CA2463223C - Method and separating module for separating particles from a dispersion, particularly blood corpuscles from blood - Google Patents
Method and separating module for separating particles from a dispersion, particularly blood corpuscles from blood Download PDFInfo
- Publication number
- CA2463223C CA2463223C CA002463223A CA2463223A CA2463223C CA 2463223 C CA2463223 C CA 2463223C CA 002463223 A CA002463223 A CA 002463223A CA 2463223 A CA2463223 A CA 2463223A CA 2463223 C CA2463223 C CA 2463223C
- Authority
- CA
- Canada
- Prior art keywords
- channel
- junction
- drain channel
- separating
- drain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000002245 particle Substances 0.000 title claims abstract description 55
- 238000000034 method Methods 0.000 title claims abstract description 28
- 210000004369 blood Anatomy 0.000 title claims abstract description 24
- 239000008280 blood Substances 0.000 title claims abstract description 24
- 239000006185 dispersion Substances 0.000 title claims abstract description 19
- 210000000601 blood cell Anatomy 0.000 title description 9
- 239000012530 fluid Substances 0.000 claims abstract description 23
- 239000000758 substrate Substances 0.000 claims abstract description 10
- 239000012472 biological sample Substances 0.000 claims abstract description 4
- 239000007788 liquid Substances 0.000 description 26
- 239000002699 waste material Substances 0.000 description 20
- 238000004458 analytical method Methods 0.000 description 15
- 230000000694 effects Effects 0.000 description 14
- 210000003743 erythrocyte Anatomy 0.000 description 14
- 238000004519 manufacturing process Methods 0.000 description 14
- 238000000926 separation method Methods 0.000 description 14
- 238000012360 testing method Methods 0.000 description 9
- 230000017531 blood circulation Effects 0.000 description 5
- 238000001914 filtration Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000011148 porous material Substances 0.000 description 5
- 230000004888 barrier function Effects 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 230000001413 cellular effect Effects 0.000 description 3
- 238000005530 etching Methods 0.000 description 3
- 238000005191 phase separation Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000000523 sample Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 238000009534 blood test Methods 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000011152 fibreglass Substances 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- 206010018910 Haemolysis Diseases 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 239000012491 analyte Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 238000010352 biotechnological method Methods 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000005534 hematocrit Methods 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 238000000608 laser ablation Methods 0.000 description 1
- 238000001471 micro-filtration Methods 0.000 description 1
- 239000011325 microbead Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 238000012123 point-of-care testing Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 239000002351 wastewater Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/04—Investigating sedimentation of particle suspensions
- G01N15/05—Investigating sedimentation of particle suspensions in blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/04—Investigating sedimentation of particle suspensions
- G01N15/05—Investigating sedimentation of particle suspensions in blood
- G01N2015/055—Investigating sedimentation of particle suspensions in blood for hematocrite determination
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1486—Counting the particles
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Dispersion Chemistry (AREA)
- Anesthesiology (AREA)
- Urology & Nephrology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Ecology (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10150549A DE10150549A1 (de) | 2001-10-12 | 2001-10-12 | Verfahren und Trennmodul zum Abtrennen von Partikeln aus einer Dispersion, insbesondere von Blutkörperchen aus Blut |
| DE10150549.3 | 2001-10-12 | ||
| PCT/EP2002/010336 WO2003033096A2 (de) | 2001-10-12 | 2002-09-14 | Verfahren und trennmodul zum abtrennen von partikeln aus einer dispersion, insbesondere von blutkörperchen aus blut |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2463223A1 CA2463223A1 (en) | 2003-04-24 |
| CA2463223C true CA2463223C (en) | 2009-08-25 |
Family
ID=7702370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002463223A Expired - Fee Related CA2463223C (en) | 2001-10-12 | 2002-09-14 | Method and separating module for separating particles from a dispersion, particularly blood corpuscles from blood |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7527740B2 (enExample) |
| EP (1) | EP1434637B1 (enExample) |
| JP (1) | JP4005022B2 (enExample) |
| AT (1) | ATE317281T1 (enExample) |
| AU (1) | AU2002340906A1 (enExample) |
| CA (1) | CA2463223C (enExample) |
| DE (2) | DE10150549A1 (enExample) |
| ES (1) | ES2257574T3 (enExample) |
| WO (1) | WO2003033096A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10313201A1 (de) * | 2003-03-21 | 2004-10-07 | Steag Microparts Gmbh | Mikrostrukturierte Trennvorrichtung und mikrofluidisches Verfahren zum Abtrennen von flüssigen Bestandteilen aus einer Flüssigkeit, die Partikel enthält |
| TW200702292A (en) * | 2005-02-28 | 2007-01-16 | Careside Medical Llc | A micro-fluidic fluid separation device and method |
| JP2007021465A (ja) * | 2005-07-12 | 2007-02-01 | Minoru Seki | 粒子を連続的に濃縮・分離するための流路構造および方法 |
| DE102005050167B4 (de) * | 2005-10-19 | 2009-02-19 | Advalytix Ag | Konzentrationsverfahren, Konzentrationsvorrichtung und Reaktionsverfahren |
| CN101454664B (zh) * | 2006-05-24 | 2013-08-21 | 国立大学法人京都大学 | 血浆分离用微流路 |
| US8075468B2 (en) * | 2008-02-27 | 2011-12-13 | Fenwal, Inc. | Systems and methods for mid-processing calculation of blood composition |
| US8685258B2 (en) * | 2008-02-27 | 2014-04-01 | Fenwal, Inc. | Systems and methods for conveying multiple blood components to a recipient |
| EP2276549A1 (en) * | 2008-03-19 | 2011-01-26 | Oncnosis Pharma Aie | Method and apparatus for separating particles in a fluid |
| JP2010071857A (ja) * | 2008-09-19 | 2010-04-02 | Sekisui Chem Co Ltd | 血漿分離装置 |
| US8980106B2 (en) | 2010-12-15 | 2015-03-17 | Abbott Laboratories | Apparatus and method for separation of whole blood into plasma or serum and cells |
| DE102012206371A1 (de) * | 2012-04-18 | 2013-10-24 | Siemens Ag | Durchflusssystem mit einer Rückhaltestruktur für Partikel und dessen Verwendung |
| WO2014128960A1 (ja) * | 2013-02-25 | 2014-08-28 | 株式会社メニコン | マイクロ流体デバイス |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3695942A (en) * | 1970-12-02 | 1972-10-03 | Amchem Prod | Zirconium rinse for phosphate coated metal surfaces |
| US3791933A (en) | 1971-02-25 | 1974-02-12 | Geomet | Rapid methods for assay of enzyme substrates and metabolites |
| US4148670A (en) * | 1976-04-05 | 1979-04-10 | Amchem Products, Inc. | Coating solution for metal surface |
| FR2417537A1 (fr) * | 1978-02-21 | 1979-09-14 | Parker Ste Continentale | Composition a base d'hafnium pour inhiber la corrosion des metaux |
| IT1111586B (it) * | 1979-03-16 | 1986-01-13 | Parker Italiana | Composizioni protettive per superfici d'acciaio e processo per la loro preparazione |
| DE3029579C2 (de) | 1980-08-05 | 1985-12-12 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren und Mittel zur Abtrennung von Plasma oder Serum aus Vollblut |
| DE3274800D1 (en) | 1981-02-05 | 1987-02-05 | Asahi Chemical Ind | Apparatus for separating blood components |
| US4457790A (en) * | 1983-05-09 | 1984-07-03 | Parker Chemical Company | Treatment of metal with group IV B metal ion and derivative of polyalkenylphenol |
| US4470853A (en) * | 1983-10-03 | 1984-09-11 | Coral Chemical Company | Coating compositions and method for the treatment of metal surfaces |
| JPS60201253A (ja) | 1984-03-26 | 1985-10-11 | Jeol Ltd | 血漿採取装置 |
| US5011551A (en) * | 1988-12-22 | 1991-04-30 | The United States Of America As Represented By The Secretary Of The Army | Protective coating for steel surfaces and method of application |
| US5125989A (en) * | 1989-04-21 | 1992-06-30 | Henkel Corporation | Method and composition for coating aluminum |
| US5656070A (en) * | 1992-11-24 | 1997-08-12 | Ensci Inc. | Corrosion inhibiting compositions containing plant derived catechol complexes |
| US5380374A (en) * | 1993-10-15 | 1995-01-10 | Circle-Prosco, Inc. | Conversion coatings for metal surfaces |
| EP0871539B1 (en) * | 1995-06-16 | 2002-02-20 | University of Washington | Tangential flow planar microfabricated fluid filter |
| US5711996A (en) * | 1995-09-28 | 1998-01-27 | Man-Gill Chemical Company | Aqueous coating compositions and coated metal surfaces |
| US5662746A (en) * | 1996-02-23 | 1997-09-02 | Brent America, Inc. | Composition and method for treatment of phosphated metal surfaces |
| JP3903098B2 (ja) | 1997-07-18 | 2007-04-11 | 富士フイルム株式会社 | 血液濾過方法 |
| WO1999009042A2 (en) | 1997-08-13 | 1999-02-25 | Cepheid | Microstructures for the manipulation of fluid samples |
| US7351376B1 (en) * | 2000-06-05 | 2008-04-01 | California Institute Of Technology | Integrated active flux microfluidic devices and methods |
| EP1309404A2 (en) * | 2000-08-07 | 2003-05-14 | Nanostream, Inc. | Fluidic mixer in microfluidic system |
| US7670559B2 (en) * | 2001-02-15 | 2010-03-02 | Caliper Life Sciences, Inc. | Microfluidic systems with enhanced detection systems |
| US7223363B2 (en) * | 2001-03-09 | 2007-05-29 | Biomicro Systems, Inc. | Method and system for microfluidic interfacing to arrays |
| US20020187072A1 (en) * | 2001-06-07 | 2002-12-12 | Nanostream, Inc. | Multi-layer microfluidic splitter |
-
2001
- 2001-10-12 DE DE10150549A patent/DE10150549A1/de not_active Withdrawn
-
2002
- 2002-09-14 CA CA002463223A patent/CA2463223C/en not_active Expired - Fee Related
- 2002-09-14 WO PCT/EP2002/010336 patent/WO2003033096A2/de not_active Ceased
- 2002-09-14 AU AU2002340906A patent/AU2002340906A1/en not_active Abandoned
- 2002-09-14 ES ES02774618T patent/ES2257574T3/es not_active Expired - Lifetime
- 2002-09-14 US US10/492,256 patent/US7527740B2/en not_active Expired - Fee Related
- 2002-09-14 AT AT02774618T patent/ATE317281T1/de active
- 2002-09-14 EP EP02774618A patent/EP1434637B1/de not_active Expired - Lifetime
- 2002-09-14 JP JP2003535890A patent/JP4005022B2/ja not_active Expired - Fee Related
- 2002-09-14 DE DE50205804T patent/DE50205804D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP4005022B2 (ja) | 2007-11-07 |
| ATE317281T1 (de) | 2006-02-15 |
| EP1434637A2 (de) | 2004-07-07 |
| EP1434637B1 (de) | 2006-02-08 |
| JP2005505770A (ja) | 2005-02-24 |
| DE50205804D1 (de) | 2006-04-20 |
| WO2003033096A2 (de) | 2003-04-24 |
| AU2002340906A1 (en) | 2003-04-28 |
| CA2463223A1 (en) | 2003-04-24 |
| ES2257574T3 (es) | 2006-08-01 |
| WO2003033096A3 (de) | 2003-12-18 |
| US20050029190A1 (en) | 2005-02-10 |
| DE10150549A1 (de) | 2003-04-17 |
| US7527740B2 (en) | 2009-05-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20180914 |