CA2477835C - Method and system for high-throughput quantitation of small molecules using laser desorption and multiple-reaction-monitoring - Google Patents

Method and system for high-throughput quantitation of small molecules using laser desorption and multiple-reaction-monitoring Download PDF

Info

Publication number
CA2477835C
CA2477835C CA2477835A CA2477835A CA2477835C CA 2477835 C CA2477835 C CA 2477835C CA 2477835 A CA2477835 A CA 2477835A CA 2477835 A CA2477835 A CA 2477835A CA 2477835 C CA2477835 C CA 2477835C
Authority
CA
Canada
Prior art keywords
laser
ions
pulse rate
analyte
ion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2477835A
Other languages
English (en)
French (fr)
Other versions
CA2477835A1 (en
Inventor
Thomas R. Covey
John J. Corr
William H. Fisher
Tung Chau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DH Technologies Development Pte Ltd
Original Assignee
DH Technologies Development Pte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DH Technologies Development Pte Ltd filed Critical DH Technologies Development Pte Ltd
Publication of CA2477835A1 publication Critical patent/CA2477835A1/en
Application granted granted Critical
Publication of CA2477835C publication Critical patent/CA2477835C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/4205—Device types
    • H01J49/421—Mass filters, i.e. deviating unwanted ions without trapping
    • H01J49/4215—Quadrupole mass filters
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0031—Step by step routines describing the use of the apparatus
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0468—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample
    • H01J49/0481—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample with means for collisional cooling
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
    • H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)
CA2477835A 2002-03-28 2003-03-27 Method and system for high-throughput quantitation of small molecules using laser desorption and multiple-reaction-monitoring Expired - Fee Related CA2477835C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36819502P 2002-03-28 2002-03-28
US60/368,195 2002-03-28
PCT/IB2003/001915 WO2003083448A2 (en) 2002-03-28 2003-03-27 Method and system for high-throughput quantitation of small molecules using laser desorption and multiple-reaction-monitoring

Publications (2)

Publication Number Publication Date
CA2477835A1 CA2477835A1 (en) 2003-10-09
CA2477835C true CA2477835C (en) 2011-11-22

Family

ID=28675456

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2477835A Expired - Fee Related CA2477835C (en) 2002-03-28 2003-03-27 Method and system for high-throughput quantitation of small molecules using laser desorption and multiple-reaction-monitoring

Country Status (6)

Country Link
US (2) US20060151691A1 (enExample)
EP (1) EP1488446A2 (enExample)
JP (2) JP2005521874A (enExample)
AU (1) AU2003230093A1 (enExample)
CA (1) CA2477835C (enExample)
WO (1) WO2003083448A2 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7405397B2 (en) * 2002-03-28 2008-07-29 Mds Sciex Inc. Laser desorption ion source with ion guide coupling for ion mass spectroscopy
US7388194B2 (en) * 2002-03-28 2008-06-17 Mds Sciex Inc. Method and system for high-throughput quantitation using laser desorption and multiple-reaction-monitoring
GB0305796D0 (en) * 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
JP2007538262A (ja) * 2004-05-19 2007-12-27 アプレラ コーポレイション 質量分析を使用する発現の定量化
US20070054345A1 (en) * 2004-05-19 2007-03-08 Hunter Christie L Expression quantification using mass spectrometry
US20080206737A1 (en) * 2004-05-19 2008-08-28 Hunter Christie L Expression quantification using mass spectrometry
US20070037286A1 (en) * 2005-02-09 2007-02-15 Subhasish Purkayastha Thyroxine-containing compound analysis methods
US20060183238A1 (en) 2005-02-09 2006-08-17 Applera Corporation Amine-containing compound analysis methods
JP4830450B2 (ja) * 2005-11-02 2011-12-07 株式会社島津製作所 質量分析装置
US7423260B2 (en) * 2005-11-04 2008-09-09 Agilent Technologies, Inc. Apparatus for combined laser focusing and spot imaging for MALDI
EP1958233B1 (en) * 2005-12-07 2017-06-14 DH Technologies Development Pte. Ltd. Automated analysis of complex matrices using mass spectrometer
US7750312B2 (en) * 2006-03-07 2010-07-06 Dh Technologies Development Pte. Ltd. Method and apparatus for generating ions for mass analysis
US20070287160A1 (en) * 2006-04-21 2007-12-13 Chou Judy H Methods for high throughput screening of cell lines
EP2047244A1 (en) * 2006-07-19 2009-04-15 MDS Analytical Technologies, a business unit Of MDS Inc., doing busi. through its SCIEX div. Method of operating a mass spectrometer to provide resonant excitation ion transfer
EP2047243A4 (en) * 2006-07-19 2011-11-23 Mds Analytical Tech Bu Mds Inc DYNAMIC PICTURE PATTERN FOR USE WITH MALDI-MS
JP5227556B2 (ja) * 2007-09-06 2013-07-03 株式会社日立製作所 分析装置
US9274248B2 (en) * 2009-01-21 2016-03-01 Schlumberger Technology Corporation Downhole mass spectrometry
JP5454484B2 (ja) * 2011-01-31 2014-03-26 株式会社島津製作所 三連四重極型質量分析装置
ES2676829T3 (es) 2012-01-10 2018-07-25 Expression Pathology, Inc. Ensayo de SRM/MRM para la proteína receptor de insulina
CN103227096B (zh) * 2012-01-30 2016-06-22 华中师范大学 一种激光诱导电子捕获质谱解析离解脂质分子方法
EP2924425B1 (en) * 2012-11-22 2019-09-11 Shimadzu Corporation Tandem quadrupole mass spectrometer
US8624181B1 (en) * 2013-03-15 2014-01-07 Agilent Technologies, Inc. Controlling ion flux into time-of-flight mass spectrometers
CN105209896B (zh) * 2013-05-21 2019-06-28 Dh科技发展私人贸易有限公司 使用质谱法的物种检测
WO2016125120A1 (en) * 2015-02-06 2016-08-11 Dh Technologies Development Pte. Ltd. Lipid screening platform allowing a complete solution for lipidomics research
KR102618817B1 (ko) 2020-09-22 2023-12-27 세메스 주식회사 제조 공장에서 반송 차량을 제어하는 방법, 차량 제어 장치, 및 물품 반송 시스템

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331702B1 (en) * 1999-01-25 2001-12-18 University Of Manitoba Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
CA2227806C (en) * 1998-01-23 2006-07-18 University Of Manitoba Spectrometer provided with pulsed ion source and transmission device to damp ion motion and method of use
US6348688B1 (en) * 1998-02-06 2002-02-19 Perseptive Biosystems Tandem time-of-flight mass spectrometer with delayed extraction and method for use
US6507019B2 (en) * 1999-05-21 2003-01-14 Mds Inc. MS/MS scan methods for a quadrupole/time of flight tandem mass spectrometer
DE60044899D1 (de) 1999-06-11 2010-10-14 Applied Biosystems Llc Maldi ionenquelle mit gasimpuls, vorrichtung und verfahren zur ermittlung des molekulargewichtes labilen moleküle
DE10027794A1 (de) * 2000-06-07 2001-12-13 Basf Ag Verfahren zur Analyse Enzym-katalysierter Umsetzungen mit MALDI-TOF-Massenspektrometrie
US6747274B2 (en) * 2001-07-31 2004-06-08 Agilent Technologies, Inc. High throughput mass spectrometer with laser desorption ionization ion source

Also Published As

Publication number Publication date
AU2003230093A1 (en) 2003-10-13
JP2009282038A (ja) 2009-12-03
WO2003083448A3 (en) 2003-12-31
US20030213901A1 (en) 2003-11-20
CA2477835A1 (en) 2003-10-09
JP2005521874A (ja) 2005-07-21
AU2003230093A8 (en) 2003-10-13
US20060151691A1 (en) 2006-07-13
US6930305B2 (en) 2005-08-16
EP1488446A2 (en) 2004-12-22
WO2003083448A2 (en) 2003-10-09

Similar Documents

Publication Publication Date Title
CA2477835C (en) Method and system for high-throughput quantitation of small molecules using laser desorption and multiple-reaction-monitoring
JP2005521874A5 (enExample)
Krutchinsky et al. On the mature of the chemical noise in MALDI mass spectra
JP4564696B2 (ja) 不安定な分子の分子量を決定するための方法および装置
JP5198260B2 (ja) 質量スペクトル測定における複数イオン注入
US6809318B2 (en) Method of transmitting ions for mass spectroscopy
US7193206B2 (en) Ambient pressure matrix-assisted laser desorption ionization (MALDI) apparatus and method of analysis
DK1050061T4 (en) Spectrometer equipped with pulsed ion source and transmission device for attenuation of ion movement and method of use thereof
US20100237238A1 (en) Protein sequencing with maldi mass spectrometry
US20090039282A1 (en) Matrix-assisted laser desorption with high ionization yield
WO2013127262A1 (zh) 一种低压下产生分析用离子的方法和装置
US7405397B2 (en) Laser desorption ion source with ion guide coupling for ion mass spectroscopy
O’Connor et al. A high pressure matrix-assisted laser desorption ion source for Fourier transform mass spectrometry designed to accommodate large targets with diverse surfaces
US7388194B2 (en) Method and system for high-throughput quantitation using laser desorption and multiple-reaction-monitoring
WO1999001889A1 (en) Novel mass spectrometer
JP2005243426A (ja) 質量分析装置
GB2468394A (en) Pulsed laser system for MALDI mass spectrometry
GB2453407A (en) Matrix-assisted laser desorption with high ionization yield
Bush et al. Chapter 1: Introduction
Lehmann Do MALDI mass spectra reflect condensed-phase chemistry? and Development of a continuous-flow interface for MALDI mass spectrometry

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20140327