CA2453245A1 - Fluoro linkers and their use as linkers for enzyme-activated drug conjugates - Google Patents

Fluoro linkers and their use as linkers for enzyme-activated drug conjugates Download PDF

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Publication number
CA2453245A1
CA2453245A1 CA002453245A CA2453245A CA2453245A1 CA 2453245 A1 CA2453245 A1 CA 2453245A1 CA 002453245 A CA002453245 A CA 002453245A CA 2453245 A CA2453245 A CA 2453245A CA 2453245 A1 CA2453245 A1 CA 2453245A1
Authority
CA
Canada
Prior art keywords
gly
leu
cys
formula
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002453245A
Other languages
English (en)
French (fr)
Inventor
Francesco Angelucci
Antonino Suarato
Michele Caruso
Alessandra Scolaro
Enrico Pesenti
Daniela Faiardi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2453245A1 publication Critical patent/CA2453245A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002453245A 2001-08-10 2002-07-29 Fluoro linkers and their use as linkers for enzyme-activated drug conjugates Abandoned CA2453245A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0119578.3 2001-08-10
GBGB0119578.3A GB0119578D0 (en) 2001-08-10 2001-08-10 Fluoro linkers
PCT/EP2002/008637 WO2003014069A1 (en) 2001-08-10 2002-07-29 Fluoro linkers and their use as linkers for enzyme-activated drug conjugates

Publications (1)

Publication Number Publication Date
CA2453245A1 true CA2453245A1 (en) 2003-02-20

Family

ID=9920208

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002453245A Abandoned CA2453245A1 (en) 2001-08-10 2002-07-29 Fluoro linkers and their use as linkers for enzyme-activated drug conjugates

Country Status (6)

Country Link
US (1) US20050107543A1 (ja)
EP (1) EP1414792A1 (ja)
JP (1) JP2004537592A (ja)
CA (1) CA2453245A1 (ja)
GB (1) GB0119578D0 (ja)
WO (1) WO2003014069A1 (ja)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6350756B1 (en) 2001-01-18 2002-02-26 California Pacific Medical Center Camptothecin derivatives
US6403604B1 (en) 2001-03-01 2002-06-11 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6855720B2 (en) 2001-03-01 2005-02-15 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6703399B2 (en) * 2002-05-06 2004-03-09 The Stehlin Foundation For Cancer Research Halo-alkyl esters of camptothecins and methods of treating cancer using these compounds
US6699875B2 (en) 2002-05-06 2004-03-02 The Stehlin Foundation For Cancer Research Cascade esters of camptothecins and methods of treating cancer using these compounds
WO2003101998A1 (en) * 2002-06-03 2003-12-11 California Pacific Medical Center Nitrogen-based homo-camptothecin derivatives
US7875602B2 (en) 2005-10-21 2011-01-25 Sutter West Bay Hospitals Camptothecin derivatives as chemoradiosensitizing agents
CN102375040B (zh) * 2010-08-23 2014-02-05 中国科学院上海药物研究所 一种测定人或动物全血中喜明替康和吉咪替康含量的方法
EP2592103A1 (en) 2011-11-08 2013-05-15 Adriacell S.p.A. Polymer aldehyde derivatives
KR101444877B1 (ko) * 2011-12-30 2014-10-01 주식회사 삼양바이오팜 감마폴리글루탐산으로 구성된 현장 가교 수화겔 및 그의 제조 방법
EP2914600A2 (en) 2012-10-30 2015-09-09 Nerviano Medical Sciences S.r.l. Functionalized 9-bromo-camptothecin derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9721069D0 (en) * 1997-10-03 1997-12-03 Pharmacia & Upjohn Spa Polymeric derivatives of camptothecin
GB9721070D0 (en) * 1997-10-03 1997-12-03 Pharmacia & Upjohn Spa Bioactive derivatives of camptothecin
JP2004177996A (ja) * 2002-11-22 2004-06-24 Toshiba Corp 階層型データベース装置及び階層型データベースの構築方法
JP4138462B2 (ja) * 2002-11-22 2008-08-27 株式会社東芝 階層構造表示装置および階層構造表示方法
JP3660667B2 (ja) * 2003-07-29 2005-06-15 株式会社東芝 データ処理装置、データ処理方法およびプログラム
JP4153883B2 (ja) * 2004-03-02 2008-09-24 株式会社東芝 階層型データベース装置および階層型データベース装置における製品選定方法およびプログラム
JP4181080B2 (ja) * 2004-03-31 2008-11-12 株式会社東芝 階層型データベース管理システム、階層型データベース管理方法及び階層型データベース管理プログラム

Also Published As

Publication number Publication date
EP1414792A1 (en) 2004-05-06
US20050107543A1 (en) 2005-05-19
JP2004537592A (ja) 2004-12-16
WO2003014069A1 (en) 2003-02-20
GB0119578D0 (en) 2001-10-03

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