CA2447632C - Fusion protein agonist comprising a growth hormone binding portion and an external domain of a growth hormone receptor - Google Patents
Fusion protein agonist comprising a growth hormone binding portion and an external domain of a growth hormone receptor Download PDFInfo
- Publication number
- CA2447632C CA2447632C CA2447632A CA2447632A CA2447632C CA 2447632 C CA2447632 C CA 2447632C CA 2447632 A CA2447632 A CA 2447632A CA 2447632 A CA2447632 A CA 2447632A CA 2447632 C CA2447632 C CA 2447632C
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- fusion protein
- cell
- growth hormone
- leu
- vector
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
- Y10S530/815—Carrier is a synthetic polymer
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
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- Hematology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0014765A GB0014765D0 (en) | 2000-06-16 | 2000-06-16 | Binding agent |
| GB0014765.2 | 2000-06-16 | ||
| GB0105969A GB0105969D0 (en) | 2001-03-10 | 2001-03-10 | Binding agent |
| GB0105969.0 | 2001-03-10 | ||
| GB0106487.2 | 2001-03-16 | ||
| GB0106487A GB0106487D0 (en) | 2001-03-16 | 2001-03-16 | Agent |
| PCT/GB2001/002645 WO2001096565A2 (en) | 2000-06-16 | 2001-06-18 | Binding agents: chimeric ligand/receptor proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2447632A1 CA2447632A1 (en) | 2001-12-20 |
| CA2447632C true CA2447632C (en) | 2011-08-02 |
Family
ID=27255767
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2447632A Expired - Fee Related CA2447632C (en) | 2000-06-16 | 2001-06-18 | Fusion protein agonist comprising a growth hormone binding portion and an external domain of a growth hormone receptor |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7446183B2 (https=) |
| EP (2) | EP2316944A3 (https=) |
| JP (1) | JP4660062B2 (https=) |
| AU (1) | AU2001274234A1 (https=) |
| CA (1) | CA2447632C (https=) |
| WO (1) | WO2001096565A2 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4660062B2 (ja) * | 2000-06-16 | 2011-03-30 | アステリオン・リミテッド | 結合剤 |
| GB2389115B (en) * | 2001-12-14 | 2005-03-16 | Asterion Ltd | Polypeptide having a plurality of modified growth hormone receptor binding domains of growth hormone |
| JP2007527695A (ja) | 2003-04-09 | 2007-10-04 | アステリオン・リミテッド | グリコシルホスファチジルイノシトールを含有するポリペプチド |
| DE10353593A1 (de) * | 2003-11-17 | 2005-06-23 | Klinikum der Universität München Großhadern-Innenstadt | Leptinantagonist und Verfahren zur quantitativen Messung von Leptin |
| EP1771467A2 (en) * | 2004-07-26 | 2007-04-11 | Asterion Limited | Linkers |
| GB0600122D0 (en) * | 2006-01-05 | 2006-02-15 | Univ Cardiff | Mutation in the growth hormone receptor |
| GB0606946D0 (en) * | 2006-04-06 | 2006-05-17 | Asterion Ltd | Polypeptide antagonist |
| GB0618082D0 (en) * | 2006-09-14 | 2006-10-25 | Asterion Ltd | Growth factor |
| GB0717985D0 (en) | 2007-07-20 | 2007-10-24 | Asterion Ltd | Growth hormone fusion proteins |
| EP2185582A2 (en) * | 2007-08-03 | 2010-05-19 | Asterion Limited | Erythropoietin fusion proteins |
| US20110182848A1 (en) * | 2007-08-03 | 2011-07-28 | Asterion Limited | Granulocyte colony stimulating factor |
| GB0715216D0 (en) * | 2007-08-03 | 2007-09-12 | Asterion Ltd | Leptin |
| GB0715213D0 (en) * | 2007-08-06 | 2007-09-12 | Asterlon Ltd | Igf-1 |
| GB0715383D0 (en) * | 2007-08-08 | 2007-09-19 | Asterion Ltd | Interferon |
| GB0719818D0 (en) * | 2007-10-11 | 2007-11-21 | Asterion Ltd | Growth hormone fusion polypeptides |
| WO2009077731A2 (en) * | 2007-12-19 | 2009-06-25 | Asterion Limited | Prolactin fusion proteins |
| GB0725201D0 (en) * | 2007-12-24 | 2008-01-30 | Asterion Ltd | Peptide fusion proteins |
| JP2011512134A (ja) * | 2008-02-19 | 2011-04-21 | アステリオン・リミテッド | 修飾リンカー |
| GB0808402D0 (en) * | 2008-05-09 | 2008-06-18 | Asterion Ltd | Tsh |
| GB0812019D0 (en) * | 2008-07-02 | 2008-08-06 | Asterion Ltd | Insulin |
| GB201104285D0 (en) * | 2011-03-15 | 2011-04-27 | Asterion Ltd | Modified receptor fusion proteins |
| EP2606908A1 (en) | 2011-12-19 | 2013-06-26 | Ipsen Pharma S.A.S. | Novel pharmaceutical composition for a long acting growth hormone fusion protein (LAGH) |
| RS61391B1 (sr) | 2012-06-08 | 2021-02-26 | Alkermes Pharma Ireland Ltd | Ligandi modifikovani primenom cirkularnog permutiranja kao agonisti i antagonisti |
| GB201520021D0 (en) * | 2015-11-13 | 2015-12-30 | Asterion Ltd | Fusion polypeptide |
| US20220396609A1 (en) * | 2019-11-01 | 2022-12-15 | Senti Biosciences, Inc. | Chimeric receptor sensors |
| IL306074A (en) | 2021-03-24 | 2023-11-01 | Alkermes Inc | UPAR antibodies and fusion proteins with them |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK151585D0 (da) | 1985-04-03 | 1985-04-03 | Nordisk Gentofte | Dna-sekvens |
| US4857637A (en) * | 1986-05-07 | 1989-08-15 | Genentech, Inc. | Methods and compositions for immunologically modulating growth hormone receptor activity |
| EP0441889A1 (fr) | 1988-11-07 | 1991-08-21 | Commission des Communautés Européennes | Hormone de croissance humaine modifiee |
| JP3417558B2 (ja) | 1991-05-10 | 2003-06-16 | ジェネンテク，インコーポレイテッド | 配位子作用薬および拮抗薬の選択 |
| DE741187T1 (de) * | 1995-05-05 | 1997-04-30 | Hoffmann La Roche | Rekombinante Obesitäts-(OB)-Proteine |
| CA2230492C (en) | 1995-09-21 | 2009-05-26 | Genentech, Inc. | Human growth hormone variants |
| DE19608813C2 (de) * | 1996-03-07 | 1998-07-02 | Angewandte Gentechnologie Syst | Konjugat zur Beeinflussung von Wechselwirkungen zwischen Proteinen |
| US6187564B1 (en) * | 1997-07-10 | 2001-02-13 | Beth Israel Deaconess Medical Center | DNA encoding erythropoietin multimers having modified 5′ and 3′ sequences and its use to prepare EPO therapeutics |
| IL122818A0 (en) | 1997-07-10 | 1998-08-16 | Yeda Res & Dev | Chimeric interleukin-6 soluble receptor/ligand protein analogs thereof and uses thereof |
| JPH11285388A (ja) | 1998-04-03 | 1999-10-19 | Jcr Pharmaceuticals Co Ltd | キメラレセプター発現細胞とその用途 |
| US6472179B2 (en) | 1998-09-25 | 2002-10-29 | Regeneron Pharmaceuticals, Inc. | Receptor based antagonists and methods of making and using |
| JP4660062B2 (ja) * | 2000-06-16 | 2011-03-30 | アステリオン・リミテッド | 結合剤 |
| GB2389115B (en) * | 2001-12-14 | 2005-03-16 | Asterion Ltd | Polypeptide having a plurality of modified growth hormone receptor binding domains of growth hormone |
-
2001
- 2001-06-18 JP JP2002510682A patent/JP4660062B2/ja not_active Expired - Fee Related
- 2001-06-18 US US10/311,473 patent/US7446183B2/en not_active Expired - Fee Related
- 2001-06-18 AU AU2001274234A patent/AU2001274234A1/en not_active Abandoned
- 2001-06-18 WO PCT/GB2001/002645 patent/WO2001096565A2/en not_active Ceased
- 2001-06-18 EP EP10075428A patent/EP2316944A3/en not_active Withdrawn
- 2001-06-18 CA CA2447632A patent/CA2447632C/en not_active Expired - Fee Related
- 2001-06-18 EP EP01940731A patent/EP1290170A2/en not_active Withdrawn
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2008
- 2008-07-18 US US12/175,582 patent/US8173782B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20090054336A1 (en) | 2009-02-26 |
| AU2001274234A1 (en) | 2001-12-24 |
| WO2001096565A3 (en) | 2002-08-01 |
| WO2001096565A2 (en) | 2001-12-20 |
| JP2004503243A (ja) | 2004-02-05 |
| US7446183B2 (en) | 2008-11-04 |
| CA2447632A1 (en) | 2001-12-20 |
| US20040071655A1 (en) | 2004-04-15 |
| US8173782B2 (en) | 2012-05-08 |
| EP2316944A2 (en) | 2011-05-04 |
| JP4660062B2 (ja) | 2011-03-30 |
| EP2316944A3 (en) | 2011-11-02 |
| EP1290170A2 (en) | 2003-03-12 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20150618 |