CA2447779C - Dihydropyrrolo[1,2-a]indole and tetrahydropyrido[1,2-a]-indole derivatives as prostaglandin d2 receptor antagonists - Google Patents

Dihydropyrrolo[1,2-a]indole and tetrahydropyrido[1,2-a]-indole derivatives as prostaglandin d2 receptor antagonists Download PDF

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Publication number
CA2447779C
CA2447779C CA2447779A CA2447779A CA2447779C CA 2447779 C CA2447779 C CA 2447779C CA 2447779 A CA2447779 A CA 2447779A CA 2447779 A CA2447779 A CA 2447779A CA 2447779 C CA2447779 C CA 2447779C
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CA
Canada
Prior art keywords
ch3s
halogen
optionally substituted
compound
phe
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2447779A
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English (en)
French (fr)
Other versions
CA2447779A1 (en
Inventor
Zhaoyin Wang
Christian Beaulieu
Claude Dufresne
Daniel Guay
Yves Leblanc
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Merck Canada Inc
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Merck Frosst Canada Ltd
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Publication date
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Publication of CA2447779A1 publication Critical patent/CA2447779A1/en
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Publication of CA2447779C publication Critical patent/CA2447779C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
CA2447779A 2001-05-23 2002-05-22 Dihydropyrrolo[1,2-a]indole and tetrahydropyrido[1,2-a]-indole derivatives as prostaglandin d2 receptor antagonists Expired - Fee Related CA2447779C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29307701P 2001-05-23 2001-05-23
US60/293,077 2001-05-23
PCT/CA2002/000745 WO2002094830A2 (en) 2001-05-23 2002-05-22 DIHYDROPYRROLO[1,2-A]INDOLE AND TETRAHYDROPYRIDO[1,2-a]-INDOLE DERIVATIVES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS

Publications (2)

Publication Number Publication Date
CA2447779A1 CA2447779A1 (en) 2002-11-28
CA2447779C true CA2447779C (en) 2010-08-31

Family

ID=23127559

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2447779A Expired - Fee Related CA2447779C (en) 2001-05-23 2002-05-22 Dihydropyrrolo[1,2-a]indole and tetrahydropyrido[1,2-a]-indole derivatives as prostaglandin d2 receptor antagonists

Country Status (9)

Country Link
US (1) US7144913B2 (https=)
EP (1) EP1395590B1 (https=)
JP (1) JP4279561B2 (https=)
AT (1) ATE340796T1 (https=)
AU (1) AU2002302248B2 (https=)
CA (1) CA2447779C (https=)
DE (1) DE60215000T2 (https=)
ES (1) ES2272712T3 (https=)
WO (1) WO2002094830A2 (https=)

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Also Published As

Publication number Publication date
DE60215000D1 (de) 2006-11-09
WO2002094830A8 (en) 2003-04-10
ATE340796T1 (de) 2006-10-15
DE60215000T2 (de) 2007-08-09
EP1395590A2 (en) 2004-03-10
ES2272712T3 (es) 2007-05-01
US20040180934A1 (en) 2004-09-16
WO2002094830A3 (en) 2003-03-06
WO2002094830A2 (en) 2002-11-28
AU2002302248B2 (en) 2008-03-06
CA2447779A1 (en) 2002-11-28
JP4279561B2 (ja) 2009-06-17
US7144913B2 (en) 2006-12-05
EP1395590B1 (en) 2006-09-27
JP2004534774A (ja) 2004-11-18

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