CA2460360A1 - Systematical administration of some oxazolidinones, e.g. linezolid, for the treatment for ocular infections - Google Patents
Systematical administration of some oxazolidinones, e.g. linezolid, for the treatment for ocular infections Download PDFInfo
- Publication number
- CA2460360A1 CA2460360A1 CA002460360A CA2460360A CA2460360A1 CA 2460360 A1 CA2460360 A1 CA 2460360A1 CA 002460360 A CA002460360 A CA 002460360A CA 2460360 A CA2460360 A CA 2460360A CA 2460360 A1 CA2460360 A1 CA 2460360A1
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- Prior art keywords
- compound
- formula
- pharmaceutically acceptable
- mixtures
- acceptable salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 239000004922 lacquer Substances 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
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- 235000012245 magnesium oxide Nutrition 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
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- 238000012986 modification Methods 0.000 description 1
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- ACTNHJDHMQSOGL-UHFFFAOYSA-N n',n'-dibenzylethane-1,2-diamine Chemical compound C=1C=CC=CC=1CN(CCN)CC1=CC=CC=C1 ACTNHJDHMQSOGL-UHFFFAOYSA-N 0.000 description 1
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- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
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- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- ALDITMKAAPLVJK-UHFFFAOYSA-N prop-1-ene;hydrate Chemical group O.CC=C ALDITMKAAPLVJK-UHFFFAOYSA-N 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
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- 230000029983 protein stabilization Effects 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 150000003212 purines Chemical class 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- GHBFNMLVSPCDGN-UHFFFAOYSA-N rac-1-monooctanoylglycerol Chemical compound CCCCCCCC(=O)OCC(O)CO GHBFNMLVSPCDGN-UHFFFAOYSA-N 0.000 description 1
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- 235000002906 tartaric acid Nutrition 0.000 description 1
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical class C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
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- 239000002562 thickening agent Substances 0.000 description 1
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- 230000000699 topical effect Effects 0.000 description 1
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32215301P | 2001-09-14 | 2001-09-14 | |
| US32211501P | 2001-09-14 | 2001-09-14 | |
| US60/322,153 | 2001-09-14 | ||
| US60/322,115 | 2001-09-14 | ||
| PCT/US2002/025977 WO2003024528A1 (en) | 2001-09-14 | 2002-09-11 | Systematical administration of some oxazolidinones, e.g. linezolid, for the treatment for ocular infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2460360A1 true CA2460360A1 (en) | 2003-03-27 |
Family
ID=26983274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002460360A Abandoned CA2460360A1 (en) | 2001-09-14 | 2002-09-11 | Systematical administration of some oxazolidinones, e.g. linezolid, for the treatment for ocular infections |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20030069235A1 (https=) |
| EP (1) | EP1425068A1 (https=) |
| JP (1) | JP2005507884A (https=) |
| KR (1) | KR20040035769A (https=) |
| CN (1) | CN1281211C (https=) |
| BR (1) | BR0212466A (https=) |
| CA (1) | CA2460360A1 (https=) |
| IL (1) | IL160490A0 (https=) |
| MX (1) | MXPA04002071A (https=) |
| NZ (1) | NZ531353A (https=) |
| PL (1) | PL370033A1 (https=) |
| WO (1) | WO2003024528A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108283622A (zh) * | 2018-04-03 | 2018-07-17 | 广州君博医药科技有限公司 | 一种缓释型利奈唑胺眼用药物及其制备方法 |
| WO2021184339A1 (en) | 2020-03-20 | 2021-09-23 | Merck Sharp & Dohme Corp. | Oxazolidinone compound and methods of use thereof as an antibacterial agent |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5688792A (en) * | 1994-08-16 | 1997-11-18 | Pharmacia & Upjohn Company | Substituted oxazine and thiazine oxazolidinone antimicrobials |
| CN1305374A (zh) * | 1998-07-14 | 2001-07-25 | 法玛西雅厄普约翰美国公司 | 治疗眼部感染的噁唑烷酮 |
| ATE337002T1 (de) * | 1999-09-13 | 2006-09-15 | Insite Vision Inc | Topische behandlung zur vorbeugung von augeninfektionen |
| US6696426B2 (en) * | 2000-08-22 | 2004-02-24 | Pharmacia Corporation | Preservative free ophthalmic oxazolidinone antibiotic drug delivery systems |
| PE20020578A1 (es) * | 2000-10-10 | 2002-08-14 | Upjohn Co | Una composicion de antibiotico topico para el tratamiento de infecciones oculares |
-
2002
- 2002-09-10 US US10/238,449 patent/US20030069235A1/en not_active Abandoned
- 2002-09-11 MX MXPA04002071A patent/MXPA04002071A/es active IP Right Grant
- 2002-09-11 EP EP02775708A patent/EP1425068A1/en not_active Withdrawn
- 2002-09-11 KR KR10-2004-7003679A patent/KR20040035769A/ko not_active Ceased
- 2002-09-11 BR BR0212466-1A patent/BR0212466A/pt not_active IP Right Cessation
- 2002-09-11 PL PL02370033A patent/PL370033A1/xx not_active Application Discontinuation
- 2002-09-11 JP JP2003528621A patent/JP2005507884A/ja active Pending
- 2002-09-11 NZ NZ531353A patent/NZ531353A/en unknown
- 2002-09-11 IL IL16049002A patent/IL160490A0/xx unknown
- 2002-09-11 CN CNB028154673A patent/CN1281211C/zh not_active Expired - Fee Related
- 2002-09-11 WO PCT/US2002/025977 patent/WO2003024528A1/en not_active Ceased
- 2002-09-11 CA CA002460360A patent/CA2460360A1/en not_active Abandoned
-
2005
- 2005-06-23 US US11/159,897 patent/US20050234052A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003024528A1 (en) | 2003-03-27 |
| US20030069235A1 (en) | 2003-04-10 |
| IL160490A0 (en) | 2004-07-25 |
| MXPA04002071A (es) | 2005-02-17 |
| KR20040035769A (ko) | 2004-04-29 |
| NZ531353A (en) | 2006-09-29 |
| CN1545428A (zh) | 2004-11-10 |
| US20050234052A1 (en) | 2005-10-20 |
| HK1068564A1 (en) | 2005-04-29 |
| CN1281211C (zh) | 2006-10-25 |
| EP1425068A1 (en) | 2004-06-09 |
| PL370033A1 (en) | 2005-05-16 |
| BR0212466A (pt) | 2004-10-19 |
| JP2005507884A (ja) | 2005-03-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |