CA2458040A1 - Inhibiteurs de protease antivirale - Google Patents

Inhibiteurs de protease antivirale Download PDF

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Publication number
CA2458040A1
CA2458040A1 CA002458040A CA2458040A CA2458040A1 CA 2458040 A1 CA2458040 A1 CA 2458040A1 CA 002458040 A CA002458040 A CA 002458040A CA 2458040 A CA2458040 A CA 2458040A CA 2458040 A1 CA2458040 A1 CA 2458040A1
Authority
CA
Canada
Prior art keywords
compound according
phenyl
mmol
compound
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002458040A
Other languages
English (en)
Inventor
Anna Stanemyr
Bjoern Classon
Bertil Samuelsson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Medivir AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medivir AB filed Critical Medivir AB
Publication of CA2458040A1 publication Critical patent/CA2458040A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/36—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • AIDS & HIV (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des composés de la formule (I) où X et Y représentent hydroxy ou H. A' et A'' sont des fonctions amine terminale telles que valinamide ou indanolamine. Z', Z'' et les ( )n groupes adjacents représentent indépendamment alkylaryle. Ces composés sont utiles comme inhibiteurs d'aspartyle sida-protéase ayant une activité particulièrement bonne en présence de sérum humain.
CA002458040A 2001-08-29 2002-08-29 Inhibiteurs de protease antivirale Abandoned CA2458040A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0102892-7 2001-08-29
SE0102892A SE0102892D0 (sv) 2001-08-29 2001-08-29 Antivirals I
PCT/SE2002/001549 WO2003018537A1 (fr) 2001-08-29 2002-08-29 Inhibiteurs de protease antivirale

Publications (1)

Publication Number Publication Date
CA2458040A1 true CA2458040A1 (fr) 2003-03-06

Family

ID=20285183

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002458040A Abandoned CA2458040A1 (fr) 2001-08-29 2002-08-29 Inhibiteurs de protease antivirale

Country Status (6)

Country Link
EP (1) EP1421060A1 (fr)
JP (1) JP2005501118A (fr)
CA (1) CA2458040A1 (fr)
IL (1) IL160626A0 (fr)
SE (1) SE0102892D0 (fr)
WO (1) WO2003018537A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014169456A1 (fr) * 2013-04-18 2014-10-23 西安力邦医药科技有限责任公司 Utilisation de 7-a-[9-(4,4,5,5,5-pentafluoro-pentyl-sulfinyl)nonyl]-estra-1,3,5(10)-triène-3,17b-diol et de ses dérivés

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9701245D0 (sv) * 1997-04-04 1997-04-04 Bjoern Classon Antivirals

Also Published As

Publication number Publication date
WO2003018537A1 (fr) 2003-03-06
IL160626A0 (en) 2004-07-25
JP2005501118A (ja) 2005-01-13
EP1421060A1 (fr) 2004-05-26
SE0102892D0 (sv) 2001-08-29

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Legal Events

Date Code Title Description
FZDE Discontinued