CA2454136A1 - 5-aminolevulinic acid and esters, in combination with another photosensitizer, as photosensitizing agents in photochemotherapy, and their uses in_treating wounds - Google Patents
5-aminolevulinic acid and esters, in combination with another photosensitizer, as photosensitizing agents in photochemotherapy, and their uses in_treating wounds Download PDFInfo
- Publication number
- CA2454136A1 CA2454136A1 CA002454136A CA2454136A CA2454136A1 CA 2454136 A1 CA2454136 A1 CA 2454136A1 CA 002454136 A CA002454136 A CA 002454136A CA 2454136 A CA2454136 A CA 2454136A CA 2454136 A1 CA2454136 A1 CA 2454136A1
- Authority
- CA
- Canada
- Prior art keywords
- ala
- wound
- photosensitizer
- ala ester
- ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 210000000936 intestine Anatomy 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
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- 239000002353 niosome Substances 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002405 nuclear magnetic resonance imaging agent Substances 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 229940006093 opthalmologic coloring agent diagnostic Drugs 0.000 description 1
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- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- FHHPUSMSKHSNKW-SMOYURAASA-M sodium deoxycholate Chemical compound [Na+].C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 FHHPUSMSKHSNKW-SMOYURAASA-M 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
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- 239000003381 stabilizer Substances 0.000 description 1
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- 150000003751 zinc Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0118251.8 | 2001-07-26 | ||
| GBGB0118251.8A GB0118251D0 (en) | 2001-07-26 | 2001-07-26 | Method |
| PCT/GB2002/003386 WO2003011265A2 (en) | 2001-07-26 | 2002-07-25 | 5-aminolevulinic acid and esters, in combination with another phtosensitizer, as photosensitizing agents in photochemotherapy, and their uses in treating wounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2454136A1 true CA2454136A1 (en) | 2003-02-13 |
Family
ID=9919248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002454136A Abandoned CA2454136A1 (en) | 2001-07-26 | 2002-07-25 | 5-aminolevulinic acid and esters, in combination with another photosensitizer, as photosensitizing agents in photochemotherapy, and their uses in_treating wounds |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20040259949A1 (enExample) |
| EP (1) | EP1414430A2 (enExample) |
| JP (1) | JP2005501050A (enExample) |
| KR (1) | KR20040030863A (enExample) |
| CN (1) | CN1533271A (enExample) |
| CA (1) | CA2454136A1 (enExample) |
| CZ (1) | CZ2004257A3 (enExample) |
| GB (1) | GB0118251D0 (enExample) |
| HU (1) | HUP0401192A3 (enExample) |
| MX (1) | MXPA04000647A (enExample) |
| NO (1) | NO20040321L (enExample) |
| RU (1) | RU2004105655A (enExample) |
| WO (1) | WO2003011265A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7888526B2 (en) | 2004-03-26 | 2011-02-15 | Photocure Asa | Acid addition salts of 5-aminolevulinic acid or its derivatives |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0018528D0 (en) | 2000-07-27 | 2000-09-13 | Photocure Asa | Compounds |
| NL1020336C2 (nl) * | 2002-04-09 | 2003-10-13 | Photobiochem Leiden N V | Toepassing van een verbinding voor de bereiding van een farmaceutisch preparaat voor het behandelen van brandwonden, en een werkwijze voor het behandelen van brandwonden. |
| NL1022597C2 (nl) * | 2003-02-05 | 2004-08-06 | Photobiochem N V | Toepassing van een fotosensitizerverbinding voor de bereiding van een farmaceutisch preparaat, werkwijze voor het bereiden van een farmaceutisch preparaat en een werkwijze voor het behandelen van een zoogdier. |
| TR200504022T1 (tr) * | 2003-03-24 | 2006-08-21 | Hetero Drugs Limited | (S)-sitalopram oksalatın yeni sıvı kristal formları. |
| GB0420888D0 (en) * | 2004-09-20 | 2004-10-20 | Photopharmica Ltd | Compounds and uses |
| GB0424833D0 (en) | 2004-11-10 | 2004-12-15 | Photocure Asa | Method |
| US8685421B2 (en) | 2006-07-07 | 2014-04-01 | Surmodics, Inc. | Beaded wound spacer device |
| ATE454146T1 (de) * | 2006-08-29 | 2010-01-15 | Stichting Tech Wetenschapp | Pharmazeutische zusammensetzung zur behandlung von mykotischen hauterkrankungen und verfahren zu ihrer herstellung |
| JP2011506425A (ja) * | 2007-12-14 | 2011-03-03 | フォトデルマ エスアー | 治療的及び美容的方法に有用な新規化合物 |
| EP2268311A4 (en) * | 2008-04-04 | 2014-08-27 | Immunolight Llc | NON-INVASIVE SYSTEMS AND IN SITU PHOTOBIOMODULATION METHODS |
| RU2395315C1 (ru) * | 2008-12-01 | 2010-07-27 | Государственное унитарное предприятие г. Москвы Международный научный и клинический центр "Интермедбиофизхим" (ГУП МНКЦ "Интермедбиофизхим") | Способ фотодинамической терапии гнойных ран и трофических язв |
| GB0823472D0 (en) | 2008-12-23 | 2009-01-28 | Photocure Asa | Product |
| GB0900461D0 (en) * | 2009-01-12 | 2009-02-11 | Photocure Asa | Photodynamic therapy device |
| CN102458388B (zh) | 2009-06-11 | 2016-09-28 | 光治疗Asa公司 | 半固体组合物及药物制品 |
| GB0914286D0 (en) * | 2009-08-14 | 2009-09-30 | Pci Biotech As | Method |
| GB0914287D0 (en) | 2009-08-14 | 2009-09-30 | Pci Biotech As | Compositions |
| JP2013521251A (ja) | 2010-03-01 | 2013-06-10 | フォトキュア エイエスエイ | 美容組成物 |
| EP2585111A1 (en) | 2010-06-23 | 2013-05-01 | Photocure ASA | Hyperosmotic preparations comprising 5 -amino levulinic acid or derivative as photosensitizing agent |
| BR112013000613A2 (pt) | 2010-07-09 | 2016-06-28 | Photocure Asa | composições secas e dispositivos que contêm tais composições secas |
| WO2012012616A1 (en) * | 2010-07-21 | 2012-01-26 | Patty-Fu Giles | Photoactive vitamin nanoparticles for the treatment of chronic wounds |
| US20140056964A1 (en) * | 2010-12-06 | 2014-02-27 | The University Of British Columbia | Granzyme b inhibitor compositions, methods and uses for promoting wound healing |
| CN104152530B (zh) | 2010-12-24 | 2017-09-19 | 爱科来株式会社 | 癌细胞的检测方法 |
| KR101254752B1 (ko) * | 2011-02-28 | 2013-04-15 | 부산대학교 산학협력단 | 광역동치료의 광증감제로 사용하기 위한 구연산을 이용한 아미노레불리닉산 트라이머 |
| KR101254758B1 (ko) * | 2011-02-28 | 2013-04-15 | 부산대학교병원 | 광역동치료의 광증감제로 사용하기 위한 이디티에이를 이용한 아미노레불리닉산 테트라머 |
| WO2012172821A1 (ja) * | 2011-06-16 | 2012-12-20 | Ｓｂｉファーマ株式会社 | アレルギー性鼻炎の治療剤 |
| US20140276107A1 (en) | 2011-10-14 | 2014-09-18 | Photocure Asa | Photodynamic diagnosis |
| EP2779956A1 (en) | 2011-10-14 | 2014-09-24 | Photocure ASA | Stent |
| WO2013092505A1 (en) | 2011-12-19 | 2013-06-27 | Photocure Asa | Irradiation apparatus |
| CA2888241C (en) | 2012-10-16 | 2020-12-29 | Surmodics, Inc. | Wound packing device and methods |
| GB201306369D0 (en) | 2013-04-09 | 2013-05-22 | Photocure As | Irradiation device |
| WO2014203833A1 (ja) * | 2013-06-19 | 2014-12-24 | Ｓｂｉファーマ株式会社 | プロトポルフィリンｉｘ生成促進用医薬組成物 |
| US10201457B2 (en) | 2014-08-01 | 2019-02-12 | Surmodics, Inc. | Wound packing device with nanotextured surface |
| RU2604399C1 (ru) * | 2015-12-01 | 2016-12-10 | Сергей Владимирович Москвин | Способ лазерной терапии больных трофическими язвами |
| RU2661084C1 (ru) * | 2017-07-21 | 2018-07-11 | Федеральное Агентство Научных Организаций Федеральное Государственное Бюджетное Научное Учреждение "Федеральный Научно-Клинический Центр Реаниматологии И Реабилитологии" (Фнкц Рр) | Способ комплексного лечения пролежней у пациентов с длительной иммобилизацией |
| CN109453408A (zh) * | 2018-11-16 | 2019-03-12 | 江南大学 | 抗菌创伤敷料及其制备方法 |
| CN112062713B (zh) * | 2020-08-04 | 2023-03-31 | 浙江工业大学 | 具铁螯合性和pdt活性的ala-hpo杂合衍生物及其制备方法与应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5234940A (en) * | 1989-07-28 | 1993-08-10 | Queen's University | Photochemotherapeutic method using 5-aminolevulinic acid and precursors thereof |
| US5913884A (en) * | 1996-09-19 | 1999-06-22 | The General Hospital Corporation | Inhibition of fibrosis by photodynamic therapy |
| GB0018528D0 (en) * | 2000-07-27 | 2000-09-13 | Photocure Asa | Compounds |
-
2001
- 2001-07-26 GB GBGB0118251.8A patent/GB0118251D0/en not_active Ceased
-
2002
- 2002-07-25 RU RU2004105655/15A patent/RU2004105655A/ru not_active Application Discontinuation
- 2002-07-25 CN CNA028145801A patent/CN1533271A/zh active Pending
- 2002-07-25 US US10/484,743 patent/US20040259949A1/en not_active Abandoned
- 2002-07-25 CA CA002454136A patent/CA2454136A1/en not_active Abandoned
- 2002-07-25 EP EP02747590A patent/EP1414430A2/en not_active Withdrawn
- 2002-07-25 CZ CZ2004257A patent/CZ2004257A3/cs unknown
- 2002-07-25 MX MXPA04000647A patent/MXPA04000647A/es unknown
- 2002-07-25 WO PCT/GB2002/003386 patent/WO2003011265A2/en not_active Ceased
- 2002-07-25 KR KR10-2004-7001165A patent/KR20040030863A/ko not_active Withdrawn
- 2002-07-25 JP JP2003516496A patent/JP2005501050A/ja active Pending
- 2002-07-25 HU HU0401192A patent/HUP0401192A3/hu unknown
-
2004
- 2004-01-23 NO NO20040321A patent/NO20040321L/no not_active Application Discontinuation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7888526B2 (en) | 2004-03-26 | 2011-02-15 | Photocure Asa | Acid addition salts of 5-aminolevulinic acid or its derivatives |
| US8692014B2 (en) | 2004-03-26 | 2014-04-08 | Photocure Asa | Acid addition salts of 5-aminolevulinic acid or its derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003011265A2 (en) | 2003-02-13 |
| WO2003011265A3 (en) | 2003-04-24 |
| CN1533271A (zh) | 2004-09-29 |
| CZ2004257A3 (cs) | 2004-08-18 |
| KR20040030863A (ko) | 2004-04-09 |
| HUP0401192A2 (hu) | 2004-12-28 |
| US20040259949A1 (en) | 2004-12-23 |
| RU2004105655A (ru) | 2005-04-10 |
| NO20040321L (no) | 2004-03-19 |
| GB0118251D0 (en) | 2001-09-19 |
| HUP0401192A3 (en) | 2005-07-28 |
| MXPA04000647A (es) | 2004-05-17 |
| JP2005501050A (ja) | 2005-01-13 |
| EP1414430A2 (en) | 2004-05-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |