JP4690651B2 - 二環式ｎ−アリールアミド類 - Google Patents

二環式ｎ−アリールアミド類 Download PDF

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Publication number
JP4690651B2
JP4690651B2 JP2003552758A JP2003552758A JP4690651B2 JP 4690651 B2 JP4690651 B2 JP 4690651B2 JP 2003552758 A JP2003552758 A JP 2003552758A JP 2003552758 A JP2003552758 A JP 2003552758A JP 4690651 B2 JP4690651 B2 JP 4690651B2
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JP
Japan
Prior art keywords
compounds
hydrogen
general formula
alkyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2003552758A
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English (en)
Japanese (ja)
Other versions
JP2005517657A (ja
JP2005517657A5 (OSRAM
Inventor
ヨアヒム・ルイトレ
フランク−ゲルハルト・ベース
クリスティーナ・エルプ
ティモ・フレスナー
マルティン・ヘンドリクス
マリア・ファン・カムペン
クリストフ・メトフェッセル
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Bayer Schering Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma AG filed Critical Bayer Schering Pharma AG
Publication of JP2005517657A publication Critical patent/JP2005517657A/ja
Publication of JP2005517657A5 publication Critical patent/JP2005517657A5/ja
Application granted granted Critical
Publication of JP4690651B2 publication Critical patent/JP4690651B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2003552758A 2001-12-19 2002-12-06 二環式ｎ−アリールアミド類 Expired - Fee Related JP4690651B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10162375.5 2001-12-19
DE10162375A DE10162375A1 (de) 2001-12-19 2001-12-19 Bicyclische N-Aryl-amide
PCT/EP2002/013835 WO2003051874A1 (de) 2001-12-19 2002-12-06 Bicyclische n-arylamide

Publications (3)

Publication Number Publication Date
JP2005517657A JP2005517657A (ja) 2005-06-16
JP2005517657A5 JP2005517657A5 (OSRAM) 2006-01-26
JP4690651B2 true JP4690651B2 (ja) 2011-06-01

Family

ID=7709793

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003552758A Expired - Fee Related JP4690651B2 (ja) 2001-12-19 2002-12-06 二環式ｎ−アリールアミド類

Country Status (8)

Country Link
US (1) US7247728B2 (OSRAM)
EP (1) EP1458716B1 (OSRAM)
JP (1) JP4690651B2 (OSRAM)
AU (1) AU2002352221A1 (OSRAM)
CA (1) CA2470726C (OSRAM)
DE (2) DE10162375A1 (OSRAM)
ES (1) ES2274114T3 (OSRAM)
WO (1) WO2003051874A1 (OSRAM)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
GB0220581D0 (en) 2002-09-04 2002-10-09 Novartis Ag Organic Compound
ES2405594T3 (es) * 2002-09-25 2013-05-31 Memory Pharmaceuticals Corporation Idazoles, benzotiazoles y benzisotiazoles, y preparación y usos de los mismos
US20040157626A1 (en) * 2003-02-10 2004-08-12 Vincent Park Paging methods and apparatus
US8196000B2 (en) * 2003-04-02 2012-06-05 Qualcomm Incorporated Methods and apparatus for interleaving in a block-coherent communication system
US7434145B2 (en) * 2003-04-02 2008-10-07 Qualcomm Incorporated Extracting soft information in a block-coherent communication system
DE10334724A1 (de) * 2003-07-30 2005-02-24 Bayer Healthcare Ag N-Biarylamide
EP1697378B1 (en) * 2003-12-22 2007-11-21 Memory Pharmaceuticals Corporation Indoles, 1h-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof
US7423164B2 (en) 2003-12-31 2008-09-09 Ut-Battelle, Llc Synthesis of ionic liquids
BRPI0508771A (pt) 2004-03-25 2007-08-14 Memory Pharm Corp indazóis, benzotiazóis, benzoisotiazóis, benzisoxazóis, e a preparação e usos dos mesmos
US7488737B2 (en) 2004-04-22 2009-02-10 Memory Pharmaceutical Corporation Indoles, 1H-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof
KR20070015607A (ko) 2004-05-07 2007-02-05 메모리 파마슈티칼스 코포레이션 1ｈ-인다졸, 벤조티아졸, 1,2-벤조이속사졸,1,2-벤조이소티아졸, 및 크로몬 및 그의 제조법 및 용도
PE20060437A1 (es) 2004-06-18 2006-06-08 Novartis Ag COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR
GB0415746D0 (en) 2004-07-14 2004-08-18 Novartis Ag Organic compounds
RU2418797C2 (ru) 2004-12-22 2011-05-20 Мемори Фармасьютиклз Корпорейшн Лиганды никотинового рецептора альфа-7, их получение и применение
KR20080048550A (ko) * 2005-09-23 2008-06-02 메모리 파마슈티칼스 코포레이션 인다졸, 벤조티아졸, 벤조이소티아졸, 벤즈이속사졸,피라졸로피리딘, 이소티아졸로피리딘, 및 이들의 제법 및용도
GB0521508D0 (en) 2005-10-21 2005-11-30 Novartis Ag Organic compounds
GB0525672D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
GB0525673D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
CA2744278C (en) 2008-11-19 2015-09-08 Envivo Pharmaceuticals, Inc. Treatment of cognitive disorders with (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and pharmaceutically acceptable salts thereof
RU2011150248A (ru) * 2009-05-11 2013-06-20 Энвиво Фармасьютикалз, Инк. Лечение когнитивных расстройств с определенными рецепторами альфа-7 никотиновой кислоты в комбинации с ингибиторами ацетилхолинэстеразы
CN103221411B (zh) 2010-05-17 2016-05-11 富瑞姆制药公司 (R)-7-氯-N-(奎宁环-3-基)苯并[b]噻吩-2-甲酰胺盐酸盐单水合物的晶型
CA2872005A1 (en) 2012-05-08 2013-11-14 Forum Pharmaceuticals, Inc. Methods of maintaining, treating or improving cognitive function
US20170152263A1 (en) * 2014-06-20 2017-06-01 Aurigene Discovery Technologies Limited Substituted Indazole Compounds as IRAK4 Inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4605652A (en) * 1985-02-04 1986-08-12 A. H. Robins Company, Inc. Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes
US5206235A (en) * 1991-03-20 1993-04-27 Merck & Co., Inc. Benzo-fused lactams that promote the release of growth hormone
SE0000540D0 (sv) * 2000-02-18 2000-02-18 Astrazeneca Ab New compounds
AU2002215609A1 (en) * 2000-06-28 2002-01-08 Bristol-Myers Squibb Company Fused cyclic compounds as modulators of nuclear hormone receptor function
DE20013068U1 (de) * 2000-07-27 2001-11-29 AUTEFA Automation GmbH, 86316 Friedberg Fördereinrichtung für Kannen in einem Kannenlager

Also Published As

Publication number Publication date
CA2470726C (en) 2012-01-31
JP2005517657A (ja) 2005-06-16
DE10162375A1 (de) 2003-07-10
ES2274114T3 (es) 2007-05-16
EP1458716A1 (de) 2004-09-22
US7247728B2 (en) 2007-07-24
WO2003051874A1 (de) 2003-06-26
AU2002352221A1 (en) 2003-06-30
DE50208287D1 (de) 2006-11-09
US20050107460A1 (en) 2005-05-19
EP1458716B1 (de) 2006-09-27
CA2470726A1 (en) 2003-06-26

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