CA2479730A1

CA2479730A1 - Novel compositions and methods in cancer

Novel compositions and methods in cancer Download PDF

Info

Publication number: CA2479730A1
Authority: CA; Canada
Prior art keywords: cancer; expression; polypeptide; polynucleotide; protein
Prior art date: 2002-03-21
Legal status : Abandoned

Application number

CA002479730A

Other languages

English (en)

French (fr)

Inventor

David W. Morris

Current Assignee

Sagres Discovery Inc

Original Assignee

Individual

Priority date

2002-03-21

Filing date

2003-03-21

Publication date

2003-10-02

2003-03-21 Application filed by Individual filed Critical Individual

2003-10-02 Publication of CA2479730A1 publication Critical patent/CA2479730A1/en

Status Abandoned legal-status Critical Current

Links

206010028980 Neoplasm Diseases 0.000 title claims abstract description 216
238000000034 method Methods 0.000 title claims abstract description 213
201000011510 cancer Diseases 0.000 title claims abstract description 130
239000000203 mixture Substances 0.000 title claims abstract description 50
230000014509 gene expression Effects 0.000 claims abstract description 218
108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 150
102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 136
229920001184 polypeptide Polymers 0.000 claims abstract description 124
102000040430 polynucleotide Human genes 0.000 claims abstract description 114
108091033319 polynucleotide Proteins 0.000 claims abstract description 114
239000002157 polynucleotide Substances 0.000 claims abstract description 114
238000012216 screening Methods 0.000 claims abstract description 42
108090000623 proteins and genes Proteins 0.000 claims description 555
102000004169 proteins and genes Human genes 0.000 claims description 361
150000007523 nucleic acids Chemical class 0.000 claims description 163
239000000523 sample Substances 0.000 claims description 141
210000001519 tissue Anatomy 0.000 claims description 141
102000039446 nucleic acids Human genes 0.000 claims description 138
108020004707 nucleic acids Proteins 0.000 claims description 138
241000282414 Homo sapiens Species 0.000 claims description 111
230000027455 binding Effects 0.000 claims description 94
238000009739 binding Methods 0.000 claims description 94
230000000694 effects Effects 0.000 claims description 89
239000003795 chemical substances by application Substances 0.000 claims description 78
239000012634 fragment Substances 0.000 claims description 65
108020004999 messenger RNA Proteins 0.000 claims description 57
239000012867 bioactive agent Substances 0.000 claims description 46
125000003729 nucleotide group Chemical group 0.000 claims description 46
239000002773 nucleotide Substances 0.000 claims description 43
108020004414 DNA Proteins 0.000 claims description 42
125000003275 alpha amino acid group Chemical group 0.000 claims description 40
206010006187 Breast cancer Diseases 0.000 claims description 37
208000026310 Breast neoplasm Diseases 0.000 claims description 35
239000007787 solid Substances 0.000 claims description 34
239000000427 antigen Substances 0.000 claims description 30
108091007433 antigens Proteins 0.000 claims description 29
102000036639 antigens Human genes 0.000 claims description 29
230000000295 complement effect Effects 0.000 claims description 28
230000001105 regulatory effect Effects 0.000 claims description 26
108091026890 Coding region Proteins 0.000 claims description 24
230000000692 anti-sense effect Effects 0.000 claims description 24
239000013604 expression vector Substances 0.000 claims description 24
241001465754 Metazoa Species 0.000 claims description 23
239000003814 drug Substances 0.000 claims description 23
108091028043 Nucleic acid sequence Proteins 0.000 claims description 20
238000012360 testing method Methods 0.000 claims description 20
102000006311 Cyclin D1 Human genes 0.000 claims description 15
101000931462 Homo sapiens Protein FosB Proteins 0.000 claims description 15
229940000406 drug candidate Drugs 0.000 claims description 15
238000002493 microarray Methods 0.000 claims description 15
102100020847 Protein FosB Human genes 0.000 claims description 14
108010058546 Cyclin D1 Proteins 0.000 claims description 13
208000000236 Prostatic Neoplasms Diseases 0.000 claims description 13
230000003321 amplification Effects 0.000 claims description 13
238000003199 nucleic acid amplification method Methods 0.000 claims description 13
206010060862 Prostate cancer Diseases 0.000 claims description 12
102100038895 Myc proto-oncogene protein Human genes 0.000 claims description 11
229940079593 drug Drugs 0.000 claims description 11
239000003112 inhibitor Substances 0.000 claims description 11
238000003786 synthesis reaction Methods 0.000 claims description 11
206010009944 Colon cancer Diseases 0.000 claims description 10
101001030211 Homo sapiens Myc proto-oncogene protein Proteins 0.000 claims description 10
102100023050 Nuclear factor NF-kappa-B p105 subunit Human genes 0.000 claims description 9
108091093018 PVT1 Proteins 0.000 claims description 9
208000029742 colonic neoplasm Diseases 0.000 claims description 9
238000012544 monitoring process Methods 0.000 claims description 9
102100036089 Fascin Human genes 0.000 claims description 8
101000979342 Homo sapiens Nuclear factor NF-kappa-B p105 subunit Proteins 0.000 claims description 7
206010058467 Lung neoplasm malignant Diseases 0.000 claims description 7
201000005202 lung cancer Diseases 0.000 claims description 7
208000020816 lung neoplasm Diseases 0.000 claims description 7
210000002966 serum Anatomy 0.000 claims description 7
101001021925 Homo sapiens Fascin Proteins 0.000 claims description 6
230000000890 antigenic effect Effects 0.000 claims description 6
230000003053 immunization Effects 0.000 claims description 6
108700026244 Open Reading Frames Proteins 0.000 claims description 5
206010033128 Ovarian cancer Diseases 0.000 claims description 5
206010061535 Ovarian neoplasm Diseases 0.000 claims description 5
208000000453 Skin Neoplasms Diseases 0.000 claims description 4
206010061902 Pancreatic neoplasm Diseases 0.000 claims description 3
208000005718 Stomach Neoplasms Diseases 0.000 claims description 3
239000013068 control sample Substances 0.000 claims description 3
206010017758 gastric cancer Diseases 0.000 claims description 3
208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 3
208000008443 pancreatic carcinoma Diseases 0.000 claims description 3
201000011549 stomach cancer Diseases 0.000 claims description 3
101150088884 SNL1 gene Proteins 0.000 claims description 2
201000000849 skin cancer Diseases 0.000 claims description 2
230000001093 anti-cancer Effects 0.000 claims 4
229940125648 antineoplastic drug candidate Drugs 0.000 claims 2
201000002528 pancreatic cancer Diseases 0.000 claims 1
238000001514 detection method Methods 0.000 abstract description 39
238000011282 treatment Methods 0.000 abstract description 35
230000001225 therapeutic effect Effects 0.000 abstract description 32
238000003745 diagnosis Methods 0.000 abstract description 22
230000002265 prevention Effects 0.000 abstract description 2
235000018102 proteins Nutrition 0.000 description 347
210000004027 cell Anatomy 0.000 description 193
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 49
238000003556 assay Methods 0.000 description 43
238000009396 hybridization Methods 0.000 description 43
201000010099 disease Diseases 0.000 description 41
241000699666 Mus <mouse, genus> Species 0.000 description 38
235000001014 amino acid Nutrition 0.000 description 37
239000000047 product Substances 0.000 description 34
206010025323 Lymphomas Diseases 0.000 description 32
-1 Jung Proteins 0.000 description 31
230000003211 malignant effect Effects 0.000 description 27
150000001413 amino acids Chemical class 0.000 description 26
108091034117 Oligonucleotide Proteins 0.000 description 25
230000000875 corresponding effect Effects 0.000 description 25
150000001875 compounds Chemical class 0.000 description 24
238000006467 substitution reaction Methods 0.000 description 24
201000009030 Carcinoma Diseases 0.000 description 23
238000000018 DNA microarray Methods 0.000 description 20
230000035772 mutation Effects 0.000 description 19
150000003839 salts Chemical class 0.000 description 19
108060003951 Immunoglobulin Proteins 0.000 description 18
102000018358 immunoglobulin Human genes 0.000 description 18
238000003780 insertion Methods 0.000 description 18
230000037431 insertion Effects 0.000 description 18
238000003752 polymerase chain reaction Methods 0.000 description 18
239000000126 substance Substances 0.000 description 18
239000013615 primer Substances 0.000 description 17
108020004711 Nucleic Acid Probes Proteins 0.000 description 16
208000032839 leukemia Diseases 0.000 description 16
239000002853 nucleic acid probe Substances 0.000 description 16
239000013598 vector Substances 0.000 description 16
230000003834 intracellular effect Effects 0.000 description 15
102000052575 Proto-Oncogene Human genes 0.000 description 14
108700020978 Proto-Oncogene Proteins 0.000 description 14
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 14
230000015572 biosynthetic process Effects 0.000 description 14
239000003446 ligand Substances 0.000 description 14
208000024891 symptom Diseases 0.000 description 14
241001430294 unidentified retrovirus Species 0.000 description 14
108091032973 (ribonucleotides)n+m Proteins 0.000 description 13
238000004458 analytical method Methods 0.000 description 13
239000011324 bead Substances 0.000 description 13
238000006243 chemical reaction Methods 0.000 description 13
239000002299 complementary DNA Substances 0.000 description 13
238000005516 engineering process Methods 0.000 description 13
102000035160 transmembrane proteins Human genes 0.000 description 13
108091005703 transmembrane proteins Proteins 0.000 description 13
241000124008 Mammalia Species 0.000 description 12
239000003153 chemical reaction reagent Substances 0.000 description 12
230000004048 modification Effects 0.000 description 12
238000012986 modification Methods 0.000 description 12
239000008194 pharmaceutical composition Substances 0.000 description 12
102000005962 receptors Human genes 0.000 description 12
238000002560 therapeutic procedure Methods 0.000 description 12
238000007792 addition Methods 0.000 description 11
230000004075 alteration Effects 0.000 description 11
238000003491 array Methods 0.000 description 11
230000001965 increasing effect Effects 0.000 description 11
230000002401 inhibitory effect Effects 0.000 description 11
239000002777 nucleoside Substances 0.000 description 11
238000004393 prognosis Methods 0.000 description 11
108020003175 receptors Proteins 0.000 description 11
108010047041 Complementarity Determining Regions Proteins 0.000 description 10
108010041986 DNA Vaccines Proteins 0.000 description 10
241000699670 Mus sp. Species 0.000 description 10
239000002253 acid Substances 0.000 description 10
230000001580 bacterial effect Effects 0.000 description 10
230000004071 biological effect Effects 0.000 description 10
230000004927 fusion Effects 0.000 description 10
230000013595 glycosylation Effects 0.000 description 10
238000006206 glycosylation reaction Methods 0.000 description 10
238000000338 in vitro Methods 0.000 description 10
229940021995 DNA vaccine Drugs 0.000 description 9
241000283984 Rodentia Species 0.000 description 9
239000002671 adjuvant Substances 0.000 description 9
239000002246 antineoplastic agent Substances 0.000 description 9
238000012217 deletion Methods 0.000 description 9
230000037430 deletion Effects 0.000 description 9
239000003623 enhancer Substances 0.000 description 9
230000006870 function Effects 0.000 description 9
238000001415 gene therapy Methods 0.000 description 9
230000012010 growth Effects 0.000 description 9
210000004408 hybridoma Anatomy 0.000 description 9
230000010354 integration Effects 0.000 description 9
239000000758 substrate Substances 0.000 description 9
230000009261 transgenic effect Effects 0.000 description 9
238000005406 washing Methods 0.000 description 9
YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 8
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 8
102000004190 Enzymes Human genes 0.000 description 8
108090000790 Enzymes Proteins 0.000 description 8
241000282412 Homo Species 0.000 description 8
241000700605 Viruses Species 0.000 description 8
230000004913 activation Effects 0.000 description 8
238000010171 animal model Methods 0.000 description 8
239000012472 biological sample Substances 0.000 description 8
229940088598 enzyme Drugs 0.000 description 8
238000003384 imaging method Methods 0.000 description 8
230000028993 immune response Effects 0.000 description 8
238000009169 immunotherapy Methods 0.000 description 8
239000012528 membrane Substances 0.000 description 8
239000000243 solution Substances 0.000 description 8
241000894007 species Species 0.000 description 8
235000000346 sugar Nutrition 0.000 description 8
239000003981 vehicle Substances 0.000 description 8
230000003612 virological effect Effects 0.000 description 8
102000053602 DNA Human genes 0.000 description 7
108700020796 Oncogene Proteins 0.000 description 7
108010090804 Streptavidin Proteins 0.000 description 7
208000009956 adenocarcinoma Diseases 0.000 description 7
238000013459 approach Methods 0.000 description 7
150000001720 carbohydrates Chemical class 0.000 description 7
231100000504 carcinogenesis Toxicity 0.000 description 7
230000001413 cellular effect Effects 0.000 description 7
229940127089 cytotoxic agent Drugs 0.000 description 7
230000007423 decrease Effects 0.000 description 7
230000003247 decreasing effect Effects 0.000 description 7
208000035475 disorder Diseases 0.000 description 7
230000002255 enzymatic effect Effects 0.000 description 7
239000000499 gel Substances 0.000 description 7
229940124452 immunizing agent Drugs 0.000 description 7
238000001727 in vivo Methods 0.000 description 7
239000000463 material Substances 0.000 description 7
210000004379 membrane Anatomy 0.000 description 7
229910052751 metal Inorganic materials 0.000 description 7
239000002184 metal Substances 0.000 description 7
125000003835 nucleoside group Chemical group 0.000 description 7
238000002360 preparation method Methods 0.000 description 7
238000011002 quantification Methods 0.000 description 7
150000003384 small molecules Chemical class 0.000 description 7
239000007790 solid phase Substances 0.000 description 7
229940124597 therapeutic agent Drugs 0.000 description 7
238000013518 transcription Methods 0.000 description 7
230000035897 transcription Effects 0.000 description 7
230000002103 transcriptional effect Effects 0.000 description 7
241000894006 Bacteria Species 0.000 description 6
208000005623 Carcinogenesis Diseases 0.000 description 6
108091005461 Nucleic proteins Chemical group 0.000 description 6
102000043276 Oncogene Human genes 0.000 description 6
230000033228 biological regulation Effects 0.000 description 6
230000036952 cancer formation Effects 0.000 description 6
230000008859 change Effects 0.000 description 6
230000008878 coupling Effects 0.000 description 6
238000010168 coupling process Methods 0.000 description 6
238000005859 coupling reaction Methods 0.000 description 6
238000011156 evaluation Methods 0.000 description 6
125000000524 functional group Chemical group 0.000 description 6
230000002209 hydrophobic effect Effects 0.000 description 6
238000003018 immunoassay Methods 0.000 description 6
230000002163 immunogen Effects 0.000 description 6
238000011534 incubation Methods 0.000 description 6
125000005647 linker group Chemical group 0.000 description 6
238000004519 manufacturing process Methods 0.000 description 6
150000003833 nucleoside derivatives Chemical class 0.000 description 6
239000002245 particle Substances 0.000 description 6
230000008569 process Effects 0.000 description 6
235000013930 proline Nutrition 0.000 description 6
238000007423 screening assay Methods 0.000 description 6
231100000765 toxin Toxicity 0.000 description 6
108020004705 Codon Proteins 0.000 description 5
238000002965 ELISA Methods 0.000 description 5
241000238631 Hexapoda Species 0.000 description 5
ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 5
108010038807 Oligopeptides Proteins 0.000 description 5
102000015636 Oligopeptides Human genes 0.000 description 5
206010035226 Plasma cell myeloma Diseases 0.000 description 5
ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 5
108010076504 Protein Sorting Signals Proteins 0.000 description 5
241000700159 Rattus Species 0.000 description 5
102000040945 Transcription factor Human genes 0.000 description 5
108091023040 Transcription factor Proteins 0.000 description 5
102100023132 Transcription factor Jun Human genes 0.000 description 5
150000001412 amines Chemical group 0.000 description 5
125000000539 amino acid group Chemical group 0.000 description 5
239000005557 antagonist Substances 0.000 description 5
210000004369 blood Anatomy 0.000 description 5
239000008280 blood Substances 0.000 description 5
239000000872 buffer Substances 0.000 description 5
230000004663 cell proliferation Effects 0.000 description 5
235000018417 cysteine Nutrition 0.000 description 5
239000002254 cytotoxic agent Substances 0.000 description 5
231100000599 cytotoxic agent Toxicity 0.000 description 5
238000011161 development Methods 0.000 description 5
230000018109 developmental process Effects 0.000 description 5
230000003828 downregulation Effects 0.000 description 5
239000000284 extract Substances 0.000 description 5
239000003102 growth factor Substances 0.000 description 5
239000007924 injection Substances 0.000 description 5
238000002347 injection Methods 0.000 description 5
230000003993 interaction Effects 0.000 description 5
239000003550 marker Substances 0.000 description 5
239000011159 matrix material Substances 0.000 description 5
230000001404 mediated effect Effects 0.000 description 5
238000000746 purification Methods 0.000 description 5
230000005855 radiation Effects 0.000 description 5
230000001177 retroviral effect Effects 0.000 description 5
230000009870 specific binding Effects 0.000 description 5
239000003053 toxin Substances 0.000 description 5
108700012359 toxins Proteins 0.000 description 5
230000004614 tumor growth Effects 0.000 description 5
108091003079 Bovine Serum Albumin Proteins 0.000 description 4
108010001857 Cell Surface Receptors Proteins 0.000 description 4
102000004127 Cytokines Human genes 0.000 description 4
108090000695 Cytokines Proteins 0.000 description 4
241000701022 Cytomegalovirus Species 0.000 description 4
239000003155 DNA primer Substances 0.000 description 4
ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 4
208000017604 Hodgkin disease Diseases 0.000 description 4
108010091358 Hypoxanthine Phosphoribosyltransferase Proteins 0.000 description 4
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 4
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 4
239000000020 Nitrocellulose Substances 0.000 description 4
208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 4
241000283973 Oryctolagus cuniculus Species 0.000 description 4
108091093037 Peptide nucleic acid Proteins 0.000 description 4
241000288906 Primates Species 0.000 description 4
240000004808 Saccharomyces cerevisiae Species 0.000 description 4
235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 4
ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 4
230000009471 action Effects 0.000 description 4
239000000556 agonist Substances 0.000 description 4
125000003277 amino group Chemical group 0.000 description 4
230000008901 benefit Effects 0.000 description 4
239000011230 binding agent Substances 0.000 description 4
238000001574 biopsy Methods 0.000 description 4
229960002685 biotin Drugs 0.000 description 4
235000020958 biotin Nutrition 0.000 description 4
239000011616 biotin Substances 0.000 description 4
229940098773 bovine serum albumin Drugs 0.000 description 4
239000011575 calcium Substances 0.000 description 4
239000000969 carrier Substances 0.000 description 4
230000032823 cell division Effects 0.000 description 4
238000010367 cloning Methods 0.000 description 4
OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 4
239000003937 drug carrier Substances 0.000 description 4
MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 4
108020001507 fusion proteins Proteins 0.000 description 4
102000037865 fusion proteins Human genes 0.000 description 4
238000001476 gene delivery Methods 0.000 description 4
239000011521 glass Substances 0.000 description 4
UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 4
FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 description 4
238000002649 immunization Methods 0.000 description 4
238000007901 in situ hybridization Methods 0.000 description 4
230000006698 induction Effects 0.000 description 4
230000001939 inductive effect Effects 0.000 description 4
239000002502 liposome Substances 0.000 description 4
210000003563 lymphoid tissue Anatomy 0.000 description 4
210000004962 mammalian cell Anatomy 0.000 description 4
230000007246 mechanism Effects 0.000 description 4
201000001441 melanoma Diseases 0.000 description 4
150000002739 metals Chemical class 0.000 description 4
108091005573 modified proteins Proteins 0.000 description 4
102000035118 modified proteins Human genes 0.000 description 4
229920001220 nitrocellulos Polymers 0.000 description 4
210000004940 nucleus Anatomy 0.000 description 4
210000000056 organ Anatomy 0.000 description 4
230000000144 pharmacologic effect Effects 0.000 description 4
230000000704 physical effect Effects 0.000 description 4
210000002381 plasma Anatomy 0.000 description 4
230000001566 pro-viral effect Effects 0.000 description 4
230000002285 radioactive effect Effects 0.000 description 4
238000011160 research Methods 0.000 description 4
230000004044 response Effects 0.000 description 4
238000012163 sequencing technique Methods 0.000 description 4
125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 4
RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 4
238000001890 transfection Methods 0.000 description 4
235000002374 tyrosine Nutrition 0.000 description 4
125000001493 tyrosinyl group Chemical class [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 4
230000003827 upregulation Effects 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
206010003571 Astrocytoma Diseases 0.000 description 3
241000283690 Bos taurus Species 0.000 description 3
102000000844 Cell Surface Receptors Human genes 0.000 description 3
241000699800 Cricetinae Species 0.000 description 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
108090000786 Fascin Proteins 0.000 description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
208000010747 Hodgkins lymphoma Diseases 0.000 description 3
101001050288 Homo sapiens Transcription factor Jun Proteins 0.000 description 3
241000725303 Human immunodeficiency virus Species 0.000 description 3
102100029098 Hypoxanthine-guanine phosphoribosyltransferase Human genes 0.000 description 3
241000713333 Mouse mammary tumor virus Species 0.000 description 3
238000000636 Northern blotting Methods 0.000 description 3
101710163270 Nuclease Proteins 0.000 description 3
239000004677 Nylon Substances 0.000 description 3
108020005187 Oligonucleotide Probes Proteins 0.000 description 3
MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
238000012408 PCR amplification Methods 0.000 description 3
241000276498 Pollachius virens Species 0.000 description 3
239000002202 Polyethylene glycol Substances 0.000 description 3
239000004793 Polystyrene Substances 0.000 description 3
XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Chemical class CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 3
102000001253 Protein Kinase Human genes 0.000 description 3
102100027584 Protein c-Fos Human genes 0.000 description 3
102000014400 SH2 domains Human genes 0.000 description 3
108050003452 SH2 domains Proteins 0.000 description 3
108091027544 Subgenomic mRNA Proteins 0.000 description 3
108700019146 Transgenes Proteins 0.000 description 3
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
102000044209 Tumor Suppressor Genes Human genes 0.000 description 3
108700025716 Tumor Suppressor Genes Proteins 0.000 description 3
108700005077 Viral Genes Proteins 0.000 description 3
150000007513 acids Chemical class 0.000 description 3
DZBUGLKDJFMEHC-UHFFFAOYSA-N acridine Chemical compound C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 description 3
239000000074 antisense oligonucleotide Substances 0.000 description 3
238000012230 antisense oligonucleotides Methods 0.000 description 3
238000002869 basic local alignment search tool Methods 0.000 description 3
230000000975 bioactive effect Effects 0.000 description 3
210000000481 breast Anatomy 0.000 description 3
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
239000000919 ceramic Substances 0.000 description 3
238000012512 characterization method Methods 0.000 description 3
125000003636 chemical group Chemical group 0.000 description 3
238000004587 chromatography analysis Methods 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
239000007822 coupling agent Substances 0.000 description 3
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 3
125000000151 cysteine group Chemical class N[C@@H](CS)C(=O)* 0.000 description 3
230000001419 dependent effect Effects 0.000 description 3
238000002405 diagnostic procedure Methods 0.000 description 3
230000004069 differentiation Effects 0.000 description 3
238000006073 displacement reaction Methods 0.000 description 3
239000000975 dye Substances 0.000 description 3
235000013601 eggs Nutrition 0.000 description 3
239000012530 fluid Substances 0.000 description 3
230000002068 genetic effect Effects 0.000 description 3
150000004676 glycans Chemical class 0.000 description 3
239000001963 growth medium Substances 0.000 description 3
125000000623 heterocyclic group Chemical group 0.000 description 3
238000013537 high throughput screening Methods 0.000 description 3
210000005260 human cell Anatomy 0.000 description 3
230000003100 immobilizing effect Effects 0.000 description 3
238000003119 immunoblot Methods 0.000 description 3
229940127121 immunoconjugate Drugs 0.000 description 3
238000011065 in-situ storage Methods 0.000 description 3
230000002779 inactivation Effects 0.000 description 3
238000009830 intercalation Methods 0.000 description 3
239000007788 liquid Substances 0.000 description 3
230000004807 localization Effects 0.000 description 3
210000004072 lung Anatomy 0.000 description 3
210000004698 lymphocyte Anatomy 0.000 description 3
230000001394 metastastic effect Effects 0.000 description 3
206010061289 metastatic neoplasm Diseases 0.000 description 3
TWXDDNPPQUTEOV-FVGYRXGTSA-N methamphetamine hydrochloride Chemical compound Cl.CN[C@@H](C)CC1=CC=CC=C1 TWXDDNPPQUTEOV-FVGYRXGTSA-N 0.000 description 3
238000010369 molecular cloning Methods 0.000 description 3
210000000214 mouth Anatomy 0.000 description 3
238000002703 mutagenesis Methods 0.000 description 3
231100000350 mutagenesis Toxicity 0.000 description 3
201000000050 myeloid neoplasm Diseases 0.000 description 3
230000001613 neoplastic effect Effects 0.000 description 3
229920001778 nylon Polymers 0.000 description 3
239000002751 oligonucleotide probe Substances 0.000 description 3
230000036961 partial effect Effects 0.000 description 3
239000012071 phase Substances 0.000 description 3
230000026731 phosphorylation Effects 0.000 description 3
238000006366 phosphorylation reaction Methods 0.000 description 3
229920003023 plastic Polymers 0.000 description 3
239000004033 plastic Substances 0.000 description 3
230000008488 polyadenylation Effects 0.000 description 3
229920001223 polyethylene glycol Polymers 0.000 description 3
229920001282 polysaccharide Polymers 0.000 description 3
239000005017 polysaccharide Substances 0.000 description 3
229920002223 polystyrene Polymers 0.000 description 3
230000000750 progressive effect Effects 0.000 description 3
238000000159 protein binding assay Methods 0.000 description 3
108060006633 protein kinase Proteins 0.000 description 3
230000004850 protein–protein interaction Effects 0.000 description 3
238000003127 radioimmunoassay Methods 0.000 description 3
230000010076 replication Effects 0.000 description 3
PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 3
230000003248 secreting effect Effects 0.000 description 3
230000028327 secretion Effects 0.000 description 3
235000004400 serine Nutrition 0.000 description 3
210000003491 skin Anatomy 0.000 description 3
238000010561 standard procedure Methods 0.000 description 3
150000008163 sugars Chemical class 0.000 description 3
238000012546 transfer Methods 0.000 description 3
230000009466 transformation Effects 0.000 description 3
210000004881 tumor cell Anatomy 0.000 description 3
241000701161 unidentified adenovirus Species 0.000 description 3
HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
JTLDBJGKDYQKGB-UHFFFAOYSA-N 3,4-bis(4-methoxyphenyl)-2-methylbenzoic acid Chemical compound C1=CC(OC)=CC=C1C1=CC=C(C(O)=O)C(C)=C1C1=CC=C(OC)C=C1 JTLDBJGKDYQKGB-UHFFFAOYSA-N 0.000 description 2
VPFUWHKTPYPNGT-UHFFFAOYSA-N 3-(3,4-dihydroxyphenyl)-1-(5-hydroxy-2,2-dimethylchromen-6-yl)propan-1-one Chemical compound OC1=C2C=CC(C)(C)OC2=CC=C1C(=O)CCC1=CC=C(O)C(O)=C1 VPFUWHKTPYPNGT-UHFFFAOYSA-N 0.000 description 2
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
NJYVEMPWNAYQQN-UHFFFAOYSA-N 5-carboxyfluorescein Chemical compound C12=CC=C(O)C=C2OC2=CC(O)=CC=C2C21OC(=O)C1=CC(C(=O)O)=CC=C21 NJYVEMPWNAYQQN-UHFFFAOYSA-N 0.000 description 2
BZTDTCNHAFUJOG-UHFFFAOYSA-N 6-carboxyfluorescein Chemical compound C12=CC=C(O)C=C2OC2=CC(O)=CC=C2C11OC(=O)C2=CC=C(C(=O)O)C=C21 BZTDTCNHAFUJOG-UHFFFAOYSA-N 0.000 description 2
LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 description 2
208000030507 AIDS Diseases 0.000 description 2
108010066676 Abrin Proteins 0.000 description 2
229930024421 Adenine Natural products 0.000 description 2
GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 2
108010088751 Albumins Proteins 0.000 description 2
102000009027 Albumins Human genes 0.000 description 2
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
241000271566 Aves Species 0.000 description 2
108090001008 Avidin Proteins 0.000 description 2
241000193830 Bacillus <bacterium> Species 0.000 description 2
244000063299 Bacillus subtilis Species 0.000 description 2
235000014469 Bacillus subtilis Nutrition 0.000 description 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
201000000274 Carcinosarcoma Diseases 0.000 description 2
102000014914 Carrier Proteins Human genes 0.000 description 2
241000700198 Cavia Species 0.000 description 2
208000005243 Chondrosarcoma Diseases 0.000 description 2
108091035707 Consensus sequence Proteins 0.000 description 2
239000004971 Cross linker Substances 0.000 description 2
IGXWBGJHJZYPQS-SSDOTTSWSA-N D-Luciferin Chemical compound OC(=O)[C@H]1CSC(C=2SC3=CC=C(O)C=C3N=2)=N1 IGXWBGJHJZYPQS-SSDOTTSWSA-N 0.000 description 2
230000004544 DNA amplification Effects 0.000 description 2
230000006820 DNA synthesis Effects 0.000 description 2
230000004568 DNA-binding Effects 0.000 description 2
102000004163 DNA-directed RNA polymerases Human genes 0.000 description 2
CYCGRDQQIOGCKX-UHFFFAOYSA-N Dehydro-luciferin Natural products OC(=O)C1=CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 CYCGRDQQIOGCKX-UHFFFAOYSA-N 0.000 description 2
229920002307 Dextran Polymers 0.000 description 2
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
241000196324 Embryophyta Species 0.000 description 2
241000283086 Equidae Species 0.000 description 2
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
241000588724 Escherichia coli Species 0.000 description 2
241000282326 Felis catus Species 0.000 description 2
201000008808 Fibrosarcoma Diseases 0.000 description 2
BJGNCJDXODQBOB-UHFFFAOYSA-N Fivefly Luciferin Natural products OC(=O)C1CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 BJGNCJDXODQBOB-UHFFFAOYSA-N 0.000 description 2
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
239000004471 Glycine Substances 0.000 description 2
AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
108010031186 Glycoside Hydrolases Proteins 0.000 description 2
102000005744 Glycoside Hydrolases Human genes 0.000 description 2
229920000209 Hexadimethrine bromide Polymers 0.000 description 2
101000979338 Homo sapiens Nuclear factor NF-kappa-B p100 subunit Proteins 0.000 description 2
108090000144 Human Proteins Proteins 0.000 description 2
102000003839 Human Proteins Human genes 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
108010021625 Immunoglobulin Fragments Proteins 0.000 description 2
102000008394 Immunoglobulin Fragments Human genes 0.000 description 2
229930010555 Inosine Natural products 0.000 description 2
UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 description 2
102100034343 Integrase Human genes 0.000 description 2
102000000589 Interleukin-1 Human genes 0.000 description 2
108010002352 Interleukin-1 Proteins 0.000 description 2
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
208000007766 Kaposi sarcoma Diseases 0.000 description 2
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 2
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 2
206010024305 Leukaemia monocytic Diseases 0.000 description 2
DDWFXDSYGUXRAY-UHFFFAOYSA-N Luciferin Natural products CCc1c(C)c(CC2NC(=O)C(=C2C=C)C)[nH]c1Cc3[nH]c4C(=C5/NC(CC(=O)O)C(C)C5CC(=O)O)CC(=O)c4c3C DDWFXDSYGUXRAY-UHFFFAOYSA-N 0.000 description 2
208000028018 Lymphocytic leukaemia Diseases 0.000 description 2
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
239000004472 Lysine Substances 0.000 description 2
OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 2
206010027145 Melanocytic naevus Diseases 0.000 description 2
206010027406 Mesothelioma Diseases 0.000 description 2
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
208000034578 Multiple myelomas Diseases 0.000 description 2
101710135898 Myc proto-oncogene protein Proteins 0.000 description 2
108091061960 Naked DNA Proteins 0.000 description 2
102100023059 Nuclear factor NF-kappa-B p100 subunit Human genes 0.000 description 2
201000010133 Oligodendroglioma Diseases 0.000 description 2
229910019142 PO4 Inorganic materials 0.000 description 2
206010061332 Paraganglion neoplasm Diseases 0.000 description 2
108091005804 Peptidases Proteins 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
108010004729 Phycoerythrin Proteins 0.000 description 2
239000004698 Polyethylene Substances 0.000 description 2
229920000954 Polyglycolide Polymers 0.000 description 2
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
208000006994 Precancerous Conditions Diseases 0.000 description 2
239000004365 Protease Substances 0.000 description 2
108010071563 Proto-Oncogene Proteins c-fos Proteins 0.000 description 2
108010087705 Proto-Oncogene Proteins c-myc Proteins 0.000 description 2
102000009092 Proto-Oncogene Proteins c-myc Human genes 0.000 description 2
LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 description 2
108010092799 RNA-directed DNA polymerase Proteins 0.000 description 2
108020004511 Recombinant DNA Proteins 0.000 description 2
108010008281 Recombinant Fusion Proteins Proteins 0.000 description 2
102000007056 Recombinant Fusion Proteins Human genes 0.000 description 2
102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 2
108091028664 Ribonucleotide Proteins 0.000 description 2
PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 2
108010039491 Ricin Proteins 0.000 description 2
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 2
241000700584 Simplexvirus Species 0.000 description 2
FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
238000002105 Southern blotting Methods 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
239000004809 Teflon Substances 0.000 description 2
229920006362 Teflon® Polymers 0.000 description 2
IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
102000004380 Transcription factor RelB Human genes 0.000 description 2
108090000952 Transcription factor RelB Proteins 0.000 description 2
101710150448 Transcriptional regulator Myc Proteins 0.000 description 2
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 2
108060008682 Tumor Necrosis Factor Proteins 0.000 description 2
102100040247 Tumor necrosis factor Human genes 0.000 description 2
230000001594 aberrant effect Effects 0.000 description 2
230000021736 acetylation Effects 0.000 description 2
238000006640 acetylation reaction Methods 0.000 description 2
RJURFGZVJUQBHK-UHFFFAOYSA-N actinomycin D Natural products CC1OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2C(=O)C(C(C)C)NC(=O)C1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)NC4C(=O)NC(C(N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-UHFFFAOYSA-N 0.000 description 2
230000003213 activating effect Effects 0.000 description 2
230000004658 acute-phase response Effects 0.000 description 2
229960000643 adenine Drugs 0.000 description 2
OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 2
230000002411 adverse Effects 0.000 description 2
HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 2
230000002707 ameloblastic effect Effects 0.000 description 2
239000004599 antimicrobial Substances 0.000 description 2
210000001367 artery Anatomy 0.000 description 2
108700042656 bcl-1 Genes Proteins 0.000 description 2
230000009286 beneficial effect Effects 0.000 description 2
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
229910052614 beryl Inorganic materials 0.000 description 2
230000001588 bifunctional effect Effects 0.000 description 2
238000004166 bioassay Methods 0.000 description 2
239000013060 biological fluid Substances 0.000 description 2
230000008827 biological function Effects 0.000 description 2
230000000903 blocking effect Effects 0.000 description 2
229910052791 calcium Inorganic materials 0.000 description 2
239000001506 calcium phosphate Substances 0.000 description 2
229910000389 calcium phosphate Inorganic materials 0.000 description 2
235000011010 calcium phosphates Nutrition 0.000 description 2
235000014633 carbohydrates Nutrition 0.000 description 2
238000004113 cell culture Methods 0.000 description 2
230000022131 cell cycle Effects 0.000 description 2
230000024245 cell differentiation Effects 0.000 description 2
210000001175 cerebrospinal fluid Anatomy 0.000 description 2
239000002738 chelating agent Substances 0.000 description 2
230000002759 chromosomal effect Effects 0.000 description 2
208000009060 clear cell adenocarcinoma Diseases 0.000 description 2
230000001268 conjugating effect Effects 0.000 description 2
230000021615 conjugation Effects 0.000 description 2
108091036078 conserved sequence Proteins 0.000 description 2
239000000470 constituent Substances 0.000 description 2
238000007796 conventional method Methods 0.000 description 2
238000004132 cross linking Methods 0.000 description 2
230000009260 cross reactivity Effects 0.000 description 2
108010057085 cytokine receptors Proteins 0.000 description 2
102000003675 cytokine receptors Human genes 0.000 description 2
210000000805 cytoplasm Anatomy 0.000 description 2
229940104302 cytosine Drugs 0.000 description 2
231100000433 cytotoxic Toxicity 0.000 description 2
230000001472 cytotoxic effect Effects 0.000 description 2
239000003599 detergent Substances 0.000 description 2
230000009274 differential gene expression Effects 0.000 description 2
239000003085 diluting agent Substances 0.000 description 2
230000003292 diminished effect Effects 0.000 description 2
229940042399 direct acting antivirals protease inhibitors Drugs 0.000 description 2
238000007876 drug discovery Methods 0.000 description 2
238000007878 drug screening assay Methods 0.000 description 2
230000000668 effect on calcium Effects 0.000 description 2
238000004520 electroporation Methods 0.000 description 2
239000003995 emulsifying agent Substances 0.000 description 2
238000005538 encapsulation Methods 0.000 description 2
230000002124 endocrine Effects 0.000 description 2
239000002158 endotoxin Substances 0.000 description 2
150000002148 esters Chemical class 0.000 description 2
210000003527 eukaryotic cell Anatomy 0.000 description 2
239000000835 fiber Substances 0.000 description 2
239000007850 fluorescent dye Substances 0.000 description 2
238000009472 formulation Methods 0.000 description 2
101150064107 fosB gene Proteins 0.000 description 2
230000002538 fungal effect Effects 0.000 description 2
238000001502 gel electrophoresis Methods 0.000 description 2
210000004392 genitalia Anatomy 0.000 description 2
210000004602 germ cell Anatomy 0.000 description 2
125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 description 2
229930182470 glycoside Natural products 0.000 description 2
150000002338 glycosides Chemical class 0.000 description 2
229930004094 glycosylphosphatidylinositol Natural products 0.000 description 2
238000003306 harvesting Methods 0.000 description 2
230000036541 health Effects 0.000 description 2
235000014304 histidine Nutrition 0.000 description 2
125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 description 2
238000002744 homologous recombination Methods 0.000 description 2
230000006801 homologous recombination Effects 0.000 description 2
229910052739 hydrogen Inorganic materials 0.000 description 2
239000001257 hydrogen Substances 0.000 description 2
230000001900 immune effect Effects 0.000 description 2
230000016784 immunoglobulin production Effects 0.000 description 2
229940072221 immunoglobulins Drugs 0.000 description 2
238000001114 immunoprecipitation Methods 0.000 description 2
230000008676 import Effects 0.000 description 2
238000010348 incorporation Methods 0.000 description 2
239000000411 inducer Substances 0.000 description 2
208000015181 infectious disease Diseases 0.000 description 2
230000005764 inhibitory process Effects 0.000 description 2
230000000977 initiatory effect Effects 0.000 description 2
229960003786 inosine Drugs 0.000 description 2
230000005865 ionizing radiation Effects 0.000 description 2
DRAVOWXCEBXPTN-UHFFFAOYSA-N isoguanine Chemical compound NC1=NC(=O)NC2=C1NC=N2 DRAVOWXCEBXPTN-UHFFFAOYSA-N 0.000 description 2
210000000244 kidney pelvis Anatomy 0.000 description 2
230000003902 lesion Effects 0.000 description 2
229920006008 lipopolysaccharide Polymers 0.000 description 2
239000007791 liquid phase Substances 0.000 description 2
208000003747 lymphoid leukemia Diseases 0.000 description 2
210000002540 macrophage Anatomy 0.000 description 2
239000006249 magnetic particle Substances 0.000 description 2
238000002844 melting Methods 0.000 description 2
230000011987 methylation Effects 0.000 description 2
238000007069 methylation reaction Methods 0.000 description 2
238000000520 microinjection Methods 0.000 description 2
201000006894 monocytic leukemia Diseases 0.000 description 2
208000025113 myeloid leukemia Diseases 0.000 description 2
229930014626 natural product Natural products 0.000 description 2
239000013642 negative control Substances 0.000 description 2
210000005170 neoplastic cell Anatomy 0.000 description 2
230000009826 neoplastic cell growth Effects 0.000 description 2
210000000653 nervous system Anatomy 0.000 description 2
230000007935 neutral effect Effects 0.000 description 2
230000009871 nonspecific binding Effects 0.000 description 2
238000011275 oncology therapy Methods 0.000 description 2
230000003287 optical effect Effects 0.000 description 2
239000013307 optical fiber Substances 0.000 description 2
150000007524 organic acids Chemical class 0.000 description 2
235000005985 organic acids Nutrition 0.000 description 2
150000002894 organic compounds Chemical class 0.000 description 2
210000001672 ovary Anatomy 0.000 description 2
230000002018 overexpression Effects 0.000 description 2
208000007312 paraganglioma Diseases 0.000 description 2
239000000137 peptide hydrolase inhibitor Substances 0.000 description 2
238000010647 peptide synthesis reaction Methods 0.000 description 2
239000002831 pharmacologic agent Substances 0.000 description 2
210000003800 pharynx Anatomy 0.000 description 2
150000004713 phosphodiesters Chemical class 0.000 description 2
150000003904 phospholipids Chemical class 0.000 description 2
229920000747 poly(lactic acid) Polymers 0.000 description 2
229920000642 polymer Polymers 0.000 description 2
239000011591 potassium Substances 0.000 description 2
229910052700 potassium Inorganic materials 0.000 description 2
230000003389 potentiating effect Effects 0.000 description 2
238000001556 precipitation Methods 0.000 description 2
239000002243 precursor Substances 0.000 description 2
230000002062 proliferating effect Effects 0.000 description 2
230000035755 proliferation Effects 0.000 description 2
230000000069 prophylactic effect Effects 0.000 description 2
210000002307 prostate Anatomy 0.000 description 2
230000004952 protein activity Effects 0.000 description 2
210000001938 protoplast Anatomy 0.000 description 2
ZCCUUQDIBDJBTK-UHFFFAOYSA-N psoralen Chemical compound C1=C2OC(=O)C=CC2=CC2=C1OC=C2 ZCCUUQDIBDJBTK-UHFFFAOYSA-N 0.000 description 2
150000003212 purines Chemical class 0.000 description 2
238000001959 radiotherapy Methods 0.000 description 2
230000008707 rearrangement Effects 0.000 description 2
102000027426 receptor tyrosine kinases Human genes 0.000 description 2
108091008598 receptor tyrosine kinases Proteins 0.000 description 2
238000010188 recombinant method Methods 0.000 description 2
230000009467 reduction Effects 0.000 description 2
230000003362 replicative effect Effects 0.000 description 2
239000011347 resin Substances 0.000 description 2
229920005989 resin Polymers 0.000 description 2
230000000241 respiratory effect Effects 0.000 description 2
230000004043 responsiveness Effects 0.000 description 2
238000010839 reverse transcription Methods 0.000 description 2
238000003757 reverse transcription PCR Methods 0.000 description 2
238000012552 review Methods 0.000 description 2
239000002336 ribonucleotide Substances 0.000 description 2
125000002652 ribonucleotide group Chemical group 0.000 description 2
YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
238000010845 search algorithm Methods 0.000 description 2
230000011664 signaling Effects 0.000 description 2
239000011734 sodium Substances 0.000 description 2
229910052708 sodium Inorganic materials 0.000 description 2
239000011780 sodium chloride Substances 0.000 description 2
239000001509 sodium citrate Substances 0.000 description 2
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 2
229910001415 sodium ion Inorganic materials 0.000 description 2
230000006641 stabilisation Effects 0.000 description 2
238000011105 stabilization Methods 0.000 description 2
230000008093 supporting effect Effects 0.000 description 2
239000000829 suppository Substances 0.000 description 2
230000004083 survival effect Effects 0.000 description 2
239000000725 suspension Substances 0.000 description 2
230000008685 targeting Effects 0.000 description 2
RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 2
229940113082 thymine Drugs 0.000 description 2
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 2
230000000699 topical effect Effects 0.000 description 2
238000011830 transgenic mouse model Methods 0.000 description 2
238000013519 translation Methods 0.000 description 2
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 2
230000005740 tumor formation Effects 0.000 description 2
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
229940035893 uracil Drugs 0.000 description 2
230000002485 urinary effect Effects 0.000 description 2
210000002700 urine Anatomy 0.000 description 2
210000004291 uterus Anatomy 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
238000009736 wetting Methods 0.000 description 2
239000000080 wetting agent Substances 0.000 description 2
HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
FXYPGCIGRDZWNR-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 3-[[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropyl]disulfanyl]propanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCSSCCC(=O)ON1C(=O)CCC1=O FXYPGCIGRDZWNR-UHFFFAOYSA-N 0.000 description 1
QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 description 1
VHTNTJQSKJZERS-XUVCUMPTSA-N (2s,3s,4r,5s,6s)-2-methyl-6-methylselanyloxane-3,4,5-triol Chemical compound C[Se][C@@H]1O[C@@H](C)[C@@H](O)[C@@H](O)[C@@H]1O VHTNTJQSKJZERS-XUVCUMPTSA-N 0.000 description 1
MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 description 1
WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
PXFBZOLANLWPMH-UHFFFAOYSA-N 16-Epiaffinine Natural products C1C(C2=CC=CC=C2N2)=C2C(=O)CC2C(=CC)CN(C)C1C2CO PXFBZOLANLWPMH-UHFFFAOYSA-N 0.000 description 1
125000003287 1H-imidazol-4-ylmethyl group Chemical group [H]N1C([H])=NC(C([H])([H])[*])=C1[H] 0.000 description 1
150000003923 2,5-pyrrolediones Chemical class 0.000 description 1
OEXZVWQQTFVIDS-UHFFFAOYSA-N 2-(chloromethyl)-3,4-bis(4-methoxyphenyl)benzoic acid Chemical compound C1=CC(OC)=CC=C1C1=CC=C(C(O)=O)C(CCl)=C1C1=CC=C(OC)C=C1 OEXZVWQQTFVIDS-UHFFFAOYSA-N 0.000 description 1
DWWYUMNNFKUIJS-UHFFFAOYSA-N 2-(hydroxymethyl)-3,4-bis(4-methoxyphenyl)benzoic acid Chemical compound C1=CC(OC)=CC=C1C1=CC=C(C(O)=O)C(CO)=C1C1=CC=C(OC)C=C1 DWWYUMNNFKUIJS-UHFFFAOYSA-N 0.000 description 1
XQCZBXHVTFVIFE-UHFFFAOYSA-N 2-amino-4-hydroxypyrimidine Chemical compound NC1=NC=CC(O)=N1 XQCZBXHVTFVIFE-UHFFFAOYSA-N 0.000 description 1
ASJSAQIRZKANQN-CRCLSJGQSA-N 2-deoxy-D-ribose Chemical compound OC[C@@H](O)[C@@H](O)CC=O ASJSAQIRZKANQN-CRCLSJGQSA-N 0.000 description 1
BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
BIGBDMFRWJRLGJ-UHFFFAOYSA-N 3-benzyl-1,5-didiazoniopenta-1,4-diene-2,4-diolate Chemical compound [N-]=[N+]=CC(=O)C(C(=O)C=[N+]=[N-])CC1=CC=CC=C1 BIGBDMFRWJRLGJ-UHFFFAOYSA-N 0.000 description 1
VXGRJERITKFWPL-UHFFFAOYSA-N 4',5'-Dihydropsoralen Natural products C1=C2OC(=O)C=CC2=CC2=C1OCC2 VXGRJERITKFWPL-UHFFFAOYSA-N 0.000 description 1
125000002103 4,4'-dimethoxytriphenylmethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)(C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H])C1=C([H])C([H])=C(OC([H])([H])[H])C([H])=C1[H] 0.000 description 1
TVZGACDUOSZQKY-LBPRGKRZSA-N 4-aminofolic acid Chemical compound C1=NC2=NC(N)=NC(N)=C2N=C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 TVZGACDUOSZQKY-LBPRGKRZSA-N 0.000 description 1
HUDPLKWXRLNSPC-UHFFFAOYSA-N 4-aminophthalhydrazide Chemical compound O=C1NNC(=O)C=2C1=CC(N)=CC=2 HUDPLKWXRLNSPC-UHFFFAOYSA-N 0.000 description 1
NLPWSMKACWGINL-UHFFFAOYSA-N 4-azido-2-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(N=[N+]=[N-])C=C1O NLPWSMKACWGINL-UHFFFAOYSA-N 0.000 description 1
QRXMUCSWCMTJGU-UHFFFAOYSA-N 5-bromo-4-chloro-3-indolyl phosphate Chemical compound C1=C(Br)C(Cl)=C2C(OP(O)(=O)O)=CNC2=C1 QRXMUCSWCMTJGU-UHFFFAOYSA-N 0.000 description 1
WQZIDRAQTRIQDX-UHFFFAOYSA-N 6-carboxy-x-rhodamine Chemical compound OC(=O)C1=CC=C(C([O-])=O)C=C1C(C1=CC=2CCCN3CCCC(C=23)=C1O1)=C2C1=C(CCC1)C3=[N+]1CCCC3=C2 WQZIDRAQTRIQDX-UHFFFAOYSA-N 0.000 description 1
206010069754 Acquired gene mutation Diseases 0.000 description 1
HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
208000016557 Acute basophilic leukemia Diseases 0.000 description 1
206010048998 Acute phase reaction Diseases 0.000 description 1
208000004804 Adenomatous Polyps Diseases 0.000 description 1
108010000239 Aequorin Proteins 0.000 description 1
VJVQKGYHIZPSNS-FXQIFTODSA-N Ala-Ser-Arg Chemical compound C[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H](C(O)=O)CCCN=C(N)N VJVQKGYHIZPSNS-FXQIFTODSA-N 0.000 description 1
102000002260 Alkaline Phosphatase Human genes 0.000 description 1
108020004774 Alkaline Phosphatase Proteins 0.000 description 1
208000012791 Alpha-heavy chain disease Diseases 0.000 description 1
241000710929 Alphavirus Species 0.000 description 1
206010002198 Anaphylactic reaction Diseases 0.000 description 1
201000003076 Angiosarcoma Diseases 0.000 description 1
108020000948 Antisense Oligonucleotides Proteins 0.000 description 1
108020005544 Antisense RNA Proteins 0.000 description 1
101001007348 Arachis hypogaea Galactose-binding lectin Proteins 0.000 description 1
241000203069 Archaea Species 0.000 description 1
239000004475 Arginine Substances 0.000 description 1
HCAUEJAQCXVQQM-ACZMJKKPSA-N Asn-Glu-Asp Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(O)=O HCAUEJAQCXVQQM-ACZMJKKPSA-N 0.000 description 1
206010065869 Astrocytoma, low grade Diseases 0.000 description 1
102100022717 Atypical chemokine receptor 1 Human genes 0.000 description 1
108020004513 Bacterial RNA Proteins 0.000 description 1
206010004146 Basal cell carcinoma Diseases 0.000 description 1
208000035821 Benign schwannoma Diseases 0.000 description 1
239000005711 Benzoic acid Substances 0.000 description 1
DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 1
208000007690 Brenner tumor Diseases 0.000 description 1
206010073258 Brenner tumour Diseases 0.000 description 1
208000003170 Bronchiolo-Alveolar Adenocarcinoma Diseases 0.000 description 1
125000001433 C-terminal amino-acid group Chemical group 0.000 description 1
239000002126 C01EB10 - Adenosine Substances 0.000 description 1
101150025841 CCND1 gene Proteins 0.000 description 1
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
241000222128 Candida maltosa Species 0.000 description 1
241000282472 Canis lupus familiaris Species 0.000 description 1
241000283707 Capra Species 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
206010007275 Carcinoid tumour Diseases 0.000 description 1
108010078791 Carrier Proteins Proteins 0.000 description 1
108090000994 Catalytic RNA Proteins 0.000 description 1
102000053642 Catalytic RNA Human genes 0.000 description 1
206010008583 Chloroma Diseases 0.000 description 1
201000009047 Chordoma Diseases 0.000 description 1
208000006332 Choriocarcinoma Diseases 0.000 description 1
206010008805 Chromosomal abnormalities Diseases 0.000 description 1
206010061764 Chromosomal deletion Diseases 0.000 description 1
208000031404 Chromosome Aberrations Diseases 0.000 description 1
WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 1
102000008186 Collagen Human genes 0.000 description 1
108010035532 Collagen Proteins 0.000 description 1
108020004635 Complementary DNA Proteins 0.000 description 1
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
108700032819 Croton tiglium crotin II Proteins 0.000 description 1
101710095468 Cyclase Proteins 0.000 description 1
102000016736 Cyclin Human genes 0.000 description 1
108050006400 Cyclin Proteins 0.000 description 1
102000003903 Cyclin-dependent kinases Human genes 0.000 description 1
108090000266 Cyclin-dependent kinases Proteins 0.000 description 1
ZGERHCJBLPQPGV-ACZMJKKPSA-N Cys-Ser-Gln Chemical compound C(CC(=O)N)[C@@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CS)N ZGERHCJBLPQPGV-ACZMJKKPSA-N 0.000 description 1
HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 1
239000003298 DNA probe Substances 0.000 description 1
230000004543 DNA replication Effects 0.000 description 1
102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
108010014303 DNA-directed DNA polymerase Proteins 0.000 description 1
108090000626 DNA-directed RNA polymerases Proteins 0.000 description 1
108010092160 Dactinomycin Proteins 0.000 description 1
241000702421 Dependoparvovirus Species 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 description 1
108010053187 Diphtheria Toxin Proteins 0.000 description 1
102000016607 Diphtheria Toxin Human genes 0.000 description 1
108010035533 Drosophila Proteins Proteins 0.000 description 1
241000255601 Drosophila melanogaster Species 0.000 description 1
208000037162 Ductal Breast Carcinoma Diseases 0.000 description 1
208000007033 Dysgerminoma Diseases 0.000 description 1
206010058314 Dysplasia Diseases 0.000 description 1
102000001301 EGF receptor Human genes 0.000 description 1
108060006698 EGF receptor Proteins 0.000 description 1
241000257465 Echinoidea Species 0.000 description 1
201000009051 Embryonal Carcinoma Diseases 0.000 description 1
101710202200 Endolysin A Proteins 0.000 description 1
102000004533 Endonucleases Human genes 0.000 description 1
108010042407 Endonucleases Proteins 0.000 description 1
102100030013 Endoribonuclease Human genes 0.000 description 1
101710199605 Endoribonuclease Proteins 0.000 description 1
206010014958 Eosinophilic leukaemia Diseases 0.000 description 1
206010014967 Ependymoma Diseases 0.000 description 1
206010066919 Epidemic polyarthritis Diseases 0.000 description 1
208000031637 Erythroblastic Acute Leukemia Diseases 0.000 description 1
208000036566 Erythroleukaemia Diseases 0.000 description 1
208000006168 Ewing Sarcoma Diseases 0.000 description 1
108060002716 Exonuclease Proteins 0.000 description 1
101710082714 Exotoxin A Proteins 0.000 description 1
102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
208000035126 Facies Diseases 0.000 description 1
201000006107 Familial adenomatous polyposis Diseases 0.000 description 1
206010053717 Fibrous histiocytoma Diseases 0.000 description 1
241000192125 Firmicutes Species 0.000 description 1
208000004463 Follicular Adenocarcinoma Diseases 0.000 description 1
108090000123 Fos-related antigen 1 Proteins 0.000 description 1
102000003817 Fos-related antigen 1 Human genes 0.000 description 1
101150096607 Fosl2 gene Proteins 0.000 description 1
241000233866 Fungi Species 0.000 description 1
241000287828 Gallus gallus Species 0.000 description 1
206010017708 Ganglioneuroblastoma Diseases 0.000 description 1
208000008999 Giant Cell Carcinoma Diseases 0.000 description 1
208000002966 Giant Cell Tumor of Bone Diseases 0.000 description 1
FTIJVMLAGRAYMJ-MNXVOIDGSA-N Gln-Ile-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H](N)CCC(N)=O FTIJVMLAGRAYMJ-MNXVOIDGSA-N 0.000 description 1
CBEUFCJRFNZMCU-SRVKXCTJSA-N Glu-Met-Leu Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(O)=O CBEUFCJRFNZMCU-SRVKXCTJSA-N 0.000 description 1
102000042092 Glucose transporter family Human genes 0.000 description 1
108091052347 Glucose transporter family Proteins 0.000 description 1
SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
ZZJVYSAQQMDIRD-UWVGGRQHSA-N Gly-Pro-His Chemical compound NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1cnc[nH]1)C(O)=O ZZJVYSAQQMDIRD-UWVGGRQHSA-N 0.000 description 1
244000068988 Glycine max Species 0.000 description 1
235000010469 Glycine max Nutrition 0.000 description 1
229920002683 Glycosaminoglycan Polymers 0.000 description 1
108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 1
208000005234 Granulosa Cell Tumor Diseases 0.000 description 1
108010043121 Green Fluorescent Proteins Proteins 0.000 description 1
102000004144 Green Fluorescent Proteins Human genes 0.000 description 1
HVLSXIKZNLPZJJ-TXZCQADKSA-N HA peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 HVLSXIKZNLPZJJ-TXZCQADKSA-N 0.000 description 1
208000002125 Hemangioendothelioma Diseases 0.000 description 1
208000006050 Hemangiopericytoma Diseases 0.000 description 1
208000001258 Hemangiosarcoma Diseases 0.000 description 1
RXVOMIADLXPJGW-GUBZILKMSA-N His-Asp-Glu Chemical compound [H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O RXVOMIADLXPJGW-GUBZILKMSA-N 0.000 description 1
LYCVKHSJGDMDLM-LURJTMIESA-N His-Gly Chemical compound OC(=O)CNC(=O)[C@@H](N)CC1=CN=CN1 LYCVKHSJGDMDLM-LURJTMIESA-N 0.000 description 1
208000002291 Histiocytic Sarcoma Diseases 0.000 description 1
208000021519 Hodgkin lymphoma Diseases 0.000 description 1
101000690301 Homo sapiens Aldo-keto reductase family 1 member C4 Proteins 0.000 description 1
101000678879 Homo sapiens Atypical chemokine receptor 1 Proteins 0.000 description 1
101000736088 Homo sapiens PC4 and SFRS1-interacting protein Proteins 0.000 description 1
101001116548 Homo sapiens Protein CBFA2T1 Proteins 0.000 description 1
101001074035 Homo sapiens Zinc finger protein GLI2 Proteins 0.000 description 1
108010001336 Horseradish Peroxidase Proteins 0.000 description 1
CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical class Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 1
206010048643 Hypereosinophilic syndrome Diseases 0.000 description 1
RENBRDSDKPSRIH-HJWJTTGWSA-N Ile-Phe-Met Chemical compound N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCSC)C(=O)O RENBRDSDKPSRIH-HJWJTTGWSA-N 0.000 description 1
102000009786 Immunoglobulin Constant Regions Human genes 0.000 description 1
108010009817 Immunoglobulin Constant Regions Proteins 0.000 description 1
108700005091 Immunoglobulin Genes Proteins 0.000 description 1
102000016844 Immunoglobulin-like domains Human genes 0.000 description 1
108050006430 Immunoglobulin-like domains Proteins 0.000 description 1
208000007866 Immunoproliferative Small Intestinal Disease Diseases 0.000 description 1
208000026350 Inborn Genetic disease Diseases 0.000 description 1
206010061218 Inflammation Diseases 0.000 description 1
108010001127 Insulin Receptor Proteins 0.000 description 1
102100036721 Insulin receptor Human genes 0.000 description 1
102000019223 Interleukin-1 receptor Human genes 0.000 description 1
108050006617 Interleukin-1 receptor Proteins 0.000 description 1
102000000588 Interleukin-2 Human genes 0.000 description 1
108010002350 Interleukin-2 Proteins 0.000 description 1
102000010789 Interleukin-2 Receptors Human genes 0.000 description 1
108010038453 Interleukin-2 Receptors Proteins 0.000 description 1
108010002386 Interleukin-3 Proteins 0.000 description 1
101150021395 JUND gene Proteins 0.000 description 1
201000008869 Juxtacortical Osteosarcoma Diseases 0.000 description 1
244000285963 Kluyveromyces fragilis Species 0.000 description 1
235000014663 Kluyveromyces fragilis Nutrition 0.000 description 1
241001138401 Kluyveromyces lactis Species 0.000 description 1
241000235058 Komagataella pastoris Species 0.000 description 1
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 description 1
ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
JTTHKOPSMAVJFE-VIFPVBQESA-N L-homophenylalanine Chemical compound OC(=O)[C@@H](N)CCC1=CC=CC=C1 JTTHKOPSMAVJFE-VIFPVBQESA-N 0.000 description 1
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 description 1
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
TYYLDKGBCJGJGW-UHFFFAOYSA-N L-tryptophan-L-tyrosine Natural products C=1NC2=CC=CC=C2C=1CC(N)C(=O)NC(C(O)=O)CC1=CC=C(O)C=C1 TYYLDKGBCJGJGW-UHFFFAOYSA-N 0.000 description 1
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
108010001831 LDL receptors Proteins 0.000 description 1
102000000853 LDL receptors Human genes 0.000 description 1
241000194034 Lactococcus lactis subsp. cremoris Species 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
208000018142 Leiomyosarcoma Diseases 0.000 description 1
201000004462 Leydig Cell Tumor Diseases 0.000 description 1
WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
208000000265 Lobular Carcinoma Diseases 0.000 description 1
108060001084 Luciferase Proteins 0.000 description 1
239000005089 Luciferase Substances 0.000 description 1
YKIRNDPUWONXQN-GUBZILKMSA-N Lys-Asn-Gln Chemical compound C(CCN)C[C@@H](C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)O)N YKIRNDPUWONXQN-GUBZILKMSA-N 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
208000035771 Malignant Sertoli-Leydig cell tumor of the ovary Diseases 0.000 description 1
208000007054 Medullary Carcinoma Diseases 0.000 description 1
102000018697 Membrane Proteins Human genes 0.000 description 1
108010052285 Membrane Proteins Proteins 0.000 description 1
208000002030 Merkel cell carcinoma Diseases 0.000 description 1
201000009574 Mesenchymal Chondrosarcoma Diseases 0.000 description 1
206010054949 Metaplasia Diseases 0.000 description 1
206010027476 Metastases Diseases 0.000 description 1
229920000168 Microcrystalline cellulose Polymers 0.000 description 1
206010057269 Mucoepidermoid carcinoma Diseases 0.000 description 1
208000010357 Mullerian Mixed Tumor Diseases 0.000 description 1
241000699660 Mus musculus Species 0.000 description 1
101001002507 Mus musculus Immunoglobulin-binding protein 1 Proteins 0.000 description 1
KWYHDKDOAIKMQN-UHFFFAOYSA-N N,N,N',N'-tetramethylethylenediamine Chemical compound CN(C)CCN(C)C KWYHDKDOAIKMQN-UHFFFAOYSA-N 0.000 description 1
NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical class ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 description 1
RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 description 1
229930193140 Neomycin Natural products 0.000 description 1
108010025020 Nerve Growth Factor Proteins 0.000 description 1
102000007072 Nerve Growth Factors Human genes 0.000 description 1
206010029260 Neuroblastoma Diseases 0.000 description 1
241000221960 Neurospora Species 0.000 description 1
208000007256 Nevus Diseases 0.000 description 1
GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
108010077850 Nuclear Localization Signals Proteins 0.000 description 1
108091007494 Nucleic acid- binding domains Proteins 0.000 description 1
230000004989 O-glycosylation Effects 0.000 description 1
GVOIQSXBMLNCLC-UHFFFAOYSA-N OOOS Chemical compound OOOS GVOIQSXBMLNCLC-UHFFFAOYSA-N 0.000 description 1
208000007871 Odontogenic Tumors Diseases 0.000 description 1
BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
208000010191 Osteitis Deformans Diseases 0.000 description 1
206010073261 Ovarian theca cell tumour Diseases 0.000 description 1
208000027868 Paget disease Diseases 0.000 description 1
241001494479 Pecora Species 0.000 description 1
108010067902 Peptide Library Proteins 0.000 description 1
BQMFWUKNOCJDNV-HJWJTTGWSA-N Phe-Val-Ile Chemical compound [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O BQMFWUKNOCJDNV-HJWJTTGWSA-N 0.000 description 1
102000045595 Phosphoprotein Phosphatases Human genes 0.000 description 1
108700019535 Phosphoprotein Phosphatases Proteins 0.000 description 1
241000235648 Pichia Species 0.000 description 1
208000009077 Pigmented Nevus Diseases 0.000 description 1
208000019262 Pilomatrix carcinoma Diseases 0.000 description 1
208000007641 Pinealoma Diseases 0.000 description 1
208000002151 Pleural effusion Diseases 0.000 description 1
229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
239000004952 Polyamide Substances 0.000 description 1
229920002732 Polyanhydride Polymers 0.000 description 1
229920001710 Polyorthoester Polymers 0.000 description 1
239000004743 Polypropylene Substances 0.000 description 1
102100033237 Pro-epidermal growth factor Human genes 0.000 description 1
108010001267 Protein Subunits Proteins 0.000 description 1
102000002067 Protein Subunits Human genes 0.000 description 1
108010001859 Proto-Oncogene Proteins c-rel Proteins 0.000 description 1
102000000850 Proto-Oncogene Proteins c-rel Human genes 0.000 description 1
101000762949 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) Exotoxin A Proteins 0.000 description 1
238000012341 Quantitative reverse-transcriptase PCR Methods 0.000 description 1
IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 description 1
108020004518 RNA Probes Proteins 0.000 description 1
239000003391 RNA probe Substances 0.000 description 1
208000007660 Residual Neoplasm Diseases 0.000 description 1
201000000582 Retinoblastoma Diseases 0.000 description 1
108700025701 Retinoblastoma Genes Proteins 0.000 description 1
102000006382 Ribonucleases Human genes 0.000 description 1
108010083644 Ribonucleases Proteins 0.000 description 1
241000710942 Ross River virus Species 0.000 description 1
102000000395 SH3 domains Human genes 0.000 description 1
108050008861 SH3 domains Proteins 0.000 description 1
206010039491 Sarcoma Diseases 0.000 description 1
241000710961 Semliki Forest virus Species 0.000 description 1
206010040070 Septic Shock Diseases 0.000 description 1
101710113029 Serine/threonine-protein kinase Proteins 0.000 description 1
208000000097 Sertoli-Leydig cell tumor Diseases 0.000 description 1
108010071390 Serum Albumin Proteins 0.000 description 1
102000007562 Serum Albumin Human genes 0.000 description 1
208000003252 Signet Ring Cell Carcinoma Diseases 0.000 description 1
BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 1
241000710960 Sindbis virus Species 0.000 description 1
108020004682 Single-Stranded DNA Proteins 0.000 description 1
208000009574 Skin Appendage Carcinoma Diseases 0.000 description 1
108010017622 Somatomedin Receptors Proteins 0.000 description 1
102000004584 Somatomedin Receptors Human genes 0.000 description 1
101000582398 Staphylococcus aureus Replication initiation protein Proteins 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
235000014962 Streptococcus cremoris Nutrition 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
241000282887 Suidae Species 0.000 description 1
101000930762 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) Signal recognition particle receptor FtsY Proteins 0.000 description 1
206010042553 Superficial spreading melanoma stage unspecified Diseases 0.000 description 1
108091008874 T cell receptors Proteins 0.000 description 1
230000005867 T cell response Effects 0.000 description 1
102000016266 T-Cell Antigen Receptors Human genes 0.000 description 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
239000004098 Tetracycline Substances 0.000 description 1
RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical class OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 description 1
GQPQJNMVELPZNQ-GBALPHGKSA-N Thr-Ser-Trp Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)O)N)O GQPQJNMVELPZNQ-GBALPHGKSA-N 0.000 description 1
201000009365 Thymic carcinoma Diseases 0.000 description 1
108010034949 Thyroglobulin Proteins 0.000 description 1
102000009843 Thyroglobulin Human genes 0.000 description 1
206010044248 Toxic shock syndrome Diseases 0.000 description 1
231100000650 Toxic shock syndrome Toxicity 0.000 description 1
108010033576 Transferrin Receptors Proteins 0.000 description 1
102000007238 Transferrin Receptors Human genes 0.000 description 1
HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
229940122618 Trypsin inhibitor Drugs 0.000 description 1
101710162629 Trypsin inhibitor Proteins 0.000 description 1
102000004243 Tubulin Human genes 0.000 description 1
108090000704 Tubulin Proteins 0.000 description 1
206010054094 Tumour necrosis Diseases 0.000 description 1
LUMQYLVYUIRHHU-YJRXYDGGSA-N Tyr-Ser-Thr Chemical compound [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(O)=O LUMQYLVYUIRHHU-YJRXYDGGSA-N 0.000 description 1
FZADUTOCSFDBRV-RNXOBYDBSA-N Tyr-Tyr-Trp Chemical compound C([C@H](N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)C1=CC=C(O)C=C1 FZADUTOCSFDBRV-RNXOBYDBSA-N 0.000 description 1
GVJUTBOZZBTBIG-AVGNSLFASA-N Val-Lys-Arg Chemical compound CC(C)[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)N GVJUTBOZZBTBIG-AVGNSLFASA-N 0.000 description 1
241000710959 Venezuelan equine encephalitis virus Species 0.000 description 1
241000251539 Vertebrata <Metazoa> Species 0.000 description 1
JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 description 1
208000036142 Viral infection Diseases 0.000 description 1
208000008383 Wilms tumor Diseases 0.000 description 1
206010052428 Wound Diseases 0.000 description 1
208000027418 Wounds and injury Diseases 0.000 description 1
241000235015 Yarrowia lipolytica Species 0.000 description 1
240000008042 Zea mays Species 0.000 description 1
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
235000002017 Zea mays subsp mays Nutrition 0.000 description 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
102100035558 Zinc finger protein GLI2 Human genes 0.000 description 1
230000002159 abnormal effect Effects 0.000 description 1
150000001242 acetic acid derivatives Chemical class 0.000 description 1
208000006336 acinar cell carcinoma Diseases 0.000 description 1
RJURFGZVJUQBHK-IIXSONLDSA-N actinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-IIXSONLDSA-N 0.000 description 1
230000036982 action potential Effects 0.000 description 1
239000012190 activator Substances 0.000 description 1
239000013543 active substance Substances 0.000 description 1
208000021841 acute erythroid leukemia Diseases 0.000 description 1
230000010933 acylation Effects 0.000 description 1
238000005917 acylation reaction Methods 0.000 description 1
239000000654 additive Substances 0.000 description 1
208000002517 adenoid cystic carcinoma Diseases 0.000 description 1
229960005305 adenosine Drugs 0.000 description 1
201000008395 adenosquamous carcinoma Diseases 0.000 description 1
108060000200 adenylate cyclase Proteins 0.000 description 1
102000030621 adenylate cyclase Human genes 0.000 description 1
238000009098 adjuvant therapy Methods 0.000 description 1
208000020990 adrenal cortex carcinoma Diseases 0.000 description 1
208000007128 adrenocortical carcinoma Diseases 0.000 description 1
238000001042 affinity chromatography Methods 0.000 description 1
238000001261 affinity purification Methods 0.000 description 1
230000032683 aging Effects 0.000 description 1
125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 description 1
PPQRONHOSHZGFQ-LMVFSUKVSA-N aldehydo-D-ribose 5-phosphate Chemical group OP(=O)(O)OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PPQRONHOSHZGFQ-LMVFSUKVSA-N 0.000 description 1
125000000217 alkyl group Chemical group 0.000 description 1
239000002168 alkylating agent Substances 0.000 description 1
230000029936 alkylation Effects 0.000 description 1
238000005804 alkylation reaction Methods 0.000 description 1
108010004469 allophycocyanin Proteins 0.000 description 1
HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
206010065867 alveolar rhabdomyosarcoma Diseases 0.000 description 1
208000006431 amelanotic melanoma Diseases 0.000 description 1
208000010029 ameloblastoma Diseases 0.000 description 1
230000009435 amidation Effects 0.000 description 1
238000007112 amidation reaction Methods 0.000 description 1
229960003896 aminopterin Drugs 0.000 description 1
229960000723 ampicillin Drugs 0.000 description 1
AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
210000002255 anal canal Anatomy 0.000 description 1
230000036783 anaphylactic response Effects 0.000 description 1
208000003455 anaphylaxis Diseases 0.000 description 1
210000004102 animal cell Anatomy 0.000 description 1
239000010775 animal oil Substances 0.000 description 1
230000003302 anti-idiotype Effects 0.000 description 1
230000009830 antibody antigen interaction Effects 0.000 description 1
230000005875 antibody response Effects 0.000 description 1
210000000628 antibody-producing cell Anatomy 0.000 description 1
210000000436 anus Anatomy 0.000 description 1
201000007436 apocrine adenocarcinoma Diseases 0.000 description 1
230000006907 apoptotic process Effects 0.000 description 1
239000012736 aqueous medium Substances 0.000 description 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
108010062796 arginyllysine Proteins 0.000 description 1
125000003118 aryl group Chemical group 0.000 description 1
125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 description 1
201000005476 astroblastoma Diseases 0.000 description 1
230000003305 autocrine Effects 0.000 description 1
230000035578 autophosphorylation Effects 0.000 description 1
239000012752 auxiliary agent Substances 0.000 description 1
210000003719 b-lymphocyte Anatomy 0.000 description 1
201000007551 basophilic adenocarcinoma Diseases 0.000 description 1
208000001119 benign fibrous histiocytoma Diseases 0.000 description 1
235000010233 benzoic acid Nutrition 0.000 description 1
150000001558 benzoic acid derivatives Chemical class 0.000 description 1
102000005936 beta-Galactosidase Human genes 0.000 description 1
108010005774 beta-Galactosidase Proteins 0.000 description 1
IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
108091008324 binding proteins Proteins 0.000 description 1
230000001851 biosynthetic effect Effects 0.000 description 1
230000006696 biosynthetic metabolic pathway Effects 0.000 description 1
210000000601 blood cell Anatomy 0.000 description 1
238000009534 blood test Methods 0.000 description 1
210000001124 body fluid Anatomy 0.000 description 1
230000036760 body temperature Effects 0.000 description 1
210000000988 bone and bone Anatomy 0.000 description 1
201000011143 bone giant cell tumor Diseases 0.000 description 1
210000004556 brain Anatomy 0.000 description 1
210000000133 brain stem Anatomy 0.000 description 1
201000008274 breast adenocarcinoma Diseases 0.000 description 1
201000003714 breast lobular carcinoma Diseases 0.000 description 1
201000011054 breast malignant phyllodes tumor Diseases 0.000 description 1
210000000621 bronchi Anatomy 0.000 description 1
KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
210000004899 c-terminal region Anatomy 0.000 description 1
239000001110 calcium chloride Substances 0.000 description 1
229910001628 calcium chloride Inorganic materials 0.000 description 1
208000035269 cancer or benign tumor Diseases 0.000 description 1
230000000711 cancerogenic effect Effects 0.000 description 1
239000002775 capsule Substances 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
231100000315 carcinogenic Toxicity 0.000 description 1
208000002458 carcinoid tumor Diseases 0.000 description 1
239000005018 casein Substances 0.000 description 1
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
235000021240 caseins Nutrition 0.000 description 1
230000015556 catabolic process Effects 0.000 description 1
230000021164 cell adhesion Effects 0.000 description 1
230000033366 cell cycle process Effects 0.000 description 1
230000003915 cell function Effects 0.000 description 1
230000010261 cell growth Effects 0.000 description 1
230000022534 cell killing Effects 0.000 description 1
239000013592 cell lysate Substances 0.000 description 1
210000000170 cell membrane Anatomy 0.000 description 1
230000009134 cell regulation Effects 0.000 description 1
230000033077 cellular process Effects 0.000 description 1
230000036755 cellular response Effects 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
235000010980 cellulose Nutrition 0.000 description 1
230000002490 cerebral effect Effects 0.000 description 1
201000002891 ceruminous adenocarcinoma Diseases 0.000 description 1
208000024188 ceruminous carcinoma Diseases 0.000 description 1
210000003679 cervix uteri Anatomy 0.000 description 1
230000003196 chaotropic effect Effects 0.000 description 1
230000005591 charge neutralization Effects 0.000 description 1
238000010382 chemical cross-linking Methods 0.000 description 1
238000007385 chemical modification Methods 0.000 description 1
230000000973 chemotherapeutic effect Effects 0.000 description 1
238000002512 chemotherapy Methods 0.000 description 1
239000012829 chemotherapy agent Substances 0.000 description 1
229960005091 chloramphenicol Drugs 0.000 description 1
WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
208000006990 cholangiocarcinoma Diseases 0.000 description 1
201000005217 chondroblastoma Diseases 0.000 description 1
238000011098 chromatofocusing Methods 0.000 description 1
201000010240 chromophobe renal cell carcinoma Diseases 0.000 description 1
210000000349 chromosome Anatomy 0.000 description 1
208000021668 chronic eosinophilic leukemia Diseases 0.000 description 1
235000013985 cinnamic acid Nutrition 0.000 description 1
229930016911 cinnamic acid Natural products 0.000 description 1
DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 1
229960004316 cisplatin Drugs 0.000 description 1
235000015165 citric acid Nutrition 0.000 description 1
229960002173 citrulline Drugs 0.000 description 1
235000013477 citrulline Nutrition 0.000 description 1
208000029664 classic familial adenomatous polyposis Diseases 0.000 description 1
238000003776 cleavage reaction Methods 0.000 description 1
210000003419 coelomocyte Anatomy 0.000 description 1
229920001436 collagen Polymers 0.000 description 1
210000001072 colon Anatomy 0.000 description 1
239000003086 colorant Substances 0.000 description 1
208000011588 combined hepatocellular carcinoma and cholangiocarcinoma Diseases 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
238000012875 competitive assay Methods 0.000 description 1
230000009137 competitive binding Effects 0.000 description 1
230000002860 competitive effect Effects 0.000 description 1
239000003184 complementary RNA Substances 0.000 description 1
238000002591 computed tomography Methods 0.000 description 1
238000011254 conventional chemotherapy Methods 0.000 description 1
229920001577 copolymer Polymers 0.000 description 1
229910052802 copper Inorganic materials 0.000 description 1
239000010949 copper Substances 0.000 description 1
235000005822 corn Nutrition 0.000 description 1
230000002596 correlated effect Effects 0.000 description 1
239000003431 cross linking reagent Substances 0.000 description 1
239000013078 crystal Substances 0.000 description 1
238000012258 culturing Methods 0.000 description 1
208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 description 1
230000001351 cycling effect Effects 0.000 description 1
208000002445 cystadenocarcinoma Diseases 0.000 description 1
230000001086 cytosolic effect Effects 0.000 description 1
210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 1
231100000135 cytotoxicity Toxicity 0.000 description 1
230000003013 cytotoxicity Effects 0.000 description 1
229960000640 dactinomycin Drugs 0.000 description 1
230000006240 deamidation Effects 0.000 description 1
230000002950 deficient Effects 0.000 description 1
230000022811 deglycosylation Effects 0.000 description 1
238000006731 degradation reaction Methods 0.000 description 1
230000002939 deleterious effect Effects 0.000 description 1
238000002716 delivery method Methods 0.000 description 1
108010005905 delta-hGHR Proteins 0.000 description 1
210000004443 dendritic cell Anatomy 0.000 description 1
239000005547 deoxyribonucleotide Substances 0.000 description 1
125000002637 deoxyribonucleotide group Chemical group 0.000 description 1
230000008021 deposition Effects 0.000 description 1
238000001212 derivatisation Methods 0.000 description 1
238000013461 design Methods 0.000 description 1
230000000368 destabilizing effect Effects 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
230000001079 digestive effect Effects 0.000 description 1
210000002249 digestive system Anatomy 0.000 description 1
LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 description 1
229960005156 digoxin Drugs 0.000 description 1
LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 description 1
238000003113 dilution method Methods 0.000 description 1
238000006471 dimerization reaction Methods 0.000 description 1
NAGJZTKCGNOGPW-UHFFFAOYSA-K dioxido-sulfanylidene-sulfido-$l^{5}-phosphane Chemical compound [O-]P([O-])([S-])=S NAGJZTKCGNOGPW-UHFFFAOYSA-K 0.000 description 1
206010013023 diphtheria Diseases 0.000 description 1
BFMYDTVEBKDAKJ-UHFFFAOYSA-L disodium;(2',7'-dibromo-3',6'-dioxido-3-oxospiro[2-benzofuran-1,9'-xanthene]-4'-yl)mercury;hydrate Chemical compound O.[Na+].[Na+].O1C(=O)C2=CC=CC=C2C21C1=CC(Br)=C([O-])C([Hg])=C1OC1=C2C=C(Br)C([O-])=C1 BFMYDTVEBKDAKJ-UHFFFAOYSA-L 0.000 description 1
238000009826 distribution Methods 0.000 description 1
NAGJZTKCGNOGPW-UHFFFAOYSA-N dithiophosphoric acid Chemical class OP(O)(S)=S NAGJZTKCGNOGPW-UHFFFAOYSA-N 0.000 description 1
PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
238000009510 drug design Methods 0.000 description 1
239000003596 drug target Substances 0.000 description 1
210000000959 ear middle Anatomy 0.000 description 1
239000012636 effector Substances 0.000 description 1
210000002969 egg yolk Anatomy 0.000 description 1
230000005672 electromagnetic field Effects 0.000 description 1
238000001962 electrophoresis Methods 0.000 description 1
238000002337 electrophoretic mobility shift assay Methods 0.000 description 1
230000009881 electrostatic interaction Effects 0.000 description 1
201000009409 embryonal rhabdomyosarcoma Diseases 0.000 description 1
210000000750 endocrine system Anatomy 0.000 description 1
230000012202 endocytosis Effects 0.000 description 1
210000002889 endothelial cell Anatomy 0.000 description 1
230000002708 enhancing effect Effects 0.000 description 1
108010028531 enomycin Proteins 0.000 description 1
210000002919 epithelial cell Anatomy 0.000 description 1
201000010877 epithelioid cell melanoma Diseases 0.000 description 1
229960003276 erythromycin Drugs 0.000 description 1
210000003238 esophagus Anatomy 0.000 description 1
235000020776 essential amino acid Nutrition 0.000 description 1
239000003797 essential amino acid Substances 0.000 description 1
230000032050 esterification Effects 0.000 description 1
238000005886 esterification reaction Methods 0.000 description 1
CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 description 1
102000013165 exonuclease Human genes 0.000 description 1
210000002744 extracellular matrix Anatomy 0.000 description 1
229940012426 factor x Drugs 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
210000004996 female reproductive system Anatomy 0.000 description 1
201000001169 fibrillary astrocytoma Diseases 0.000 description 1
201000008825 fibrosarcoma of bone Diseases 0.000 description 1
239000000945 filler Substances 0.000 description 1
238000009093 first-line therapy Methods 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
238000000684 flow cytometry Methods 0.000 description 1
230000003325 follicular Effects 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
235000003599 food sweetener Nutrition 0.000 description 1
239000001530 fumaric acid Substances 0.000 description 1
235000011087 fumaric acid Nutrition 0.000 description 1
238000002825 functional assay Methods 0.000 description 1
210000000232 gallbladder Anatomy 0.000 description 1
208000015419 gastrin-producing neuroendocrine tumor Diseases 0.000 description 1
201000000052 gastrinoma Diseases 0.000 description 1
238000001879 gelation Methods 0.000 description 1
229960003297 gemtuzumab ozogamicin Drugs 0.000 description 1
238000003209 gene knockout Methods 0.000 description 1
238000010363 gene targeting Methods 0.000 description 1
208000016361 genetic disease Diseases 0.000 description 1
208000005017 glioblastoma Diseases 0.000 description 1
201000002264 glomangiosarcoma Diseases 0.000 description 1
125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 description 1
108010042598 glutamyl-aspartyl-glycine Proteins 0.000 description 1
201000007574 granular cell carcinoma Diseases 0.000 description 1
239000008187 granular material Substances 0.000 description 1
239000005090 green fluorescent protein Substances 0.000 description 1
201000009277 hairy cell leukemia Diseases 0.000 description 1
210000002443 helper t lymphocyte Anatomy 0.000 description 1
208000006359 hepatoblastoma Diseases 0.000 description 1
206010073071 hepatocellular carcinoma Diseases 0.000 description 1
231100000844 hepatocellular carcinoma Toxicity 0.000 description 1
229940022353 herceptin Drugs 0.000 description 1
125000004404 heteroalkyl group Chemical group 0.000 description 1
239000000833 heterodimer Substances 0.000 description 1
239000008241 heterogeneous mixture Substances 0.000 description 1
208000029824 high grade glioma Diseases 0.000 description 1
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
239000005556 hormone Substances 0.000 description 1
102000054751 human RUNX1T1 Human genes 0.000 description 1
150000003840 hydrochlorides Chemical class 0.000 description 1
239000000017 hydrogel Substances 0.000 description 1
125000001165 hydrophobic group Chemical group 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
230000033444 hydroxylation Effects 0.000 description 1
238000005805 hydroxylation reaction Methods 0.000 description 1
229960002591 hydroxyproline Drugs 0.000 description 1
206010020718 hyperplasia Diseases 0.000 description 1
210000003026 hypopharynx Anatomy 0.000 description 1
150000002463 imidates Chemical class 0.000 description 1
125000001841 imino group Chemical group [H]N=* 0.000 description 1
210000002865 immune cell Anatomy 0.000 description 1
210000000987 immune system Anatomy 0.000 description 1
230000000984 immunochemical effect Effects 0.000 description 1
238000010166 immunofluorescence Methods 0.000 description 1
230000009851 immunogenic response Effects 0.000 description 1
230000005847 immunogenicity Effects 0.000 description 1
239000000367 immunologic factor Substances 0.000 description 1
230000001024 immunotherapeutic effect Effects 0.000 description 1
230000002637 immunotoxin Effects 0.000 description 1
239000002596 immunotoxin Substances 0.000 description 1
229940051026 immunotoxin Drugs 0.000 description 1
231100000608 immunotoxin Toxicity 0.000 description 1
238000012606 in vitro cell culture Methods 0.000 description 1
238000012750 in vivo screening Methods 0.000 description 1
230000000415 inactivating effect Effects 0.000 description 1
231100000405 induce cancer Toxicity 0.000 description 1
230000002757 inflammatory effect Effects 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
230000028709 inflammatory response Effects 0.000 description 1
150000007529 inorganic bases Chemical class 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
238000002743 insertional mutagenesis Methods 0.000 description 1
238000007689 inspection Methods 0.000 description 1
230000008611 intercellular interaction Effects 0.000 description 1
102000002467 interleukin receptors Human genes 0.000 description 1
108010093036 interleukin receptors Proteins 0.000 description 1
230000000968 intestinal effect Effects 0.000 description 1
210000003228 intrahepatic bile duct Anatomy 0.000 description 1
239000007928 intraperitoneal injection Substances 0.000 description 1
230000002601 intratumoral effect Effects 0.000 description 1
206010073096 invasive lobular breast carcinoma Diseases 0.000 description 1
238000005342 ion exchange Methods 0.000 description 1
239000003456 ion exchange resin Substances 0.000 description 1
229920003303 ion-exchange polymer Polymers 0.000 description 1
229910052742 iron Inorganic materials 0.000 description 1
238000001155 isoelectric focusing Methods 0.000 description 1
238000002955 isolation Methods 0.000 description 1
125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 description 1
JJWLVOIRVHMVIS-UHFFFAOYSA-N isopropylamine Chemical compound CC(C)N JJWLVOIRVHMVIS-UHFFFAOYSA-N 0.000 description 1
230000000155 isotopic effect Effects 0.000 description 1
229950003188 isovaleryl diethylamide Drugs 0.000 description 1
229960000318 kanamycin Drugs 0.000 description 1
229930027917 kanamycin Natural products 0.000 description 1
SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
229930182823 kanamycin A Natural products 0.000 description 1
108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 1
208000022013 kidney Wilms tumor Diseases 0.000 description 1
238000002372 labelling Methods 0.000 description 1
239000008101 lactose Substances 0.000 description 1
229910052747 lanthanoid Inorganic materials 0.000 description 1
150000002602 lanthanoids Chemical class 0.000 description 1
210000000867 larynx Anatomy 0.000 description 1
102000005861 leptin receptors Human genes 0.000 description 1
108010019813 leptin receptors Proteins 0.000 description 1
125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
210000004901 leucine-rich repeat Anatomy 0.000 description 1
210000000265 leukocyte Anatomy 0.000 description 1
230000000670 limiting effect Effects 0.000 description 1
125000003473 lipid group Chemical group 0.000 description 1
206010024627 liposarcoma Diseases 0.000 description 1
239000006193 liquid solution Substances 0.000 description 1
239000006194 liquid suspension Substances 0.000 description 1
229910052744 lithium Inorganic materials 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
230000007774 longterm Effects 0.000 description 1
239000006210 lotion Substances 0.000 description 1
231100000053 low toxicity Toxicity 0.000 description 1
HWYHZTIRURJOHG-UHFFFAOYSA-N luminol Chemical compound O=C1NNC(=O)C2=C1C(N)=CC=C2 HWYHZTIRURJOHG-UHFFFAOYSA-N 0.000 description 1
201000000014 lung giant cell carcinoma Diseases 0.000 description 1
210000002751 lymph Anatomy 0.000 description 1
210000004880 lymph fluid Anatomy 0.000 description 1
210000001165 lymph node Anatomy 0.000 description 1
208000012804 lymphangiosarcoma Diseases 0.000 description 1
230000001926 lymphatic effect Effects 0.000 description 1
230000000527 lymphocytic effect Effects 0.000 description 1
201000010953 lymphoepithelioma-like carcinoma Diseases 0.000 description 1
208000025036 lymphosarcoma Diseases 0.000 description 1
125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
230000002101 lytic effect Effects 0.000 description 1
229920002521 macromolecule Polymers 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
159000000003 magnesium salts Chemical class 0.000 description 1
239000000696 magnetic material Substances 0.000 description 1
238000002595 magnetic resonance imaging Methods 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
210000004995 male reproductive system Anatomy 0.000 description 1
208000018013 malignant glomus tumor Diseases 0.000 description 1
201000004102 malignant granular cell myoblastoma Diseases 0.000 description 1
201000006812 malignant histiocytosis Diseases 0.000 description 1
206010061526 malignant mesenchymoma Diseases 0.000 description 1
201000009020 malignant peripheral nerve sheath tumor Diseases 0.000 description 1
201000000289 malignant teratoma Diseases 0.000 description 1
150000002690 malonic acid derivatives Chemical class 0.000 description 1
208000027202 mammary Paget disease Diseases 0.000 description 1
238000007726 management method Methods 0.000 description 1
229960002510 mandelic acid Drugs 0.000 description 1
238000004949 mass spectrometry Methods 0.000 description 1
208000000516 mast-cell leukemia Diseases 0.000 description 1
201000008749 mast-cell sarcoma Diseases 0.000 description 1
238000005259 measurement Methods 0.000 description 1
238000011326 mechanical measurement Methods 0.000 description 1
210000001370 mediastinum Anatomy 0.000 description 1
239000002609 medium Substances 0.000 description 1
208000023356 medullary thyroid gland carcinoma Diseases 0.000 description 1
230000008018 melting Effects 0.000 description 1
206010027191 meningioma Diseases 0.000 description 1
210000000713 mesentery Anatomy 0.000 description 1
230000015689 metaplastic ossification Effects 0.000 description 1
229940098779 methanesulfonic acid Drugs 0.000 description 1
229960000485 methotrexate Drugs 0.000 description 1
YCXSYMVGMXQYNT-UHFFFAOYSA-N methyl 3-[(4-azidophenyl)disulfanyl]propanimidate Chemical compound COC(=N)CCSSC1=CC=C(N=[N+]=[N-])C=C1 YCXSYMVGMXQYNT-UHFFFAOYSA-N 0.000 description 1
WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
YACKEPLHDIMKIO-UHFFFAOYSA-N methylphosphonic acid Chemical compound CP(O)(O)=O YACKEPLHDIMKIO-UHFFFAOYSA-N 0.000 description 1
239000011325 microbead Substances 0.000 description 1
235000019813 microcrystalline cellulose Nutrition 0.000 description 1
239000008108 microcrystalline cellulose Substances 0.000 description 1
229940016286 microcrystalline cellulose Drugs 0.000 description 1
210000003632 microfilament Anatomy 0.000 description 1
239000004005 microsphere Substances 0.000 description 1
210000000110 microvilli Anatomy 0.000 description 1
235000013336 milk Nutrition 0.000 description 1
210000004080 milk Anatomy 0.000 description 1
239000008267 milk Substances 0.000 description 1
230000003278 mimic effect Effects 0.000 description 1
239000011707 mineral Substances 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
239000003226 mitogen Substances 0.000 description 1
201000010225 mixed cell type cancer Diseases 0.000 description 1
208000029638 mixed neoplasm Diseases 0.000 description 1
238000000302 molecular modelling Methods 0.000 description 1
229940035032 monophosphoryl lipid a Drugs 0.000 description 1
229940126619 mouse monoclonal antibody Drugs 0.000 description 1
201000010879 mucinous adenocarcinoma Diseases 0.000 description 1
208000010492 mucinous cystadenocarcinoma Diseases 0.000 description 1
238000002887 multiple sequence alignment Methods 0.000 description 1
230000000869 mutational effect Effects 0.000 description 1
201000005962 mycosis fungoides Diseases 0.000 description 1
201000005987 myeloid sarcoma Diseases 0.000 description 1
208000001611 myxosarcoma Diseases 0.000 description 1
229940022007 naked DNA vaccine Drugs 0.000 description 1
210000003928 nasal cavity Anatomy 0.000 description 1
208000014761 nasopharyngeal type undifferentiated carcinoma Diseases 0.000 description 1
210000001989 nasopharynx Anatomy 0.000 description 1
230000001338 necrotic effect Effects 0.000 description 1
229960004927 neomycin Drugs 0.000 description 1
230000010309 neoplastic transformation Effects 0.000 description 1
201000008026 nephroblastoma Diseases 0.000 description 1
208000007538 neurilemmoma Diseases 0.000 description 1
230000004770 neurodegeneration Effects 0.000 description 1
208000027831 neuroepithelial neoplasm Diseases 0.000 description 1
208000029974 neurofibrosarcoma Diseases 0.000 description 1
230000001272 neurogenic effect Effects 0.000 description 1
239000003900 neurotrophic factor Substances 0.000 description 1
238000006386 neutralization reaction Methods 0.000 description 1
230000003472 neutralizing effect Effects 0.000 description 1
239000002547 new drug Substances 0.000 description 1
229910017604 nitric acid Inorganic materials 0.000 description 1
230000036963 noncompetitive effect Effects 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
238000007826 nucleic acid assay Methods 0.000 description 1
208000027825 odontogenic neoplasm Diseases 0.000 description 1
235000014593 oils and fats Nutrition 0.000 description 1
239000002674 ointment Substances 0.000 description 1
229940124276 oligodeoxyribonucleotide Drugs 0.000 description 1
238000002515 oligonucleotide synthesis Methods 0.000 description 1
210000002747 omentum Anatomy 0.000 description 1
231100000590 oncogenic Toxicity 0.000 description 1
230000002246 oncogenic effect Effects 0.000 description 1
210000003463 organelle Anatomy 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
210000003300 oropharynx Anatomy 0.000 description 1
230000003204 osmotic effect Effects 0.000 description 1
201000008968 osteosarcoma Diseases 0.000 description 1
230000002611 ovarian Effects 0.000 description 1
208000012221 ovarian Sertoli-Leydig cell tumor Diseases 0.000 description 1
235000006408 oxalic acid Nutrition 0.000 description 1
125000004043 oxo group Chemical group O=* 0.000 description 1
239000006179 pH buffering agent Substances 0.000 description 1
230000000242 pagocytic effect Effects 0.000 description 1
210000002741 palatine tonsil Anatomy 0.000 description 1
210000000496 pancreas Anatomy 0.000 description 1
FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
208000004019 papillary adenocarcinoma Diseases 0.000 description 1
201000010198 papillary carcinoma Diseases 0.000 description 1
201000010210 papillary cystadenocarcinoma Diseases 0.000 description 1
208000024641 papillary serous cystadenocarcinoma Diseases 0.000 description 1
201000001494 papillary transitional carcinoma Diseases 0.000 description 1
208000031101 papillary transitional cell carcinoma Diseases 0.000 description 1
230000003076 paracrine Effects 0.000 description 1
230000001717 pathogenic effect Effects 0.000 description 1
230000001575 pathological effect Effects 0.000 description 1
230000037361 pathway Effects 0.000 description 1
230000035515 penetration Effects 0.000 description 1
210000003899 penis Anatomy 0.000 description 1
239000000816 peptidomimetic Substances 0.000 description 1
210000005105 peripheral blood lymphocyte Anatomy 0.000 description 1
210000001322 periplasm Anatomy 0.000 description 1
210000004303 peritoneum Anatomy 0.000 description 1
238000002823 phage display Methods 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
108010076042 phenomycin Proteins 0.000 description 1
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
125000000405 phenylalanyl group Chemical group 0.000 description 1
208000028591 pheochromocytoma Diseases 0.000 description 1
PHEDXBVPIONUQT-RGYGYFBISA-N phorbol 13-acetate 12-myristate Chemical compound C([C@]1(O)C(=O)C(C)=C[C@H]1[C@@]1(O)[C@H](C)[C@H]2OC(=O)CCCCCCCCCCCCC)C(CO)=C[C@H]1[C@H]1[C@]2(OC(C)=O)C1(C)C PHEDXBVPIONUQT-RGYGYFBISA-N 0.000 description 1
239000002644 phorbol ester Substances 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
235000021317 phosphate Nutrition 0.000 description 1
PTMHPRAIXMAOOB-UHFFFAOYSA-L phosphoramidate Chemical compound NP([O-])([O-])=O PTMHPRAIXMAOOB-UHFFFAOYSA-L 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
238000003566 phosphorylation assay Methods 0.000 description 1
230000000865 phosphorylative effect Effects 0.000 description 1
238000000206 photolithography Methods 0.000 description 1
230000004962 physiological condition Effects 0.000 description 1
230000001766 physiological effect Effects 0.000 description 1
230000035479 physiological effects, processes and functions Effects 0.000 description 1
230000035790 physiological processes and functions Effects 0.000 description 1
239000006187 pill Substances 0.000 description 1
208000024724 pineal body neoplasm Diseases 0.000 description 1
201000004123 pineal gland cancer Diseases 0.000 description 1
208000021857 pituitary gland basophilic carcinoma Diseases 0.000 description 1
208000031223 plasma cell leukemia Diseases 0.000 description 1
239000013612 plasmid Substances 0.000 description 1
210000004224 pleura Anatomy 0.000 description 1
229920000729 poly(L-lysine) polymer Polymers 0.000 description 1
229920001308 poly(aminoacid) Polymers 0.000 description 1
229920002647 polyamide Polymers 0.000 description 1
239000004417 polycarbonate Substances 0.000 description 1
229920000515 polycarbonate Polymers 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
239000004633 polyglycolic acid Substances 0.000 description 1
239000004626 polylactic acid Substances 0.000 description 1
229920000193 polymethacrylate Polymers 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
229920001299 polypropylene fumarate Polymers 0.000 description 1
229920001451 polypropylene glycol Polymers 0.000 description 1
239000013641 positive control Substances 0.000 description 1
230000023603 positive regulation of transcription initiation, DNA-dependent Effects 0.000 description 1
230000029279 positive regulation of transcription, DNA-dependent Effects 0.000 description 1
150000003141 primary amines Chemical class 0.000 description 1
238000007639 printing Methods 0.000 description 1
230000010469 pro-virus integration Effects 0.000 description 1
238000012545 processing Methods 0.000 description 1
150000003148 prolines Chemical class 0.000 description 1
235000019260 propionic acid Nutrition 0.000 description 1
210000005267 prostate cell Anatomy 0.000 description 1
238000001742 protein purification Methods 0.000 description 1
230000002797 proteolythic effect Effects 0.000 description 1
201000008520 protoplasmic astrocytoma Diseases 0.000 description 1
230000002685 pulmonary effect Effects 0.000 description 1
150000003230 pyrimidines Chemical class 0.000 description 1
229940107700 pyruvic acid Drugs 0.000 description 1
238000010791 quenching Methods 0.000 description 1
230000000171 quenching effect Effects 0.000 description 1
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
239000002534 radiation-sensitizing agent Substances 0.000 description 1
238000002708 random mutagenesis Methods 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
102000027427 receptor guanylyl cyclases Human genes 0.000 description 1
108091008596 receptor guanylyl cyclases Proteins 0.000 description 1
210000000664 rectum Anatomy 0.000 description 1
230000025915 regulation of apoptotic process Effects 0.000 description 1
210000002345 respiratory system Anatomy 0.000 description 1
230000000284 resting effect Effects 0.000 description 1
210000000574 retroperitoneal space Anatomy 0.000 description 1
238000004007 reversed phase HPLC Methods 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
150000003290 ribose derivatives Chemical group 0.000 description 1
210000003705 ribosome Anatomy 0.000 description 1
108091092562 ribozyme Proteins 0.000 description 1
229960004641 rituximab Drugs 0.000 description 1
229960004889 salicylic acid Drugs 0.000 description 1
210000003296 saliva Anatomy 0.000 description 1
210000003079 salivary gland Anatomy 0.000 description 1
201000007416 salivary gland adenoid cystic carcinoma Diseases 0.000 description 1
238000005464 sample preparation method Methods 0.000 description 1
208000014212 sarcomatoid carcinoma Diseases 0.000 description 1
206010039667 schwannoma Diseases 0.000 description 1
230000007017 scission Effects 0.000 description 1
150000003335 secondary amines Chemical class 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
238000000926 separation method Methods 0.000 description 1
150000003355 serines Chemical class 0.000 description 1
210000000717 sertoli cell Anatomy 0.000 description 1
230000019491 signal transduction Effects 0.000 description 1
201000008123 signet ring cell adenocarcinoma Diseases 0.000 description 1
229910000077 silane Inorganic materials 0.000 description 1
229920002379 silicone rubber Polymers 0.000 description 1
238000002741 site-directed mutagenesis Methods 0.000 description 1
201000002078 skin pilomatrix carcinoma Diseases 0.000 description 1
208000000649 small cell carcinoma Diseases 0.000 description 1
210000000813 small intestine Anatomy 0.000 description 1
229940126586 small molecule drug Drugs 0.000 description 1
210000004872 soft tissue Anatomy 0.000 description 1
239000011343 solid material Substances 0.000 description 1
238000002764 solid phase assay Methods 0.000 description 1
239000006104 solid solution Substances 0.000 description 1
238000005063 solubilization Methods 0.000 description 1
230000007928 solubilization Effects 0.000 description 1
239000002195 soluble material Substances 0.000 description 1
210000001082 somatic cell Anatomy 0.000 description 1
230000037439 somatic mutation Effects 0.000 description 1
210000004989 spleen cell Anatomy 0.000 description 1
210000004988 splenocyte Anatomy 0.000 description 1
230000002269 spontaneous effect Effects 0.000 description 1
239000007921 spray Substances 0.000 description 1
206010041823 squamous cell carcinoma Diseases 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
210000000130 stem cell Anatomy 0.000 description 1
150000003431 steroids Chemical class 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
208000028210 stromal sarcoma Diseases 0.000 description 1
230000004960 subcellular localization Effects 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
125000000547 substituted alkyl group Chemical group 0.000 description 1
IIACRCGMVDHOTQ-UHFFFAOYSA-M sulfamate Chemical compound NS([O-])(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-M 0.000 description 1
150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
208000030457 superficial spreading melanoma Diseases 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
206010042863 synovial sarcoma Diseases 0.000 description 1
230000002194 synthesizing effect Effects 0.000 description 1
238000010189 synthetic method Methods 0.000 description 1
238000007910 systemic administration Methods 0.000 description 1
239000003826 tablet Substances 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
210000001138 tear Anatomy 0.000 description 1
230000002123 temporal effect Effects 0.000 description 1
150000003512 tertiary amines Chemical class 0.000 description 1
210000001550 testis Anatomy 0.000 description 1
229960002180 tetracycline Drugs 0.000 description 1
229930101283 tetracycline Natural products 0.000 description 1
235000019364 tetracycline Nutrition 0.000 description 1
150000003522 tetracyclines Chemical class 0.000 description 1
MUUHXGOJWVMBDY-UHFFFAOYSA-L tetrazolium blue Chemical compound [Cl-].[Cl-].COC1=CC(C=2C=C(OC)C(=CC=2)[N+]=2N(N=C(N=2)C=2C=CC=CC=2)C=2C=CC=CC=2)=CC=C1[N+]1=NC(C=2C=CC=CC=2)=NN1C1=CC=CC=C1 MUUHXGOJWVMBDY-UHFFFAOYSA-L 0.000 description 1
MPLHNVLQVRSVEE-UHFFFAOYSA-N texas red Chemical compound [O-]S(=O)(=O)C1=CC(S(Cl)(=O)=O)=CC=C1C(C1=CC=2CCCN3CCCC(C=23)=C1O1)=C2C1=C(CCC1)C3=[N+]1CCCC3=C2 MPLHNVLQVRSVEE-UHFFFAOYSA-N 0.000 description 1
208000001644 thecoma Diseases 0.000 description 1
239000010409 thin film Substances 0.000 description 1
125000003396 thiol group Chemical group [H]S* 0.000 description 1
235000008521 threonine Nutrition 0.000 description 1
229940104230 thymidine Drugs 0.000 description 1
210000001541 thymus gland Anatomy 0.000 description 1
229960002175 thyroglobulin Drugs 0.000 description 1
210000001685 thyroid gland Anatomy 0.000 description 1
208000030901 thyroid gland follicular carcinoma Diseases 0.000 description 1
208000015191 thyroid gland papillary and follicular carcinoma Diseases 0.000 description 1
238000011200 topical administration Methods 0.000 description 1
231100000167 toxic agent Toxicity 0.000 description 1
239000003440 toxic substance Substances 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
231100000041 toxicology testing Toxicity 0.000 description 1
208000029335 trabecular adenocarcinoma Diseases 0.000 description 1
210000003437 trachea Anatomy 0.000 description 1
FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
230000005030 transcription termination Effects 0.000 description 1
230000007704 transition Effects 0.000 description 1
206010044412 transitional cell carcinoma Diseases 0.000 description 1
230000005945 translocation Effects 0.000 description 1
238000011269 treatment regimen Methods 0.000 description 1
YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 1
239000002753 trypsin inhibitor Substances 0.000 description 1
125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 description 1
108010044292 tryptophyltyrosine Proteins 0.000 description 1
230000004565 tumor cell growth Effects 0.000 description 1
238000013060 ultrafiltration and diafiltration Methods 0.000 description 1
230000036967 uncompetitive effect Effects 0.000 description 1
241000701447 unidentified baculovirus Species 0.000 description 1
241001515965 unidentified phage Species 0.000 description 1
210000000626 ureter Anatomy 0.000 description 1
210000003932 urinary bladder Anatomy 0.000 description 1
229960005486 vaccine Drugs 0.000 description 1
210000001215 vagina Anatomy 0.000 description 1
125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
229960003048 vinblastine Drugs 0.000 description 1
JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
230000009385 viral infection Effects 0.000 description 1
210000003905 vulva Anatomy 0.000 description 1
238000001262 western blot Methods 0.000 description 1
229940075420 xanthine Drugs 0.000 description 1
210000005253 yeast cell Anatomy 0.000 description 1
239000011701 zinc Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1