AR036352A1 - Proceso para la preparacion de 5-sulfonamido-8-hidroxi-1, 6-naftiridin-7-carboxamidas - Google Patents
Proceso para la preparacion de 5-sulfonamido-8-hidroxi-1, 6-naftiridin-7-carboxamidasInfo
- Publication number
- AR036352A1 AR036352A1 ARP020103083A ARP020103083A AR036352A1 AR 036352 A1 AR036352 A1 AR 036352A1 AR P020103083 A ARP020103083 A AR P020103083A AR P020103083 A ARP020103083 A AR P020103083A AR 036352 A1 AR036352 A1 AR 036352A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- aryl
- haloalkyl
- substituents
- optionally substituted
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 31
- 229910052736 halogen Inorganic materials 0.000 abstract 19
- 150000002367 halogens Chemical class 0.000 abstract 19
- 125000001424 substituent group Chemical group 0.000 abstract 18
- 125000000217 alkyl group Chemical group 0.000 abstract 17
- 125000003118 aryl group Chemical group 0.000 abstract 14
- 150000001875 compounds Chemical class 0.000 abstract 13
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 5
- 125000001072 heteroaryl group Chemical group 0.000 abstract 5
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 4
- 125000005213 alkyl heteroaryl group Chemical group 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 3
- 150000001412 amines Chemical class 0.000 abstract 3
- 229910052802 copper Inorganic materials 0.000 abstract 3
- 239000010949 copper Substances 0.000 abstract 3
- 208000030507 AIDS Diseases 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 208000031886 HIV Infections Diseases 0.000 abstract 2
- 208000037357 HIV infectious disease Diseases 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 239000002738 chelating agent Substances 0.000 abstract 2
- 230000008878 coupling Effects 0.000 abstract 2
- 238000010168 coupling process Methods 0.000 abstract 2
- 238000005859 coupling reaction Methods 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 239000012351 deprotecting agent Substances 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 229940124530 sulfonamide Drugs 0.000 abstract 2
- 150000003456 sulfonamides Chemical class 0.000 abstract 2
- FLBAYUMRQUHISI-UHFFFAOYSA-N 1,8-naphthyridine Chemical group N1=CC=CC2=CC=CN=C21 FLBAYUMRQUHISI-UHFFFAOYSA-N 0.000 abstract 1
- MEKOFIRRDATTAG-UHFFFAOYSA-N 2,2,5,8-tetramethyl-3,4-dihydrochromen-6-ol Chemical compound C1CC(C)(C)OC2=C1C(C)=C(O)C=C2C MEKOFIRRDATTAG-UHFFFAOYSA-N 0.000 abstract 1
- 125000004008 6 membered carbocyclic group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 108010002459 HIV Integrase Proteins 0.000 abstract 1
- 229910003844 NSO2 Inorganic materials 0.000 abstract 1
- -1 antryl Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000005708 carbonyloxy group Chemical group [*:2]OC([*:1])=O 0.000 abstract 1
- 150000003857 carboxamides Chemical class 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000010511 deprotection reaction Methods 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 230000008018 melting Effects 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000005561 phenanthryl group Chemical group 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 125000006413 ring segment Chemical group 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31337601P | 2001-08-17 | 2001-08-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR036352A1 true AR036352A1 (es) | 2004-09-01 |
Family
ID=23215476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020103083A AR036352A1 (es) | 2001-08-17 | 2002-08-15 | Proceso para la preparacion de 5-sulfonamido-8-hidroxi-1, 6-naftiridin-7-carboxamidas |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20050014780A1 (enExample) |
| EP (1) | EP1427726A1 (enExample) |
| JP (1) | JP2005504770A (enExample) |
| AR (1) | AR036352A1 (enExample) |
| CA (1) | CA2456155A1 (enExample) |
| WO (1) | WO2003016309A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE430745T1 (de) | 2000-10-12 | 2009-05-15 | Merck & Co Inc | Aza- und polyaza naphthalenyl karboxamide als inhibitoren der hiv-integrase |
| EP1558585B1 (en) * | 2002-10-04 | 2013-09-25 | Prana Biotechnology Limited | Neurologically-active compounds |
| WO2005028478A1 (en) | 2003-09-19 | 2005-03-31 | Gilead Sciences, Inc. | Aza-quinolinol phosphonate integrase inhibitor compounds |
| EP1888581A2 (en) * | 2005-05-16 | 2008-02-20 | Gilead Sciences, Inc. | Hiv-integrase inhibitor compounds |
| BRPI0722382A2 (pt) | 2006-04-14 | 2012-06-05 | Prana Biotechnology Ltd | compostos úteis para o tratamento de cáncer |
| EP3313420B1 (en) | 2015-06-25 | 2024-03-13 | The Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion, enrichment, and maintenance |
| WO2017161001A1 (en) | 2016-03-15 | 2017-09-21 | Children's Medical Center Corporation | Methods and compositions relating to hematopoietic stem cell expansion |
| DK4426434T3 (da) | 2021-11-02 | 2025-11-10 | Flare Therapeutics Inc | Pparg inverse agonists and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH214351A (de) * | 1938-08-30 | 1941-04-15 | Cilag Chemisches Ind Lab A G | Verfahren zur Darstellung eines Derivates des 2-Aminopyridins. |
| ATE430745T1 (de) * | 2000-10-12 | 2009-05-15 | Merck & Co Inc | Aza- und polyaza naphthalenyl karboxamide als inhibitoren der hiv-integrase |
-
2002
- 2002-08-13 EP EP02763531A patent/EP1427726A1/en not_active Withdrawn
- 2002-08-13 CA CA002456155A patent/CA2456155A1/en not_active Abandoned
- 2002-08-13 US US10/486,535 patent/US20050014780A1/en not_active Abandoned
- 2002-08-13 JP JP2003521232A patent/JP2005504770A/ja not_active Withdrawn
- 2002-08-13 WO PCT/US2002/027151 patent/WO2003016309A1/en not_active Ceased
- 2002-08-15 AR ARP020103083A patent/AR036352A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003016309A1 (en) | 2003-02-27 |
| US20050014780A1 (en) | 2005-01-20 |
| CA2456155A1 (en) | 2003-02-27 |
| EP1427726A1 (en) | 2004-06-16 |
| JP2005504770A (ja) | 2005-02-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR050703A1 (es) | Compuestos heterociclicos antiviricos | |
| AR043436A1 (es) | Tetrahidroisoquinolinas sustituidas para uso como moduladores 5-ht6 | |
| CL2010000350A1 (es) | Proceso para la preparacion de esteres boricos en un solvente de baja miscibilidad en agua. (divisional sol. n° 734-05). | |
| ATE185558T1 (de) | Prostaglandin-synthase hemmer | |
| ES8207120A1 (es) | Un procedimiento para la preparacion de nuevos derivados transisomericos de 4-fenil-1,2,3,4-tetrahidro-1-naftalenami-na. | |
| ES8202777A1 (es) | Un procedimiento para la preparacion de fenoxialcoxifenil derivados | |
| PE20000048A1 (es) | Prodrogas de inhibidores de aspartil proteasa | |
| KR930016389A (ko) | No 신타제 및 시클로옥시게나제의 이중 억제제, 이들의 제조방법 및 이들을 함유하는 치료 조성물 | |
| AR082581A2 (es) | Procedimientos de preparacion de combretastatinas | |
| CU20080213A7 (es) | Nuevo procedimiento para la preparación de un intermediario útil en la preparación de imidazotriazinonas sustituidas con sulfonamida | |
| AR068897A1 (es) | Inhibidores de proteasoma | |
| ES8703437A1 (es) | Procedimiento para la preparacion de 4h-3,1-benzoxazin-4-- onas y compuestos relacionados | |
| PE58599A1 (es) | 2-amino-6-(4-fenoxi-2-sustituido)-piridinas sustituidas | |
| ES8801618A1 (es) | Un procedimiento para preparar derivados de arilciclobutilalquilamina | |
| ES8606879A1 (es) | Un procedimiento para la preparacion de derivados esteroida-les | |
| EA200501104A1 (ru) | Производные пиридина, пригодные для ингибирования системы обмена натрия/кальция | |
| KR950011445A (ko) | 갈란타민 유도체, 이의 제조방법 및 약제로서의 이의 용도 | |
| KR850001198A (ko) | 카복실산 유도체의 제조방법 | |
| ES2129615T3 (es) | Uso de dimetilbenzofuranos y dimetilbenzopiranos como antagonistas 5-ht3. | |
| ES8301883A1 (es) | Procedimiento para la preparacion de derivados de ciclohexe-no | |
| ES8601913A1 (es) | Procedimiento para preparar bencimidazoles | |
| KR890006616A (ko) | 아제티디닐 퀴놀론 카복실산 및 에스테르 | |
| PE20060939A1 (es) | Metabolitos derivados de [1,4] diazepin[6,7,1-ij] quinolina y procedimiento de preparacion | |
| AR003328A1 (es) | Proceso para la preparacion de nitro-sustituido-difenileteres, utiles como herbicidas o como intermediarios en la sintesis de herbicidas | |
| ES8504792A1 (es) | Un procedimiento para preparar derivados de pirimidina |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |