CA2449189A1 - Modulateurs allosteriques positifs des recepteurs ampa naphtothiazine (paarm) - Google Patents
Modulateurs allosteriques positifs des recepteurs ampa naphtothiazine (paarm) Download PDFInfo
- Publication number
- CA2449189A1 CA2449189A1 CA002449189A CA2449189A CA2449189A1 CA 2449189 A1 CA2449189 A1 CA 2449189A1 CA 002449189 A CA002449189 A CA 002449189A CA 2449189 A CA2449189 A CA 2449189A CA 2449189 A1 CA2449189 A1 CA 2449189A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- nr6r7
- different
- halogen
- halogen atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Abstract
La présente invention concerne de nouveaux modulateurs allostériques positifs des récepteurs AMPA de formule générale (I), dans laquelle R?1¿, R?2¿, R?3¿, R?4¿ et R?5¿ ont les significations indiquées dans la description et dans les revendications, ainsi que des méthodes de préparation desdits modulateurs et leur utilisation sous forme de compositions pharmaceutiques.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10123952A DE10123952A1 (de) | 2001-05-17 | 2001-05-17 | Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
| DE10123952.1 | 2001-05-17 | ||
| PCT/EP2002/005338 WO2002100411A1 (fr) | 2001-05-17 | 2002-05-15 | Modulateurs allosteriques positifs des recepteurs ampa naphtothiazine (paarm) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2449189A1 true CA2449189A1 (fr) | 2002-12-19 |
Family
ID=7685080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002449189A Abandoned CA2449189A1 (fr) | 2001-05-17 | 2002-05-15 | Modulateurs allosteriques positifs des recepteurs ampa naphtothiazine (paarm) |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP1404340A1 (fr) |
| JP (1) | JP2004529980A (fr) |
| KR (1) | KR20040007572A (fr) |
| CN (1) | CN1533278A (fr) |
| AR (1) | AR036332A1 (fr) |
| BG (1) | BG108324A (fr) |
| BR (1) | BR0209796A (fr) |
| CA (1) | CA2449189A1 (fr) |
| CO (1) | CO5550460A2 (fr) |
| CZ (1) | CZ20033112A3 (fr) |
| DE (1) | DE10123952A1 (fr) |
| EA (1) | EA006608B1 (fr) |
| EC (1) | ECSP034852A (fr) |
| EE (1) | EE200300566A (fr) |
| HR (1) | HRP20030933A2 (fr) |
| HU (1) | HUP0401273A3 (fr) |
| IL (1) | IL158642A0 (fr) |
| MX (1) | MXPA03010373A (fr) |
| NO (1) | NO20035088L (fr) |
| NZ (1) | NZ530154A (fr) |
| PL (1) | PL364053A1 (fr) |
| SK (1) | SK14222003A3 (fr) |
| UY (1) | UY27290A1 (fr) |
| WO (1) | WO2002100411A1 (fr) |
| YU (1) | YU90403A (fr) |
| ZA (1) | ZA200308466B (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20090047534A (ko) * | 2006-08-31 | 2009-05-12 | 더 거버너스 오브 더 유니버시티 오브 앨버타 | 양성 알로스테릭 ａｍｐａ 수용체 조절인자를 사용하여 호흡 저하를 억제하는 방법 |
| CN111518058B (zh) * | 2020-05-29 | 2021-03-09 | 四川大学华西医院 | 一种噁噻嗪类化合物及其用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4345297A (en) * | 1996-09-17 | 1998-04-14 | Regents Of The University Of California, The | Benzothiadiazide derivatives and their use as allosteric up-modulators of the ampa receptor |
| JP2002518498A (ja) * | 1998-06-25 | 2002-06-25 | メルク エンド カムパニー インコーポレーテッド | ナフト［１，８−ｄｅ］チアジン−２−イルメチルカルバペネム抗菌物質 |
| DE10004572A1 (de) * | 2000-02-02 | 2001-08-09 | Boehringer Ingelheim Pharma | Neue positive allosterische AMPA-Rezeptor Modulatoren (PAARM), Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
-
2001
- 2001-05-17 DE DE10123952A patent/DE10123952A1/de not_active Withdrawn
-
2002
- 2002-05-15 BR BR0209796-6A patent/BR0209796A/pt not_active Expired - Fee Related
- 2002-05-15 IL IL15864202A patent/IL158642A0/xx unknown
- 2002-05-15 MX MXPA03010373A patent/MXPA03010373A/es unknown
- 2002-05-15 HU HU0401273A patent/HUP0401273A3/hu unknown
- 2002-05-15 EE EEP200300566A patent/EE200300566A/xx unknown
- 2002-05-15 PL PL02364053A patent/PL364053A1/xx not_active Application Discontinuation
- 2002-05-15 YU YU90403A patent/YU90403A/sh unknown
- 2002-05-15 EA EA200301167A patent/EA006608B1/ru not_active IP Right Cessation
- 2002-05-15 CZ CZ20033112A patent/CZ20033112A3/cs unknown
- 2002-05-15 CA CA002449189A patent/CA2449189A1/fr not_active Abandoned
- 2002-05-15 EP EP02750931A patent/EP1404340A1/fr not_active Withdrawn
- 2002-05-15 CN CNA028100832A patent/CN1533278A/zh active Pending
- 2002-05-15 JP JP2003503232A patent/JP2004529980A/ja not_active Abandoned
- 2002-05-15 KR KR10-2003-7014965A patent/KR20040007572A/ko not_active Application Discontinuation
- 2002-05-15 NZ NZ530154A patent/NZ530154A/en unknown
- 2002-05-15 WO PCT/EP2002/005338 patent/WO2002100411A1/fr not_active Application Discontinuation
- 2002-05-15 SK SK1422-2003A patent/SK14222003A3/sk unknown
- 2002-05-15 UY UY27290A patent/UY27290A1/es not_active Application Discontinuation
- 2002-05-17 AR ARP020101827A patent/AR036332A1/es not_active Suspension/Interruption
-
2003
- 2003-10-30 ZA ZA200308466A patent/ZA200308466B/en unknown
- 2003-11-07 BG BG108324A patent/BG108324A/bg active Pending
- 2003-11-14 HR HR20030933A patent/HRP20030933A2/xx not_active Application Discontinuation
- 2003-11-14 NO NO20035088A patent/NO20035088L/no not_active Application Discontinuation
- 2003-11-17 EC EC2003004852A patent/ECSP034852A/es unknown
- 2003-12-01 CO CO03105591A patent/CO5550460A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1533278A (zh) | 2004-09-29 |
| SK14222003A3 (sk) | 2004-05-04 |
| AR036332A1 (es) | 2004-09-01 |
| NZ530154A (en) | 2005-09-30 |
| ZA200308466B (en) | 2004-05-24 |
| MXPA03010373A (es) | 2004-03-16 |
| CZ20033112A3 (en) | 2004-03-17 |
| CO5550460A2 (es) | 2005-08-31 |
| BG108324A (bg) | 2004-12-30 |
| HUP0401273A2 (hu) | 2004-10-28 |
| IL158642A0 (en) | 2004-05-12 |
| KR20040007572A (ko) | 2004-01-24 |
| HRP20030933A2 (en) | 2004-04-30 |
| ECSP034852A (es) | 2003-12-24 |
| PL364053A1 (en) | 2004-12-13 |
| JP2004529980A (ja) | 2004-09-30 |
| NO20035088D0 (no) | 2003-11-14 |
| NO20035088L (no) | 2003-11-14 |
| UY27290A1 (es) | 2002-12-31 |
| EA200301167A1 (ru) | 2004-06-24 |
| BR0209796A (pt) | 2004-06-01 |
| EP1404340A1 (fr) | 2004-04-07 |
| DE10123952A1 (de) | 2002-11-21 |
| EE200300566A (et) | 2004-02-16 |
| WO2002100411A1 (fr) | 2002-12-19 |
| HUP0401273A3 (en) | 2006-11-28 |
| EA006608B1 (ru) | 2006-02-24 |
| YU90403A (sh) | 2006-05-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |