CA2470726C - Bicyclic n-arylamides - Google Patents
Bicyclic n-arylamides Download PDFInfo
- Publication number
- CA2470726C CA2470726C CA2470726A CA2470726A CA2470726C CA 2470726 C CA2470726 C CA 2470726C CA 2470726 A CA2470726 A CA 2470726A CA 2470726 A CA2470726 A CA 2470726A CA 2470726 C CA2470726 C CA 2470726C
- Authority
- CA
- Canada
- Prior art keywords
- salts
- solvates
- compounds
- general formula
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 125000002619 bicyclic group Chemical group 0.000 title abstract description 4
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- 150000001875 compounds Chemical class 0.000 claims description 49
- -1 1-Aza-bicyclo[3.2.1 ]octyl Chemical group 0.000 claims description 38
- 150000003839 salts Chemical class 0.000 claims description 25
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 15
- 239000001257 hydrogen Substances 0.000 claims description 15
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 10
- 229910052736 halogen Inorganic materials 0.000 claims description 9
- 150000002367 halogens Chemical class 0.000 claims description 9
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 8
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 8
- 125000001624 naphthyl group Chemical group 0.000 claims description 8
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 8
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 8
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 8
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims description 5
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims description 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 4
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 4
- 125000003354 benzotriazolyl group Chemical group N1N=NC2=C1C=CC=C2* 0.000 claims description 4
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10162375A DE10162375A1 (de) | 2001-12-19 | 2001-12-19 | Bicyclische N-Aryl-amide |
| DE10162375.5 | 2001-12-19 | ||
| PCT/EP2002/013835 WO2003051874A1 (de) | 2001-12-19 | 2002-12-06 | Bicyclische n-arylamide |
Publications (2)
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| CA2470726A1 CA2470726A1 (en) | 2003-06-26 |
| CA2470726C true CA2470726C (en) | 2012-01-31 |
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| CA2470726A Expired - Fee Related CA2470726C (en) | 2001-12-19 | 2002-12-06 | Bicyclic n-arylamides |
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| EP (1) | EP1458716B1 (OSRAM) |
| JP (1) | JP4690651B2 (OSRAM) |
| AU (1) | AU2002352221A1 (OSRAM) |
| CA (1) | CA2470726C (OSRAM) |
| DE (2) | DE10162375A1 (OSRAM) |
| ES (1) | ES2274114T3 (OSRAM) |
| WO (1) | WO2003051874A1 (OSRAM) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
| GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
| KR101129933B1 (ko) | 2002-09-25 | 2012-03-23 | 메모리 파마슈티칼스 코포레이션 | 인다졸, 벤조티아졸 및 벤조이소티아졸 및 그의 제조 및용도 |
| US20040157626A1 (en) * | 2003-02-10 | 2004-08-12 | Vincent Park | Paging methods and apparatus |
| US8196000B2 (en) * | 2003-04-02 | 2012-06-05 | Qualcomm Incorporated | Methods and apparatus for interleaving in a block-coherent communication system |
| US7434145B2 (en) * | 2003-04-02 | 2008-10-07 | Qualcomm Incorporated | Extracting soft information in a block-coherent communication system |
| DE10334724A1 (de) * | 2003-07-30 | 2005-02-24 | Bayer Healthcare Ag | N-Biarylamide |
| JP4824578B2 (ja) | 2003-12-22 | 2011-11-30 | メモリー・ファーマシューティカルズ・コーポレイション | インドール類、１，２−ベンズイソオキサゾール類、および１，２−ベンゾイソチアゾール類、ならびにそれらの製造と使用 |
| US7423164B2 (en) | 2003-12-31 | 2008-09-09 | Ut-Battelle, Llc | Synthesis of ionic liquids |
| JP4995075B2 (ja) | 2004-03-25 | 2012-08-08 | メモリー・ファーマシューティカルズ・コーポレイション | インダゾール、ベンゾチアゾール、ベンゾイソチアゾール、ベンズイソキサゾール、ならびにそれらの調製および使用 |
| JP2007534692A (ja) | 2004-04-22 | 2007-11-29 | メモリー・ファーマシューティカルズ・コーポレイション | インドール、１ｈ−インダゾール、１，２−ベンズイソキサゾール、１，２−ベンゾイソチアゾール、ならびにその調製および使用 |
| WO2005111038A2 (en) * | 2004-05-07 | 2005-11-24 | Memory Pharmaceuticals Corporation | 1h-indazoles, benzothiazoles, 1,2-benzoisoxazoles, 1,2-benzoisothiazoles, and chromones and preparation and uses thereof |
| PE20060437A1 (es) | 2004-06-18 | 2006-06-08 | Novartis Ag | COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR |
| GB0415746D0 (en) | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
| US7625924B2 (en) | 2004-12-22 | 2009-12-01 | Memory Pharmaceuticals Corporation | Nicotinic alpha-7 receptor ligands and preparation and uses thereof |
| JP2009509964A (ja) * | 2005-09-23 | 2009-03-12 | メモリー・ファーマシューティカルズ・コーポレイション | インダゾール類、ベンゾチアゾール類、ベンゾイソオキサゾール類、ピラゾロピリジン類、イソチアゾロピリジン類、およびそれらの製造と用途 |
| GB0521508D0 (en) | 2005-10-21 | 2005-11-30 | Novartis Ag | Organic compounds |
| GB0525673D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| GB0525672D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
| HUE037938T2 (hu) | 2008-11-19 | 2018-09-28 | Forum Pharmaceuticals Inc | Skizofrénia negatív tüneteinek kezelése (R)-7-klór-N-(kinuklidin-3-il)benzo[b]tiofén-2-karboxamiddal és ennek gyógyszerészetileg elfogadható sójával |
| JP5808319B2 (ja) * | 2009-05-11 | 2015-11-10 | フォルム ファーマシューティカルズ、インコーポレイテッド | アセチルコリンエステラーゼ阻害剤と組み合わせた特定のα７ニコチン酸受容体を用いた認知障害の治療 |
| ES2570657T3 (es) | 2010-05-17 | 2016-05-19 | Forum Pharmaceuticals Inc | Una forma cristalina de hidrocloruro de (R)-7-cloro-n-(quinuclidin-3-il)benzo[b]tiofeno-2-carboxamida monohidrato |
| WO2013169646A1 (en) | 2012-05-08 | 2013-11-14 | Envivo Pharmaceuticals, Inc. | Methods of maintaining, treating or improving cognitive function |
| MX2016017147A (es) * | 2014-06-20 | 2017-06-07 | Aurigene Discovery Tech Ltd | Compuestos de indazole substituidos como inhibidores de irak4. |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4605652A (en) * | 1985-02-04 | 1986-08-12 | A. H. Robins Company, Inc. | Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes |
| US5206235A (en) * | 1991-03-20 | 1993-04-27 | Merck & Co., Inc. | Benzo-fused lactams that promote the release of growth hormone |
| SE0000540D0 (sv) * | 2000-02-18 | 2000-02-18 | Astrazeneca Ab | New compounds |
| JP2004515462A (ja) * | 2000-06-28 | 2004-05-27 | ブリストル−マイヤーズ スクイブ カンパニー | 核ホルモン・レセプタ機能のモジュレーターとしての縮合環式化合物 |
| DE20013068U1 (de) * | 2000-07-27 | 2001-11-29 | AUTEFA Automation GmbH, 86316 Friedberg | Fördereinrichtung für Kannen in einem Kannenlager |
-
2001
- 2001-12-19 DE DE10162375A patent/DE10162375A1/de not_active Withdrawn
-
2002
- 2002-12-06 JP JP2003552758A patent/JP4690651B2/ja not_active Expired - Fee Related
- 2002-12-06 DE DE50208287T patent/DE50208287D1/de not_active Expired - Lifetime
- 2002-12-06 CA CA2470726A patent/CA2470726C/en not_active Expired - Fee Related
- 2002-12-06 EP EP02787913A patent/EP1458716B1/de not_active Expired - Lifetime
- 2002-12-06 US US10/497,511 patent/US7247728B2/en not_active Expired - Lifetime
- 2002-12-06 ES ES02787913T patent/ES2274114T3/es not_active Expired - Lifetime
- 2002-12-06 AU AU2002352221A patent/AU2002352221A1/en not_active Abandoned
- 2002-12-06 WO PCT/EP2002/013835 patent/WO2003051874A1/de not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002352221A1 (en) | 2003-06-30 |
| US20050107460A1 (en) | 2005-05-19 |
| JP2005517657A (ja) | 2005-06-16 |
| ES2274114T3 (es) | 2007-05-16 |
| JP4690651B2 (ja) | 2011-06-01 |
| DE50208287D1 (de) | 2006-11-09 |
| EP1458716B1 (de) | 2006-09-27 |
| CA2470726A1 (en) | 2003-06-26 |
| DE10162375A1 (de) | 2003-07-10 |
| EP1458716A1 (de) | 2004-09-22 |
| US7247728B2 (en) | 2007-07-24 |
| WO2003051874A1 (de) | 2003-06-26 |
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