CA2456155A1 - Process for preparing 5-sulfonamido-8-hydroxy-1, 6-naphthyridine-7-carboxamides - Google Patents

Process for preparing 5-sulfonamido-8-hydroxy-1, 6-naphthyridine-7-carboxamides Download PDF

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Publication number
CA2456155A1
CA2456155A1 CA002456155A CA2456155A CA2456155A1 CA 2456155 A1 CA2456155 A1 CA 2456155A1 CA 002456155 A CA002456155 A CA 002456155A CA 2456155 A CA2456155 A CA 2456155A CA 2456155 A1 CA2456155 A1 CA 2456155A1
Authority
CA
Canada
Prior art keywords
alkyl
compound
aryl
haloalkyl
process according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002456155A
Other languages
English (en)
French (fr)
Inventor
Peter E. Maligres
David Askin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2456155A1 publication Critical patent/CA2456155A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002456155A 2001-08-17 2002-08-13 Process for preparing 5-sulfonamido-8-hydroxy-1, 6-naphthyridine-7-carboxamides Abandoned CA2456155A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31337601P 2001-08-17 2001-08-17
US60/313,376 2001-08-17
PCT/US2002/027151 WO2003016309A1 (en) 2001-08-17 2002-08-13 Process for preparing 5-sulfonamido-8-hydroxy-1, 6-naphthyridine-7-carboxamides

Publications (1)

Publication Number Publication Date
CA2456155A1 true CA2456155A1 (en) 2003-02-27

Family

ID=23215476

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002456155A Abandoned CA2456155A1 (en) 2001-08-17 2002-08-13 Process for preparing 5-sulfonamido-8-hydroxy-1, 6-naphthyridine-7-carboxamides

Country Status (6)

Country Link
US (1) US20050014780A1 (enExample)
EP (1) EP1427726A1 (enExample)
JP (1) JP2005504770A (enExample)
AR (1) AR036352A1 (enExample)
CA (1) CA2456155A1 (enExample)
WO (1) WO2003016309A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1326865B1 (en) 2000-10-12 2009-05-06 Merck & Co., Inc. Aza- and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors
ES2440217T3 (es) * 2002-10-04 2014-01-28 Prana Biotechnology Limited Compuestos neurológicamente activos
ATE433974T1 (de) 2003-09-19 2009-07-15 Gilead Sciences Inc Azachinolinolphosphonatverbindungen als integraseinhibitoren
US20070072831A1 (en) * 2005-05-16 2007-03-29 Gilead Sciences, Inc. Integrase inhibitor compounds
BRPI0722382A2 (pt) 2006-04-14 2012-06-05 Prana Biotechnology Ltd compostos úteis para o tratamento de cáncer
JP6980534B2 (ja) 2015-06-25 2021-12-15 ザ チルドレンズ メディカル センター コーポレーション 造血幹細胞の増大、富化、および維持に関する方法および組成物
WO2017161001A1 (en) 2016-03-15 2017-09-21 Children's Medical Center Corporation Methods and compositions relating to hematopoietic stem cell expansion
SMT202500447T1 (it) 2021-11-02 2026-01-12 Flare Therapeutics Inc Agonisti inversi di pparg e loro usi

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH214351A (de) * 1938-08-30 1941-04-15 Cilag Chemisches Ind Lab A G Verfahren zur Darstellung eines Derivates des 2-Aminopyridins.
EP1326865B1 (en) * 2000-10-12 2009-05-06 Merck & Co., Inc. Aza- and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors

Also Published As

Publication number Publication date
WO2003016309A1 (en) 2003-02-27
JP2005504770A (ja) 2005-02-17
AR036352A1 (es) 2004-09-01
EP1427726A1 (en) 2004-06-16
US20050014780A1 (en) 2005-01-20

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Legal Events

Date Code Title Description
FZDE Discontinued