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002480790A Abandoned CA2480790A1 (en) | 2002-04-01 | 2003-03-25 | Use of antithrombin iii in treating acute lung injury |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20090221475A9 (enExample) |
| EP (1) | EP1494696A4 (enExample) |
| JP (2) | JP2005527570A (enExample) |
| KR (2) | KR20100117148A (enExample) |
| CN (1) | CN100384469C (enExample) |
| AU (3) | AU2003233428B2 (enExample) |
| CA (1) | CA2480790A1 (enExample) |
| IL (2) | IL164078A0 (enExample) |
| NZ (1) | NZ535487A (enExample) |
| WO (1) | WO2003084476A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050169908A1 (en) * | 2004-01-23 | 2005-08-04 | Kazunori Murakami | Use of aerosolized antithrombin to treat acute lung injury |
| US20050192226A1 (en) * | 2004-02-20 | 2005-09-01 | Perenlei Enkhbaatar | Method of preventing fibrin clots in pulmonary tissue through the use of aerosolized anticoagulants |
| US20050245444A1 (en) * | 2004-04-30 | 2005-11-03 | Yann Echelard | Method of using recombinant human antithrombin for neurocognitive disorders |
| US20060121004A1 (en) * | 2004-12-07 | 2006-06-08 | Yann Echelard | Methods of reducing the incidence of rejection in tissue transplantation through the use of recombinant human antithrombin |
| US8753882B2 (en) | 2010-10-12 | 2014-06-17 | Vetgel Technologies | Methods and compositions for treating respiratory conditions using platelet enriched plasma |
| WO2012090067A1 (en) | 2010-12-30 | 2012-07-05 | Lfb Biotechnologies | Glycols as pathogen inactivating agents |
| WO2014140927A2 (en) | 2013-02-13 | 2014-09-18 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Proteins with modified glycosylation and methods of production thereof |
| EP3594230A1 (en) | 2013-02-13 | 2020-01-15 | Laboratoire Français du Fractionnement et des Biotechnologies | Highly galactosylated anti-tnf-alpha antibodies and uses thereof |
| ES2793176T3 (es) | 2013-07-05 | 2020-11-13 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies Sa | Matriz de cromografía de afinidad |
| CN106536056B (zh) | 2014-06-13 | 2021-07-16 | 儿童医学中心公司 | 分离线粒体的产品和方法 |
| FR3038517B1 (fr) | 2015-07-06 | 2020-02-28 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Utilisation de fragments fc modifies en immunotherapie |
| EP4653048A2 (en) | 2016-01-15 | 2025-11-26 | The Children's Medical Center Corporation | Therapeutic use of mitochondria and combined mitochondrial agents |
| CN113905724A (zh) * | 2019-04-15 | 2022-01-07 | 儿童医学中心公司 | 包含线粒体的雾化组合物及其使用方法 |
| WO2022177724A1 (en) * | 2021-02-17 | 2022-08-25 | University Of Rochester | Methods of treating, diagnosing and predicting prognosis of sepsis |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08782B2 (ja) * | 1986-11-22 | 1996-01-10 | 株式会社ミドリ十字 | 抗炎症剤 |
| DE4117078A1 (de) * | 1991-05-25 | 1992-11-26 | Boehringer Ingelheim Kg | Verfahren zur herstellung therapeutisch anwendbarer aerosole |
| JPH06256213A (ja) * | 1993-03-03 | 1994-09-13 | Green Cross Corp:The | ヒト由来アンチトロンビン−ｉｉｉの医薬用途 |
| US6127347A (en) * | 1994-01-12 | 2000-10-03 | Univ Michigan | Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes |
| US6355626B1 (en) * | 1994-05-13 | 2002-03-12 | The Trustees Of The University Of Pennsylvania | Antithrombin agents in treatment of asthma |
| US5843705A (en) * | 1995-02-21 | 1998-12-01 | Genzyme Transgenic Corporation | Transgenically produced antithrombin III |
| US6562781B1 (en) * | 1995-11-30 | 2003-05-13 | Hamilton Civic Hospitals Research Development Inc. | Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates |
| US7045585B2 (en) * | 1995-11-30 | 2006-05-16 | Hamilton Civic Hospital Research Development Inc. | Methods of coating a device using anti-thrombin heparin |
| JPH09176040A (ja) * | 1995-12-27 | 1997-07-08 | Green Cross Corp:The | ヘパリンコファクターｉｉの医薬用途 |
| US6063593A (en) * | 1996-11-12 | 2000-05-16 | University Of Southern California University Park Campus | TGFβ1 responsive bone marrow derived cells to express a recombinant protein |
| US6124257A (en) * | 1997-08-28 | 2000-09-26 | Lezdey; John | Method of treatment |
| DE69939179D1 (de) * | 1998-10-20 | 2008-09-04 | Childrens Hosp Medical Center | Surfactant protein d zur vorbeugung und diagnose des lungenemphysems |
| US6838428B2 (en) * | 1998-10-20 | 2005-01-04 | Children's Hospital Medical Center | Surfactant protein D for the prevention and diagnosis of pulmonary emphysema |
| DE10045047A1 (de) * | 2000-09-12 | 2002-03-21 | Beate Kehrel | Arzneimittel enthaltend aktiviertes Antithrombin III |
| AU2440802A (en) * | 2000-10-18 | 2002-04-29 | Massachusetts Inst Technology | Methods and products related to pulmonary delivery of polysaccharides |
| DE10132307A1 (de) * | 2001-07-06 | 2003-01-30 | Aventis Behring Gmbh | Arzneizubereitung zur Inhalation von Antithrombin bei entzündlichen Lungenerkrankungen und ARDS |
| US20050169908A1 (en) * | 2004-01-23 | 2005-08-04 | Kazunori Murakami | Use of aerosolized antithrombin to treat acute lung injury |
| US20050192226A1 (en) * | 2004-02-20 | 2005-09-01 | Perenlei Enkhbaatar | Method of preventing fibrin clots in pulmonary tissue through the use of aerosolized anticoagulants |
-
2003
- 2003-03-25 NZ NZ535487A patent/NZ535487A/en not_active IP Right Cessation
- 2003-03-25 US US10/396,855 patent/US20090221475A9/en not_active Abandoned
- 2003-03-25 JP JP2003581716A patent/JP2005527570A/ja active Pending
- 2003-03-25 CA CA002480790A patent/CA2480790A1/en not_active Abandoned
- 2003-03-25 KR KR1020107022448A patent/KR20100117148A/ko not_active Ceased
- 2003-03-25 IL IL16407803A patent/IL164078A0/xx active IP Right Grant
- 2003-03-25 KR KR10-2004-7015636A patent/KR20040105838A/ko not_active Ceased
- 2003-03-25 CN CNB03807463XA patent/CN100384469C/zh not_active Expired - Fee Related
- 2003-03-25 EP EP03728277A patent/EP1494696A4/en not_active Withdrawn
- 2003-03-25 AU AU2003233428A patent/AU2003233428B2/en not_active Revoked
- 2003-03-25 WO PCT/US2003/009053 patent/WO2003084476A2/en not_active Ceased
-
2004
- 2004-09-14 IL IL164078A patent/IL164078A/en not_active IP Right Cessation
-
2008
- 2008-10-31 AU AU2008243077A patent/AU2008243077A1/en not_active Withdrawn
-
2011
- 2011-08-12 JP JP2011176604A patent/JP2011225625A/ja not_active Withdrawn
- 2011-10-10 AU AU2011236070A patent/AU2011236070A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| KR20040105838A (ko) | 2004-12-16 |
| CN100384469C (zh) | 2008-04-30 |
| NZ535487A (en) | 2008-12-24 |
| US20090221475A9 (en) | 2009-09-03 |
| AU2008243077A1 (en) | 2008-11-27 |
| US20040192595A1 (en) | 2004-09-30 |
| EP1494696A4 (en) | 2006-01-25 |
| WO2003084476A3 (en) | 2004-04-22 |
| AU2003233428A1 (en) | 2003-10-20 |
| EP1494696A2 (en) | 2005-01-12 |
| JP2005527570A (ja) | 2005-09-15 |
| WO2003084476A2 (en) | 2003-10-16 |
| JP2011225625A (ja) | 2011-11-10 |
| KR20100117148A (ko) | 2010-11-02 |
| AU2003233428B2 (en) | 2008-07-31 |
| CN1774258A (zh) | 2006-05-17 |
| AU2011236070A1 (en) | 2011-11-03 |
| IL164078A0 (en) | 2005-12-18 |
| IL164078A (en) | 2011-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20141218 |