CA2464994A1 - Method and device for the delivery of a substance - Google Patents

Method and device for the delivery of a substance Download PDF

Info

Publication number
CA2464994A1
CA2464994A1 CA002464994A CA2464994A CA2464994A1 CA 2464994 A1 CA2464994 A1 CA 2464994A1 CA 002464994 A CA002464994 A CA 002464994A CA 2464994 A CA2464994 A CA 2464994A CA 2464994 A1 CA2464994 A1 CA 2464994A1
Authority
CA
Canada
Prior art keywords
microabrader
skin
microprotrusions
substance
abrading
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002464994A
Other languages
English (en)
French (fr)
Inventor
John A. Mikszta
Ronald J. Pettis
Jason B. Alarcon
John M. Brittingham
John P. Dekker, Iii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2464994A1 publication Critical patent/CA2464994A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/54Chiropodists' instruments, e.g. pedicure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/32Surgical cutting instruments
    • A61B2017/320004Surgical cutting instruments abrasive
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023Drug applicators using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046Solid microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061Methods for using microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Coating Apparatus (AREA)
CA002464994A 2001-10-29 2002-10-29 Method and device for the delivery of a substance Abandoned CA2464994A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US33071301P 2001-10-29 2001-10-29
US60/330,713 2001-10-29
US33316201P 2001-11-27 2001-11-27
US60/333,162 2001-11-27
PCT/US2002/034504 WO2003051284A2 (en) 2001-10-29 2002-10-29 Method and device for the delivery of a substance

Publications (1)

Publication Number Publication Date
CA2464994A1 true CA2464994A1 (en) 2003-06-26

Family

ID=26987410

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002464994A Abandoned CA2464994A1 (en) 2001-10-29 2002-10-29 Method and device for the delivery of a substance

Country Status (12)

Country Link
US (1) US20030093040A1 (enExample)
EP (1) EP1439870B1 (enExample)
JP (1) JP2005511248A (enExample)
CN (1) CN1662266A (enExample)
AT (1) ATE420676T1 (enExample)
AU (1) AU2002365144A1 (enExample)
BR (1) BR0213686A (enExample)
CA (1) CA2464994A1 (enExample)
DE (1) DE60230894D1 (enExample)
ES (1) ES2319625T3 (enExample)
MX (1) MXPA04003953A (enExample)
WO (1) WO2003051284A2 (enExample)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6641591B1 (en) 1999-08-26 2003-11-04 John H. Shadduck Instruments and techniques for controlled removal of epidermal layers
CA2451816A1 (en) * 2001-06-29 2003-01-09 Becton, Dickinson And Company Intradermal delivery of vaccines and gene therapeutic agents via microcannula
US20060018877A1 (en) * 2001-06-29 2006-01-26 Mikszta John A Intradermal delivery of vacccines and therapeutic agents
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
JP4469610B2 (ja) * 2002-02-04 2010-05-26 ベクトン・ディキンソン・アンド・カンパニー 皮膚アクセス部材
MXPA05000597A (es) 2002-07-19 2005-04-28 3M Innovative Properties Co Dispositivos de microaguja y aparatos de administracion por microaguja.
US7422567B2 (en) * 2002-08-29 2008-09-09 Becton, Dickinson And Company Microabrader with controlled abrasion features
TW200518771A (en) * 2003-06-30 2005-06-16 Alza Corp Formulations for coated microprojections containing non-volatile counterions
WO2005020912A2 (en) * 2003-08-25 2005-03-10 3M Innovative Properties Company Delivery of immune response modifier compounds
CN100548228C (zh) * 2003-11-13 2009-10-14 阿尔扎公司 用于透皮递送的组合物和装置
EP1718452A1 (en) * 2004-02-23 2006-11-08 3M Innovative Properties Company Method of molding for microneedle arrays
SE0402100D0 (sv) * 2004-08-30 2004-08-30 Bonsens Ab Molded micro-needles
EP2995331B1 (en) 2004-09-10 2018-09-05 Becton, Dickinson and Company Reconstituting infusion device and method of reconstituting medicament
US20070053965A1 (en) * 2005-02-25 2007-03-08 Gruenenthal Gmbh Kit comprising a plaster, optionally containing an active substance, and an agent that at least partially reduces skin irritation
CA2620943A1 (en) * 2005-09-02 2007-03-08 Iomai Corporation Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs and uses thereof
DE102005044737A1 (de) * 2005-09-19 2007-03-29 Braun Gmbh Verfahren zum Entfernen von Haaren, Haarentfernungsgerät und Aufsatz hierfür
CA2629193C (en) 2005-11-18 2016-03-29 3M Innovative Properties Company Coatable compositions, coatings derived therefrom and microarrays having such coatings
WO2007064486A1 (en) * 2005-11-30 2007-06-07 3M Innovative Properties Company Microneedle arrays and methods of use thereof
US8048089B2 (en) 2005-12-30 2011-11-01 Edge Systems Corporation Apparatus and methods for treating the skin
US20090157094A1 (en) * 2006-01-12 2009-06-18 Nanopass Technologies Ltd. Device for superficial abrasive treatment of the skin
US10172644B2 (en) 2006-03-29 2019-01-08 Edge Systems Llc Devices, systems and methods for treating the skin
WO2014151104A1 (en) 2013-03-15 2014-09-25 Edge Systems Llc Devices, systems and methods for treating the skin
US9566088B2 (en) 2006-03-29 2017-02-14 Edge Systems Llc Devices, systems and methods for treating the skin
EP2021021A2 (en) * 2006-05-12 2009-02-11 Oklahoma Medical Research Foundation Anthrax compositions and methods of use and production
US20100030100A1 (en) * 2007-02-06 2010-02-04 Hisamitsu Pharmaceutical Co., Inc. Microneedle Device For Diagnosis Of Allergy
KR20100129269A (ko) 2008-01-04 2010-12-08 엣지 시스템즈 코포레이션 피부 처리 장치 및 방법
US9056193B2 (en) 2008-01-29 2015-06-16 Edge Systems Llc Apparatus and method for treating the skin
US20110159035A1 (en) * 2008-08-01 2011-06-30 Masahiro Goto S/o type transdermal immunizing agent
WO2011005894A1 (en) * 2009-07-07 2011-01-13 Naya Touch, Inc. Dermal roller with therapeutic microstructures
EP2451367B1 (en) 2009-07-08 2020-01-22 Edge Systems Corporation Devices for treating the skin using time-release substances
GB201007207D0 (en) * 2010-04-29 2010-06-16 Univ Cork Method
JP5788019B2 (ja) * 2011-11-18 2015-09-30 南部化成株式会社 経皮投薬装置
US9044582B2 (en) * 2012-06-26 2015-06-02 Franklin J. Chang Apparatus and method for transdermal fluid delivery
US10238812B2 (en) 2013-03-15 2019-03-26 Edge Systems Llc Skin treatment systems and methods using needles
US10194935B2 (en) * 2013-12-31 2019-02-05 L'oreal Shear-induced dermal infusion
WO2015148688A1 (en) * 2014-03-26 2015-10-01 Nanomed Skincare, Inc. Plunger-like mass transportation device for dermal and transdermal delivery of a liquid or solid composition
CN107708583B (zh) * 2014-12-18 2020-06-26 皇家飞利浦有限公司 微晶磨皮装置
EP3795204B1 (en) 2014-12-23 2023-10-25 HydraFacial LLC Device for treating the skin using a rollerball
US10179229B2 (en) 2014-12-23 2019-01-15 Edge Systems Llc Devices and methods for treating the skin using a porous member
KR102628349B1 (ko) 2015-07-08 2024-01-24 하이드라페이셜 엘엘씨 모발 성장을 촉진하기 위한 디바이스, 시스템 및 방법
CN108056845A (zh) * 2017-12-15 2018-05-22 深圳清华大学研究院 一种侧路腰椎椎间融合器
JP7562515B2 (ja) 2018-09-24 2024-10-07 クリスタル バイオテック インコーポレイテッド ネザートン症候群の治療のための組成物及び方法
US11291474B2 (en) 2020-01-06 2022-04-05 Ed F. Nicolas Skin treatment tool applicator tip
EP4294446A4 (en) * 2021-02-18 2024-12-04 Agonex Biopharmaceuticals, Inc. SYSTEMS, DEVICES AND FORMULATIONS FOR THE ADMINISTRATION OF FRACTIONATED HISTAMINE
USD1065551S1 (en) 2021-09-10 2025-03-04 Hydrafacial Llc Skin treatment device
USD1016615S1 (en) 2021-09-10 2024-03-05 Hydrafacial Llc Container for a skin treatment device
USD1042807S1 (en) 2021-10-11 2024-09-17 Hydrafacial Llc Skin treatment tip
GB2622416B (en) * 2022-09-15 2025-04-02 Ndm Tech Ltd Skin preparation device
USD1084369S1 (en) 2023-02-10 2025-07-15 Hydrafacial Llc Skin treatment tip
DE102024101897A1 (de) * 2024-01-23 2025-07-24 Gwenaël Bauer Dermabrasionswerkzeug mit auspressbarem Fluidbehälter

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3289670A (en) * 1964-03-09 1966-12-06 Milo Bundy Corp Device for abrading and applying biologicals to the skin of a patient
US3556080A (en) * 1968-04-08 1971-01-19 Lincoln Lab Inc Skin allergy testing device
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
OA05448A (fr) * 1975-10-16 1981-03-31 Manufrance Manufacture Francai Dispositif vaccinateur multipénétrant.
US4270548A (en) * 1979-09-05 1981-06-02 Aller-Screen, Inc. Allergy testing method
FR2474856A1 (fr) * 1980-01-31 1981-08-07 Merieux Inst Dispositif scarificateur
FR2498443B2 (fr) * 1981-01-26 1986-03-28 Merieux Inst Dispositif scarificateur
US4483348A (en) * 1982-03-25 1984-11-20 Nathan Sher Skin testing device
US4597764A (en) * 1983-09-28 1986-07-01 Bruce Black Ossicular replacement prosthesis
US4568343A (en) * 1984-10-09 1986-02-04 Alza Corporation Skin permeation enhancer compositions
US4746515A (en) * 1987-02-26 1988-05-24 Alza Corporation Skin permeation enhancer compositions using glycerol monolaurate
AU614092B2 (en) * 1987-09-11 1991-08-22 Paul Max Grinwald Improved method and apparatus for enhanced drug permeation of skin
TW279133B (enExample) * 1990-12-13 1996-06-21 Elan Med Tech
US5273528A (en) * 1992-07-10 1993-12-28 Skeen Mikell L Livestock inoculator
DE4307869C2 (de) * 1993-03-12 1996-04-04 Microparts Gmbh Mikrostrukturkörper und Verfahren zu deren Herstellung
US5679647A (en) * 1993-08-26 1997-10-21 The Regents Of The University Of California Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides
US5885211A (en) * 1993-11-15 1999-03-23 Spectrix, Inc. Microporation of human skin for monitoring the concentration of an analyte
US5380337A (en) * 1994-01-24 1995-01-10 Romaine; Richard A. Mesh-type skin biopsy appliance
US5660680A (en) * 1994-03-07 1997-08-26 The Regents Of The University Of California Method for fabrication of high vertical aspect ratio thin film structures
JP2551742B2 (ja) * 1994-05-23 1996-11-06 三星電機株式会社 医薬品投与用皮膚傷形成装置
US5591139A (en) * 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
US6368333B2 (en) * 1994-06-29 2002-04-09 Mattioli Engineering Ltd. V-shaped handpiece for dermabrasion
WO1996037155A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical device and method for enhancing delivery of compounds through the skin
WO1996037256A1 (en) * 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
US5958589A (en) * 1995-07-07 1999-09-28 The United States Of America As Represented By The Secretary Of Agriculture Starch-based microcellular foams
DE19525607A1 (de) * 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
US5658515A (en) * 1995-09-25 1997-08-19 Lee; Abraham P. Polymer micromold and fabrication process
US6032060A (en) * 1996-01-25 2000-02-29 3M Innovative Properties Company Method for conditioning skin and an electrode by passing electrical energy
AUPN814496A0 (en) * 1996-02-19 1996-03-14 Monash University Dermal penetration enhancer
US5919364A (en) * 1996-06-24 1999-07-06 Regents Of The University Of California Microfabricated filter and shell constructed with a permeable membrane
DE69722414T2 (de) * 1996-07-03 2004-05-19 Altea Therapeutics Corp. Mehrfache mechanische mikroperforierung von haut oder schleimhäuten
JP4054381B2 (ja) * 1996-09-17 2008-02-27 デカ・プロダクツ・リミテッド・パートナーシップ 移送による薬伝達システム
US5910306A (en) * 1996-11-14 1999-06-08 The United States Of America As Represented By The Secretary Of The Army Transdermal delivery system for antigen
US5980898A (en) * 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
US6065864A (en) * 1997-01-24 2000-05-23 The Regents Of The University Of California Apparatus and method for planar laminar mixing
US5928207A (en) * 1997-06-30 1999-07-27 The Regents Of The University Of California Microneedle with isotropically etched tip, and method of fabricating such a device
US5931794A (en) * 1997-10-21 1999-08-03 Pitesky; Isadore Allergy testing apparatus
US6077229A (en) * 1997-10-21 2000-06-20 Pitesky; Isadore Allergy testing apparatus
US5999847A (en) * 1997-10-21 1999-12-07 Elstrom; John A. Apparatus and method for delivery of surgical and therapeutic agents
AU739616B2 (en) * 1997-12-11 2001-10-18 Alza Corporation Device for enhancing transdermal agent flux
US5970998A (en) * 1998-02-27 1999-10-26 The Regents Of The University Of California Microfabricated cantilever ratchet valve, and method for using same
US6173202B1 (en) * 1998-03-06 2001-01-09 Spectrx, Inc. Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue
US6106751A (en) * 1998-03-18 2000-08-22 The Regents Of The University Of California Method for fabricating needles via conformal deposition in two-piece molds
US7004933B2 (en) * 1998-05-29 2006-02-28 Light Bioscience L.L.C. Ultrasound enhancement of percutaneous drug absorption
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US6162232A (en) * 1999-03-18 2000-12-19 Shadduck; John H. Instruments and techniques for high-velocity fluid abrasion of epidermal layers with skin cooling
US6582442B2 (en) * 2000-02-28 2003-06-24 Dynatronics Corporation Method and system for performing microabrasion
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6312612B1 (en) * 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6835184B1 (en) * 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US6331266B1 (en) * 1999-09-29 2001-12-18 Becton Dickinson And Company Process of making a molded device
ES2238333T3 (es) * 1999-12-10 2005-09-01 Alza Corporation Aparato de tratamiento dermico para la administracion prolongada de farmacos por via transdermica.
EP1239775B1 (en) * 1999-12-16 2005-03-16 ALZA Corporation Device for enhancing transdermal flux of sampled agents
US6706032B2 (en) * 2000-06-08 2004-03-16 Massachusetts Institute Of Technology Localized molecular and ionic transport to and from tissues
MXPA03003303A (es) * 2000-10-13 2004-12-13 Johnson & Johnson Retenedor del miembro de microprotrusion para aplicador de impacto.
US6821281B2 (en) * 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
US20030135166A1 (en) * 2001-09-28 2003-07-17 Gonnelli Robert R. Switchable microneedle arrays and systems and methods relating to same

Also Published As

Publication number Publication date
EP1439870B1 (en) 2009-01-14
EP1439870A2 (en) 2004-07-28
ATE420676T1 (de) 2009-01-15
WO2003051284A2 (en) 2003-06-26
CN1662266A (zh) 2005-08-31
US20030093040A1 (en) 2003-05-15
MXPA04003953A (es) 2004-06-18
JP2005511248A (ja) 2005-04-28
EP1439870A4 (en) 2006-03-01
AU2002365144A1 (en) 2003-06-30
ES2319625T3 (es) 2009-05-11
DE60230894D1 (enExample) 2009-03-05
WO2003051284A3 (en) 2004-01-29
BR0213686A (pt) 2006-05-23

Similar Documents

Publication Publication Date Title
EP1439870B1 (en) Device for the delivery of a substance
EP1289599B1 (en) Applicator having abrading surface coated with substance to be applied to skin
US7582069B2 (en) Method and device for the delivery of a substance
Kim et al. Delivery systems for intradermal vaccination
JP4382356B2 (ja) 微小突起アレイ免疫感作貼付剤および方法
EP1392389B1 (en) Microprojection array having a beneficial agent containing coating
JP2004531578A (ja) ワクチンおよび遺伝子治療剤のマイクロカニューレによる皮内送達
AU2001261757A1 (en) Applicator having abrading surface coated with substance to be applied to skin
CA2619452A1 (en) Coatable transdermal delivery microprojection assembly
EP3251722B1 (en) Microprojection array having a beneficial agent containing coating and method of forming the coating thereon
AU2002327186A1 (en) Intradermal delivery of vaccines and gene therapeutic agents via microcannula
AU2007203302A1 (en) Microprojection array immunization patch and method
ZA200309003B (en) Microprojection array immunization patch and method.
AU2002311839A1 (en) Microprojection array immunization patch and method
NZ538043A (en) Composition having a beneficial agent for forming a solid coating on microprojections array

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued