CA2456881A1 - Somatostatin analogues and their use somatostatin analogues binding to all somatostatin receptor and their use - Google Patents

Somatostatin analogues and their use somatostatin analogues binding to all somatostatin receptor and their use Download PDF

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Publication number
CA2456881A1
CA2456881A1 CA002456881A CA2456881A CA2456881A1 CA 2456881 A1 CA2456881 A1 CA 2456881A1 CA 002456881 A CA002456881 A CA 002456881A CA 2456881 A CA2456881 A CA 2456881A CA 2456881 A1 CA2456881 A1 CA 2456881A1
Authority
CA
Canada
Prior art keywords
somatostatin
somatostatin analogues
analogues
group
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002456881A
Other languages
English (en)
French (fr)
Inventor
Helmut Robert Maecke
Jean Claude Reubi
Hans Rink
Klaus-Peter Eisenwiener
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Bern
University Hospital of Basel
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2456881A1 publication Critical patent/CA2456881A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA002456881A 2001-08-10 2002-08-07 Somatostatin analogues and their use somatostatin analogues binding to all somatostatin receptor and their use Abandoned CA2456881A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01203033.4 2001-08-10
EP01203033A EP1283216A1 (en) 2001-08-10 2001-08-10 Somatostatin analogues binding to all somatostatin receptor subtypes and their use
PCT/EP2002/009004 WO2003014158A1 (en) 2001-08-10 2002-08-07 Somatostatin analogues and their use somatostatin analogues binding to all somatostatin receptor and their use

Publications (1)

Publication Number Publication Date
CA2456881A1 true CA2456881A1 (en) 2003-02-20

Family

ID=8180776

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002456881A Abandoned CA2456881A1 (en) 2001-08-10 2002-08-07 Somatostatin analogues and their use somatostatin analogues binding to all somatostatin receptor and their use

Country Status (12)

Country Link
US (2) US7192570B2 (enExample)
EP (2) EP1283216A1 (enExample)
JP (1) JP2005508886A (enExample)
AT (1) ATE328005T1 (enExample)
AU (1) AU2002333396B2 (enExample)
CA (1) CA2456881A1 (enExample)
CY (1) CY1105177T1 (enExample)
DE (1) DE60211917T2 (enExample)
DK (1) DK1419178T3 (enExample)
ES (1) ES2266616T3 (enExample)
PT (1) PT1419178E (enExample)
WO (1) WO2003014158A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1283216A1 (en) * 2001-08-10 2003-02-12 Mallinckrodt Inc. Somatostatin analogues binding to all somatostatin receptor subtypes and their use
DK1603598T3 (da) * 2003-03-19 2009-01-26 Univ Bern Radiomærkede konjugater baseret på substans P og anvendelser heraf
US20080233084A1 (en) * 2005-10-14 2008-09-25 Otto Boerman Interleukin-8 Labelled Via One or More Site Specifically Conjugated Hydrazinonicotinamide (Hynic) Moieties and its Use in Diagnosis of Infection and Inflammation
ES2410207T3 (es) 2006-10-16 2013-07-01 The Salk Institute For Biological Studies Antagonistas de la somatostatina selectivos para receptor(SSTR2)
US8691761B2 (en) 2006-10-16 2014-04-08 Jean E. F. Rivier Somatostatin receptor 2 antagonists
WO2009012288A2 (en) 2007-07-17 2009-01-22 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Trifunctional imaging agent for monoclonal antibody tumor-targeted imaging
US9186128B2 (en) 2008-10-01 2015-11-17 Covidien Lp Needle biopsy device
US9332973B2 (en) 2008-10-01 2016-05-10 Covidien Lp Needle biopsy device with exchangeable needle and integrated needle protection
US8968210B2 (en) 2008-10-01 2015-03-03 Covidien LLP Device for needle biopsy with integrated needle protection
US11298113B2 (en) 2008-10-01 2022-04-12 Covidien Lp Device for needle biopsy with integrated needle protection
US9782565B2 (en) 2008-10-01 2017-10-10 Covidien Lp Endoscopic ultrasound-guided biliary access system
GB0903496D0 (en) * 2009-02-27 2009-04-08 Cambridge Entpr Ltd Methods for identification
ES2351569B8 (es) * 2009-05-07 2012-06-20 Bcn Peptides S.A. Ligandos peptídicos de receptores de somatostatina.
GB0922369D0 (en) 2009-12-22 2010-02-03 Hammersmith Imanet Ltd Labelled biotin conjugates
TWI523863B (zh) * 2012-11-01 2016-03-01 艾普森藥品公司 體抑素－多巴胺嵌合體類似物
JP2016503402A (ja) * 2012-11-01 2016-02-04 イプセン ファルマ ソシエテ パール アクシオン サンプリフィエＩｐｓｅｎ Ｐｈａｒｍａ Ｓ．Ａ．Ｓ． ソマトスタチン類似体及びそのダイマー
JP6410339B2 (ja) * 2013-03-25 2018-10-24 国立大学法人千葉大学 放射性核種標識オクトレオチド誘導体
AU2017217271C1 (en) 2016-02-09 2021-08-05 Cdrd Ventures Inc. Somatostatin receptor antagonist compounds and methods of using the same
CA3050094C (en) 2017-01-12 2024-01-02 Radiomedix Inc. Treatment of cancer cells overexpressing somatostatin receptors using ocreotide derivatives chelated to radioisotopes
CN108440664A (zh) * 2018-03-27 2018-08-24 上海欣科医药有限公司 一种用于癌症检测的生长抑素类似物及其制备方法和应用
CN112538103B (zh) * 2020-12-28 2022-10-25 合肥科生景肽生物科技有限公司 制备生长激素释放抑制素的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5819669B2 (ja) * 1978-10-28 1983-04-19 白井松新薬株式会社 新規生理活性ペプチド化合物及びその製造法
US5620675A (en) * 1992-06-23 1997-04-15 Diatech, Inc. Radioactive peptides
US6051206A (en) * 1994-06-03 2000-04-18 Diatide, Inc Radiolabeled somatostatin-derived peptides for imaging and therapeutic uses
US6355613B1 (en) * 1996-07-31 2002-03-12 Peptor Limited Conformationally constrained backbone cyclized somatostatin analogs
US6180082B1 (en) * 1997-11-24 2001-01-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Method to enhance tissue accumulation of radiolabeled compounds
US6358491B1 (en) * 1999-08-27 2002-03-19 Berlex Laboratories, Inc. Somatostatin analogs
CA2316767A1 (en) * 1999-09-01 2001-03-01 Bridget Mccarthy Cole Somatostatin antagonists and agonists that act at the sst subtype 2 receptor
EP1283216A1 (en) 2001-08-10 2003-02-12 Mallinckrodt Inc. Somatostatin analogues binding to all somatostatin receptor subtypes and their use

Also Published As

Publication number Publication date
EP1419178A1 (en) 2004-05-19
JP2005508886A (ja) 2005-04-07
CY1105177T1 (el) 2010-03-03
ES2266616T3 (es) 2007-03-01
EP1419178B1 (en) 2006-05-31
US20070154392A1 (en) 2007-07-05
US7541018B2 (en) 2009-06-02
US7192570B2 (en) 2007-03-20
DE60211917T2 (de) 2007-01-18
WO2003014158A1 (en) 2003-02-20
DK1419178T3 (da) 2006-10-02
US20040242842A1 (en) 2004-12-02
DE60211917D1 (de) 2006-07-06
PT1419178E (pt) 2006-09-29
EP1283216A1 (en) 2003-02-12
ATE328005T1 (de) 2006-06-15
AU2002333396B2 (en) 2008-05-22

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ES2410207T3 (es) Antagonistas de la somatostatina selectivos para receptor(SSTR2)
AU2002333396A1 (en) Somatostatin analogues and their use somatostatin analogues binding to all somatostatin receptor and their use
CA2222524C (en) Somatostatin peptides
EP0804468B1 (en) Method of making an omega-functionalized amino acid derivative
US7084244B2 (en) Conformationally constrained backbone cyclized peptide analogs
US7238775B2 (en) Receptor(SSTR4)-selective somatostatin analogs
JP2003503369A (ja) ソマトスタチンアゴニスト

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued