CA2461227C - Methods and compositions to determine the chemosensitizing dose of suramin used in combination therapy - Google Patents
Methods and compositions to determine the chemosensitizing dose of suramin used in combination therapy Download PDFInfo
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- CA2461227C CA2461227C CA2461227A CA2461227A CA2461227C CA 2461227 C CA2461227 C CA 2461227C CA 2461227 A CA2461227 A CA 2461227A CA 2461227 A CA2461227 A CA 2461227A CA 2461227 C CA2461227 C CA 2461227C
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- suramin
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- 238000000034 method Methods 0.000 title abstract description 47
- 230000003034 chemosensitisation Effects 0.000 title description 42
- 238000002648 combination therapy Methods 0.000 title description 7
- 239000000203 mixture Substances 0.000 title description 2
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- 239000002254 cytotoxic agent Substances 0.000 claims abstract description 33
- 231100000599 cytotoxic agent Toxicity 0.000 claims abstract description 33
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- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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- A61K31/28—Compounds containing heavy metals
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Landscapes
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- Medicinal Chemistry (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32470401P | 2001-09-24 | 2001-09-24 | |
| US60/324,704 | 2001-09-24 | ||
| PCT/US2002/030210 WO2003026574A2 (en) | 2001-09-24 | 2002-09-24 | Methods and compositions to determine the chemosensitizing dose of suramin used in combination therapy |
Publications (2)
| Publication Number | Publication Date |
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| CA2461227A1 CA2461227A1 (en) | 2003-04-03 |
| CA2461227C true CA2461227C (en) | 2012-05-15 |
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| EP (1) | EP1429713A4 (https=) |
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| AU (1) | AU2002330088B2 (https=) |
| CA (1) | CA2461227C (https=) |
| IL (1) | IL161036A0 (https=) |
| WO (1) | WO2003026574A2 (https=) |
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| US6905669B2 (en) | 2001-04-24 | 2005-06-14 | Supergen, Inc. | Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase |
| US6982253B2 (en) | 2002-06-05 | 2006-01-03 | Supergen, Inc. | Liquid formulation of decitabine and use of the same |
| US20050043233A1 (en) | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| US7250416B2 (en) | 2005-03-11 | 2007-07-31 | Supergen, Inc. | Azacytosine analogs and derivatives |
| WO2009018233A1 (en) * | 2007-07-30 | 2009-02-05 | Ardea Biosciences, Inc. | Derivatives of n-(arylamino) sulfonamides including polymorphs as inhibitors of mek as well as compositions, methods of use and methods for preparing the same |
| US7700567B2 (en) | 2005-09-29 | 2010-04-20 | Supergen, Inc. | Oligonucleotide analogues incorporating 5-aza-cytosine therein |
| WO2007065016A2 (en) * | 2005-12-02 | 2007-06-07 | Au Jessie L S | Methods and compositions to improve activity and reduce toxicity of stents |
| EP2750768B1 (en) | 2011-08-30 | 2018-10-03 | Astex Pharmaceuticals, Inc. | Decitabine derivative formulations |
| CN104398517A (zh) * | 2014-11-28 | 2015-03-11 | 四川大学 | 乙胺嘧啶的新用途及治疗肿瘤的药物组合物 |
| AU2016287585B2 (en) | 2015-07-02 | 2020-12-17 | Otsuka Pharmaceutical Co., Ltd. | Lyophilized pharmaceutical compositions |
| TW201718598A (zh) * | 2015-08-27 | 2017-06-01 | 美國禮來大藥廠 | Ｅｚｈ２抑制劑 |
| KR20200035438A (ko) | 2017-08-03 | 2020-04-03 | 오쓰까 세이야꾸 가부시키가이샤 | 약물 화합물 및 이의 정제 방법 |
| JP2022145629A (ja) * | 2021-03-18 | 2022-10-04 | 学校法人産業医科大学 | スラミンを含む組成物 |
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| US5597830A (en) * | 1994-12-20 | 1997-01-28 | Warner-Lambert Company | Combination chemotherapy |
| KR20000015944A (ko) * | 1996-05-24 | 2000-03-15 | 팜 윌리암 엔. | 신체 통로의 질병을 치료 또는 예방하기 위한조성물 및 방법 |
| NZ337376A (en) * | 1997-03-11 | 2002-02-01 | Aeterna Lab Inc | Compositions for treating tumors containing shark cartilage extracts and anti-neoplastic agents |
| US6506783B1 (en) * | 1997-05-16 | 2003-01-14 | The Procter & Gamble Company | Cancer treatments and pharmaceutical compositions therefor |
| JP2003503313A (ja) * | 1999-06-03 | 2003-01-28 | ジェシー エル エス オウ | 細胞増殖及び細胞死を変調する方法及び組成物 |
| US6420378B1 (en) * | 1999-10-15 | 2002-07-16 | Supergen, Inc. | Inhibition of abnormal cell proliferation with camptothecin and combinations including the same |
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| EP1429713A2 (en) | 2004-06-23 |
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| JP2005508322A (ja) | 2005-03-31 |
| AU2002330088B2 (en) | 2009-09-03 |
| IL161036A0 (en) | 2004-08-31 |
| WO2003026574A2 (en) | 2003-04-03 |
| US20110142794A1 (en) | 2011-06-16 |
| CN100441176C (zh) | 2008-12-10 |
| US8580857B2 (en) | 2013-11-12 |
| EP1429713A4 (en) | 2007-08-08 |
| CN1589138A (zh) | 2005-03-02 |
| HK1074167A1 (zh) | 2005-11-04 |
| US20040180955A1 (en) | 2004-09-16 |
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